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Louisiana Cancer Facts & Figures,Cervix Uteri CancerLouisiana Tumor RegistrySeptember, 2017

Cervix Uteri Cancer* Cervical cancer had the second highest incident rate inLouisiana compared to other states nation-wide.1 Louisiana had the 9th highest number of female deathsattributed to Cervical cancer in the United States1 Cervical cancer was ranked 10th out of the top 10 mostcommon cancers in Louisiana African American women.1 Around 230 new cervical cancer cases are expected tobe diagnosed and about 80 persons are expected to dieof this cancer in Louisiana in 20172.* ICD O 3/WHO 2008 code: C530-C539; excluding ICD-O-3 histology (type): 9050-9055, 9140, 9590-99921 Data source: State Cancer Profiles2 Data source: American Cancer Society, Cancer Facts & Figures 2017

Cervix Uteri Cancer Incidence Rates#,1Louisiana vs. US,2 2010-2014Rate Per White FemaleOnly invasive cases.to the 2000 U.S. standard population.2 Incidence data source:18 SEER registries.#1 Age-adjusted8.7Black Female

Incidence Rates # of Cervix Uteri Cancer in the U.S.All Races, Females, 2010-2014#Louisiana:Rate: 8.9 per 100,000Rank: 8thOnly invasive cases.

Cervix Uteri Cancer : Age-Specific IncidenceRates# Louisiana, 2010-201440White FemaleBlack FemaleRate per 100,0003530252015105020-#Only invasive cases.30-40-5060Age at Diagnosis70-80

Incidence Rate Per 100,000Cervix Uteri Cancer : Age-Specific IncidenceRates# between US and LA Females, 2010-20144035U.S.LA30252015105015- 20- 25- 30- 35- 40- 45- 50- 55- 60- 65- 70- 75- 80- 85Age at DiagnosisOnly invasive cases.U.S. data source:18 SEER registries.#

Cervix Uteri Cancer : Age-Specific IncidenceRates# by Race, 2010-201440Rate per 100,00035LA WhiteU.S. WhiteLA BlackU.S. Black30252015105020-30-Only invasive cases.U.S. data source:18 SEER registries.#4050Age at Diagnosis60-70-80

Incidence Rates # of Cervix Uteri Cancer in theLouisiana , All Races, Females, 2010-2014#Only invasive cases.

Cervix Uteri Cancer Incidence Rates #,1,2 by Region3Louisiana, White Females, 2010-2014Rate Per 100,00098765432109.18.17.68.59.28.06.4Only invasive cases.to the 2000 U.S. standardpopulation.2 Data source for U.S. was the 18 SEER registries.3 LTR Regions* Incidence rate of regions/Louisiana is significantly different from that of the U.S.#1 Age-adjusted7.97.97.4

Rate Per 100,000Cervix Uteri Cancer Incidence Rates1,2# by RegionLouisiana, Black Females, 2010-2014161412108642014.8#10.2 10.6 10.111.313.3# 13.711.0Only invasive cases.to the 2000 U.S. standardpopulation.2 Data source for U.S. was the 18 SEER registries.3 LTR Regions* Incidence rate of regions/Louisiana is significantly different from that of the U.S.#1 Age-adjusted11.58.7

Cervix Uteri Cancer : Trends of Incidence Rates#,1,2Whites, 1988-2014Rate per 100,00025LA Female20U.S.Female1510501988199319982003Year of DiagnosisOnly invasive cases.to the 2000 U.S. standard population.2 U.S. data source: 18 SEER registries.#1 Age-adjusted20082013

Cervix Uteri Cancer : Trends of Incidence Rates#,1,2Blacks, 1988-201425Rate per 100,000201510501986LA FemalesUS Females1990199419982002Year of DiagnosisOnly invasive cases.to the 2000 U.S. standard population.2 U.S. data source: 18 SEER registries.#1 Age-adjusted200620102014

