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qPCR for who you areQuantStudio real-time PCR anddigital PCR systems

Every lab is unique. That’s why you deservea PCR platform that perfectly fits yourneeds. Perhaps you’re looking for versatilityon a budget, or reliable results from limitedsamples. Maybe your research requires highthroughput for maximum productivity,or absolute answers to take your workto the next level. Whatever you need,there’s a QuantStudio qPCR systemthat’s just right for your research.

Your research. Your way.QuantStudio real-time PCR and digital PCR systemsReal-time PCR onlyQuantStudio 6 FlexReal-time & digital PCRDigital PCR onlyQuantStudio 12K FlexQuantStudio 3DQuantStudio 7 FlexPrice Colors5 colors6 colors(21 filter combinations)6 colors(21 filter combinations)2 colors(endpoint detection)ChemistrySYBR , TaqMan SYBR , TaqMan SYBR , TaqMan TaqMan only96-well96-well Fast384-well96-well96-well Fast384-wellTaqMan Array Card(384-well microfluidic card)96-well96-well Fast384-wellTaqMan Array Card(384-well microfluidic card)OpenArray (3,072 through-holes)20,000 hput*************AvailableblocksBlock changeBlock change from front in less than 1 minute, no tools requiredn/a21 CFR Part 11enablementOptional software module availablen/aAvailable to monitor up to 15 networked instruments simultaneouslyn/aRemotemonitoringIntuitivetouch screenKeyapplicationsYesYesYesYes Quantification ofmolecular standards Absolute quantification Pathogen detection Load determination Copy number variation Digital PCRGene expressionmiRNA profilingSNP genotypingCopy number variationProtein thermal shiftHigh resolution meltPathogen detectionGene expressionmiRNA profilingSNP genotypingCopy number variationProtein thermal shiftHigh resolution meltPathogen detectionGene expressionmiRNA profilingSNP genotypingCopy number variationProtein thermal shiftHigh resolution meltPathogen detectionPharmacogenomicsDigital PCRLife Technologies QuantStudio real-time PCR and digital PCR systems2

I need room to growFlexibility for today, tomorrow, and beyond.QuantStudio 6 FlexReal-Time PCR SystemKey benefitsThe QuantStudio 6 Flex Real-TimePCR System is ideal for laboratorieswith multiple applications or end userson a limited budget. With an upgradablepath to a QuantStudio 7 Flex System toaccommodate automation or TaqMan Array Cards, the QuantStudio 6 FlexSystem is the ideal qPCR platform ifyour needs change in the future.With one instrument, you can interchange between96-well, 96-well Fast, and 384-well formats.Flexibility that minimizes large up-frontcapital investmentSkip the learning curveThe intuitive software, easy touch screen setup, and effortlessblock change are designed to let you get started right away.Performance you can trustDetect as small as 1.5-fold changes in singleplex reactionsand with 10 logs dynamic range.Upgrade capabilities when you need itThe QuantStudio 6 Flex System can be seamlesslyupgraded to a QuantStudio 7 Flex by a field serviceengineer to give you additional automation, throughput,and multiplexing capabilities.Application spotlightIdentify more new variants quickly and accurately with high resolution meltHigh resolution melt (HRM) analysis is based on detecting smalldifferences in PCR melting (dissociation) curves. It is enabled by improveddsDNA-binding dyes used in conjunction with real-time PCR instrumentationthat has precise temperature ramp control and advanced data capturecapabilities. Achieve high-throughput HRM analysis using the QuantStudio 6 Flex System and 384-well block with MeltDoctor software, built-inprotocols, and calibrations.Advantages of HRM Low reagent and sample consumption Fast, simple workflow Thermal optimization not required3Life Technologies QuantStudio real-time PCR and digital PCR systems

The QuantStudio 6 Flex Real-Time PCRSystem gives you flexibility at an affordableprice.Life Technologies QuantStudio real-time PCR and digital PCR systems4

I need more versatilityMoving from application to application is now easier thanever with additional dyes, formats, and automation potential.QuantStudio 7 FlexReal-Time PCR SystemThe QuantStudio 7 Flex Real-Time PCRSystem delivers the proven reliability,sensitivity, and accuracy of the ViiA 7System in a new industrial design. TheQuantStudio 7 Flex System is optimized toenable the broadest range of quantitativePCR applications. Key benefitsAccomplish more, fasterRun hundreds of real-time PCR reactions effortlesslyusing TaqMan Array Microfluidic Cards integratedwith the Twister robot. The QuantStudio 7 FlexSystem can maximize your throughput capabilitiesfor automated environments.High application versatilityOptimized protocols, reagents, and intuitive software areavailable for the broadest range of applications, including: Gene expression High resolution melt Long non-codingRNA analysis SNP genotyping Pri-miRNA Analysis Protein thermal shift Mutation detection MicroRNA profilingGet results you can trustGet improved well-to-well and instrument-to-instrumentdata accuracy with the OptiFlex System featuring sixdecoupled excitation and emission filter channels, with21 filter combinations for maximum multiplexing andchemistry flexibility.Application spotlightIdentification of novel pathways contributing to immune responseThe TaqMan Human Immune Array Card is a cost-effective, easy-to-usemicrofluidic card for quantitative gene expression analysis of targetsknown to have implications in immune response. The gene targets on theTaqMan Human Immune Array Card include cytokines, chemokines,growth factors, immune regulators, apoptosis markers, ischemiamarkers, tissue-specific markers, and others, including classicendogenous markers. The array is cost-effective, convenient, andeasy to use without needing expensive robotics. Results are reproducibleand consistent across samples, studies, and labs—providing the samedata quality from card to card and lot to lot—even with different operators.Hundreds of customizable and predefined TaqMan Array Microfluidic5Life Technologies QuantStudio real-time PCR and digital PCR systems

Advance your research furtherwith the application versatility of theQuantStudio 7 Flex Real-Time PCR System. LifeLifeTechnologiesTechnologies ndDigitaldigital PCR Systemssystems6

I need maximum productivityHarness the power of high-throughput technology formaximum productivity with minimum effort.QuantStudio 12KFlex SystemKey benefitsMiniaturization at lower costThe QuantStudio 12K Flex System acceleratesmany high-throughput research applicationssuch as:OpenArray technology is a broadly applicable nanoliterfluidics platform for low-volume, solution-phase reactions,and enables lower reagent and assay costs, and rapidparallel processing.Unparalleled throughput Drug discoveryProduce up to 110,000 data points in an 8-hour day with theOpenArray block and a single GeneAmp 9700 thermalcycler. Furthermore, when equipped with the OpenArray block, Twister automation robot, and several GeneAmp 9700thermal cyclers, you have the capacity to analyze more than 2million data points per day. Pharmaceutical target confirmation MicroRNA profiling Agriculture molecular testingSeamless switch from qPCR to digital PCRIncrease the precision and sensitivity of your experiments whenyou need it by interchanging real-time PCR and digital PCRapplications using QuantStudio digital kits and DigitalSuite software with OpenArray blocks.Increased data integrity and quality control—with results you can trustThe integrated sample tracking and security, auditing, andelectronic signature (SAE) module assist you in 21 CFRPart 11 compliance.Application spotlightPharmacogenomicsPharmacogenomics is the understanding of drug efficacy based on individuals’ unique genomic composition.The QuantStudio 12K Flex System and OpenArray technology provide a simple, cost-effective, and fast screening workflow.1. Load samplesonto OpenArray PlateMinimal hands-on time72. Cycle & imageOpenArray Plates110,000 data points per 8-hr dayLife Technologies QuantStudio real-time PCR and digital PCR systems3. AnalyzeresultsAssists with 21 CFR part 11compliance

With the QuantStudio 12K Flex Real-Time PCR Systemand OpenArray technology, a single user can generatefrom 1 to over 12,000 data points in a single run withminimal hands-on time. LifeLifeTechnologiesTechnologies ndDigitaldigital PCR Systemssystems8

I need absolute answersTake your research to the next level with technologythat is as innovative as your research.QuantStudio 3D DigitalPCR SystemKey benefitsSimple workflowThe QuantStudio 3D Digital PCR Systemleverages high-density nanofluidic chiptechnology for investigations that involvedetecting rare events, analyzing smalldifferences between two targets, or countingthe exact number of targets in a sample. Dueto the higher precision, sensitivity, and absolutenature of digital PCR, it is ideal for thefollowing applications: Qualification of molecular standards used intraditional real-time PCR experimentsA streamlined workflow with minimal sample handlingenables turnkey processing. Just load and go.AffordableLess than half the price of competing platforms, making newdigital PCR technology within reach for most labs.Absolute quantification20,000 reaction wells yield data in copies/μL with highprecision and sensitivity without the need for a standard curve.Sealed systemLimit contaminants with a sealed chip and no exposedsample transfer steps.Run experiments without batching Pathogen detection and load determination Rare-target detection such as somatic mutationdetection in oncology research GMO detection and contamination assessment Generation of references and standardsEach chip can be individually run, not requiring a minimumnumber of samples per run.Easily fits in populated spacesSmall footprint (7" x 5" x 9") will fit most benchtops andcan be moved when needed.Compatible Copy number variationUse your existing TaqMan Real-Time Assays for a digital result.Application spotlightDetermining low copy number in equivocal tissueMany cancers are regulated by mutations in a specific gene or group of genes, or copy number changes.These aberrations can be associated with aggressiveness of the disease or prognosis. Digital PCRprovides a fast and easy workflow to precisely identify low copy numbers that have small differences.Compared to immunohistochemistry by fluorescence in situ hybridization, digital PCR is less impactedby tissue heterogeneity and provides clearer results.100%Sample partitionedinto many reactions9Positive reactionNegative reactionLife Technologies QuantStudio real-time PCR and digital PCR systemsAbsolutequantification

The QuantStudio 3D Digital PCR Systemenables sensitive and precise absolute targetquantification without the use of a referenceor standard curve. LifeLifeTechnologiesTechnologies ndDigitaldigital PCR Systemssystems 10

Additional real-time PCR solutionsYou are a clinical labThe QuantStudio Dx instrument provides yourclinical laboratory with performance you can trust,the security you demand, and flexibility you needfor your workflow. For more information on theQuantStudio Dx Real-Time PCR System, go tolifetechnologies.com/quantstudiodxYou are new to qPCRThe StepOne and StepOnePlus Real-Time PCRSystems are remarkably simple, low-pricedsystems that enable high-quality results andare designed with a user-friendly yet powerfulinterface for researchers new to real-time PCR.For more information, go tolifetechnologies.com/steponeplusYou have validated protocolsThe 7500 and 7500 Fast Real-Time PCR Systems’proven performance is known across the worldfor validated research applications in humanidentification, food testing, and animal health.For more information, go tolifetechnologies.com/abqpcrStepOne, StepOnePlus, 7500, and 7500 Fast Systems are for Research Use Only. Not for use in diagnostic procedures.11 Life Technologies QuantStudio real-time PCR and digital PCR systems