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AppendixPresentation 8 - FerreeRAC-GWVI Meeting MinutesJuly 18-19, 2007Page 170 of 302Presentation 8 - Thomas FerreeEEG Programfor Gulf War ResearchThomas Ferree, PhDDepartment o f RadiologyUT Southwestern Medical CenterCellular Sources of EEG
Cortical Sources of EEGAdded Value of EEG for Gulf War ResearchGeneral Measure neural activity with millisecond timing Detect oscillations within and between brain areas Impairment within areas or communication between areas?Word-Word Binding Associate oscillations with cognitive processes Distinguish processes through their temporal orderingContinuous Performance Ability to analyze continuously through time Power spectrum correlates with performance
Event-related oscillationsEEG Analysis Domains and Clinical IndicesTime Series AnalysisEvent-related transients (peak amplitude, latency)Event-related oscillations (amplitude, timing)Spatial AnalysisElectric head modelingSource localization (functional networks)Integration with functional MRISpatial co-registrationSimultaneous recordingFunctional connectivityCoherence (magnitude, phase, connectivity maps)Relationship to fMRI and DWI
Electric Head Modeling: Two Components2. Conductivity1. GeometryTissueM ean σStdev σB ra in0 .2 50 .1 3CSF1.7 90 .0 2S k u ll0 .0 1 80 .0 1 4S calp0 .4 40 .2Can measure conductivitynon-invasively with EIT:(Electric Impedance Tomography)Electric Source SourceCurrent
Simultaneous EEG and Functional MRIMotivations Best of both worlds: spatial and temporal resolution Match recording environment and stimulation parameters Match subject state, e.g., alertness, etc. Avoid training effects ConvenienceChallenges Artifacts induced by MR magnetic fields Optimize cognitive paradigms for EEG and fMRILarger Goals Clarify relationship between neural oscillations and fMRI maps Improved statistical tests for functional activationStandard MRI
Integrated EEG-fMRIVisualizing Dynamic Cortical ActivityHedden and Gabrieli, Nature (2006)
EEG Program DevelopmentDone IRB approval for EEG, EEG-fMRI Protocols for cap application, cleaning, etc. System integrity Data quality and artifact reduction EEG pilot studies in normal subjects Preliminary analyses of EEG dataTo Do Integrate EEG/EIT into full pilot studies Extend IRB approval to EIT Space renovations, booth installation Equipment upgrades, purchases New hires, trainingMain CollaboratorsUT SouthwesternRichard BriggsPriya XavierAudrey ChangAman GoyalKaundinya GopinathMette PosamentierPat CarmackJeff SpenceUT DallasJohn HartMandy MaguireGail TillmanCliff CalleyMatt BrierTim GreenSMUWayne WoodwardHenry Gray.More To Come
EEG Program for Gulf War Research. Thomas Ferree, PhD . Department of Radiology . SMU; Wayne Woodward ; Henry Gray.More To Come; Title: Presentation 8 - Thomas Ferree: EEG Program for Gulf War Research; July 18-19, 2007 Author: Thomas Ferree, PhD Created Date:
