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How to Use theLantus SoloSTAR Pre-filled Insulin PenA Quick Reference GuideGo online to www.lantussolostar.com for a free videodemonstration or call the 24-hour helpline1-800-633-1610 to talk to a Lantus SoloSTAR expertaaLeave a message and a Lantus SoloSTAR expert will call you back.STARring the #1-prescribed insulinbbBased on TRx data from IMS Health, NPATM Monthly database, time period fromMay 2003 to November 2011.Indications and Usage for Lantus Prescription Lantus is a long-acting insulin used to treat adults with type 2 diabetes andadults and children (6 years and older) with type 1 diabetes for the control of high blood sugar.It should be taken once a day at the same time each day to lower blood glucose. Do not useLantus to treat diabetic ketoacidosis.Important Safety Information for Lantus Do not take Lantus if you are allergic to insulin or any of the inactive ingredients in Lantus .Please see additional Important Safety Information for Lantus on page 9.Please see accompanying full prescribing information for Lantus .

Before starting, take a lookat the Lantus SoloSTAR pen and its partsCongratulations on using the Lantus SoloSTAR insulinpen. Lantus SoloSTAR is easy to use and easy to inject.This quick reference guide is a short version of theinstruction leaflet. It is designed to help make it easier tolearn the steps.Reading this guide will help to make sure that you inject theright amount of insulin every time. Otherwise, you may gettoo little or too much insulin, and that can affect your bloodsugar levels.Lantus SoloSTAR pen is grey If you are using a new or unopened pen, remember totake it out of the refrigerator 1 to 2 hours before using it.There is less discomfort when you inject your insulin if itis at room temperatureOuterneedle capPen needleInner needlecap(not included)*Needle Do not use the pen past the expiration date on the boxProtectivesealThese instructions are supplied as a guide only. Read thefull instruction leaflet accompanying the pen before youuse Lantus SoloSTAR for the first time. To help ensurean accurate dose each time, follow all steps in the leaflet.Filled withLantus , a longlasting insulinIf there’s anything you don’t understand or if you have anyquestions, ask your healthcare providers. You can also goonline to www.lantussolostar.com or call the 24-hoursupport line at 1-800-633-1610.Pen capRubbersealPenInsulinreservoirVisit www.lantushelpteam.com to sign up forFREE online educational sessionsHas a flat,smooth buttonLantus SoloSTAR is a disposable prefilled insulin pen.Please talk to your healthcare provider about proper injectiontechnique and follow instructions in the Instruction Leafletthat accompanies the pen.Please see additional Important Safety Information forLantus on page 9.Please see accompanying full prescribing informationfor Lantus .02Important Safety Informationfor Lantus SoloSTAR 1DosewindowDoseselectorInjectionbutton*Sanofi US recommends using the BD Ultra-Fine pen needles.2

For additional help, visitwww.lantussolostar.comor call 1-800-633-16101How to get ready foran injectionHow to do itWhat to do1. Remove pen capAlways store UNOPENED Lantus SoloSTAR pensin the refrigeratorWhy? The cooler temperature will protect the insulinin the pen until you are ready to use itDon’t inject cold insulin. Wait until the pen hasbeen out of the refrigerator and warms up to roomtemperature. After opening the pen, you shouldnot refrigerate it, and you can use it for up to28 days2. Before beginning, check to see that the insulin in the penis clear and colorless. If it is not clear or has particles, donot use that Lantus SoloSTAR pen. Use another pen orcall the 24-hour helpline at 1-800-633-1610Why? Injecting cold insulin could make it feel moreuncomfortable. But it’s not dangerousAlways wash your hands with soap and waterbefore an injectionWhy? Washing your hands will kill a lot of bacteria onthem. That will help prevent getting an infectionor contaminating the penUSEDON’T USEDOs and DON’TsDO check the expiration date on the pen box.DON’T use the pen past the expiration date on the box.DON’T refrigerate the pen after opening it.DON’T use the pen if it has been open for longer than28 days.Important Safety Informationfor Lantus You must test your blood sugar levels while using insulin,such as Lantus . Do not make any changes to your dose ortype of insulin without talking to your healthcare provider.Any change of insulin should be made cautiously and onlyunder medical supervision.Please see additional Important Safety Information forLantus on page 9.Please see accompanying full prescribing informationfor Lantus .3

For additional help, visitwww.lantussolostar.comor call 1-800-633-16102How to correctly attacha needleHow to do itWhat to do1. Keep the needle straight and not on an angle when youscrew it on. Don’t make the needle too tight. If you havea push-on needle, keep it straight as you push it onAlways use a new needle. (Remember, needlesare not supplied with the pen. See page 11 ortalk to your healthcare provider)Why? Re-using a needle can block the insulinfrom injecting correctly and can also causecontamination and infection. Also, theneedle can become dull and make theinjection less comfortableRIGHTThe needle for the pen is available as ascrew-on needle or as a push-on needleWRONG2. After you have attached the needle, take off the outerneedle cap— Don’t throw the outer needle cap away; you will needit to safely remove the needle after your injectionDOs and DON’TsDO throw away the inner needle cap.DO use a new needle for each injection.DO hold the needle straight when attaching it.DON’T throw away the outer needle cap.3. Remove the inner needle cap and throw it awayImportant Safety Informationfor Lantus Do NOT dilute or mix Lantus with any other insulin orsolution. It will not work as intended and you may loseblood sugar control, which could be serious. Lantus mustonly be used if the solution is clear and colorless with noparticles visible. Do not share needles, insulin pens orsyringes with others.Please see additional Important Safety Information forLantus on page 9.Please see accompanying full prescribing informationfor Lantus .4

