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Cancer Research at NCCU:Building Capacity and Partnerships2018 Partnerships to Advance Cancer Health EquityJuly 23, 2018Session: “Maximizing Institutional Research Capacity Through BuildingRelationships and Collaborating Within the Institution”.Dr. M. RicardoDr. Kevin P. Williams, Dr. M. Ricardo Richardsonand Dr. DeepakKumarRichardson,Dr. KevinP. Williams and Dr. DeepakKumar

North Carolina Central University Founded in 1910 as an HBCU; a component of the 17-memberUniversity of North Carolina system. Strong commitment to training students who pursue degrees inSTEM, and Health Disparities research. Houses two signature biomedical research institutes: the JuliusL. Chambers Biomedical Biotechnology Research Institute(JLC-BBRI, est. 1998) and the BiomanufacturingResearch Institute and Technology Enterprise(BRITE, est. 2008).

Strong Leadership SupportChancellorDr. Johnson O. AkinleyeProvostDr. Felecia NaveDr. Johnson O. AkinleyeAssociate Provost/Dean forResearch & Sponsored ProgramsDr. Eun ParkBBRI DirectorDr. Deepak KumarDr. Felecia M. NaveBRITE DirectorDr. Hernán NavarroDr. Eun ParkDr. Hernán NavarroDr. Deepak Kumar

Cancer Research ProgramNorth Carolina Central University Basic and Translational Research Outreach and Community Engagement Education and Training

NCCU Cancer Research Program: MilestonesBBRI1998U56: NCCU-BBRI/UNCLINEBERGERPARTNERSHIP INCANCER RESEARCH(Harewood K; Earp S)2001P20: PARTNERSHIPS TOELIMINATE DISPARITIES INCANCER OUTCOMES(White S; Skinner C)2002P20: NCCU EXPORTCENTER FOREXCELLENCE(Harewood K:PI)2002R25: NCCU-WFU BIOMEDICALSCIENCES BRIDGEPARTNERSHIP(Howlett A: PI)2003NCCU CancerResearchBRITEProgram20062004RTP

NCCU Cancer Research Program: MilestonesDOD: NCCU/BBRIDuke/Urology Partnershipin Prostate CancerResearch(Richardson R: PI)2007U54(Richardson R;INBS PhDEarp S: PIs)20102012P20U54Komen GTDRNCCU-Duke “CTSI”(Williams KP; RCMI U54Renewed (Williams KP: PI) Patierno S: PIs) (Kumar D: PI) (Calhoun F: PI)20152015201620172018RTP

NCCU Cancer Research Program: 2018NCCU CancerResearch ProgramDrug Discovery(DD):Gordon IbeanuRob OnyenwokeJohn ScottAlfred WilliamsKevin WilliamsWeifan ZhengCancer Biology (CB):Ricardo RichardsonKevin WilliamsDeepak KumarXiaoxin ChenDelores GrantJodie FlemingSean KimbroSomnath MukhopadhyayAntonio BainesXiaohe YangTinChung LeungRob OnyenwokeCancer WorkingGroup:Ricardo RichardsonKevin WilliamsDeepak KumarFaye CalhounJonathan LivingstonXiaoxin ChenCommunityOutreach andCancer Education(COCE)Jonathan LivingstonSeronda RobinsonCherise HaringtonAmber BurginLaHoma RomockiCarla OldhamWendy Heck-GrilloJohn Sollers

NCCU-UNC LCCC U54Partnership ObjectivesTo expand research collaborations that spansthe two institutionsTo train students and junior/ midlevel faculty inmultidisciplinary cancer research aimed at reducingcancer disparitiesTo expand and consolidate programs ofcommunity outreach and educationDr. Ricardo Richardson (PI)U54CA156735

