B. A. Psychology Adelphi University, N'.Y. January 1971 . M. A .

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PR'DFESSIONAL DATAVictor J . DeNObl'e1106 0ldbury RoadMidllothiian, Virginia 23113Telephone : (804) 794-274I8 or (804)', 274-5570 (Work)-Borni : December 3', 1949'Education :SchoolDe reePh .D . Psychology Adelphi University, N' .Y. Adelphil Universi'ty, N .Y.-.1A'dellphi University, Ni .Y.Postdoctoral ResearchUniversity of Minnesota, MNB . A . PsychologyM. A . PsychologyYearJanuary 1971January 1974January 1976'1978 - 1980Title of Dissertat'ion : .Response Acceleration and Suppression Produced by Response-Iindependent FoodPresentation im Rats with Septal Lesions . Presented i'n the Eastern .Psycho logical' Association„ 1974 .Research Experience :1980 - PresentProject Leader, Beh avioral Ph a rmacology Laboratory, Ph il i p Morris Research Center, Richmond,, Virginia1978 - 1980'Research Associate,, Psychiatry Research Unit, University ofMinnesota1974 - 1977Senior Research Scientist, Department of Psychiatry,Downstate Medical Cent'er,, Brooklyn, New York1976 - 1977Researchi Associate,, Department'ofBi'opsychologyandi Anatomy,Downstate Medical Center, Brooklyn, New York1!972 - 1973Research Assistant, Experimental PsychologyAdel'phi University, Garden City, New York1971 - 1'9T2Research Assistant', Department of Neuroanatomy,Medical Center, : Brooklyn, New YorkLaboratory,DownsWeOO

Grants Awardied :Oral Selif-Administration of Pentobarbital by Rats . 1979,- 1980Pr iincipal' IlnvestigatorOral Self-Admini',stration of Pentobarbital and Ethanol by Rats . 1979 - 1980 Principal InvestigatorPherrcyclidine (PCP)l : A Behavioral Profile in Mankeys . 1,979' - 1982Co-Prirnc i,pal Invest ig,atorMajor R e Se arch InterEsts , :Behavioral Pharmacology,, Physiological Psyc h ology„ Psychopharmacology, Experiimental and Cl in i cal P syc :h ology wi th am emphasis on b rain-b ehav i'or re lation shi ps , Psychopathology . Teaching Experience :' Adjunct Associate Professor at State Univrersity of' New York, Farmingdale,1977 - 1978 .Adj'unct Assistant Professor at City University of Ne w York ,, Brookli ynu Co lilege ,1976 - 1978 .AAdjunct Le actur er at Ci ty Uhti ve r s i ty of New York,, Broo k lyn College,1973 - 1976 .Adjunct Lec turer at St ate, Un ilversity of New, York, farm ingd ale „ 1976 - 197'7 . Adjunct Lecturer at Adelptiii Uni'viersity, 1972'- 1976 .Adjunct Lec turer at Long Is 1'and' University, Brooklyn C amptis, 197 4 . Courses Taught :Un de rgradu ate :Introductory Psychol'ogySensation and PerceptionPsycholo9yIIAbrnormal PsychologyPsychopathology Child DevelopmentPhysioliogicaT Psychology Mental HygieneNeuroan tomy Lab, Learni g TiheoryGraduate: C3'Physiological Psychology Advanced Physiological Psychology ( ;Physiological Basis of Niental' DiseaseMethods in Cl ini,cal Research !- CJ1Q

Students Adiviised':Underg,raduat'e : .Summa cum 1'aud'e H nor's Thesis : Dave Svi'ki s .Dhrected'Research : Jackie SpektorVi'siting Graduate Student : Liz Critcher, University of TennesseeCliinical Experiei nce:197'7 - 1978 Counselor/I'nstructor, NYS Drinking Driver Program1969, - 1970 Staff member of the Psychiatric Evaluation Unit at Central IslipState Psychiatric Hospital, Islip, New York .Professional Affiliations : . Society for NeuroscienceThe National Association for the Advancement of . VScienceNew York Acad'emy of ScienceI'SG'DAR - International Study Group .fmr Drugs as ReinforcersAmerican Psychological AssociationEastern Psychological AssociationPublications :DeNoble, V .J ., Drag,an,, Y ., and Carron, L ., Behavioral effects ofintraventricul!arly admini'stered' (-)-nicotine on fixed ratio schedules of foodpresentation in rats . Phychopfiarmaco] ogy, 1982, 77, 316-321 .DeNoble, V .J,, Svikis, D . and' Mei'sch, R .AI., Orall'y delivered pentobarbital as areinforcer for rhesus monkeys with conc rrent access to water : Effects ofconcentration, fixedi ratio size, andi liquid' positions . Pharmacology,Biochemistry and, Behavior, 1982', 16,, 113-117 .DeNoble, V .J ., Svikis, D . and Meisch, R .A ., Studies of the oral self-administration ofpentobiarbitial byrhesius mo nkeyswithconcurrent ac,cesstowater.ExcerptaMdi,Ses620198,3aPi ckens, R ., Muchow, D ., and' DeNoble, V .J ., Methohlexi'tali-rei'nforced respondingrats : effects of fixed ratio size and i'njection, dose . Journali of Pharmacol'ogyand Experimenta1' Therapeutic s, 1981, 216, 205-209' .DeNoblle, V:J ., and Begleiter, H ., Impairment of acquisition of' a DRIL sched'ulefollowing prolonged ethanol consunption . Pharmacology, Biochemistry andBehavior, 1979, 10, (3'), 393-3916 .DeNoble, V .J ., and BegTeit'er, H ., Se)f-administration of alcohol iln monkeys :the effects of prior exposure . Pharmacology, Biochemi'stry and Behavior, 1978,8, (4), 391-397 .-3,

