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L I F E S C I E N C E T E C H N O LO G I E SProduced by the Science/AAAS Custom Publishing OfficeNew ProductsREFRIGERATED CENTRIFUGEThe new refrigerated centrifuge 5424 R sets the new lab standard with established ergonomics,outstanding quality, and superior temperature control. The 24 place centrifuge 5424 R can spinup to 21,130 x g and can accurately cool to set temperatures from -10 C to 40 C. The FastTempfunction allows for superfast eight-minute precooling to 4 C. This refrigerated microcentrifugeincludes a condensation drain to eliminate water accumulation and to prevent corrosion. Centrifuge 5424 R also has incredible versatility with four different rotor options. Options includethe unique Kit rotor, which is designed with an extended rim to support tube caps when usingMiniPrep spin column kits.EppendorfFor more info: 800-645-3050eshop.eppendorfna.comSELF-STANDING CENTRIFUGE TUBESNew 50 mL clear polypropylene (PP) self-standing centrifuge tubescombine ease of use, chemical resistance, and high speed tolerance. The circular collar around the base allows the centrifuge tubeto stand up on a bench without further support. A rigid, high-qualityscrew cap ensures an airtight seal that virtually eliminates all leakage when used under recommended conditions. Each centrifugetube features black printed graduations clearly marked for ease ofuse. Affordably priced, these self-standing centrifuge tubes can bespun up to 9,400G and will withstand repeated autoclaving at 121 Cor long-term storage at -20 C. For easy identiÀcation each centrifugetube has a large white solvent resistant writing area. Porvair selfstanding centrifuge tubes are supplied in packs of 500 with innerbags of 50 either natural or sterile. Production of these self-standingcentrifuge tubes is carried out in a Class 10000 / ISO Class VII cleanenvironment to ISO 9001:2008 and EN ISO 13485:2003 manufacturing standards to ensure all products are free from DNA/RNA, DNase/RNase, and Pyrogen contamination.Porvair SciencesFor info: RESSURE REACTORto set up and has a fail-safe mechanism to protect the operator.AsyntFor info: 44-(0)-1638-781709WATER BATHSA line of general purpose water baths have been designed to provideexceptional temperature control in a wide variety of clinical and laboratory applications. Equipped with sensitive microprocessor-basedPID controllers, these versatile water baths maintain bath temperatures from ambient 5 to 100 C with 0.1 precision and 0.2 Cuniformity. They are available with 2 L, 5 L, 10 L, 20 L, or 28 L singlechamber reservoirs. In addition to precise temperature control, thewater baths also feature a digital temperature readout, one-touchset point recall, and three user-deÀned temperature preset buttonsfor the quick selection of frequently used temperature set points.Bath temperature can be displayed in either degrees Celsius orFahrenheit. For added operational convenience, all models includea steeply gabled tilting cover that accommodates glassware of varying heights and permits easy loading and removal of samples whileallowing condensate to drain neatly back into the bath.PolyScienceFor info: 800-229-7569Designed to be used in conjunction with a simple benchtop magnetic stirrer or stirrer/hotplate the Parallel High Pressure Reactoris a cost effective lightweight unit suitable for stirred or nonstirredapplications. Proven in applications including homogeneous andheterogeneous catalysis, hydrogenation, corrosion testing, parallelsynthesis, and screening, the Parallel High Pressure Reactor canbe purposely conÀgured to optimally suit your application. Manufactured in 316 stainless steel, the standard Parallel High PressureReactor offers the user 10 x 30 mL reaction vessels that can beconÀgured to operate up to 300 C and 100 Bar pressure. However, systems can be built to accommodate reaction volumes from5 mL to 50 L and constructed in a wide range of materials including Hastelloy, Inconel, Titanium, and alloy steels to provide an optimized solution for almost any application. Designed by chemistsfor chemists each Parallel High Pressure Reactor is extremely easywww.asynt.comwww.polyscience.comMEDIA BOTTLESTriForest PETG square media bottles are ideal for the storage ofmedia, laboratory reagents, biological buffers, and sterile productpackaging. Each bottle is supplied with a patented polyethylenetamper-evident cap. The bottles are made with Eastar, which offersan excellent gas barrier with limited permeability to CO2 and O2. Thebottles are manufactured in an ISO 9001 facility in compliance withUSP Class VI standards. They are optically clear and highly durable.They are supplied radiation sterilized to SAL 10-6. PETG square media bottles are available in 2,000 mL, 1,000 mL, 500 mL, 250 mL,125 mL, 60 mL, and 30 mL sizes, in varying conÀgurations.TriForest EnterprisesFor info: 888-777-9956www.triforest.comElectronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations arefeatured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products ormaterials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.www.sciencemag.org/productsSCIENCEVOL 33724 AUGUST 2012989