NCCU-LCCC PARTNERSHIP IN CANCER RESEARCHPSCCelette Skinner, ChairSteven AkmanLee LimbirdTrevor ArcherVictoria SeewaldtKaren HubbardLorna H McNeillProjectsFull Project 1Jodie Fleming (NCCU)Keith Burridge (LCCC)Full Project 2Lahoma Romocki (NCCU)Vijay Sivaraman (NCCU)Jennifer Smith (LCCC)Lorna H. McNeill, PhD, MPHAssociate Professor & ChairDepartment of Health DisparitiesUniversity of TexasMD Anderson Cancer CenterFull Project 3ClarLynda Williams-DeVane (NCCU)Melissa Troester (LCCC)PIsM. R. Richardson (NCCU)Shelton Earp (LCCC)Program Managers:Cynthia Taylor (NCCU)Susan Lucas (LCCC)IACNCCU: M. R. RichardsonFaye CalhounGregory ColeLa Verne ReidDeepak KumarLCCC: Shelton EarpChad EllisGary JohnsonAndrew OlshanWendy BrewsterAndrew Olshan, PhDProfessorDepartment of EpidemiologyLCCC/UNC-CHCoresOutreachJohn J. Sollers (NCCU)Cherise Harrington (NCCU)Laura Linnan (LCCC)Veronica Carlisle (LCCC-CHE)Amber Burgin (NCCU-CHE)Research EducationWendy Heck-Grillo (NCCU)LaHoma Romocki (NCCU)Laura Linnan (LCCC)Temitope Keku (LCCC)Pilot Project 1Cherise Harrington (NCCU)Laura Linnan (LCCC)Pilot Project 2Xiaoxin Chen (NCCU)Michael Ben Major (LCCC)HistopathologyXiaoxin Chen (NCCU)Christopher Ryan Miller (LCCC)Page 1U54CA156735

P20CA202924:NCCU-DUKE Cancer DisparitiesTranslational Research PartnershipDr. Kevin P. Williams,Principal Investigator BRITE, NCCUDr. Steven R. Patierno,Principal Investigator DCI, Duke Admin Core Cancer Research Pilot Projects Prostate Cancer Inflammatory Breast Cancer Cancer Research Education Program rship

P20 StructureIAC:NCCU: Luke ChenM. R. Richardson (U54 PI)Deepak KumarKevin WilliamsDuke: Donald McDonnellNeil SpectorDavid HsuSteven PatiernoPROJECTS:Pilot 1: Prostate CancerRob Onyenwoke (ESI NCCU)Jennifer Freedman (ESI Duke)Steven Patierno (Mentor Duke)Tyler Allen (Postdoc Duke)Pilot 2: IBCMaria Dixon (Postdoc NCCU)Kevin Williams (Mentor NCCU)Gayathri Devi (Mentor Duke)PIs:NCCU: Kevin WilliamsDuke: Steven PatiernoEAC:Trevor ArcherCathrine HoyoMarvella FordCAB:Program Managers:Vonna’ Woodard (NCCU)Holly Hough (Duke)Patricia WigfallPao Wa LinMarsha EdwardsEric IrelandC-REP:C-REP Co-LeadersCarla Oldham (NCCU):Nadine Barrett (DCI)C-REP Advisory TeamAntonio Baines (NCCU)Faye Calhoun (NCCU)Gayathri Devi (Duke/NCCU Liaison)Terry Hyslop (Duke)Mark Dewhirst (Duke)C-REP MentorsExternal Evaluator:ETR Services

P20: NCCU-Duke C-REP Translational ImmersionExperience Program PhD students & Postdocs from NCCU and DukeClinical Trial AccrualBiospecimen BankingDrug Discovery

P20: Development Activities Mentor-mentee training Workshops- All Pathway to Independence Grant Workshop at Duke –P20 ESIs: R21 submission in June 2018 Presentations at AACR and GMaP conferences Attend CRCHD Professional Development Workshop Joint PublicationsDr. Maria Dixon, PostdocP20 Pilot Project 2

