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Discover the consistency and control of the first and only phaco handpiecewith a built-in pressure sensor.1

Smooth phaco performancethat prioritizes outcomes as much as you doThe CENTURION Vision System with ACTIVE SENTRY Handpiece is redefining phacoemulsification performance.Its innovative design and real-time surge reduction can helpyou offer a new baseline of safety, consistency and control toevery cataract patient. Unprecedented responsiveness1,2- The ACTIVE SENTRY Handpiece is the first and only phacohandpiece equipped with a pressure sensor Superior surge reduction3- The handpiece communicates with hardware and software formore consistent procedures Stability from start to finish3- CENTURION Active Fluidics Technology dynamicallymanages IOP in a wide range of surgical settings1-3 Taking safety to the next level- The INTREPID Hybrid Tip incorporatesproprietary polymer technology to reduce damageto the capsular bag and other tissues4US-CNT-19-E-0682a

Smooth phaco performancethat prioritizes outcomes as much as you doThe CENTURION Vision System with ACTIVE SENTRY Handpiece is supported by advanced procedural technologiesdesigned to add even more efficiency to your phaco experience.EFFICIENCY Streamlined phacoemulsification5-7- INTREPID Balanced Tip versus older design:- Superior torsional performance5-7- Shorter ultrasound and aspiration times5,6- Reduced energy use5,6- Minimal heat production5- Less fluid needed5- INTREPID Hybrid Tip:- Designed to provide efficient performancesimilar to the INTREPID Balanced TipUS-CNT-19-E-0682a

Scientific innovationhas never been so uneventfulWhen your procedures match your expectations, you can provide a newbaseline of safety, consistency and control for your patients. Designed toreduce post-occlusion surge, the ACTIVE SENTRY Handpiece helps tomaintain stability in the anterior chamber and improve consistencyduring every procedure. With less variance in surge amplitude, you’ll beable to minimize yet another variable in the surgical experience.The first and only phaco handpiecewith a built-in fluidics pressure sensor.US-CNT-19-E-0682a

Superior surge reduction3The ACTIVE SENTRY Handpiece communicates with hardware and software for more consistent procedures.The ACTIVE SENTRY Handpiece alerts Active Fluidics Technology as fluctuation occurs in the anterior chamber,triggering immediate adjustments designed to stabilize the anterior chamber and ensure consistency.3Simulated Eye Volume After Occlusion Break2(IOP 50 mmHg; Vac Setting 500 mmHg;Asp Rate 40 cc/min)The ACTIVE SENTRY Handpiece provides realtime, superior surge reduction after occlusionbreaks, ensuring more consistent volume and IOP.1,3US-CNT-19-E-0682aTechnical Overview, Surge Mitigation:ACTIVE SENTRY Handpiece8(Surge Volume, IOP Setpoint 55 mmHg)

Mitigating risks to help safeguard your outcomes3The ACTIVE SENTRY Handpiece performs at a higher level when variables arise, as it is designed to reducepotential issues that could otherwise endanger outcomes.Maintains target IOP across cases Sensor automatically recognizes patient eyelevel (PEL) in every case Eliminates need for manual adjustmentsIOP Error vs. PEL Offset9US-CNT-19-E-0682aCompensates for average incision leakage Sensor automatically detects difference inaspiration and irrigation rates Increases irrigation flow for consistent pressureIOP Error vs. Incision Leakage9

Engineered for safer, controlled phaco performance3The CENTURION Vision System with ACTIVE SENTRY HandpieceThe CENTURION Vision System withACTIVE SENTRY Handpiece consistentlypreserves more volume, for less surgeand a greater safety profile.3consistently preserves more volume, for less surge and a greatersafety profile across a variety of vacuum levels.3Engineered for safe, controlled phaco performance across a variety of vacuum levels3Phakic Eye Testing10Vacuum Limit(mmHg)Surge Volume(µL)Percent Volume Lossin Phakic EyePercent Volume Lossin Aphakic EyeCENTURION VisionSystem200–60017–777%–31%4%–17%AMO ��65%15%–35%DORC EVA*B&L Stellaris PC**Trademarks are the property of their respective owners.US-CNT-19-E-0682aAphakic Eye Testing10

The evolution of fluidics in phacoGravity fluidicsUses bottle height to regulate IOPHyper-pressurized fluidicsUses air pump to achieve high irrigation pressure in bottleActive Fluidics TechnologyUses compression plates to maintain surgeon-selected target IOPActive Fluidics Technology with ACTIVE SENTRY HandpieceCombines Active Fluidics Technology with irrigation pressuresensor in handpieceUS-CNT-19-E-0682a

3. Active Fluidics TechnologyUses compression plates to adjust1. Fluidics pressure sensorDetects changes in anteriorpressure on BSS irrigating solution bag,compensating for changes in the eyechamber stability as they occur4. QuickValve technology2. ACTIVE SENTRY HandpieceReleases fluid into aspiration lineSignals to CENTURION VisionSystem hardware and software thatadjustments are needed to maintainconsistent IOPUS-CNT-19-E-0682a

