WIXLIB

Core-Shell Selectivity that a C18 just can’t give you!STMSBipheylhenylBnip RemarkableSeparation Power Rugged and Reliable 100 % AqueousStable

KinetexCore-Shell AdvantageKinetex Core-Shell Technology produces increased efficiencies over traditional,fully porous columns on the market, yielding remarkable chromatographic resolution, higher peak capacities, and greater sensitivity, so labs can get the most outof every HPLC/UHPLC analysis.Kinetex Core-ShellLessBand BroadeningFully PorousMoreBand BroadeningIf you are not completely satisfiedwith Kinetex core-shell columns,send in your comparative data to asimilar product within 45 days andkeep the column for FREE. 2014 Phenomenex, Inc. All rights reserved.2

TMSSMTSMTTMSTMSBiphenylTMSCore-Shell lthe High PerformanceKinetex Biphenyl!pp. 4-5Comprehensive pain panel testing . p. 6Extended lifetime with biological samples . p. 7Wide range of Kinetex selectivities . p. 8Full scalability from HPLC to UHPLC . p. 9Reproducibility and quality you can rely on . p. 10Ordering information . p. 11Transform your reversed phase analysis .PhenomenexlWEB: www.phenomenex.com3

Transform Your ReversedPhase AnalysisThink high performance, enhanced retention, and the ability to go where a traditional C18 can’t. The Kinetex Biphenyl offers the high performance benefitsof a core-shell particle with a unique stationary phase capable of becomingthe go-to selectivity for reversed phase method development. Use KinetexBiphenyl columns to get enhanced retention, higher sensitivity, and overallbetter results; especially for aromatic compounds.Mycotoxins21951Kinetex 2.6 µm Biphenyl1.7e6Enhanced Retentionand Sensitivity21.5e6Intensity, cps101.0e611128,9App ID 219515.0e575,61340.052195267min7minWaters SunFire 3.5 µm C181.7e6Intensity, cps1.5e6Conditions for all columns:Column: Kinetex 2.6 µm BiphenylWaters SunFire 3.5 µm C18Dimensions: 50 x 2.1 mmMobile Phase: A: 5 mM Ammonium acetatewith 0.1% Acetic acidB: Methanol with 5 mMAmmonium acetate with0.1% Acetic acidGradient: Time (min)%B02225805.2988988.012112Flow Rate: 0.45 mL/minTemperature: 40 CDetection: MS/MS (AB SCIEX API 4000 )Sample: 1. 15-Acetyldeoxynivalenol2. DAS3. FB14. HT2 Toxin5. FB26. T2 Toxin7. Aflatoxin M18. Aflatoxin G29. Ochratoxin A10. Aflatoxin G111. Aflatoxin B212. Aflatoxin B11.0e612,2109,51118,7App ID 219525.0e56340.056Waters and SunFire are registered trademarks of Waters Corporation.Phenomenex is in no way affiliated with Waters Corporation. Comparative separations may not be representative of all applications.4

Core-Shell TechnologyEnhanced Separation PowerKinetex Biphenyl is a high efficiency core-shell product capable of addingextra separation power to your analysis of non-polar and polar compounds.Imagine what you could do with this new chromatography solution.Opiate Isomers2199221993Kinetex 2.6 µm BiphenylFused-Core 2.7 µm C18Impressive Increasein ResolutionIntensity, cps4.0e40.0123minApp ID 219932.0e42.0e4App ID 21992Intensity, cps4.0e40.0Conditions for all columns:Column: Kinetex 2.6 µm BiphenylFused-Core 2.7 µm C18Dimensions: 50 x 2.1 mmMobile Phase: A: Water with 0.1 % Formic acidB: Methanol with 0.1 % Formic acidGradient: Time low Rate: 0.6 mL/minTemperature: 40 CDetection: MS/MS (AB SCIEX API 4000 )Sample: 1. Morphine2. Hydromorphone3. NorhydrocodoneCustomer Example - Polar Therapeutic DrugKinetex 5 µm Biphenyl vs. Fully Porous 5 µm C18100C18Biphenyl 2x Increasein Retention%Share your Kinetex success stories Core is a registered trademark of Advanced Materials Technology, Inc.Phenomenex is in no way affiliated with Advanced Materials Technology, Inc. Comparative separations may not be representative of all applications.PhenomenexlWEB: www.phenomenex.com5

