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Final ProgramWednesday, September 7, 20227:30 – 9:00 AMSession 1Sapphire BCFGJKNOOpening Remarks and Keynote Lecture7:307:457:558:10Presidential Remarks and WelcomeMichelle A. Albert, MD, MPH, FAHA, American Heart Association PresidentCurt D. Sigmund, PhD, FAHA, Chair, Council on HypertensionR. Ariel Gomez, MD, FAHA, Chair, Hypertension 2022 Program CommitteeOpening Keynote Lecture:Challenges and New Approaches to Drug Discovery for G Protein Coupled ReceptorsBrian Kobilka, MD, Department of Molecular and Cellular Physiology, Stanford University School ofMedicine9:00 – 10:00 AMSession 2Sapphire BCFGJKNORecent Advances in HypertensionAdipose Biology in the Cardiovascular System: Advances, Tools and Context in HypertensionModerators: Stephanie Watts, PhD, FAHA and Clintoria R. Williams, PhD, FAHA9:00The Multifaceted Roles of Adipose TissueChristy Gliniak9:20A Unique Adipocyteprogenitor Population Promotes Age-Related AdiposityQiong (Annabel) Wang, PhD9:40Adipose Tissue in the CV systemAndres Contreras, DVM, MS, PhD10:00 AMBreak10:30 AM – 12:00 PMSession 3Sapphire BCFGJKNORecent Advances in HypertensionSodium-Potassium Ratio: Effects and the Implications for the PublicModerators: Stephen Juraschek, MD, PhD, FAHA and Alexander Staruschenko, PhD, FAHA10:30Non-Traditional Mechanisms of Salt-SensitivitySrividya Kidambi, MD, MS10: 55Beneficial Effects of a High Potassium DietPaul A. Welling, MD, FAHA
11:20Population Effects of Dietary ChangesKirsten Bibbins-Domingo, MD, PhD11:45Discussion/Q&A12:00 PMSession 4Sapphire DHMeet the Nobel Networking EventBrian Kobilka, MD, Department of Molecular and Cellular Physiology, Stanford University School of Medicine(Open to all, Limited Attendance)1:30 – 3:00 PMConcurrent Session 5ASapphire 400Trainee Advocacy Committee (TAC) Jr Faculty Showcase SessionModerators: Jessica L Faulkner, PhD and Francisco Rios, PhD11:3021:4532:0042:1552:3062:45Germline Mutagenesis Induces Blood Pressure And Heart Rate Variation In Mice UncoveringNovel Insights On The Genesis Of Cardiovascular Disease RisksSamantha Kuwada Teixeira,Roberto Pontes, Luiz Fernando Zuleta, Rogerio Rosa, Heart Inst - FMUSP, Sao Paulo, Brazil; LetíciaBertoline, FMUSP, Sao Paulo, Brazil; Jianhui Wang, darui xu, Ctr for the Genetics of Host Defense, Univof Texas Southwestern Medical Ctr, Dallas, TX; Jamie L Russell, UT SOUTHWESTERN MEDICALCENTER, Dallas, TX; Xiaoming Zhan, Mihwa Choi, Miao Tang, Ctr for the Genetics of Host Defense,Univ of Texas Southwestern Medical Ctr, Dallas, TX; Xiaohong Li, Sara Ludwig, Bruce Beutler, Jose EKrieger, Univ Sao Paulo Med Sch, Sao Paulo Sp, BrazilReducing Blood Pressure By Decreasing Na/k Pump Activities Using Synchronization ModulationElectric Field Lei Wang, UNIVERSITY OF SOUTH FLORIDA, Tampa, FLTreatment With Ligilactobacillus Improves Gut Permeability And Hypertension In SpontaneouslyHypertensive RatsMasashi Mukohda, Okayama Univ of Science, Imabari Ehime, Japan; Takanori Yano, Okayama Univ ofScience, Okayama Okayama, Japan; Toshiyasu Matsui, Okayama Univ of Science, Imabari Ehime, Japan;Sho Nakamura, Nagoya Univ, Aichi Nagoya, Japan; Jiro Miyamae, Okayama Univ of Science, ImabariEhime, Japan; Risuke Mizuno, Okayama Univ of Science, Imabari; Hiroshi Ozaki, Okayama Univ ofScience, Imabari Ehime, JapanPro-angiogenic Effects Of The Thrombospondin-1 Inhibitor Lskl In Preeclampsia ModelsCasandra Marc, Allahnah Achille, Univ de Montréal, Montreal, QC, Canada; Geneviève Frégeau, LydiaHannou, Isabelle Vachon, CIUSSS Nord-de-l'Île-de-Montréal, Montreal, QC, Canada; CathyVaillancourt, INRS - Armand-Frappier Santé Biotechnologie Res Ctr, Montreal, QC, Canada; Julie LLavoie, CHUM, Montreal, QC, Canada; Mariane Bertagnolli, McGill Univ, Montreal, QC, CanadaLoss Of Resident Renal Dendritic Cells Prevents Salt-sensitive Hypertension And Proinflammatory Cytokine ProductionMasaaki Yoshigi, UNIVERSITY UTAH, Salt Lake City, UT; Deborah Stuart, Univ of Utah, CottonwoodHeights, UT; Kennedy Koehler, Harini Srinivasan, Univ of Utah, Salt Lake Cty, UT; Douglas C Eaton,EMORY UNIV SCHOOL MEDICINE, Atlanta, GA; Nirupama Ramkumar, UNIVERSITY OF UTAH,Salt Lake Cty, UT; Brandi M Wynne, Univ of Utah, Salt Lake Cty, UTLiver-specific Bmal1 Deletion In Mice Increases Aortic Stiffness With Age-dependent AlterationsIn The Vasculature
