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ProgramWednesday, June 1, 20162 – 5 p.m.Meeting of SubcommitteesThursday, June 2, 2016Friday, June 3, 20168 a.m.8:30 a.m.8 a.m.8:30 a.m.Registration and Continental BreakfastWelcome and IntroductionDavid J. Goldberg, M.D.8:40 – 10 a.m.Special Session on Feeding and Nutrition8:40 a.m.Difficulties Optimizing Nutrition for Post-operative PatientsMelanie Savoca, M.S., R.D., C.N.S.C., L.D.N.9 a.m.Do Infants with CHD Grow Normally, and Does It Matter?Kevin D. Hill, M.D., M.S.9:20 a.m.The Stomach and the Brain: The Relationship Between Growth and NeurodevelopmentalOutcomesChitra Ravishankar, M.D.9:40 a.m. Panel Discussion10 a.m. Break10:15 – 11 a.m.Roundtable DiscussionExperience from 10 Years of Cardiac Neurodevelopmental Follow-up ProgramsJennifer L. Butcher, Ph.D.Dawn Ilardi, Ph.D., A.B.P.P.-C.N.Kathleen Mussatto, Ph.D., R.N.Gretchen Carroll, M.A.Alisa Burnham, M.D.Erica Sood, Ph.,D.11 a.m.The Newburger – Bellinger AwardSteven P. Miller, M.D.11:45 a.m.Update from the Steering CommitteeNoon Closing Remarks and AdjournDavid J. Goldberg, M.D.RegistrationOverviewAMA Credit Designation StatementThe 2016 Cardiac Neurodevelopmental Symposiumwill bring together leaders from across the UnitedStates to focus on the crucial issue of childhooddevelopment in children born with congenital heartdisease. This two-day symposium will focus on riskfactors for altered neuro-architecture, opportunitiesfor intervention and current outcomes for thisat-risk population. We will have a special sectionon the challenge of initiating and maintainingadequate nutrition and on special issues related tochromosomal differences. In addition, we will havea roundtable discussion focused on the challengesand opportunities for cardiac neurodevelopmentalprograms from around the country.The Children’s Hospital of Philadelphia designatesthis live activity for a maximum of 9.50 AMA PRACategory 1 Credits . Physicians should claim onlythe credit commensurate with the extent of theirparticipation in the activity.Cardiac Neurodevelopmental SymposiumGeneral informationThe conference will be held in the Ruth and TristramColket, Jr. Translational Research Building at TheChildren’s Hospital of Philadelphia. The registrationfee is 350 for physicians and 250 for otherhealthcare professionals and includes continentalbreakfast, breaks, lunch, parking and syllabusmaterial.Course Objectives Discuss the types of risks encountered by a fetus,infant and child with congenital heart disease Explore ongoing research focused on improvingthe neurodevelopmental environment experiencedby the patient with congenital heart diseasethrough gestation and through the exposure tocardiac surgery and recovery Review the current neurodevelopmental outcomesfor children with congenital heart disease Comprehend how differences in genetics mayimpact neurodevelopmental outcome within thegroup of patients with congenital heart diseaseNursing Accreditation StatementThe Children’s Hospital of Philadelphia isan approved provider of continuing nursingeducation by the Pennsylvania State NursesAssociation an accredited approver by the AmericanNurses Credentialing Center’s Commission onAccreditation.Hotel AccommodationsA block of rooms has been reserved at reduced ratesat The Sheraton Philadelphia Downtown. The groupovernight rate is 179 single and double occupancyplus a 15.5 percent room tax. Participants arerequired to make their own hotel reservations bycalling the Sheraton directly at 1-800-325-3535.Please mention the name of the conference whenmaking your reservation. A shuttle to and from