ComprehensivePain Panel TestingImportant methods demand high performance and complete reliability. If asystem or column interrupts the flow of samples, time and money can be lost.Find more Clinical applications at:The new Kinetex Biphenyl ensures that your comprehensive screens displaywww.phenomenex.com/ClinicalApps the needed performance with a ruggedness and reliability that will keep youat ease.22104PainPanel ScreenKinetex 2.6 µm BiphenylConditions for all separations:Column: Kinetex 2.6 µm BiphenylDimensions: 50 x 3.0 mmPart No.: 00B-4622-Y0Mobile Phase: A: Water with 0.1 % Formic AcidB: Methanol with 0.1 % Formic AcidGradient: Time (min)%B0100.5102254.5804.51855.5855.5110710Flow Rate: 0.6 mL/minTemperature: 40 CDetection: MS/MS (AB SCIEX API 5000 )Full Panel2.0e61.8e6Intensity, cps1.6e61.4e61.2e61.0e68.0e5App ID 221046.0e54.0e52.0e500123422108 Opiates2.0e65min622109 Benzodiazepines22110 olamDiazepam6minIntensity, cps5.0e5App ID 221090.0Intensity, cpsApp ID 22108Intensity, cps6.0e51.0e6Drugs of Abuse1.0e68.0e56.0e5App ID cgonineMeprobamatePCPCarisoprodolSufentanil6min

Core-Shell TechnologyImproved Retentionof Clinical SamplesPainPanel - Opiates2197221974Kinetex 2.6 µm BiphenylDramaticImprovementin Retention6,0e5Intensity, cpsApp ID 219722.0e54,0e52,0e5App ID 219744.0e50,00.0123451minConditions for all columns:Column: Kinetex 2.6 µm BiphenylFused-Core 2.7 µm C18Dimensions: 50 x 2.1 mmMobile Phase: A: Water with 0.1 % Formic acidB: Methanol with 0.1 % Formic acidGradient: Time (min)%B054954.5954.5156523Flow Rate: 0.5 mL/minTemperature: 40 CDetection: MS/MS (AB SCIEX API 4000 )Sample: 1. Morphine11.2. Oxymorphone12.3. Hydromorphone13.4. Naloxone14.5. Codeine15.6. Oxycodone16.7. Naltrexone17.8. Hydrocodone18.9. Norfentanyl19.10. ntanilMethadoneExtended Lifetimewith Biological Samples5Kinetex Biphenyl Stability in Urine (First 1000 injections)54433Retention Time (min)Intensity, cps6.0e5Fused-Core 2.7 µm C1821210002000200400600400Injection zepamTemazepamTriazolamFused-Core is a registered trademark of Advanced Materials Technology, Inc.Phenomenex is in no way affiliated with Advanced Materials Technology, Inc. Comparative separations may not be representative of all applications.PhenomenexlWEB: www.phenomenex.com7