Chamber stability at every moment,control throughout every procedureActive Fluidics Technology uses compression plates to apply and release pressure on the BSS irrigatingsolution bag as changes in the anterior chamber are detected, actively working to maintain target IOP.3 Compensates for varying aspiration flow rates in real time3,11 Less IOP fluctuation versus gravity and pressurized fluidics3,11“With the CENTURION Vision System withACTIVE SENTRY Handpiece, there was lessmovement of the posterior capsule with afaster recovery of chamber and bag volume.”– Cesar Espiritu, MD, vice-chairman of theManila Doctors Hospital ophthalmology departmentPaid Alcon ConsultantUS-CNT-19-E-0682a

Dynamic IOP control1-3Flow rates vary during every case. Unlike gravity and pressurized fluidics, Active Fluidics Technology detects and compensates to help maintain surgeon-selected IOP.IOP as Aspiration Rate Rises3Gravity vs. Active Fluidics IOP vs. Aspiration Flow Rate3,11 PressurizedBottle Compared with Active Fluidics *Trademarks are the property of their respective owners.Flow rates vary during every case. Unlike gravity and pressurized fluidics, Active Fluidics Technology detects and compensates to help maintain surgeon-selected IOP.US-CNT-19-E-0682a

Exceptional efficiency to reduce time, energy and risk5,6,12The uniquely efficient combination of OZil Handpiece technology and innovative fluidicsstreamlines phacoemulsification procedures while making them easier on patients’ eyes.5-7,12 Accelerated cataract removal*,5,6 Reduced repulsion13 Reduced energy output5 Less fluid use5,6 Enhanced torsional efficiency5-7Cumulative Dissipated I Vision SystemConfiguration(n 97)Group difference (95% confidence interval):–2.79 (–3.44 to –2.13) percent-seconds;data reflect least squares mean standard error.CENTURION Vision SystemConfiguration(n 98)US-CNT-19-E-0682aINFINITI Vision SystemConfiguration(n 97)Group difference (95% confidence interval):–6.12 (–9.82 to –2.43) mL; data reflect leastsquares mean standard error.CENTURION Configuration: CENTURION Vision System, 45 Balanced Tip with INTREPID Ultra Sleeve INFINITI Configuration: INFINITI Vision System, 45 Mini Flared Kelman with Ultra Sleeve*As compared to the INFINITI Vision System, bottle gravity system.9%Faster151.851005000CENTURION Vision SystemConfiguration(n 98)167.63150Aspiration Time, seconds39%4.32Aspiration Time660Aspiration Fluid Used, mLCDE, percent-seconds7.11Aspiration Fluid Used6CENTURION Vision SystemConfiguration(n 98)INFINITI Vision SystemConfiguration(n 97)Group difference (95% confidence interval):–15.78 (–26.49 to –5.07) seconds; data reflectleast squares mean standard error.

Energy delivery designed to protect5Versus traditional and Ellips* FX ultrasound modalities, OZil phaco Handpiece andthe Balanced Tip deliver 60% less temperature rise and safer heat transfer.12Ellips* FX IRTemperature Recording12Temporal plot oftemperature atincisionUS-CNT-19-E-0682aOZil Torsional Handpiece IRTemperature Recording12Temporal plot oftemperature atincision*Trademarks are the property of their respective owners.Temperature RiseUnder Occlusion & Load12

Taking our legacy of safety to the nextlevel with the INTREPID Hybrid TipElevating the patient protection of the INTREPID Balanced Tip with proprietarypolymer technologyTwo proven technologies — one innovative design for reducing damage to thecapsular bag and other tissues1: Rounded polymer edge designed to reduce the risk of capsular tears Cutting performance suitable for cataract densities up to3 Fluidics performance and configuration similarto the INTREPID Balanced TipINTREPID Balanced TipUS-CNT-19-E-0682aINTREPID Hybrid Tip

Sophisticated performancethrough versatile phaco technologyEfficiency at your fingertipsINTREPID Balanced Tip offers: More lateral movement at tip, less shaft movement at incision site5 Minimal heat production5 Minimized corneal stromal changes and complications5 Alternative “straight” tip for torsional phacoAdaptability for a variety of casesINTREPID Transformer I/A Handpiece allows for: Coaxial or bimanual cortical removal Easier transitions with an all-in-one handpieceUS-CNT-19-E-0682a

Improve outcomeswith controlled phaco performanceThe CENTURION Vision System with ACTIVE SENTRY Handpiece: Reduces surge by detecting pressure and triggeringprecise adjustments to ensure consistency3 Maintains target IOP — regardless of PEL — with Active Fluidics Technology3,11 Maintains stability across a variety of vacuum levels3 Reduces phaco procedure times, as well as fluid use*,5,6 Protects patient’s eye from heat injury5,12 With INTREPID Hybrid Tips, helps reduce the risk of capsular tears and improvepatient safety in the OR4*As compared to the INFINITI Vision System, bottle gravity system.Contact your Alcon representative to learnmore about improving your baseline ofsafety and efficiency.US-CNT-19-E-0682a