MCGSBS Program Catalog 2022-2023 Revised 5-2-2022 - Mayo Clinic College .

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Mayo Clinic Graduate School of Biomedical SciencesPh.D., Master’s and Certificate Programs2022-2023Course and Program Cataloghttps://college.mayo.edu

Table of ContentsBoard of Governors. 1Mayo Clinic Mission . 2Academic Calendar (2022-2023). 5Academic Calendar (2023-2024). 6Career Development Internships . 9Policies - at a glance . 11Doctor of Philosophy Program in Biomedical Sciences . 14M.D. – Ph.D. Program. 21Ph.D. Degree ProgramsBiochemistry and Molecular Biology Track . 23Biomedical Engineering and Physiology Track . 25Clinical and Translational Sciences Track. 28Immunology Track. 31Molecular Pharmacology and Experimental Therapeutics Track . 33Neuroscience Track . 35Regenerative Sciences . 38Virology and Gene Therapy Track . 42Postdoctoral Basic Science Master’s Degree Programs . 43Artificial Intelligence in Health Care Track . 46Biochemistry and Molecular Biology Track . 48Clinical and Translational Sciences Track. 49Immunology Track. 53Molecular Pharmacology and Experimental Therapeutics Track . 54Regenerative Sciences Track . 55Virology and Gene Therapy Track . 57Employee-Professional Master’s Degree Programs . 59Biochemistry and Molecular Biology Track . 62Biomedical Engineering and Physiology Track . 64Immunology Track. 66Molecular Pharmacology and Experimental Therapeutics Track . 67Neuroscience Track . 69Virology and Gene Therapy Track . 71Clinical Master’s Degree Programs . 73Orthodontics Clinical Master’s Track . 77Periodontics Clinical Master’s Track. 78Prosthodontics Clinical Master’s Track . 79

OB/GYN - Female Pelvic Medicine/Reconstructive Surgery Master’s Track . 80OB/GYN - Gynecologic Oncology Master’s Track . 81OB/GYN - Maternal Fetal Medicine Master’s Track . 82OB/GYN - Reproductive Endocrinology and Infertility Master’s Track . 83Orthopedics . 84Certificate Degree Programs . 85Artificial Intelligence in Health Care Track . 86Clinical and Translational Sciences Track. 87Course ListingsAnatomy . 90Artificial Intelligence in Health Care .90Biochemistry and Molecular Biology . 92Biomedical Engineering and Physiology . 95Core . 102Clinical and Translational Science. 104Dentistry . 116Dermatology . 120Immunology . 120MDPH (M.D. – Ph.D.) . 122MGS. 123Molecular Pharmacology and Experimental Therapeutics . 124Neuroscience . 126Obstetrics and Gynecology . 128Orthopedics . 130Regenerative Sciences . 131Virology and Gene Therapy . 132Student Services . 134Policies/Procedures/Regulations – FullAbsence and Leave Policy . 137Academic Progress and Graduation Requirements Policy. 141Appointment Eligibility Policy. 143Attendance, Absences, and Tardiness Policy . 145Course Management Policy . 146Credit Transfer Policy . 147Deficiencies and Unsatisfactory Progress Policy. 149Grievance Procedure . 150Satisfactory Academic Progress (SAP) for Financial Aid Recipients Policy . 152Student Records and the Family Education Rights Privacy Act (FERPA) . 154Warning, Probation, Dismissal, and Appeal Policy . 156Warning, Probation, Dismissal, and Appeal Procedure . 157Withdrawal and Tuition Refund Policy. 162Veteran Benefits Educational Assistance Policy. 163Acknowledgements . 164