Wide Range ofKinetex SelectivitiesChoose from an extensive selection of phases for greater flexibility in UHPLC/HPLC method development. Kinetex columns come in a variety of stationaryphases to cover a full spectrum of applications ranging from acids and bases,to isomers and extremely polar compounds.Steroids21966Kinetex 2.6 µm Biphenyl140632204587910App ID 21966mAU0024min21968mAUKinetex 2.6 µm C1812 4App ID 21968640537208910002min421969mAUKinetex 2.6 µm XB-C1813 4220579810App ID 21969640Conditions for all columns:Column: Kinetex 2.6 µm BiphenylKinetex 2.6 µm C18Kinetex 2.6 µm XB-C18Kinetex 2.6 µm Phenyl-HexylDimensions: 50 x 4.6 mmMobile Phase: A: WaterB: AcetonitrileGradient: 20 to 60 % B in 6 minutesFlow Rate: 1.85 mL/minTemperature: 30 CDetection: UV @ 220 nmSamples: 1. Estriol2. Hydrocortisone3. Prednisone4. Cortisone5. Corticosterone6. β-Estradiol7. Cortisone Acetate8. 17-Hydroxyprogesterone9. 21-Hydroxyprogesterone10. Deoxycorticosterone0024min21967mAUKinetex 2.6 µm Phenyl-Hexyl122034579810App ID 219676400024minTake your pick from six stationary phases!8PhaseSelectivityKinetex BiphenylExcellent reversed phase and aromatic retention and selectivityKinetex C18General hydrophobic selectivity and increased retention of polar basic compoundsKinetex XB-C18Excellent hydrophobic selectivity and increased retention of polar acidic compoundsKinetex C8Less hydrophobic than a C18 phaseKinetex Phenyl-HexylGreater retention and separation of aromatic hydrocarbonsKinetex HILICIncreased polar retention under HILIC conditionsWant more?- Applications- Development tips- Method comparisonsRequest your full Kinetexproduct guide at:www.phenomenex.com/KinetexRequest

Core-Shell TechnologyFull Scalability fromHPLC to UHPLCKinetex 1.7 µmand 1.3 µm Biphenylare coming soon!With four fully scalable particle sizes, Kinetex Core-Shell Technology allows youto easily develop and transfer methods to and from any LC platform you choose.Kinetex 5 µm C1821436 for HPLC and PREP LC methods3 µm or better efficiencies at 5 µm pressures405µm5620 mAU123App ID 214364001234minKinetex 2.6 µm C1821435Achieve sub-2 µm performance on HPLCand UHPLC systems4052.6µm620mAU123App ID 214354001234minKinetex 1.7 µm C1820 % higher efficiency than fully porous214341.7 µm columns46201mAU1.7µm523App ID 2143440001234minKinetex 1.3 µm C1821433Incredible UHPLC efficiency and performancegains4045App ID 214336201mAU1.3µm23001234min* Gingerols analyzed on 50 x 2.1 mm columns.PhenomenexlWEB: www.phenomenex.com9

Reproducibility and QualityYou Can Rely OnYour time and energy is incredibly important and should never be spent on issues with column irreproducibility. Whileother manufacturers skimp on quality, Phenomenex has and always will take extra steps to ensure that you get thehighest quality products, each and every time. Trust us. We are overwhelmingly passionate when it comes to makingsure our products live up to the standards that you demand.Batch-to-BatchReproducibility22107100 % Aqueous StableDrugs of Abuse - Kinetex 2.6 µm Biphenyl1.4e621978Batch min23minApp ID 221076.0e52.0e511223344556min45minAfter 24 hr storagein 100 % water2.0e4App ID 219788.0e52.0e4Intensity, cps3.0e41.0e64.0e51.0e41.0e40123221071.4e6Batch 301.2e61.0e68.0e56.0e5App ID 22107Intensity, cps5Batch 281.2e63.0e44.0e52.0e501234* Conditions for this test can be found on page 6.104Amphetamine - Final Injection219781.4e656min1.0e40122107Intensity, cpsApp ID 219788.0e5Intensity, cps1.0e6App ID 22107Intensity, cps1.2e600Amphetamine - Initial InjectionConditions for above separations:Column: Kinetex 2.6 µm BiphenylDimensions: 50 x 2.1 mmPart No.: 00B-4622-ANMobile Phase: 0.1 % Formic Acid in WaterFlow Rate: 0.5 mL/minInjection Volume: 5 µLTemperature: 40 CDetection: MS (AB SCIEX API 3000 )Sample: Amphetamine (500 ng/mL)