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Last updated on October 8, 2018NAME: Degui Zhi, Ph.D.PRESENT TITLE:Associate ProfessorCenter for Precision HealthSchool of Biomedical Informatics & School of Public HealthUniversity of Texas Health Science Center at HoustonWORK ADDRESS:7000 Fannin St Suite 820Houston, TX 77030Office Phone: (713) 500-3629Email: Degui.Zhi.@uth.tmc.eduCITIZENSHIP: ChinaUNDERGRADUATE EDUCATION:1993-1997B.S. in computer science, Peking University (Beijing University)GRADUATE EDUCATION:1997-1999M.Sc. in computer science, National University of SingaporePOSTGRADUATE TRAINING:2001-2006Ph.D. in Bioinformatics, University of California, San Diego.MILITARY SERVICE (IF APPLICABLE): NoneACADEMIC & ADMINISTRATIVE APPOINTMENTS:2009-2015Assistant Professor, Section on Statistical Genetics, Department ofBiostatistics, School of Public Health, University of Alabama atBirmingham2014-2016Member, Biostatistics Core, Nutrition Obesity Research Center(NORC), University of Alabama at BirminghamAssociate Scientist, Nutrition Obesity Research Center (NORC),University of Alabama at BirminghamAssociate Professor with Tenure, Department of Biostatistics, School ofPublic Health, University of Alabama at BirminghamAssociate Professor, Department of Biostatistics, School of PublicHealth, University of Texas Health Science Center at HoustonAssociate Professor, School of Biomedical Informatics, University ofTexas Health Science Center at Houston2010-20162015-201620162016-PREVIOUS RESEARCH EXPERIENCEDegui ZhiCVPage 1 of 31

Last updated on October 8, 20181997-1999Graduate student researcher, Department of ComputerScience, School of Computing, National University ofSingapore1999-2000Full-time research assistant, Department of ComputationalScience, National University of Singapore2000-2001Research assistant, Department of Computer Science andEngineering, University of California, Santa Cruz2001Summer intern, Arena Pharmaceutical Inc., San Diego2001-2006Research assistant, Department of Computer Science,University of California, San Diego2004Summer visiting student researcher, Max Planck Institute forMolecular Genetics, Berlin, Germany2004-2006Visiting research assistant, Burnham Institute, La Jolla,California2006-2009Postdoctoral fellow, Department of Plant and MicrobialBiology, University of California, Berkeley.PROFESSIONAL MEMBERSHIPSInternational Society of Computational Biology (ISCB), 2006-presentSigma Xi, 2007-presentReuter Insight Expert, 2008-presentAmerican Society of Human Genetics, 2008-presentAmerican Association for the Advancement of Science, 2007-presentHONORS AND AWARDS:First class award (top 10), National Mathematics Olympic, Liaoning Province, China,1992.Max-Planck-Society fellowship, 2004.Travel award, Workshop on Genomic Impact of Eukaryotic Transposable Elements,2006.Outstanding Poster award (4 out of 171), RECOMB, 2007.NIH Pathway to independence K99/R00, 2007-2012.Best Paper award, the Science Unbound Foundation, for Best paper by a UAB basedinvestigator in the area of statistical genetics, 2013.Degui ZhiCVPage 2 of 31

Last updated on October 8, 2018EDITORIAL POSITIONS:EDITORIAL BOARDReview editor, Frontiers in Statistical Genetics and Methodology2010-Review editor, Frontiers in Bioinformatics and Computational Biology2011Review editor, Frontiers in Evolutionary and Population Genetics2011-Review editor, Frontiers in Epigenetics2011-Editorial board member, Journal of Medical Statistics and Informatics 2012Academic editor, PLOS ONE2013-Academic editor, PeerJ2015-GUEST EDITORIAL ACTIVITYGuest editor, Biomedical Data Integration, Modeling, and Simulation in the Era of BigData and Translational Medicine. BioMed Research International2014Guest editor, Research Topic: Identification of rare genetic variants contributing tohuman diseases. Frontiers in Genetics,2015SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES:Degui ZhiAd hoc reviewerNIH IAR Reviewer Challenge GrantsPanel ZRG1 PSE-C/J (58) R2009ReviewerItalian Ministry of Health ResearchersCall2010,2011,2013Ad hoc StatisticalreviewerNIH MGB Section2010ReviewerTuskegee/UAB partnership pilot grant2010ReviewerPortuguese Foundation for Science andTechnology, Diagnostic, Therapies andPublic Health Evaluation Panel2012ReviewerKansas City Area Life Sciences Institute(KCALSI) Patton Trust Grant Program2012ReviewerNIH RFA-RM-14-001: Computational2014Analyses Exploiting ReferenceEpigenomic Maps [ZRG1 IMST-R (51) R]study section panelReviewerNIH K99/R00 Grants Panel ZGM1 TWDY (KR)2014, 2014Ad hoc ReviewerNIH IRAP Study Section2015Ad hoc ReviewerNIA review panel on the Social andBehavioral Science of Aging2015CVPage 3 of 31