For additional help, visitwww.lantussolostar.comor call 1-800-633-16103How to do a safety testHow to do itWhat to do1. Dial a test dose of 2 UnitsIt is very important to always do a safety testbefore an injectionWhy? The safety test removes air bubbles, whichhelps you get the most accurate dose. It alsomakes sure that the pen and needle areworking right. The safety test does not wasteinsulin (there is a little extra insulin in the penfor the tests)02412. Hold the pen with the needle pointing up. Then gently tapthe reservoir so the air bubbles rise up to the needleDOs and DON’TsDO hold the pen with the needle pointing up.DO use another needle if no insulin comes out after doingthe test 3 times.DON’T use the pen if no insulin comes out after using asecond needle.3. Press the injection button all the way in (A) and check tosee that insulin comes out of the needle (B)—The dial will automatically go back to zero after youperform the testAB021Important Safety Informationfor Lantus (insulin glargine [rDNA origin] injection)The most common side effect of insulin, includingLantus , is low blood sugar (hypoglycemia), which maybe serious. Some people may experience symptoms suchas shaking, sweating, fast heartbeat, and blurred vision.Severe hypoglycemia may be serious and life threatening. Itmay cause harm to your heart or brain. Other possible sideeffects may include injection site reactions, includingchanges in fat tissue at the injection site, and allergicreactions, including itching and rash. In rare cases, someallergic reactions may be life threatening.4. If no insulin comes out, repeat the test 2 more times5. If there is still no insulin coming out, use a new needleand do the safety test againIMPORTANT! If there is still no insulin coming out after thefourth test, DO NOT USE THAT PEN; USE ANOTHER PEN.If you don’t have any pens left, call your pharmacy. You canalso call the 24-hour helpline at 1-800-633-1610.Please see additional Important Safety Information forLantus on page 9.Please see accompanying full prescribing informationfor Lantus .5

For additional help, visitwww.lantussolostar.comor call 1-800-633-16104How to select the doseHow to do itWhat to do1. Dial your dose (This example shows a dose of 10 units)Make sure the dose window is at “0” beforedialing your dose81012Why? If the dose window is not at 0, you will injectmore insulin than you need. That can affectyour blood sugar levelMake sure to remove the protective seal2. If you don’t dial the right dose, you can dial backup or downCheck to see that you have enough insulin in thepen for your dose. Try dialing your dose. If the pendoesn’t let you dial your dose, then you don’thave enough insulin left. Your dose cannot bedialed past the number of units left in the pen—Dose cannot be dialed past the number of units leftin the pen3. You cannot dial more than 80 units because thepen automatically has a safety stop. If you need adose of more than 80 units you must give yourselfanother injectionDOs and DON’TsIf you have enough insulin left in the pen, you can redialthe rest of your dose. If you don’t have enough insulin,use a new penDON’T force the dose selector when dialing your dose.DON’T push the injection button while dialing your dose.DON’T try to set the dose selector to half units or thepen may jam.—You must attach a new needle and discard the one youjust used (See step 6 on page 8)Important Safety Informationfor Lantus Tell your doctor about other medicines and supplementsyou are taking because they can change the way insulinworks. Before starting Lantus , tell your doctor about allyour medical conditions including if you have liver or kidneyproblems, are pregnant or planning to become pregnant, orare breast-feeding or planning to breast-feed.Please see additional Important Safety Information forLantus on page 9.Please see accompanying full prescribing informationfor Lantus .6

For additional help, visitwww.lantussolostar.comor call 1-800-633-16105How to inject your doseHow to do itWhat to do1. Keeping the pen straight, insert the needle into your skinInject your dose into one of the3 areas shown in the pictureupper armsWhy? These areas have morefat and less nerveendings. You may feel lessdiscomfort in these areasabdomen288 8300 1032 123thighsChoose a new spot in the area each time youinject a dose2. Using your thumb, press the injection button allthe way downWhy? Injecting in the same spot can make a smalldepression in your skin or make it thicken.This may cause more discomfort0124Never force the needleWhy? Forcing the needle can hurt and may damageit. It can also affect how much insulin you get3. Then slowly count to 10. Counting to 10 will make surethat you get your full insulin doseDOs and DON’Ts10 secsDO count to 10 after pressing the button.DO take the needle from your skin if you dial another dose.DON’T rub the injection spot after an injection.DON’T inject in the same spot every time.01244. After counting a full 10 seconds, release the button andremove the needle from your skinImportant Safety Informationfor Lantus SoloSTAR Lantus SoloSTAR is a disposable prefilled insulin pen.Please talk to your healthcare provider about proper injectiontechnique and follow instructions in the Instruction Leafletthat accompanies the pen.Please see additional Important Safety Information forLantus on page 9.Please see accompanying full prescribing informationfor Lantus .7