theconference will be provided each day. The specialroom rate will be available until Monday, May 2.After that date, reservations will be accepted on aspace and rate availability basis.Cancellation and Refund PolicyThe Children’s Hospital of Philadelphia reservesthe right to cancel or postpone any course dueto any unforeseen circumstances. In the eventof cancellation or postponement, The Children’sHospital of Philadelphia will refund any registrationfees, less a 40 service charge, but is not responsiblefor any related costs, charges or expenses toparticipants, including cancellation charges assessedby airlines or travel agencies. In order to processACCME Accreditation Statementrefunds for course withdrawals, cancellation must beThe Children’s Hospital of Philadelphia is accredited received in writing by Monday, May 23, 2016. Norefunds will be issued thereafter.by the Accreditation Council for ContinuingMedical Education (ACCME) to provide continuingServices for People with Disabilitieseducation for physicians.If special arrangements are required for anindividual with a disability to attend thismeeting, please contact the Continuing MedicalEducation Department at 215-590-5263.Wednesday – Friday, June 1 – 3, 2016Registration Deadline: Monday, May 23, 2016Nameq M.D. q D.O. q C.R.N.P. q R.N. q OtherSpecialtyInstitutionHome AddressCity State ZIPPhone FaxEmailConference Registration Fees:Physicians 350Others 250Method of Payment(Please make checks payable to The Children’s Hospital of Philadelphia.)q Personal check q Institutional checkq MasterCardq Discoverq American Expressq VISACredit Card #Exp. DateMail or fax the completed registration form and payment to:Ms. Micah HollidayContinuing Medical EducationThe Children’s Hospital of Philadelphia34th Street and Civic Center BoulevardPhiladelphia, PA 19104215-590-5CME Fax 215-590-4342 hollidaydm@email.chop.edu 2016 The Children’s Hospital of Philadelphia, All Rights Reserved. 16CME0070/1.2M/03-16Register online at www.chop.edu/cmeRegistration and Continental BreakfastWelcome and IntroductionDavid J. Goldberg, M.D.8:40 – 10:30 a.m.The At-risk Brain8:40 a.m.Neonatal Flow Patterns in the Fetus with Congenital Heart DiseaseMichael Seed, M.D.8:55 a.m.Brain Development in CHD: What Do We Know and What Does It Mean?Shabnam Peyvandi, M.D.9:10 a.m.Pre-operative Lesion: How and Why They Appear and Do They MatterDaniel J. Licht, M.D.9:25 a.m.Operative Strategies; The Limits of Cerebral Perfusion and Total Circulatory ArrestChristopher Mascio, M.D.9:40 a.m.Impact of Length of Stay and Exposure to ECMO on Developmental OutcomesMatthew J. O’Connor, M.D.9:55 a.m.Cerebral Perfusion in the Toddler with Single Ventricle Heart Disease: Links to Brain Lesionsand Hemodynamics and Possible Effects on Neurodevelopmental OutcomeMark Fogel, M.D., F.A.C.C., F.A.H.A., F.A.A.P.10:10 a.m. Panel Discussion10:30 a.m. Break10:45 a.m. – noon Can We Change the Substrate?10:45 a.m.Fetal Hyperoxia, Middle Cerebral Artery Flow and Neurodevelopmental Outcomes: Putting thePieces TogetherAnita Szwast, M.D.11:05 a.m.Neuroprotective Strategies for the FetusJ. William Gaynor, M.D.11:25 a.m.Anesthetic Management to Prevent Ischemic Neurological InjuryKenneth Brady, M.D.11:45 a.m.Panel DiscussionNoonLunch1 – 3 p.m.The Post-hospital Phenotype1 p.m.How to Address Developmental Needs in the ICU/CCUBarbara Medoff-Cooper, Ph.D, B.S.N., M.S., F.A.A.N.1:20 p.m.Neuorodevelopmental Outcomes/Challenges in the Pre-school YearsKaren Uzark, P.N.P.1:40 p.m.The Grade School Years: Lessons from the SVR CohortCaren Goldberg, M.D.2 p.m.The Adolescent Brain and the Impact of Congenital Heart