Last updated on October 8, 2018Ad hoc ReviewerNIH BMRD panel2016ReviewerPennsylvania Department of Health FinalPerformance Review2016ReviewerNIH BD2K Mentored CareerDevelopment Award study section panel2016ReviewerNIH NIGMS R35 panel2017ReviewerNIH review panel for Mechanisms of2017Disparities in Chronic Liver Diseases andCancerReviewerNIH review panel for Social EpigenomicsResearch Focused on Minority Healthand Health Disparities2018Ad hoc ReviewerNIH BDMA panel2018SERVICE ON THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTONCOMMITTEES:SERVICE ON SBMI COMMITTEES:Member, Faculty Search Committee, Center for Precision Health, School of BiomedicalInformatics, UTHealth, 2016-2017Member, Faculty Search Committee, Center for Systems Medicine, School ofBiomedical Informatics, UTHealth, 2017Member, Curriculum Committee, School of Biomedical Informatics, UTHealth, 2016Member, Data Governance Committee, School of Biomedical Informatics, UTHealth,2016Speaker, SBMI PASS Day 2018SERVICE ON UTHEALTH COMMITTEES:NoneSERVICE TO THE COMMUNITY:JOURNAL AND CONFERENCE REFEREESAdvances in Bioinformatics 2009American Journal of Clinical Nutrition 2014Bioinformatics 2006, 2007, 2008, 2009, 2009, 2010, 2011, 2013, 2013, 2013, 2015,2015, 2016, 2017, 2018, 2018BMC Bioinformatics 2012, 2013, 2016BMC Genetics 2012Computational and Mathematical Methods in Medicine 2013Computational Statistics and Data Analysis 2009, 2010Degui ZhiCVPage 4 of 31

Last updated on October 8, 2018European Conferences on Computational Biology (ECCB) 2006European Journal of Clinical Investigation 2011Frontiers in Genetics 2011, 2013, 2014, 2015Genes 2010Genetic Epidemiology 2012, 2013, 2015Genetics Research 2012Genome Medicine 2016 2018Genome Research 2011Human Genetics 2012Human Heredity 2010, 2014International Journal of Obesity 2014Int’l Conf. on Research in Computational Molecular Biology (RECOMB) 2005, 2016,2018ICIBM 2016 2018ISMB 2018Journal of Biomedicine and Biotechnology 2010Journal of Computational and Graphical Statistics 2012Journal of Medical Genetics 2012Journal of Obesity 2012Molecular Biology and Evolution 2009Molecular Ecology Resources 2015Molecular Systems Biology 2008Nature Biotechnology 2011(co-review)Nature Communications 2013Nature Methods 2011Nucleic Acids Research 2007, 2011Obesity 2014PeerJ 2015PLOS Genetics 2015, 2017PLOS ONE, 2012, 2013, 2015Respiratory Research, 2013Science Translational Medicine 2018CONFERENCE ORGANIZATIONMember, UAB Research Computing Day Program Committee, 2011Co-investigator, Workshop on next-generation sequencing data analysis, 2011, (NIHR13 grant funded, PI: Cui)Degui ZhiCVPage 5 of 31