Mayo Clinic College of Medicine and Science – ArizonaMayo Clinic Graduate School of BiomedicalSciences - Arizona13400 East Shea BlvdScottsdale, AZ 85259https://college.mayo.eduNhan L. Tran, Ph.D.Associate Dean, Mayo Clinic Graduate School of BiomedicalSciencesMayo Clinic College of Medicine and Science – FloridaMayo Clinic Graduate School of BiomedicalSciences - Florida4500 San Pablo Rd SJacksonville, FL 32224https://college.mayo.eduEvette S. Radisky, Ph.D.Associate Dean, Mayo Clinic Graduate School of BiomedicalSciencesMayo Clinic College of Medicine and Science – RochesterMayo Clinic Graduate School of BiomedicalSciences - Rochester200 First Street SWRochester, MN 55905Phone: 507-284-1339Fax: 507-293-0838https://college.mayo.eduStephen C. Ekker, Ph.D.Dean, Mayo Clinic Graduate School of Biomedical SciencesMembers of Mayo Clinic Board of GovernorsGianrico Farrugia, M.D.Chair, MemberAmy K. Hara, M.D.MemberDennis E. DahlenEx-OfficioChristina K. ZornSecretary, MemberClaudi F. Luccinetti, M.D.MemberEvanthia Galanis, M.D.Ex-OfficioMatthew R. Callstrom, M.D., Ph.D.MemberSarah A. McLaughlin, M.D.MemberGregory J. Gores, M.D.Ex-OfficioRoshanak DidehbanMemberCharanjit S. Rihal, M.D.MemberTina E. HolmesEx-OfficioAbimbola O. Famuyide, M.B.B.S.MemberKent R. Thielen, M.D.MemberFrederic B. Meyer, M.D.Ex-OfficioRafael Fonseca, M.D.MemberAmy W. Williams, M.D.MemberJoshua B. MurphyEx-OfficioRichard J. Gray, M.D.MemberPrathibha Varkey, M.B.B.S., M.B.A.Ex-Officio1

Mayo Clinic MissionTo inspire hope and contribute to health and well-being by providing the best care to every patientthrough integrated clinical practice, education, and research.Mayo Clinic Primary ValueThe needs of the patient come first.Mayo Clinic Value StatementsThese values, which guide Mayo Clinic’s mission to this day, are an expression of the vision and intent ofour founders, the original Mayo physicians, and the Sisters of Saint Francis.RespectTreat everyone in our diverse community including patients, their families, and colleagues with dignity.IntegrityAdhere to the highest standards of professionalism, ethics, and personal responsibility, worthy of thetrust our patients place in us.CompassionProvide the best care, treating patients and family members with sensitivity and empathy.HealingInspire hope and nurture the well-being of the whole person, respecting physical, emotional, andspiritual needs.TeamworkValue the contributions of all, blending the skills of individual staff members in unsurpassedcollaboration.InnovationInfuse and energize the organization, enhancing the lives of those we serve, through the creative ideasand unique talents of each employee.ExcellenceDeliver the best outcomes and highest quality service through the dedicated effort of every team member.StewardshipSustain and re-invest in our mission and extended communities by wisely managing our human, naturaland material resources.2

Mayo Clinic Graduate School of Biomedical Sciences MissionThe overriding mission of the Mayo Clinic Graduate School of Biomedical Sciences (MCGSBS) is to trainfuture leaders in biomedical research and education. In order to pursue this goal, we will: Enroll outstanding studentsUtilize the unique education, research and clinical practice resources of Mayo Clinic to foster theindividual academic strengths of each student;Engage students in interactive learning and research experiences that enhance their criticalthinking, problem solving, and biomedical knowledge.A fundamental goal of MCGSBS is to promote an academic environment that supports trainee andfaculty development and facilitates biomedical innovation.3

Mayo Clinic College of Medicine and ScienceFredric B. Meyer, M.D.Juanita Kious Waugh Executive Dean for EducationJohn D. PoeChair, Department of Education AdministrationShannon K. Laughlin-Tommaso, M.D.Associate Dean for Education Diversity, Equity and InclusionMayo Clinic Graduate School of Biomedical SciencesStephen C. Ekker, Ph.D.DeanBruce F. Horazdovsky, Ph.D.Associate Dean, Academic AffairsJ. Luis Lujan, Ph.D., M.S.Associate Dean, Student AffairsVirginia Shapiro, Ph.D.Associate Dean, Faculty AffairsNhan L. Tran, Ph.D.Associate Dean, Mayo Clinic ArizonaJoseph C. Loftus, Ph.D.Assistant Dean, Mayo Clinic in ArizonaEvette Radisky, Ph.D.Associate Dean, Mayo Clinic in FloridaWilfried O. Rossoll, Ph.D.Assistant Dean, Mayo Clinic FloridaJason D. Doles, Ph.D.Assistant Dean, Diversity and InclusionChristopher K. Pierret, Ph.D.Assistant Dean, Academic AffairsKaren S. Nation, MBA/HCMAdministratorRachel L. Halsrud, M.B.A.Operations ManagerHayden T. Nielsen, M.H.S.Operations Manager, Mayo Clinic in ArizonaCaitlyn J. FoerstOperations Manager, Mayo Clinic in Florida4