Paramita Pati, Carmen De Miguel, Jackson Colson, Telisha Millender-Swain, Shannon Bailey, JenniferS Pollock, Univ of Alabama at Birmingham, Birmingham, ALConcurrent Session 5BCobalt 500TAC Oral Abstract Session: Epigenetics: The Genome and BeyondModerators: Megan M. Shuey, MS, PhD and Benard Ogola -induced Neurovascular Dysfunction At Single-cell ResolutionSamantha M Schaeffer, Weill Cornell Med, New york, NY; Monica M Santisteban, Giuseppe Faraco,WEILL CORNELL MEDICAL COLLEGE, New York, NY; Lidia Garcia-bonilla, Josef Anrather,WCMC, New York, NY; Costantino Iadecola, WEILL CORNELL MEDICAL COLLEGE, New York,NYGenetic Studies Identify A Novel Role Of CCDC93 In Arterial Relaxation And Central SystolicBlood PressureNitin Kumar, Univ of Michigan, Ann Arbor, MI; Min-Lee Yang, Issaquah, WA; Pengfei Sun, , PekingUniv First hospital, Beijing, China; Kristina Hunker, Univ of Michigan, Ann Arbor, MI; Yan Zhang,Peking Univ First hospital, Beijing, China; Santhi K Ganesh, INTERNAL MEDICINE/DIV CARDIOMED, Ann Arbor, MIA Genetic Variant Of Regulatory Associated Protein Of Mtor Complex 1 (raptor) Is AssociatedWith Blood PressureHayat Aljaibeji, Mahyar heydarpour, Brigham and Women's Hosp, BOSTON, MA; Ana Maria Stanton,Brigham and Women's Hosp, Harvard Medical Sch, Boston, MA; Luminita Pojoga, bwh, Boston, MA;Gordon Harold Williams, Brigham and Women's Hosp, Boston, MAPhosphodiesterase 3a Catalytic-domain Mutants Cause Hypertension With BrachydactylyCharlotte Kayser, Andreas Bock, Max Delbrück Ctr, Berlin, Germany; Lisette Leeuwen, Dept ofGenetics, Univ Medical Ctr Groningen, Groningen, Netherlands; Johanna Herkert, Yvonne Vos, Dept ofGenetics, Univ Medical Ctr Groningen, Gronigen, Netherlands; Alexa Kidd, Canterbury District HealthBoard, Christchurch, New Zealand; Atakan Aydin, Oliver Daumke, Martin Lohse, Max-Delbrück-Ctr forMolecular Med in the Helmholtz Association (MDC), Berlin, Germany; Friedrich C Luft,EXPERIMENTAL AND CLINICAL RESEARCH, Berlin, GermanyEpigenetic Determinants Of Renin Cell IdentityJason P. Smith, Alexandre Goes Martini, Nathan Sheffield, Univ of Virginia, Charlottesville, VA; MariaSequeira Lopez, Roberto Ariel Gomez, UNIVERSITY OF VIRGINIA, Charlottesville, VAL-type Calcium Channel Subunit Alpha1d (CACNA1D) Gene Polymorphisms Associate WithHigher Blood Pressure And Salt Sensitivity Of Blood PressureAna Maria Stanton, Mahyar Heydarpour, Jonathan S Williams, Gordon Harold Williams, Gail K Adler,Div of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hosp, Harvard Medical Sch,Boston, MAConcurrent Session 5CSapphire DHTAC Oral Abstract Session: New Paradigms in Immune ResponseModerators: Jing Wu, PhD and Daria Golosova, MD, PhD131:30Microbial Metabolites Induce Pro-inflammatory Mechanisms In Children With Chronic KidneyDisease