DiseaseJane Newburger, M.D., M.P.H.2:20 p.m.Psychosocial Predictors of Quality of Life in CHD SurvivorsBradley Marino, M.D., M.P.P., M.S.C.E.2:40 p.m.Panel Dicussion3 p.m.Break3:20 – 4:20 p.m.The Impact of Genetics on Neurodevelopmental Outcomes3:20 p.m.Genetic Modifier of Neurodevelopmental OutcomesRyan Davies, M.D.3:40 p.m.Neurodevelopmental Outcomes in Children with CHD Due to a Chromosome 22q11.2 DeletionDonna McDonald-McGinn, M.S., L.C.G.C.4 p.m.Panel Discussion4:20 p.m.Closing RemarksDavid J. Goldberg, M.D.4:30 p.m.ReceptionGeneral Information

ProgramWednesday, June 1, 20162 – 5 p.m.Meeting of SubcommitteesThursday, June 2, 2016Friday, June 3, 20168 a.m.8:30 a.m.8 a.m.8:30 a.m.Registration and Continental BreakfastWelcome and IntroductionDavid J. Goldberg, M.D.8:40 – 10 a.m.Special Session on Feeding and Nutrition8:40 a.m.Difficulties Optimizing Nutrition for Post-operative PatientsMelanie Savoca, M.S., R.D., C.N.S.C., L.D.N.9 a.m.Do Infants with CHD Grow Normally, and Does It Matter?Kevin D. Hill, M.D., M.S.9:20 a.m.The Stomach and the Brain: The Relationship Between Growth and NeurodevelopmentalOutcomesChitra Ravishankar, M.D.9:40 a.m. Panel Discussion10 a.m. Break10:15 – 11 a.m.Roundtable DiscussionExperience from 10 Years of Cardiac Neurodevelopmental Follow-up ProgramsJennifer L. Butcher, Ph.D.Dawn Ilardi, Ph.D., A.B.P.P.-C.N.Kathleen Mussatto, Ph.D., R.N.Gretchen Carroll, M.A.Alisa Burnham, M.D.Erica Sood, Ph.,D.11 a.m.The Newburger – Bellinger AwardSteven P. Miller, M.D.11:45 a.m.Update from the Steering CommitteeNoon Closing Remarks and AdjournDavid J. Goldberg, M.D.RegistrationOverviewAMA Credit Designation StatementThe 2016 Cardiac Neurodevelopmental Symposiumwill bring together leaders from across the UnitedStates to focus on the crucial issue of childhooddevelopment in children born with congenital heartdisease. This two-day symposium will focus on riskfactors for altered neuro-architecture, opportunitiesfor intervention and current outcomes for thisat-risk population. We will have a special sectionon the challenge of initiating and maintainingadequate nutrition and on special issues related tochromosomal differences. In addition, we will havea roundtable discussion focused on the challengesand opportunities for cardiac neurodevelopmentalprograms from around the country.The Children’s Hospital of Philadelphia designatesthis live activity for a maximum of 9.50 AMA PRACategory 1 Credits . Physicians should claim onlythe credit commensurate with the extent of theirparticipation in the activity.Cardiac Neurodevelopmental SymposiumGeneral informationThe conference will be held in the Ruth and TristramColket, Jr. Translational Research Building at TheChildren’s Hospital of Philadelphia. The registrationfee is 350 for physicians and 250 for otherhealthcare professionals and includes continentalbreakfast, breaks, lunch, parking and syllabusmaterial.Course Objectives Discuss the types of risks encountered by a fetus,infant and child with congenital heart disease Explore ongoing research focused on improvingthe neurodevelopmental environment experiencedby the patient with congenital heart diseasethrough gestation and through the exposure tocardiac surgery and recovery Review the current neurodevelopmental outcomesfor children with congenital heart disease Comprehend how differences in genetics mayimpact neurodevelopmental outcome within thegroup of patients with congenital heart diseaseNursing Accreditation StatementThe Children’s Hospital of Philadelphia isan approved provider of continuing nursingeducation by the Pennsylvania State NursesAssociation