2022-2023 Academic CalendarSummer Quarter (Term 202310)Registration for summer quarter courses opens – June 1, 2022Registration for summer quarter courses due – June 17, 2022Summer quarter begins – July 5, 2022Independence Day Holiday (observed) – July 4, 2022Last date to register or withdraw – Before one-half of the course is completedLabor Day Holiday – September 6, 2022Last day of quarter – September 23, 2022Fall Quarter (Term 202320)Registration for fall quarter courses opens – September 1, 2022Registration for fall quarter courses due – September 16, 2022Fall quarter begins – September 26, 2022Last date to register or withdraw – Before one-half of the course is completedThanksgiving Holiday – Thursday, November 24, 2022Last day of quarter – December 16, 2022Winter Quarter (Term 202330)Registration for winter quarter courses opens – December 1, 2022Registration for winter quarter courses due – December 16, 2022Winter quarter begins – January 3, 2023Last date to register or withdraw – Before one-half of the course is completedLast day of quarter – March 24, 2023Spring Quarter (Term 202340)Registration for spring quarter courses opens – March 1, 2023Registration for spring quarter courses due – March 17, 2023Spring quarter begins – April 3, 2023Last date to register or withdraw – Before one-half of the course is completedMemorial Day Holiday – May 29, 2023Last day of quarter – June 23, 20235

2023-2024 Academic CalendarSummer Quarter (Term 202410)Registration for summer quarter courses opens – June 1, 2023Registration for summer quarter courses due – June 16, 2023Summer quarter begins – July 3, 2023Independence Day Holiday (observed) – July 4, 2023Last date to register or withdraw – Before one-half of the course is completedLabor Day Holiday – September 4, 2023Last day of quarter – September 22, 2023Fall Quarter (Term 202420)Registration for fall quarter courses opens – September 1, 2023Registration for fall quarter courses due – September 15, 2023Fall quarter begins – September 25, 2023Last date to register or withdraw – Before one-half of the course is completedThanksgiving Holiday – Thursday, November 23, 2023Last day of quarter – December 15, 2023Winter Quarter (Term 202430)Registration for winter quarter courses opens – December 1, 2023Registration for winter quarter courses due – December 15, 2023Winter quarter begins – January 2, 2024Last date to register or withdraw – Before one-half of the course is completedLast day of quarter – March 22, 2024Spring Quarter (Term 202440)Registration for spring quarter courses opens – March 1, 2024Registration for spring quarter courses due – March 15, 2024Spring quarter begins – April 1, 2024Last date to register or withdraw – Before one-half of the course is completedMemorial Day Holiday – May 27, 2024Last day of quarter – June 21, 20246

IntroductionMayo Clinic Graduate School of Biomedical SciencesHistoryThe Mayo Clinic developed gradually from the family medical practice of Dr. William Worrall Mayo andhis sons, Dr. William James Mayo, and Dr. Charles Horace Mayo. The elder Dr. Mayo came to Rochesterin 1863 to practice medicine. His sons assisted him during their boyhood years and later joined him in thepractice of medicine. As the demand for their services increased, the Mayos invited other physicians towork with them.This pioneering venture in the private group practice of medicine became known in the early 1900s asMayo Clinic. This name today describes an organization of over 3,300 scientists and medical and surgicalspecialists working together as a team for the advancement of medical and biomedical education,research in medicine and related sciences, and medical care.Mayo awarded its first Ph.D. degree in 1917 in affiliation with the University of Minnesota. Since 1984,Mayo has been an independent, degree granting institution. In January 1989, MCGSBS became a separateunit that administers Ph.D. and Master’s degree programs in the biomedical sciences. Enrollmentcurrently includes approximately 300 Ph.D. and M.D.-Ph.D. candidates, and 100 Master’s candidates inbiomedical science.Other educational components of Mayo Clinic include: Mayo Clinic School of Graduate Medical Education, organized in 1915 to offer programs ofgraduate medical education. Enrollment currently includes nearly 1,600 residents and fellows inclinical fields. Mayo Clinic Alix School of Medicine (MCASOM), an undergraduate medical school offering theM.D. degree, opened in 1972. Current enrollment includes over 200 students on the Rochester,Minnesota campus and 200 on the MCASOM Arizona campus. Mayo Clinic School of Health Sciences, organized in 1973 to provide training and certification inthe health professions allied to medicine. The school offers 120 programs with an enrollment ofmore than 1,800. Mayo Clinic School of Continuous Professional Development, organized in 1977 to providecontinuing education for care providers within Mayo Clinic, nationally and internationally.Mayo Clinic is accredited by The Higher Learning Commission, https://www.hlcommission.org/.Mayo Clinic College of Medicine and Science is registered with the Minnesota Office of Higher Educationpursuant to Minnesota Statutes sections 136A .61 to 136A .71. Registration is not an endorsement of theinstitution. Credits earned at the institution may not transfer to all other institutions.7