Begleiter, H ., DeNoble, V .J ., an& Por ;jesz, B ., Protracted brain ; dysfunctionafter alcohol withdrawal in monkeys : 8i ologikal Effects of Alcohol, Edited byH . 3egleiter, Plenum Press, 231-251', 19,80 .DeNoble, V .J,., and Begleiter, H ., Fi'xed-ratiio performance and blood' alcohol1'evels in monkeys . Psychopharmacology, 1977, 55, 2'13-21'6 .Detioble,V .Ji., and Caplan, M .,, Enhancedl response acceleration or suppressionproduced by response independent food presentations in rats with septallesions . Journal of Comparative and Physiological Psychology, 1977, 91, 107119 .rDe.Noble, V .J ., and Beg,lei'ter, H ., Response suppression on a mixedi schedule ofreinforcemen tduring al cohol withdrawal, Pharmacolog,y,Bioc hemistr,yand'Behavior, 1976, 5, (2), 227-2'3'0 .DeNoble, V .J .,, Robbins, D., and' Caplan, M ., A/ technique for facil'itati'on ofsk,ulilsuturesin the rat . P'hysiolog,yand Behavior, T973, 11, 739442 .Invited Presentations : . -DeNoble,I V .J ., Feeding Processes : Diet and, Meal' Patterning in Obese Rats .Chai rpers ioni Fifty-Fourth Annu a l Meet i'% of East e rn, Psychological Asso ciat iom,1983 .DeNoble, V .J . Drugs As Reinforcers . Chairperson, Section on NonhumanPrimates . Eiighth Inter national ; Congress of Pharmacology, ogy , 1981 . DeNoble, V .J .', Svikis, D . andi Meisch, R .A'., Orally deliivered' pentobarbital as areinforcer for rhesus monkeys wiith, concurrent access to water : effects ofc oncentrati o n, fixed ratio size, and l iquiid' positions . E ilghtN In t ernatiiona l Co ngres s of Pharmacology, Nogawai, Kawasaki, J apani, July 1981 .Presentations :DeNbble, V .J ., Ry!an, F .J ., Dragan, Y'.P ., Mele, P .C ., Nawora,l,, J . and Kornfeld',R . Ant ago nism of Chronic Nicotine Ad'm i ni strati on :, Effects on schedulecontrolled behav iior in r ats . 1'2tK Annual Meeting of the So ciety fo r Neuros c i ence :, October 31 - Nowember 5, 1982, Mi nneapo l i s, MN . DeNoble, V .J' ., Dragan, Y ., Carron, L . and Mele, P .C . Intraventricul'ar (-)nicotine infusions disrupt fixed-ratio performance in rats . American Psyctiological Association, 90th Convention, August 23-27, 1982, Washington, D .C .DeNoblle, V .J'., and Carron, L. Studies on the effects of' int raverotricul'arinfusions o (-)-nisoti!ne on behavior maintained under fixed-ratio schedules .Society for Neuroscience, Los Angeles, CA, 1981 .NDeNoble, V'.J . a nd MeiscK, R .A.tk-aliydevrpntobail-srenfoQhsiumonkey: effects of concurrent water, side position, andidrug con- acentration . Committee on Problems of Drug Dependence ISGDAR session,, Hyannis, Massachusetts, 19801.-4-G1

Pickens, R ., Muchow, D ., and DeNobl'e, V .J ., Intravenous methohexital selfadm i ni str a t i oni by rats . Committee on Problems ofi C1rug Dependenc e ISGIDA R session, Hy anrnis,, M a s sachiu setts, 1980as a reinforcer for monkeys with.J ., and Meisch, R' .A ., Ppntoba bi'tal.DeNobl ,Vconcurrent access to water . American Psychological Associatiiorn, Montreal, .Q,uebec, Canada, 1980 .ManuscriptsDeNbble, V .J., Mele, P .C . and Ryan, F .J . Nicotine as a Positive Reinforcer forRats : Effects of Infusion Dose and Fixed-Ratio Size . Journali of Pharmacologyand Experimental Therap,eutics . InRevie.w.J ., Ryan, F .J ., Dragan, Y .P ., .DeMbl',V Mel'e, P .C ., Nawral', J . andi Kornfeldl,.AntagonismofChroni'c Nicotiine Admi',nistr ;ation :Effectson ScheduleRControlled Behavior in Rats . Pharmacology Biochemistry Behavior . In Review .DeNoble, V .J ., Dragan, Y .P ., and Mele,* P .C . / .Brain Sites Involwed' in, theMediation of the Behavioral EffectsofIntraventrically Administered (-)rNicotine . In New York - P .M . Review .Committ;ee Appointments :Animal Facility Representative to the Committee on Animal Care, University ofMi rnnesot a .

B. A. Psychology Adelphi University, N'.Y. January 1971. M. A. Psychology Adelphil Universi'ty, N.Y.-. January 1974 1 Ph.D. Psychology A'dellphi University, Ni.Y. January 1976' Postdoctoral Research University of Minnesota, MN 1978 - 1980 Title of Dissertat'ion: . Response Acceleration and Suppression Produced by Response-Iindependent Food