an accredited approver by the AmericanNurses Credentialing Center’s Commission onAccreditation.Hotel AccommodationsA block of rooms has been reserved at reduced ratesat The Sheraton Philadelphia Downtown. The groupovernight rate is 179 single and double occupancyplus a 15.5 percent room tax. Participants arerequired to make their own hotel reservations bycalling the Sheraton directly at 1-800-325-3535.Please mention the name of the conference whenmaking your reservation. A shuttle to and from theconference will be provided each day. The specialroom rate will be available until Monday, May 2.After that date, reservations will be accepted on aspace and rate availability basis.Cancellation and Refund PolicyThe Children’s Hospital of Philadelphia reservesthe right to cancel or postpone any course dueto any unforeseen circumstances. In the eventof cancellation or postponement, The Children’sHospital of Philadelphia will refund any registrationfees, less a 40 service charge, but is not responsiblefor any related costs, charges or expenses toparticipants, including cancellation charges assessedby airlines or travel agencies. In order to processACCME Accreditation Statementrefunds for course withdrawals, cancellation must beThe Children’s Hospital of Philadelphia is accredited received in writing by Monday, May 23, 2016. Norefunds will be issued thereafter.by the Accreditation Council for ContinuingMedical Education (ACCME) to provide continuingServices for People with Disabilitieseducation for physicians.If special arrangements are required for anindividual with a disability to attend thismeeting, please contact the Continuing MedicalEducation Department at 215-590-5263.Wednesday – Friday, June 1 – 3, 2016Registration Deadline: Monday, May 23, 2016Nameq M.D. q D.O. q C.R.N.P. q R.N. q OtherSpecialtyInstitutionHome AddressCity State ZIPPhone FaxEmailConference Registration Fees:Physicians 350Others 250Method of Payment(Please make checks payable to The Children’s Hospital of Philadelphia.)q Personal check q Institutional checkq MasterCardq Discoverq American Expressq VISACredit Card #Exp. DateMail or fax the completed registration form and payment to:Ms. Micah HollidayContinuing Medical EducationThe Children’s Hospital of Philadelphia34th Street and Civic Center BoulevardPhiladelphia, PA 19104215-590-5CME Fax 215-590-4342 hollidaydm@email.chop.edu 2016 The Children’s Hospital of Philadelphia, All Rights Reserved. 16CME0070/1.2M/03-16Register online at www.chop.edu/cmeRegistration and Continental BreakfastWelcome and IntroductionDavid J. Goldberg, M.D.8:40 – 10:30 a.m.The At-risk Brain8:40 a.m.Neonatal Flow Patterns in the Fetus with Congenital Heart DiseaseMichael Seed, M.D.8:55 a.m.Brain Development in CHD: What Do We Know and What Does It Mean?Shabnam Peyvandi, M.D.9:10 a.m.Pre-operative Lesion: How and Why They Appear and Do They MatterDaniel J. Licht, M.D.9:25 a.m.Operative Strategies; The Limits of Cerebral Perfusion and Total Circulatory ArrestChristopher Mascio, M.D.9:40 a.m.Impact of Length of Stay and Exposure to ECMO on Developmental OutcomesMatthew J. O’Connor, M.D.9:55 a.m.Cerebral Perfusion in the Toddler with Single Ventricle Heart Disease: Links to Brain Lesionsand Hemodynamics and Possible Effects on Neurodevelopmental OutcomeMark Fogel, M.D., F.A.C.C., F.A.H.A., F.A.A.P.10:10 a.m. Panel Discussion10:30 a.m. Break10:45 a.m. – noon Can We Change the Substrate?10:45 a.m.Fetal Hyperoxia, Middle Cerebral Artery Flow and Neurodevelopmental Outcomes: Putting thePieces TogetherAnita Szwast, M.D.11:05 a.m.Neuroprotective Strategies for the FetusJ. William