FacultyAll staff appointments are made to Mayo Clinic and this staff constitutes the faculty for the educationalprograms of Mayo Clinic. The 4,000 plus faculty members include full-time investigators in thebiomedical sciences, clinician investigators, and clinicians. Each member of the staff is full-time salariedand individual staff members have ample opportunity to teach. Members of the staff have the overallresponsibility for undergraduate and graduate education in medicine and the biomedical sciences, forcontinuing education and research, as well as for the care of patients. Graduate faculty privileges areawarded to qualified faculty members with interest in delivering graduate level courses and insupervising candidates for graduate degrees.See listing of graduate faculty with full privileges and their research interests here.FacilitiesEducational programs, clinical practice and research are conducted within three key locations; MayoClinic campus in Rochester, Minnesota; Jacksonville, Florida; and Phoenix and Scottsdale, Arizona.TechnologyMayo Clinic in Rochester, Arizona and Florida are linked via a sophisticated telecommunications system,which provides videoconferencing and data transmission. Staff and students in Rochester, Arizona andFlorida can have live, interactive courses and seminars via TV monitors. In addition, Mayo has atelephone dialing and pager system that ties all three sites together.Mayo Clinic also provides delivery of education in a virtual setting to accommodate students who cannotbe physically present in a classroom on the Mayo campus. MCGSBS utilizes Blackboard Collaborate, aweb conferencing/webinar platform designed for use in online teaching, in addition to Zoom and othervirtual delivery tools. The Education Technology Center and Learning Solutions Center have partnered toprovide resources for students and instructors for learning in a virtual setting.Graduate Student AssociationThe Mayo Graduate Student Association is comprised of Ph.D. students pursuing graduate degrees atMCGSBS. Membership includes a representative (rep) from each track, a first year student rep, anArizona and Florida rep, a MCGSBS Education Committee member rep, an M.D.- Ph.D. program rep,social media rep, Mayo Clinic Alumni Association rep, International student rep, MRFA rep, IMSD rep,Communications Liaison, Treasurer, Secretary, and prior year president(s) emeritus. Its purpose is tofacilitate interaction among graduate students, and among students, faculty, and administration. Itprovides a means for students to give input concerning coursework and curriculum and other MCGSBSissues.8

Career Development InternshipsWhat is a Career Development Internship?Career Development Internships (CDIs) are MCGSBS-funded opportunities for upper-level PhD studentsto spend 100 hours (or more) as interns in one of several career environments. CDI internships allowMCGSBS students to explore possible interests, network with professionals, contribute to the mission ofthe CDI partner organization and gain informed appreciation for career options.The goal of the CDI program is to provide MCGSBS students with hands-on experience in diverse careerenvironments to assist with making informed career path decisions.CDI activities are flexible, allowing approximately 100 hours of paid study leave from MCGSBS duringone quarter. For off-site CDI opportunities requiring travel, the CDI program may cover travel andhousing costs. Internships are individualized. The MCGSBS intern and sponsoring CDI partner worktogether to design the ideal experience.We are ready to partner with you to create a CDI experience designed just for you! For questions, pleasecontact Carol (CJ) Prestegard at 6-5277 or email to: prestegard.carol@mayo.edu.CDI Application Process:PhD and MD/PhD students currently in MCGSBS are eligible to apply if they have:1.2.3.4.successfully completed the written and oral qualifying exams,are in good academic standing at MCGSBS (average GPA of 3.0 or higher),have selected a mentor and an area of research, andare making satisfactory PhD thesis research progress.The CDI application includes the following supporting documents, to be combined into a single pdf andemailed to Career Development Applications. If it is a competitive CDI opportunity, the single pdf willneed to be received by the deadline specified in the email announcement.1.2.3.4.CDI ApplicationLetter of recommendation from thesis mentor / or email with thesis mentor’s supportCV or resume1-page single spaced statement of interesta. Specify which of the CDI experiences is requested and an explanation for why you areinterested in this particular opportunity. Include information you wish the CDI partner toconsider.The Special CDI Offering is competitive. Applications are collected for an internal deadline, and thenreviewed internally and by the external CDI collaborator of interest. CDI awards are based on matchingqualifications and interests of the applicant with the proposed CDI partner. Applicants may indicateonly one CDI collaborator in their application.CDI Structure and Students Responsibility of Documentation9