Last updated on October 8, 2018Co-Investigator, Short Course on next-generation sequencing data analysis, 2011-2014,(NIH R25 grant funded, PI: Tiwari)Session Chair, Next-generation sequencing data analysis, ENAR, 2011.Co-organizer, UAB Microbiome Resource Workshop, 2015Chair, Publicity Committee, ICIBM, 2016Member, Program Committee, ICCABS 2017Co-Chair, Program Committee, ICIBM 2018Member, Programmer Committee, ISMB 2018Member, Programmer Committee, RECOMB-seq 2018SERVICE TO THE OTHER UNIVERSITY COMMITTEES:Leader, SSG Journal Club, Biostatistics Department, SOPH, UAB, 2009 - 2015Member, Admission Committee, Biostatistics Department, SOPH, UAB, 2009-2010,2012-2016Member, SSG curriculum committee, Biostatistics Department, SOPH, UAB, 2010Member, SSG overseas connection task force, Biostatistics Department, SOPH, UAB,2010Member, SSG Professional Development Workshop Organization Committee,Biostatistics Department, SOPH, UAB, 2010Member, UAB Research Computing Day Program Committee, 2011Alternate Senate, UAB faculty senate, 2011 – 2013Member, UAB faculty senate finance committee, 2011 – 2013Grader, UAB Department of Biostatistics qualifying exams, 2014, 2015Member, SOPH UWIRC review committee, UAB 2014CONFERENCE AND INVITED TALKSResolving difference between nearly identical repeats in fragment assembly, RECOMBsatellite meeting on DNA sequencing and characterizations, Stanford, CA, May, 2002.Comparative genomics analysis of Alu gene conversions, 1st International Conferenceand Workshop on Genomic Impact of Eukaryotic Transposable Elements, Asilomar, CA,April, 2006.Alignment-free local structural comparison by Writhe decomposition, Workshop onAlgorithms in Bioinformatics (WABI), Philadelphia, PA, September, 2007.An optimization framework for the inference of nontrivial protein domain architecture andancient homology, University of Tennessee, Knoxville, TN, April, 2008.Degui ZhiCVPage 6 of 31

Last updated on October 8, 2018Beyond Sequence Alignment: An optimization framework for the inference of nontrivialprotein domain architecture and ancient homology, Section on Statistical Genetics,School of Public Health, University of Alabama, Birmingham, AL, July, 2008.A sequence alignment-based optimization framework for the inference of nontrivialprotein domain architecture and ancient homology, Computational Systems BiologySeminar, University of Georgia, Athens, GA, July, 2008.Repeat, Repeat, Repeat (Analysis of genomic repeats), Beijing Genome Institute,Shenzhen, Guangdong, China, December, 2008.A sequence alignment-based optimization framework for the inference of nontrivialprotein domain architecture and ancient homology, Tongji University, Shanghai, China,December, 2008.Protein structural comparison, classification, and function prediction in the structuralgenomics era, University of Tennessee, Knoxville, TN, February, 2009.Bayesian Hierarchical Models for Quantifying Methylation Levels by Next-generationSequencing, Annual Meeting of ENAR, New Orleans, LA, March, 2010.Bayesian Analysis of Rare Variants with Disparate Effects in Association Studies,Annual Meeting of ENAR, Miami, FL, March, 2011.Genotype calling and haplotype inference from next-generation sequencing data. EmoryUniversity, Atlanta, GA, March, 2012.Genotype calling and haplotype inference from next-generation sequencing data.HitSEQ SIG of ISMB, Long Beach, CA, July, 2012.From genetics to epigenetics. Sino-US summer school for translational biomedicalinformatics (3S-TBI2013) Suzhou, Jiangsu Province, China, June, 2013.Genotype calling from NGS data: incorporating haplotype information in reads. NGSworkshop, International Conference on Intelligent Biology and Medicine (ICIBM),Nashville, TN, August, 2013Next-generation bioinformatics for next-generation sequencing: genotype calling andhaplotype phasing. Department of Computer and Information Sciences, University ofAlabama at Birmingham, Birmingham, AL, Oct, 2014.Inferring genotypes and haplotypes from Next-generation sequencing data. Molecularand Human Genetics Department, Baylor College of Medicine, Houston, TX, Nov, 2014.Inferring genotypes and haplotypes from Next-generation sequencing data. University ofAlabama, Tuscaloosa, AL, Mar, 2016.Identical-by-Descent in TOPMed samples. TOPMed Steering Committee and ExternalAdvisory Panel meeting, Tysons, VA, Nov, 2017.Degui ZhiCVPage 7 of 31