Cervix Uteri Cancer Mortality Rates1 Louisianavs. US2, 2010-20145LAU.S.24%4.54.2Rate per 100,00043.43.532.522.52.11.510.50White Female1 Age-adjusted2to the 2000 US standard population.Data source: National center of Health Statistics (NCHS).Black Female

Mortality Rates of Cervix Uteri Cancer in the U.S.All Races, Females, 2010-2014Louisiana:Rate: 2.9 per 100,000Rank: 6th

Mortality Rates of Cervix Uteri Cancer in theLouisiana, All Races, Females, 2010-2014

Rate per 100,000Cervix Uteri Cancer : Trends of Mortality Rates1,2,White Females,1988-201411098765432101986U.S. Female19901994LA Female19982002Year of DeathAdjusted to the 2000 US standard population.source: National Center of Health Statistics (NCHS).2 Data200620102014

Cervix Uteri Cancer: Trends of Mortality Rates1,2,Blacks,1988-2014Rate per 100,00010U.S. FemaleLA Female8642019861990199419982002Year of Diagnosis1Age-adjusted to the 2000 US standard population.source: National Center of Health Statistics (NCHS).2 Data200620102014

Cervix Uteri Cancer: Trends of Incidence # andMortality Rates of Females, by Race, Louisiana,1988-201430Rate per 100,00025White Incidence (APC:-0.7*)Black Incidence (APC:-2.8*)White Mortality (APC:-0.8*)Black Mortality (APC:-2.5*)201510501988199319982003Year of Diagnosis/Death2008Only invasive cases.*Annual average percent change (APC) were calculated using weighted least squares method.#2013

Rate per 100,000Cervix Uteri Cancer: Trends of Incidence # andMortality Rates Across Females Louisiana,1988-2014201816141210864201988Female Incidence (APC:-1.7*)Female Mortality (APC:-2.2*)199319982003Year of Diagnosis/Death2008Only invasive cases.*Annual average percent change (APC) were calculated using weighted least squares method.#2013

Cervix Uteri Cancer#: Louisiana5-Year Relative Survival by Stage1, All Races,Females, 2007-20131005-Year Relative Survival Rate (%)90Percent of Cases by onal39%100LocalizedRegionalDistant#Only invasive cases.1 The stage distribution is based on Summary Stage 2000.UnstagedUnstaged4%Localized44%

5-Year Relative Survival Rate (%)Cervix Uteri Cancer#: Louisiana5-Year Relative Survival by Stage1, White Females,2007-2013Percent of Cases by 1.24030Regional, 37%20.720100LocalizedRegionalDistantUnstaged#Only invasive cases.1 The stage distribution is based on Summary Stage 2000.Localized,48%

Cervix Uteri Cancer#: Louisiana5-Year Relative Survival by Stage1, Black Females,2007-2013Percent by cases5-Year Relative Survvial Rate gional41%100LocalizedRegionalDistantUnstaged#Only invasive cases.1 The stage distribution is based on Summary Stage 2000.Unstaged4%Localized39%

Appendix A. Regions of the LouisianaTumor RegistryRegional RegistryRegion 1 – New OrleansBeginning Dateof the RegistryAverage AnnualPopulation, 2010-2014197421,864Jefferson, Orleans, St. BernardParishes CoveredRegion 2 – Baton Rouge198323,410Ascension, Assumption, East Baton Rouge, EastFeliciana, Iberville, Livingston, Pointe Coupée, St.Helena, Tangipahoa, West Baton Rouge, West FelicianaRegion 3 – SoutheastLouisiana198317,036Lafourche, Plaquemines, St. Charles, St. James, St.John, St. Tammany, Terrebonne, WashingtonRegion 4 – Acadiana198317,032Acadia, Evangeline, Iberia, Lafayette, St. Landry, St.Martin, St. Mary, VermilionRegion 5 – SouthwestLouisiana19837,698Allen, Beauregard, Calcasieu, Cameron, Jefferson DavisRegion 6 – Central Louisiana19888,283Avoyelles, Catahoula, Concordia, Grant, La Salle,Rapides, Vernon, WinnRegion 7 – NorthwestLouisiana198814,817Bienville, Bossier, Caddo, Claiborne, De Soto,Natchitoches, Red River, Sabine, WebsterRegion 8 – NortheastLouisiana19889,061Caldwell, East Carroll, Franklin, Jackson, Lincoln,Madison, Morehouse, Ouachita, Richland, Tensas,Union, West CarrollEntire State1988119,201Source: U.S. Bureau of Census and National Cancer Institute, April 2017.

