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IV Drug Compatibility ChartThe IV drug compatibility chart is based on information from the Handbook of Injectable Drugs, 16th Edition, byLawrence A. Trissel, FASHP, copyright 2010, American Society of Health-System Pharmacists. Incompatibilitiesare based on meeting any of the following criteria: Additive Compatibility Drugs in Syringe Compatibility Y-Site Injection Compatibility (1:1 Mixture)Additionally, in some cases one brand of product may be compatible but another brand of drug is not. When thisoccurred, “incompatible” was used.Disclaimer:This IV Drug Compatibility Chart is provided as a quick reference, however since information is subject to changeit is advised that you check with a pharmacist for recommendations as well as product information to check forany changes or additional incompatibilities.Key: CompatibleIncompatibleA drug intersects with itselfThe relationship was investigated and the results were equivocal.No data available

AbataceptAbciximabAcetylcysteineAcyclovir SodiumAdenosineAldesleukinAlfentanil hydrochlorideAllopurinol SodiumAlteplase, RecombinantAmifostineAmikacin SulfateAmiodarone HydrochlorideAmphotericin B DesoxycholateAmphotericin B Lipid-BasedAmpicillin Sodium/Sulbactam SodiumAmpicillin SodiumAntihemophilic FactorArgatrobanAsparaginaseAtracurium BesylateAtropine SulfateAzacitidineAzathioprineAzithromycin Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartA

BasaliximabBendamustine HydrochlorideBenztropine MesylateBevacizumabBivalirudenBleomycin Sulfate (BLM)BortezomibBumetanideBuprenorphine HydrochlorideBusulfanButorphanol Tartrate Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartAB

Immune Globulin Intravenous, Human C1 Inhibitor, HumanCabazitaxelCalcium ChlorideCalcium GluconateCarboplatinCarmustineCefepime HydrochlorideCefotaxime SodiumCefoxitin SodiumCeftaroline Fosamil MonoacetateCeftazidimeCeftizoxime SodiumCeftriaxone SodiumCefturoxime SodiumChloramphenicol Sodium SuccinateChlorpromazine racurium BesylateCisplatinClevidipine ButyrateClindamycin PhosphateClorfarabineCyclosporineCytomegalovirus Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartC

DacarbazineDaclizumabDaptomycinDarbepoetin AlfaDaunorubicin Hydrochloride (DNR)DecitabineDenileukin DiftitoxDesmopressin AcetateDexamethasoneDexamethasone Sodium PhosphateDexmedetomidine HydrochlorideDiazepamDigoxinDiltiazem HydrochlorideDimenhydrinateDiphenhydramine HydrochlorideDobutamine HydrochlorideDocetaxelDopamine HydrochlorideDoripenemDoxorubicin Hydrochloride, ConventionalDoxycycline HyclateDrotrecogin Alfa Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartD

EnalaprilatEnoxaparin SodiumEpinephrine HydrochlorideEpirubicin HydrochlorideEpoetin Alfa RecombinantEpoprostenol SodiumEptifibatideEribulin MesylateErythromycin LactobionateEsmolol HydrochlorideEsomeprazole SodiumEstrogens ConjugatedEthacrynate SodiumEtoposide Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartE

Factor IX ConcentratesFamotidineFenoldopam MesylateFentanyl CitrateFerumoxytolFibrinogen Concentrate (Human)FilgrastimFluconazoleFludarabine PhosphateFlumazenilFluorouracilFolic AcidFosaprepitant DimeglumineFoscarnet SodiumFosphenytoin SodiumFurosemide Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartF

Ganciclovir SodiumGemcitabine HydrochlorideGemtuzumab OzogamicinGentamicin SulfateGranisetron Hydrochloride Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartG

Argatroban Calcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)Verapamil Atropine Heparin Sodium (lock flush solution)Hydrocortisone Sodium SuccinateHydromorphone Hydrochloride Alteplase (Activase, rTPA) Amiodarone (Cordarone)IV Drug Compatibility ChartH

Ibandronate SodiumIbritumomab tiuxetanIbuprofen LysineIbutilide FumarateIdarubicin HydrochlorideIfosfamideImipenem-Cilastatin SodiumImmune Globulin I.V.Inamrinone LactateIndomethacin Sodium TrihydrateInfliximabInsulin Injection (regular insulin)Interferon Alfa-2b RecombinantInterferon Gamma-1bIrinotecan HydrochlorideIron Dextran ParenteralIsoproterenol HydrochlorideIxabepilone Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartI

Ketorolac Tromethamine Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartK

Anti-Thymocyte Globulin Sterile Solution Alteplase (Activase, rTPA) ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)Verapamil Amiodarone (Cordarone)Labetalol HydrochlorideLacosamideLepirudinLeucovorin CalciumLevetiracetamLevofloxacinLevoleucovorin CalciumLevothyroxine SodiumLidocaine HydrochlorideLiothyronine SodiumLorazepamLymphocyte Immune Globulin IV Drug Compatibility ChartL

MannitolMechlorethamine HydrochlorideMelphalan HydrochlorideMeperidine HydrochlorideMesnaMethocarbamolMethotrexate, Methotrexate Sodium (Amethopterin, MTX)Methoxy Polythylene Glycol-Epoetin BetaMethyldopate HCIMethylergonovine MaleateMethylprednisoloneMetoclopramide HCIMetoprolol TartrateMetronidazoleMicafungin SodiumMidazolam HydrochlorideMilrinone LacatateMinocycline HydrochlorideMitomycinMitoxantrone HydrochlorideMorphine SulfateMoxifloxacin HydrochlorideMuromonab-CD3Mycophenolate Mofetil HCI Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartM

Naloxone HydrochlorideNatalizumabNesiritideNicardipine HydrochlorideNitroglycerinIVNitroprusside SodiumNorepinephrine Bitartrate Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartN

OfatumumabOndansetron HydrochlorideOxaliplatinOxytocin, Parenteral Alteplase (Activase, rTPA)Amiodarone (Cordarone)ArgatrobanAtropineCalcium chlorideDiltiazem (Cardizem)Dobutamine (Dobutrex)DopamineEpinephrine (Adrenalin)Esmolol (Brevibloc)Furosemide (Lasix)HeparinInsulin (regular)Lidocaine (Xylocaine)Lorazepam (Ativan)Magnesium SulfateMetoprolol Tartrate (Lopressor)Morphine SulfateNorepinephrine BitartratePantoprazole (Protonix)Phenytoin (Dilantin)Potassium chloridePropofol (Diprivan)Sodium bicarbonateSodium nitroprusside (Nipride)Succinylcholine (Anectine)VerapamilIV Drug Compatibility ChartO