141:45152:00162:15172:30182:45Hendrik Bartolomaeus, Johannes Holle, Experimental and Clinical Res Ctr, Berlin, Germany; UlrikeLoeber, Max Delbruck Ctr, Berlin; Felix Behrens, Theda Bartolomaeus, Charite - Univsmedizin Berlin,Berlin, Germany; Harithaa Anandakumar, Moritz I Wimmer, Experimental and Clinical Res Ctr, Berlin,Germany; Dai Long Vu, Berlin Inst of Health (BIH), Berlin, Germany; Sabrina Y Geisberger, Kai-UweEckardt, ECRC, Berlin; Sofia Kirke Forslund, Berlin; Andrea Thürmer, Robert Koch Inst, Berlin,Germany; Victoria McParland, Experimental and Clinical Res Ctr, Berlin, Germany; Jennifer A Kirwan,Berlin Inst of Health (BIH), Berlin, Germany; Dominik Müller, Charite - Univsmedizin Berlin, Berlin,Germany; Nicola Wilck, ECRC, BerlinGestational Diabetic Cd4 T Cells Cause Increased Glucose, Blood Pressure And PlacentalMitochondrial Dysfunction In A Novel Rat Model Of Diabetes During PregnancyEvangeline M Deer, Jan M Williams, Lorena Amaral, Sarah Fitzgerald, Owen Herrock, NathanCampbell, Babbette B Lamarca, UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, MSHypertensive Stretch On The Regulation Of The Immunological Synapse And Secretomes Of MaleAnd Female Renal Endothelial CellsAlex Colvert, Marharyta Semenikhina, Medical Univ of South Carolina, Charleston, SC; Kristine YDeleon-Pennell, Medical Univ South Carolina, Charleston, SC; Jim Oates, Medical Univ of SouthCarolina, Charleston, SC; Oleg Palygin, Medical Univ of SC, Charleston, SC; Justin P Van Beusecum,MUSC and Ralph H. Johnson VA Medical Ctr, Charleston, SCMagnesium Deficient Diet-induced Hypertension And Renal DC-specific NLRP3 InflammasomeActivationAshley L Pitzer, Annet Kirabo, Vanderbilt Univ Medical Cente, Nashville, TN; Evan C Ray, UPMCDIVISION OF NEPHROLOGY, Pittsburgh, PADual Immune Checkpoint Inhibitor Therapy Is Associated With Increased Blood Pressure InMelanoma PatientsIsik Turker, Ananya Sharma, Vanderbilt Univ Medical Ctr, Nashville, TN; Shi Huang, Nashville, TN;Douglas Johnson, Nashville, TN, Nashville, TN; Matthew R Alexander, Vanderbilt Univ Medical Ctr,Nashville, TNB Cells Induce Hypertension, AT1AA, And Complement Activation In Preeclampsia Or InResponse To A Prior Covid-19 Infection During PregnancyOwen T Herrock, Univ of Mississippi Medical Ctr, Jackson, MS; Lorena M Amaral, MEDICALCENTER- UMMC, Jackson, MS; Evangeline M Deer, Univ of MS Medical Ctr, Brandon, MS; NathanCampbell, Univ of Mississippi Medical C, Jackson, MS; Rachael Morris, Univ of Mississippi MedicalCtr, Jackson, MS; Sarah Fitzgerald, Univ of Mississippi Medical C, Jackson, MS; Baoying Zheng, Univof MS medical center, Jackson, MS; Ja'Nasa Hardy-Hardin, Univ of Mississippi Medical Ctr, Jackson,MS; Kathy Cockrell, Univ of Mississippi Medical Ctr, Jackson, MS, Jackson, MS; Babbette B Lamarca,UNIVERSITY MISSISSIPPI MEDICAL CTR, Jackson, MSSession 5DSapphire LPCPCS ConcurrentState of the Art Debates on Blood Pressure ControlModerator: Wanpen Vongpatanasin, MD, FAHA1:30Case Presentation 1Wanpen Vongpatanasin, MD, FAHA1:35Blood Pressure Control Should Focus on Less SodiumStephen P Juraschek, MD, PhD, FAHA
1:50Blood Pressure Control Should Focus on More PotassiumSwapnil Hiremath, MD, MPH, FAHA, FASN, ISHF2:052:07Rebuttal Stephen P Juraschek, MD, PhD, FAHARebuttal Swapnil Hiremath, MD, MPH, FAHA, FASN, ISHF2:09Discussion2:15Case Presentation 2Lama Ghazi, MD, PhD2:20Systolic Blood Pressure Target Should Be Less Than 130 mm Hg Among Older Adults withHypertensionMark A. Supiano, MD, AGSF2:35For Older Adults We Are Not There Yet: Systolic Blood Pressure Target Should Be 130 mm Hg orHigherSanjay Kaul, MD2:502:52Rebuttal Mark A. Supiano, MD, AGSFRebuttal Sanjay Kaul, MD2:54Discussion3:00 PMBreak3:30 – 5:30 PMConcurrent Session 6ASapphire 400Trainee Advocacy Committee (TAC) Early Career Oral Award SessionModerators: Brandi M. Wynne, MS, PhD, FAHA and Cameron G. McCarthy, PhD, FAHA193:30203:50214:10T Cell Recognition Of Isolevuglandin-adducted Proteins In Hypertension Is Mhc Class 1-restrictedNathaniel C Bloodworth, Wei Chen, Vanderbilt Univ Medical Ctr, Nashville, TN; Natalia R RuggeriBarbaro, Cellularity, Florham Park, NJ; Mingfang Ao, Amy M Palubinsky, Vanderbilt Univ Medical Ctr,Nashville, TN; Richard T O'Niel, Medical Univ of South Carolina, Charleston, SC; Elizabeth J Phillips,Vanderbilt Univ Medical Ctr, Nashville, TN; Rocco Moretti, Vanderbilt Univ, Nashville, TN; Sean SDavies, VANDERBILT UNIVERSITY, Nashville, TN; Simon A Mallal, Vanderbilt Univ Medical Ctr,Nashville, TN; Jens Meiler, Vanderbilt Univeristy, Nashville, TN; David G. Harrison, Vanderbilt UnivMedical Ctr, Nashville, TNNox5 Regulates Vascular Smooth Muscle Cell De-differentiation In Human HypertensionLivia Camargo, McGill Univ, Montreal, QC, Canada; Sheon Mary, Univ of Glasgow, Glasgow, UnitedKingdom; Sergio Lilla, Cancer Res UK Beatson Inst, Glasgow, United Kingdom; Sara Zanivan, Univ ofGlasgow, Glasgow, United Kingdom; Richard Hartley, Univ of Glasgow, Glasgow, United Kingdom,Glasgow; Christian Delles, William Fuller, Francisco J Rios, Univ of Glasgow, Glasgow, United Kingdom;Augusto C Montezano, Rhian M Touyz, McGill Univ, Montreal, QC, CanadaActivated Cd8 T Cells Interact With Distal Convoluted Tubules To Promote Salt-sensitiveHypertension Through The Ifnγ-pdl1 PathwayLance N Benson, Yunmeng Liu, Univ of Arkansas for Medical Scien, Little Rock, AR; Yunping Guo,Little Rock, AR; Yunzhao Xiong, Univ of Arkansas for Medical Scien, Little Rock, AR; Katherine Deck,Univ of Arkansas for Medical Scien, Little Rock, AR, Little Rock, AR; Christoph Mora, Univ of Arkansas
224:30234:50245:10for Medical Science, Little Rock, AR, Little Rock, AR, Little Rock, AR; Shengyu Mu, UAMS, LittleRock, ARImpaired Parasympathetic Cardiac Modulation In Long-COVID Postural Tachycardia SyndromeStefano Rigo, Vanderbilt Univ Medical Ctr, Nashville, TN; Vasile Urechie, Vanderbilt Univ MedicalCentr, Nashville, TN; Andre Diedrich, VANDERBILT MEDICAL CENTER, Nashville, TN; Luis EOkamoto, Vanderbilt Univ Medical Ctr, Nashville, TN; Italo Biaggioni, VANDERBILT UNIVERSITYMEDICAL CENTER, Nashville, TN; Cyndya A Shibao, VANDERBILT UNIV. MEDICAL CENTER,Nashville, TNQuantification Of White Matter Lesion Volume From Clinical T1 Weighted Magnetic ResonanceImages To Predict Functional Outcomes Post-thrombectomy Mohammad Iyas Kawas, AhmadShamulzai, Wake Forest Sch of Med, Winston Salem, NC; Carol Kittel, Brian Curry, Wake ForestNeurosurgery, Winston Salem, NC; Jeongchul Kim, Wake Forest Radiology, Winston Salem, NC; KyleFargen, Wake Forest Neurosurgery, Winston-Salem, NC; Christopher Whitlow, Wake Forest Radiology,Winston-Salem, NC; Stacey Quintero Wolfe, Wake Forest Neurosurgery, Winston Salem, NCArterial Stiffness Before Hypertension: A New Paradigm In YouthSarah Henson, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH; Zhiqian Gao, Elaine M Urbina,CINCINNATI CHILDRENS HOSPITAL, Cincinnati, OHConcurrent Session 6BCobalt 500TAC Oral Abstract Session: What's Salt Got to do With It?Moderators: Tiago J Costa, PhD and Monica M. Santisteban, PhD253:30263:45274:00284:15294:30RNAseq And Bioinformatics Identify New Pathways In The Thick Ascending Limb (TAL) InvolvedIn Fructose Induced Salt Sensitive HypertensionAndrew Wu, Andrew J Eaton, Paulo Caceres, Puja Shrestha-Maskey, Henry Ford Health Hypertensionand Vascular Res Dept, Detroit, MI; Indra Adrianto, Henry Ford Health, Detroit, MI; Jessica GranadosPineda, Mohammed Z Haque, Henry Ford Health Hypertension and Vascular Res Dept, Detroit, MI; JoseA Garcia Pedraza, Univ of Salamanca, Salamanca, Spain; Pablo A Ortiz, Henry Ford HealthHypertension and Vascular Res Dept, Detroit, MISex Specific Regulation Of The Sodium-chloride Cotransporter And The Salt Sensitivity Of BloodPressure In Age-dependent HypertensionKiyoung Kim, BOSTON UNIV SCHOOL MEDICINE, Boston, MA; Richard D Wainford, BOSTONUNIV SCHOOL MEDICINE, Charlestown, MAEarly Life Sodium Restriction Programs Long-term Changes In Energy Flux And AutonomicActivityAlisha A Ziegler, Connie C Grobe, John J Reho, Justin L Grobe, Jeffrey L Segar, Medical Coll ofWisconsin, Milwaukee, WIToll-Like Receptor 4 Promotes Renal Immune Cell Infiltration And The Development Of RenalDamage During Dahl Salt-Sensitive HypertensionEmily C. Burns, Medical Coll of Georgia at Augusta Univ, Augusta, GA; Samuel Walton, AugustaUniv, Grovetown, GA; John H Dasinger, Mary Shaw, Augusta Univ, Augusta, GA; Daniel J Fehrenbach,VUMC, Nashville, TN; Aron M Geurts, Medical Coll of Wisconsin, Milwaukee, WI; Justine M AbaisBattad, Augusta Univ, Augusta, GA; David L Mattson, Medical Coll Of Georgia, Augusta, GALoss Of The Circadian Protein Per1 In The Dahl Salt-sensitive Rat Causes Exacerbation OfDiurnal Blood Pressure And Disruption Of Electrolyte Homeostasis
304:45315:00325:15Adrian Zietara, Lashodya Dissanayake, Vladislav Levchenko, Univ of South Florida, Tampa, FL;Michelle L Gumz, UNIVERSITY of FLORIDA, Gainesville, FL; Alexander Staruschenko, Univ of SouthFlorida, Tampa, FLAldosterone Promotes Nanoscale Colocalization Of Epithelial Sodium Channel Subunit Alpha AndSodium Calcium Exchanger In Neuro2a CellsSimindokht Aliabadi, Elizabeth Akin, Vivek Krishnan, Univ of Nevada, Reno, Reno, NV; Scott Earley,UNIVERSITY OF NEVADA SCHOOL OF MEDI, Reno, NV; Yumei Feng Earley, UNIVERSITY OFNEVADA, RENO, Reno, NVMutagenesis Of The Cleavage Site Of (pro)renin Receptor Abrogates Aldosterone-salt-inducedHypertension And Renal Injury In MiceZiwei Fu, Univ of Utah and VAMC, Salt Lake City, UT; Huaqing Zheng, Salt Lake City, UT; TianxinYang, UNIVERSITY UTAH, Salt Lake City, UTAfferent Renal Denervation And IL-1 Receptor Blockade Attenuate The Pathogenesis OfHypertension In DOCA-salt Mice Similarly: Evidence For A Common Mechanism?Daniel C Baumann, Univ of Minnesota, Minneapolis, MN; Dusty A Van Helden, UNIVERSITY OFMINNESOTA - IBP, Minneapolis, MN; Louise C Evans, John W Osborn, Univ of Minnesota,Minneapolis, MNConcurrent Session 6CSapphire DHTAC Oral Abstract Session: Bridging the Gap Between Discovery and Clinical ScienceModerators: Robert S Hoover MD, FAHA and Matthew Alexander, MD, PhD333:30343:45354:00364:15374:30Anti-hypertensive Treatment With Acei Vs Arbs: The Differential Effect On Brain MicrostructuralIntegrity Parameters Of Raas-targeting TreatmentsLorenzo Carnevale, Valeria Berardi, I.R.C.C.S. Neuromed, Pozzilli, Italy; Daniela Carnevale, SapienzaUniv Rome - Neuromed, Pozzilli, Italy; Giuseppe Lembo, Sapienza Univ of Rome, Pozzilli, ItalyAbsence Of Tachyphylaxis And Vasorelaxant Effect Induced By Nono2p, A New Nitric OxideDonorRaiana dos Anjos Moraes, Univ of South Carolina, Columbia, SC; Fênix Alexandra de Araujo, GoncaloMoniz Inst, Oswaldo Cruz Fndn (FIOCRUZ), Salvador, Brazil; Liliane Barreto da Silva, Rafael LeonneCruz de Jesus, Daniele Santana de Brito, Federal Univ of Bahia (UFBA), Salvador, Brazil; Denise Santosde Sá, Carlos Daniel Silva da Silva, Federal Inst of Bahia (IFBA), Salvador, Brazil; Zenis Novais daRocha, Federal Univ of Bahia (UFBA), Salvador, Brazil; Fernanda Priviero, R C Webb, Univ of SouthCarolina, Columbia, SC; Darizy Flavia Silva, Federal Univ of Bahia (UFBA), Salvador, BrazilNovel Metabolites Associated With Blood Pressure During Dietary Protein And CarbohydrateInterventionsLi Changwei, Joshua D Bundy, Ling Tian, Ruiyuan Zhang, Tulane Univ, New Orleans, LA; Jing Chen,Tuland Sch of Med, New Orleans, LA; Tanika N Kelly, Jiang He, TULANE UNIVERSITY, NewOrleans, LAFailure To Achieve Optimal Blood Pressure Control Among Stroke Patients In The OutpatientSettingAnirudh Sreekrishnan, Stanford Hosp, Menlo Park, CA; Maarten G Lansberg, STANFORDUNIVERSITY, Palo Alto, CA; Yen Low, Raj Manickam, Atropos Health, Palo Alto, CA; Lironn Kraler,Stanford Hosp, Palo Alto, CASerum Chemerin As A Novel Biomarker For Preeclampsia Complications: Effects Of Statins On ItsRelease From The Placenta
Lunbo Tan, Michelle Broekhuizen, Rugina I. Neuman, Sam Schoenmakers, Erasmus MC, Rotterdam,Netherlands; Xifeng Lu, Shenzhen Technology Univ, Shenzhen, China; A.H. Jan Danser, Koen Verdonk,Erasmus MC, Rotterdam, Netherlands384:45The Association Of Supine Hypertension Versus Standing Hypotension With AdverseCardiovascular Events Among Middle-aged AdultsWilliam Earle, Beth Israel Deaconess Medical Ctr, Boston, MA; Jordan Kondo, Harvard Medical Sch,Brookline, MA; Julia Wood, Ruth-Alma N Turkson-Ocran, Karla Kendrick, Long Huu Ngo, Beth IsraelDeaconess Medical Ctr, Boston, MA; Jennifer Cluett, BIDMC-Harvard Medical Sch, Boston, MA; Ken JMukamal, Beth Israel Deaconess Medical Ctr, Boston, MA; Elizabeth Selvin, JOHNS HOPKINSUNIVERSITY, Baltimore, MD; Natalie R Malek, JOHN HOPKINS UNIVERSITY, Baltimore, MD;Pamela L Lutsey, UNIVERSITY OF MINNESOTA, Minneapolis, MN; Josef Coresh, JOHNS HOPKINSUNIVERSITY, Baltimore, MD; Stephen P Juraschek, BIDMC-Harvard Medical Sch, Boston, MA395:00Hybrid Intrinsic Frequency Machine Learning Approach For Calculation Of Total ArterialCompliance And Aortic Characteristic Impedance From A Single Carotid Waveform In HeartFailure With Preserved Ejection FractionSoha Niroumandijahromi, Ajay Vaidya, Niema M Pahlevan, Univ of Southern California, Los Angeles,CA405:15Prevalence Of Dual Indications For Antihypertensive Medications And Statins In The NationalHealth And Nutrition SurveyKASHVI GUPTA, Univ of Missouri Kansas City, Kansas City, MO; J B Byrd, UNIVERSITY OFMICHIGAN, Ann Arbor, MI; Robert D Brook, Wayne State Univ, Detroit, MI; Melvyn Rubenfire, Univof Michigan, Ann Arbor, MI; Michael P Dorsch, Univ of Michigan, Dexter, MI; Brahmajee KNallamothu, UNIVERSITY MICHIGAN HEALTH SYSTEM, Ann Arbor, MI; Venkatesh L Murthy,Univ of Michigan, Ann Arbor, MISession 6DSapphire LPPrimary Care ConcurrentSelf-Measured Blood Pressure Monitoring with Clinical Support to Improve Hypertension OutcomeModerators: Jennifer Cluett, MD and Tony Amofah, MD, MBA, FACP, FABQAURP3:30Selection of Self-Measured Blood Pressure Monitoring Devices: Accuracy and FunctionalityTammy M. Brady, MD, PhD3:48Strategies to Increase the Use of Self-Measured Blood Pressure MonitoringCAPT Fleetwood Loustalot, FNP, PhD, FAHA4:03Self-Measured Blood Pressure Telemonitoring: Lessons Learned During the COVID-19 PandemicKelsey Bryant, MD4:18Discussion4:33Building Software for Clinicians by Clinicians: How We Created a System for Asynchronous BPSelf-Monitoring and Semi-Automated Med TitrationMintu Turakhia MD MAS, FAHA, FACC, FHRS5:03Co-Intervention Support for Self-Measured Blood Pressure MonitoringRuth-Alma Turkson-Ocran, PhD, MPH, RN, FNP-BC5:18Discussion5:30 – 7:30 PM
Sapphire AEIMPoster Session 1 (TAC Competition) and ReceptionThursday, September 8, 20227:00 – 8:00 AMSapphire DHLearning StudioHypertension Management: Advanced Options Beyond MedicationSpeakers: Naomi Fisher, MD, Prof. Murray Esler and Michael Bloch, MD (Moderator)Breakfast includedSponsor: ReCor MedicalSP.01Sapphire 400NHLBI Program Project Grants: What Applicants Need to Know!Melissa Nagelin, PhDSP.02Cobalt 500American Heart Association Research: Grant Funding and Other OpportunitiesGlenn H. Dillon, PhD8:00- 9:00 AMSession 7Sapphire BCFGJKNORecent Advances in HypertensionThe RESTORE Health Equity Research NetworkModerator: Daichi Shimbo, MD8:00AHA Health Equity Impact GoalDaichi Shimbo, MD8:02Overview of the AHA RESTORE Health Equity Research NetworkGbenga Ogedegbe, MD8:10Social Determinants of Health and HypertensionYvonne Commodore-Mensah, PhD, MHS, RN, FAHA8:20Neighborhood Environment and HypertensionPhillip Levy, MD, MPH, FAHA, FACC8:30Geographic Disparities in HypertensionShakia Hardy, PhD8:40Community Health Worker Interventions for HypertensionChidinma A. Ibe, PhD8:50Panel Discussion and Q&A9:00- 10:00AMSession 8Sapphire BCFGJKNORecent Advances in HypertensionWorsening Trends in Blood Pressure Control in the US - Getting on Track at the Organizational, Community, and