P20: NCCU – Duke Inter-Institutional ResourcesNCCU/BRITE: Benefits to Duke Adjunct Faculty – NCCUPharm Science: Dr. Gayathri Devi Access for DCI Investigators toBRITE Screening Core BRITE Drug DiscoveryCollaborations with Duke Labs: G. Devi D. Hsu D. McDonnell S. Patierno/J. Freedman Access to NCCU GraduateStudents co-mentoring/researchDuke/DCI: Benefits to NCCU Duke Cancer Institute: Drs. KevinWilliams & Deepak Kumar,(Associate members) Duke IBC Colloquium: K.Williams & J. Fleming (members) Duke PATH 786: TranslationalAspects of Pathobiology (K.Williams, Lecture) Access to Duke Cores PhD/Postdocs – access to DukeInvestigators/mentors DCI support for 50% of postdoc ineach pilot

Complementary Strengths ofU54 and P20 Partnerships U54Partner – LCCC/UNCResearch – Basic Scienceand Social DeterminantsNCCU – Basic ScienceFocusEducation – UndergradsResources – LCCC &BBRI Cores P20Partner – DCI/DukeResearch – TranslationalNCCU – Drug DiscoveryFocusEducation –PhD/PostdocsResources – Duke &BRITE Cores

Mutual Benefits of U54 and P20 PartnershipsU54Benefit to NCCU Access to LCCC Cores/PublicHealth Expertise Adjunct appointments at LCCC NCCU undergraduates access toresearch programsBenefit to LCCC/UNC-CH Access to NCCU UG students Access to BBRI/BRITE Cores UNC undergraduates access tosummer internships in NCCU labsP20Benefit to NCCU Access to DukeCores/Biobank/Clinical Expertise Mentoring PhD, Postdocs &Faculty Adjunct appointments at DCI Access to Translational/ClinicalEducation Courses/WorkshopsBenefit to DCI/Duke Access to NCCU graduatestudents Access to BRITE Cores/DrugDiscovery Expertise Access to Drug Discovery courses

Seminars supported jointlyby P20 and U54

NCCU Komen Graduate Training inDisparities Research (GTDR)NCCU Breast CancerFocus Group:Kevin WilliamsJodie FlemingSean KimbroXiaohe YangJohn ScottProviding training to PhD students atNCCU with a focus onCommunity-Based Participatory Research. Trainees meet with patient advocates Learn human subjects research andIRB protocols Survey design and focus groups Planned, facilitated and hostedIBC “listening” forum atWomen’s Health Awareness Day- April 7th at NCCUMaria Dixon, PhD (NCCU)Nadine Barrett, PhD(Director, Office of HealthEquity, DCI, Duke)GTDR16377604

Dr. Deepak Kumar, BBRI Director (PI)U54MD012392

U54MD012392

Cancer Education: Achieving ProgramIntegration at NCCUMSCURRENT CANCEREDUCATION PROGRAMSAT NCCUHSBRITE FUTURESCarla OldhamUGPhDU54 PARTNERS(NCCU & UNC-CH)Wendy Heck-GrilloP20 C-REP&KOMEN GTDR(NCCU & DUKE)Carla OldhamMiddle School visitU54 Partners FellowsP20 C-REP Scholars

Support for NCCUINBS PhD ProgramPhD Program started in 2012First at NCCU since 1964May 2017Dr. Helen Oladapo,PhD StudentP20 Pilot Project 2

Thank edudkumar@nccu.edu

in Prostate Cancer Research (Richardson R: PI) 2007 U54 (Richardson R; Earp S: PIs) 2010 INBS PhD 2012. U54 Renewed. 2015. Komen GTDR (Williams KP: PI. 2015 P20 (Williams KP; ) Patierno S: PIs 2016 . MD Anderson Cancer Center . Andrew Olshan, PhD Professor Department of Epidemiology LCCC/UNC-CH. U54CA156735 . P20CA202924: NCCU-DUKE Cancer .