WEBINARClinical Validation of CancerBiomarker Signatures UsingArray TechnologyWednesday, September 12, 201212 noon ET, 9 a.m. PT, 4 p.m. GMT, 5 p.m. UKThe disruption of critical genes is a hallmark of cancer. IdentiÃcation of these genesis a Ãrst step to understanding the disease, but once the genes have been identiÃed,elucidating changes in their expression levels can aid in identifying biomarkers withthe potential to predict disease progression and point to appropriate treatments.Approaches to determine the relevance of prospective gene expression signaturesfor the identiÃcation of important disease phenotypes will be discussed. Our webinarpanelists, both cancer experts, will describe their research and how they havetranslated their own discoveries into validated gene expression signatures usingarrays.During the webinar, the speakers will: Describe their experimental approaches to validating genetic signatures Share their Ãndings demonstrating the potential correlation of gene expressionbiomarkers with known cancer phenotypes Address the most critical factors when considering validating geneexpression data Answer your questions live on air!SPEAKERSParticipantsPaul Mickey Williams, Ph.D.SAIC-FrederickFrederick, MDREGISTER NOW!webinar.sciencemag.orgTimothy J. Triche, M.D., Ph.D.University of Southern CaliforniaLos Angeles, CAWebinar sponsored byBrought to you by theScience/AAAS CustomPublishing Office

Antibodies and Related Reagents for Signal Transduction ResearchThe Highest QualityCytokines & Growth Factors.from Cell Signaling Technology:: Multi-milligram quantities available.–1.2200800.8Phospho-p38 MAPK(Thr180/Tyr182)4030200.480hIL-17A (–)60500.010.11101001000hIL-17A (ng/ml)646 µg reduced ( ) and non-reduced (-)recombinant hIL-17A.The production of IL-6 by humanforeskin fibroblasts cultured withincreasing concentrations of hIL-17Afor 48 hours was assessed.40p38 MAPK3020100hIL-17A ( )1410.01022kDaSecreted IL-660501169766553731Downstream Signaling0:: Many products are produced inmammalian cells to maximize naturalconformation and glycosylation.Bioactivity 0.1:: Endotoxin levels are routinely testedand are less than 0.01 ng/µg cytokine.PuritykDahIL-17A (ng/ml)Human foreskin fibroblasts treatedwith hIL-17A for 15 minutes wereexamined using phospho- and totalp38 MAPK antibodies.for quality products you can trust.www.cellsignal.comFor Research Use Only. Not For Use In Diagnostic Procedures.Orders (toll-free) 1-877-616-2355 Inquiries info@cellsignal.com Environmental Commitment eco.cellsignal.comCell Signaling Technology is a trademark of Cell Signaling Technology, Inc.:: Comparison of multiple lots, stringentproduct specifications, and rigorousquality control ensures maximumlot-to-lot consistency.Human Interleukin-17A (hIL-17A) #8928OD450-OD650:: Produced and bioassayed in housewith the highest purity and bioactivity. 2012 Cell Signaling Technology, Inc.The world’s highest quality antibody provider has nowextended its expertise to cytokine production.

Personal Flow Cytometry from BD Biosciences BD Pharmingen reagents and BD Accuri C6 Now you can speed discovery with the power of multiparameter cell analysis using the best-in-class BD Accuri C6 personal fl cytometer. Never before have the power and insight of personal fl cytometry been more within reach. Today, you can take .