After a student has been selected for a CDI experience, there is the expectation that the experience will bedocumented and provide to MCGSBS.1.2.3.4.5.Selected applicants will be provided with contact information for the CDI collaborator and willhave the responsibility to initiate contact.a. Record of Initial Meeting (form)Working with the CDI collaborator, the student will then develop a CDI Plan to be summarizedin a 1-2 page single-spaced .pdf documenta. The CDI Plan will indicate how the 100-hour internship will occur (a single block of time,or multiple contacts), the name and contact information for the CDI collaborator mentor,and a brief description of planned activities. The 1-2 page CDI Plan summary shouldcontain a budget proposal estimating reimbursable costs associated with any ground traveland/or accommodations. Meal costs are the responsibility of the intern. For CDIexperiences involving travel off campus, trip and reimbursement arrangements must bemade through the MCGSBS office.Prior to or shortly after the internship ending, the student will host a meeting with theCDI collaborator to review the experience.a. Record of Summary Meeting (form)Within 14 days of completion of the CDI experience, the intern will submit, to MCGSBSadministration, a brief report summarizing their experience.a. The CDI Summary will summarize in a 1- 2 page single-space document the CDIexperience.Evaluation of the CDI experience will be captured in similar surveys provided to the student andthe CDI partner. The focus of the evaluation will not be on the intern performance, but on thevalue of the CDI experience.Graduate Employment OpportunitiesSee latest employment opportunities in our most recent This Week at Mayo Clinic Graduate School ofBiomedical Sciences Newsletter (TW@MCGSBS).10

PoliciesStipendsStudents accepted into the Ph.D. program receive a fellowship, which includes stipend, tuition, and fees.The stipend, provided by Mayo Clinic Graduate School of Biomedical Sciences (MCGSBS), continuesuntil successful thesis defense or up to five years, whichever comes first, contingent upon satisfactoryperformance. Students have up to 30 days after successful thesis defense for completion of allrequirements. Support for additional years beyond the fifth (fourth for M.D.-Ph.D. students) must beprovided by the mentor. Stipends for all graduate students are set at a uniform level (planned for 35,587for 2022-2023) and are reviewed at regular intervals.Students who are accepted into the M.D.-Ph.D. program are provided a fellowship with stipend, tuition,and fees. The stipend is provided by Mayo Clinic Alix School of Medicine (MCASOM) while the studentis in the M.D. portion of training. MCGSBS provides up to four years of funding for the Ph.D. portion ofthe program. Extensions in the Ph.D. program beyond four years must be financially supported by thementor. MCASOM and MCGSBS tuition and fees are provided by a full fellowship for students acceptedinto this combined M.D.-Ph.D. program, with satisfactory performance.Clinical residents and research fellows accepted into the Master’s program continue to receive the salaryfrom their primary appointment and do not receive a stipend from MCGSBS.Employees pursuing Master’s degrees on a part-time basis receive their usual employee salary.Tuition/Program FeesAnnual tuition for graduate students is 27,000 for Ph.D. students. Tuition is 700 per quarter credit.Tuition is provided by a full fellowship for students who are enrolled in the Ph.D and M.D.-Ph.D. degreeprograms of MCGSBS. Extramural sources of funds are used to defray tuition when appropriate and alleligible students are expected to apply for individual extramural awards. Program Fees are charged formany Master’s programs to cover administrative costs. More details are available on the MCGSBSMaster’s Programs intranet site, including options for financial support.RegistrationMayo courses are primarily intended for individuals appointed to the degree programs of MCGSBS.Others may enroll if they show appropriate prerequisites and secure the course director’s approval.Tracks may have differing course enrollment criteria. Enrollment in some courses is very limited; degreecandidates are given preference for these courses. Registration information is available on the MCGSBSintranet site. Registration for MCGSBS courses is accomplished through the Registrar’s Office and mustbe made online before the applicable deadline (see Academic Calendar on previous pages).*An individual must have an active Mayo employment or education role to be eligible for MCGSBS courses.Registration for credit Unless provided through a fellowsh

Scottsdale, AZ 85259 https://college.mayo.edu . Nhan L. Tran, Ph.D. Associate Dean, Mayo Clinic Graduate School of Biomedical Sciences . Mayo Clinic College of Medicine and Science - Florida Mayo Clinic Graduate School of Biomedical Sciences - Florida . 4500 San Pablo Rd S Jacksonville, FL 32224 https://college.mayo.edu . Evette S. Radisky, Ph.D.