Gaynor, M.D.11:25 a.m.Anesthetic Management to Prevent Ischemic Neurological InjuryKenneth Brady, M.D.11:45 a.m.Panel DiscussionNoonLunch1 – 3 p.m.The Post-hospital Phenotype1 p.m.How to Address Developmental Needs in the ICU/CCUBarbara Medoff-Cooper, Ph.D, B.S.N., M.S., F.A.A.N.1:20 p.m.Neuorodevelopmental Outcomes/Challenges in the Pre-school YearsKaren Uzark, P.N.P.1:40 p.m.The Grade School Years: Lessons from the SVR CohortCaren Goldberg, M.D.2 p.m.The Adolescent Brain and the Impact of Congenital Heart DiseaseJane Newburger, M.D., M.P.H.2:20 p.m.Psychosocial Predictors of Quality of Life in CHD SurvivorsBradley Marino, M.D., M.P.P., M.S.C.E.2:40 p.m.Panel Dicussion3 p.m.Break3:20 – 4:20 p.m.The Impact of Genetics on Neurodevelopmental Outcomes3:20 p.m.Genetic Modifier of Neurodevelopmental OutcomesRyan Davies, M.D.3:40 p.m.Neurodevelopmental Outcomes in Children with CHD Due to a Chromosome 22q11.2 DeletionDonna McDonald-McGinn, M.S., L.C.G.C.4 p.m.Panel Discussion4:20 p.m.Closing RemarksDavid J. Goldberg, M.D.4:30 p.m.ReceptionGeneral Information

Course FacultyUnless otherwise noted, faculty is from The Children’s Hospital of Philadelphiaand the Perelman School of Medicine at the University of Pennsylvania.Course DirectorsGuest FacultyDavid J. Goldberg, M.D.Director, Cardiac Kids Developmental Follow-up ProgramAttending CardiologistAssistant Professor of PediatricsKenneth Brady, M.D.Texas Children’s HospitalAssociate Professor of Pediatrics and AnesthesiaBaylor College of MedicineJ. William Gaynor, M.D.Attending Cardiothoracic SurgeonDirector of Fetal Neuroprotection and Neuroplasticity ProgramProfessor of SurgeryJennifer L. Butcher, Ph.D.Psychology DirectorUniversity of Michigan Congenital Heart CenterNeurodevelopmental Follow-up ProgramAssistant Professor of PediatricsUniversity of Michigan Medical SchoolMark A. Fogel, M.D.Director, Cardiac Magnetic ResonanceProfessor, Cardiology and RadiologyDaniel J. Licht, M.D., F.A.C.C., F.A.H.A., F.A.A.P.Associate Professor, Neurology and PediatricsDirector, Steve and June Wolfson Laboratory for Clinical and Biomedical OpticsChristopher Mascio, M.D.Attending Cardiothoracic SurgeonAssistant Professor of Clinical MedicineDonna M. McDonald-McGinn, M.S., L.C.G.C.Chief, Section of Genetic CounselingDirector, 22q and You CenterAssociate Director, Clinical Genetics CenterClinical Professor of PediatricsBarbara Medoff-Cooper, Ph.D, B.S.N., M.S., F.A.A.N.Ruth M. Colket Professor in Pediatric NursingUniversity of Pennsylvania School of Nursing ScienceMatthew J. O’Connor, M.D.Attending Pediatric CardiologistAssistant Professor of PediatricsChitra Ravishankar, M.D.Attending Pediatric CardiologistAssociate Professor of PediatricsMelanie Savoca, M.S., R.D., C.N.S.C., L.D.N.Clinical DietitianAnita Szwast, M.D.Attending Pediatric CardiologistAssistant Professor of PediatricsGretchen Carroll, M.A.Education Diagnostician and School LiaisonNeurodevelopmental Education ClinicThe Heart InstituteCincinnati Children’s Hospital MedicalCenterRyan Davies, M.D.Attending Cardiothoracic SurgeonNemours/Alfred I. duPont Hospital for ChildrenAssistant Professor of SurgeryThomas Jefferson UniversityCaren Goldberg, M.D.Attending CardiologistC.S. Mott Children’s HospitalClinical Professor of PediatricsThe University of Michigan Health SystemKevin D. H

University of Michigan Congenital Heart Center. Neurodevelopmental Follow-up Program Assistant Professor of Pediatrics. University of Michigan Medical School. Gretchen Carroll, M.A. Education Diagnostician and School Liaison Neurodevelopmental Education Clinic. The Heart Institute Cincinnati Children’s Hos