Policy LevelsModerators: Cassandra Ford, PhD, RN, FAHA, FGSA and Jan Basile, MD, FAHA, FACP9:00Worrisome Trends in Blood Pressure Control in the USJan Basile, MD, FAHA, FACP9:02Successful Health System Level StrategiesJeffrey Brettler, MD9:14Leveraging Team-Based Care to Improve Blood Pressure ControlHilary K. Wall, MPH9:26Use of Multi-faceted Evidence-based Treatment Protocols can Improve BP ControlBrent M. Egan, MD, FAHA9:38Lessons from Low-and Middle-Income Countries: Global PerspectivesAndrew Moran, MD, MPH, FAHA9:50Panel Discussion10:00 AMBreak10:30 AM– 12:00 PMSession 9Sapphire BCFGJKNORecent Advances in HypertensionEditing the Genome and Epigenome: Implications for Translational MedicineModerators: Silvia Medrano, PhD and Aron Geurts, PhD10:30Deciphering the Human Genes Through Re-Engineering Human GenomeMazhar Adli, PhD10:55Ultracompact CRISPR Proteins for in vivo Genome EditingDimitrios G. Zisoulis, PhD11:20Gene Delivery to the KidneyMatthew Wilson, MD11:45Discussion/Q&A12:00- 1:30 PMLunch on your own/ Exhibits12:00- 1:30 PMSession 10Sapphire 400Trainee Advocacy Committee CHAMP lunch(Pre-Registered Only)1:30 – 3:00 PMSapphire AEIMPOSTER SESSION 21:30 – 3:00 PM
Session 11DSapphire LPPrimary Care ConcurrentSecondary Drivers of HypertensionModerators: Eugene Yang, MD and Sandra J. Taler MD, FAHA1:30Chronic Kidney Disease and Hypertension: New Clinical UpdatesDeidra C. Crews, MD, ScM, FASN, MACP1:50Prescription and Over the Counter Medications that Impact Blood PressureJohn M. Flack MD, MPH, FASH, MACP, FAHA2:10Connecting Sleep Health to Hypertension ControlS. Justin Thomas, PhD, FSBSM2:30Who and How to Evaluate for Primary AldosteronismJohn W. Funder, MD, PhD2:50Panel with Q&A3:00 PMBreak3:30- 4:00 PMSapphire BCFGJKNOSession 12Arthur C. Corcoran Memorial LectureModerator: Sarah Lindsey, PhDEvolving Concepts of the Renin-Angiotensin System: From Hypertension to COVID-19Mark C. Chappell, PhD, FAHA4:00 - 5:30 PMConcurrent 12ASapphire 400Prorenin Receptor MechanismsModerators: Yumei Feng Earley, MD, PhD, FAHA and A.H. Jan Danser, PhD4:00414:30424:4543Rising Star Lecture: Renin/Pro-Renin ReceptorNirupama Ramkumar MD, MPH, FAHARenal-derived Human Sprr Increases Blood Pressure In Female Mice But Not In Male MiceGertrude Arthur, Audrey Poupeau, Alexis Taylor, Kellea Nichols, Jacqueline Leachman, Terry Hinds,Univ of Kentucky, Lexington, KY; Analia S Loria, UNIVERSITY OF KENTUCKY, Lexington, KY;Jeffrey Osborn, Univ of Kentucky, Lexington, KY; Frederique B Yiannikouris, UNIVERSITY OFKENTUCKY, Lexington, KYA Novel (pro)renin Receptor Variant Prr24 As A Specific Renin Receptor And Key Regulator OfNkcc2 And Urine Concentrating CapabilityTianxin Yang, Yanting Chen, Ye Feng, UNIVERSITY UTAH and VAMC, Salt Lake City, UT; FeiWang, Univ of utah and VAMC, salt lake city, UT; Huaqing Zheng, Ziwei Fu, Chang-Jiang Zou,UNIVERSITY UTAH and VAMC, Salt Lake City, UT
5:00445:15Prorenin Reduces Spontaneous Firing Rate In Cells Expressing Tyrosine Hydroxylase In TheHypothalamic Paraventricular NucleusMiriam Reyes, Univ of Neveda, Reno, Reno, NV; Lucas A Souza, Univ of Nevada, Reno, Reno, NV;Yumei Feng Earley, UNIVERSITY OF NEVADA, RENO, Reno, NVStimulation Of Intrarenal Angiotensinogen Expression And The Development Of HypertensionAnd Kidney Injury In Angiotensin II-infused Hepatic Angiotensinogen Knockout MiceRyousuke Satou, Tulane Univ, New Orleans, LA; Dien Ye, Hong S Lu, Univ of Kentucky, Lexington,KY; Akemi Katsurada, Courtney M Dugas, Tulane Univ, New Orleans, LA; Alan Daugherty, Univ ofKentucky, Lexiton, KY; Shahriar Motazedian, L Gabriel Navar, Tulane Univ, New Orleans, LAConcurrent 12BThe Vasculature and HypertensionCobalt 500Moderators: Anna Dikalova, PhD and Camilla Ferreira Wenceslau, PhD, MS, FAHA454:00464:15474:30484:45495:00505:15Soluble Protein Oligomers Induce Endoplasmic Reticulum Stress In Endothelial Cells And Lead ToDecreased Calcium Levels In The Endoplasmic ReticuluEmily W. Waigi, Laena Pernomian, R. Clinton Webb, Cameron G. McCarthy, Camilla F. Wenceslau,Univ of South Carolina, Columbia, SCInduction Of Endothelial Sirt3 After Onset Of Hypertension Rescues Endothelial FunctionAnna Dikalova, Liliya Tkachuk, Mingfang Ao, Daniel Fehrenbach, Vanderbilt Univ Medical Ctr,Nashville, TN; Jack Arbiser, Emory Univ Sch of Med, Atlanta Veterans Administration Medical Center,GA; Sergey Dikalov, Vanderbilt Univ Medical Ctr, Nashville, TNPPARg Deacetylation Mitigates Aortic Stiffness And Aortic Perivascular Adipose Tissue (aPVAT)Remodeling In Obese Male MiceNicole Maddie, Maria Alicia Carrillo-Sepulveda, NYITCOM, Glen Head, NY; Li Qiang, ColumbiaUniv, New York, NYExtracellular Endothelial Microvesicles Causative Agents In Hypertension-related EndothelialDysfunctionVinicius P. Garcia, Hannah K. Fandl, Noah M. DeSouza, Auburn R. Berry, Jared J. Greiner, Univ ofColorado, Boulder, CO; Brian L. Stauffer, Univ of Colorado Anschutz Medical Campus, Denver, CO;Christopher A. DeSouza, Univ of Colorado, Boulder, COAbrogation Of Transglutaminase 2 In Vascular Smooth Muscle Cells Attenuates Doca/salt InducedHypertension In Male MiceAnnayya Aroor, UNIVERSITY OF MISSOURI, Columbia, MO; Camila Manrique, Univ of Missouri,Columbia, MO; Huma Naz, Univ of Missouri, Columbia, Columbia, MO; Jack Hulse, UNIVERSITY OFMISSOURI HEALTH, Columbia, MO; Guanghong Jia, UNIVERSITY OF MISSOURI, Columbia, MO;Adam Whaley-Connell, UNIVERSITY MISSOURI, Columbia, MO; Guido Lastra Gonzalez,UNIVERSITY OF MISSOURI HEALTH, Columbia, MOEndothelial Cell Mineralocorticoid Receptor Deletion Improves Endothelial Function, BloodPressure And Fetal Growth In The RUPP Mouse Model Of PreeclampsiaDesmond Moronge, Victor Ayulo, Gabrielle Connor, Elisabeth Mellott, Augusta Univ, Augusta, GA; IrisZ Jaffe, TUFTS MEDICAL CENTER, Boston, MA; Safia Ogbi, Augusta Univ, Augusta, GA; Jessica LFaulkner, AUGUSTA UNIVERSITY, Augusta, GAConcurrent 12CSapphire DH
Neural Control Mechanisms of Blood Pressure RegulationModerators: Annette D. de Kloet, PhD and Christopher Banek, PhD514:00524:15534:30544:45555:00565:15Exploiting Angiotensin Sensitive Vagal Afferents To Understand And Alleviate Hypertension: AClosed Loop System For Blood Pressure ControlCaitlin Baumer Harrison, Jesus Penaloza Aponte, Khalid Elsaafien, Dominique N Johnson, Alan deAraujo, Justin A Smith, Univ of Florida, Gainesville, FL; Karen Scott, Gainesville, FL; Guillaume deLartigue, Univ of Florida, Gainesville, FL; Eric G Krause, Annette D De Kloet, UNIVERSITY OFFLORIDA, Gainesville, FLCentral Gain For Sympathetic Outflow Is Increased In Postural Tachycardia SyndromeVasile Urechie, Vanderbilt Univ Medical Ctr, Nashville, TN; Stefano Rigo, Vanderbilt Univ MedicalCente, Nashville, TN; Cyndya A Shibao, VANDERBILT UNIV. MEDICAL CENTER, Nashville, TN;Luis Enrique Okamoto, Vanderbilt Univ Medical Ctr, Nashville, TN; Italo Biaggioni, VANDERBILTUNIVERSITY MEDICAL CENTER, Nashville, TN; Alfredo Gamboa, Amr Wahba, VANDERBILTUNIVERSITY MEDICAL CENTR, Nash
Andreas M. Beyer, Medical Coll of Wisconsin, Milwaukee, WI; David D Gutterman, MEDICAL COLLEGE WISCONSIN, Milwaukee, WI; Jennifer McIntosh, Medical Coll of Wisconsin, Milwaukee, WI. 106 . 9:00 . In Utero Morphine Exposure Dysregulates The Endogenous Opioid System (EOS) And Increases Risk Factors For Cardiovascular Disease In The Adulthood Offspring