Data SourcesSurveillance, Epidemiology, and End Results (SEER) Program(www.seer.cancer.gov) SEER*Stat Databases, National Cancer Institute,DCCPS, Surveillance Research Program, Surveillance Systems Branch,released April 2017, based on the November 2016 submission.For Incidence: Incidence - SEER 18 Regs Research Data Hurricane KatrinaImpacted Louisiana Cases, Nov 2016 Sub (2000-2014) Katrina/RitaPopulation Adjustment For Mortality: mortality – All COD, Aggregated With State, Total U.S. (1969-2014) Katrina/Rita Population Adjustment For Survival: Incidence - SEER 18 Regs Research Data Hurricane KatrinaImpacted Louisiana Cases, Nov 2015 Sub (1973-2013 varying)Louisiana Tumor Registry

Data Sources USCS:– U.S. Cancer Statistics Working Group. United States CancerStatistics: 1999-2014 Incidence and Mortality Web-based Report.Atlanta: U.S. Department of Health and Human Services, Centersfor Disease Control and Prevention and National Cancer Institute;2017. Available at: www.cdc.gov/uscs. Cancer Facts & Figures:– American Cancer Society. Cancer Facts & Figures 2017. Atlanta:American Cancer Society; 2017.

Data SourcesNCI State profiles Incidence Data Sources:––– Incidence data are provided by the National Program of Cancer Registries External WebSite Policy Cancer Surveillance System (NPCR-CSS), Centers for Disease Control andPrevention and by the National Cancer Institute's Surveillance, Epidemiology, and EndResults (SEER) Program External Web Site Policy.Population counts for denominators are based on Census populations as modified byNCI.Rates are calculated using SEER*Stat External Web Site Policy.Mortality Data Sources:––––Mortality data are provided by the National Vital Statistics System External Web SitePolicy at the National Center for Health Statistics of the Centers for Disease Control andPrevention.Population counts for denominators are based on Census populations as modified byNCI.Rates are calculated using SEER*Stat External Web Site Policy.Trends are determined by using Joinpoint External Web Site Policy analysis of availablehistorical data and reporting the last segment as the most recent trend.

Acknowledgements Hospital cancer registries na Cancer Registrars’ Association (http://www.lcra-usa.org/)Physicians and staff members in: Medical records offices Pathology laboratories Physician offices and clinics Hospice programs and nursing homesRegional and central offices of the Louisiana Tumor regionalregistries.html)School of Public Health, LSU Health Sciences Center–New OrleansLouisiana Cancer and Lung Trust Fund BoardCoroners’ offices

Sources of LTR Funding National Cancer Institute, SEER Program Centers for Disease Control and Prevention (CDC),National Program of Cancer Registries (NPCR) Louisiana Health Care Services Division

EditorsAlice Yeh, BSCarla B. Rosales, MPHLauren Maniscalco, MPHMeichin Hsieh, PhD, MSPH, CTRXiaocheng Wu, MD, MPH, CTRContributorsXiangrong Li, MD, MSPHBrent Mumphrey, BSTina Lefante, MPHLisa Pareti, BS, RHIT, CTRYong Yi, PhD, MS

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Around 230 new cervical cancer cases are expected to be diagnosed and about 80 persons are expected to die of this cancer in Louisiana in 20172. * ICD_O_3/WHO 2008 code: C530-C539; excluding ICD-O-3 histology (type): 9050-9055, 9140, 9590-9992 1Data source: State Cancer Profiles 2Data source: American Cancer Society, Cancer Facts & Figures 2017