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Tricia Ann Thornton-WellsCurriculum VitaeCenter for Human Genetics ResearchVanderbilt University519 Light HallNashville, TN 37232615.343.58512009 Linden AvenueNashville, TN UCATION and TRAINING1991-1995Vanderbilt University, B.A. (Philosophy)2000-2005Vanderbilt University, M.S. (Biomedical Informatics)Thesis Title: Comparison of Three Clustering Methods for Dissecting TraitHeterogeneity in Simulated Genotypic Data2000-2006Vanderbilt University, Ph.D. (Neuroscience)Dissertation Title: Confronting Complexity: A Comprehensive Statistical andComputational Strategy for Identifying the Missing Link between Genotypeand Phenotype2007Functional MRI Visiting Fellowship, Athinoula A. Martinos Center forBiomedical Imaging, Mass Gen Hospital, Harvard-MIT, Boston, MAAPPOINTMENTS and POSITIONSACADEMIC:2000-2006Graduate Research Assistant (Statistical Genetics & Bioinformatics)Mentors: Jonathan L. Haines, Ph.D. and Jason H. Moore, Ph.D.Department of Molecular Physiology and BiophysicsCenter for Human Genetics ResearchVanderbilt University, Nashville, TN2006-2009Postdoctoral Fellow (Neuroimaging / Neurodevelopment)Mentors: Elisabeth Dykens, Ph.D. and John Gore, Ph.D.Biobehavioral Intervention Training ProgramVanderbilt Kennedy Center for Research on Human DevelopmentVanderbilt University Institute of Imaging ScienceVanderbilt University, Nashville, TN2009-2010Research InstructorCenter for Human Genetics ResearchDivision of Human Genomics, Dept. of Molecular Physiology & BiophysicsVanderbilt University, Nashville, TN2010-PresAssistant Professor (tenure-track)Center for Human Genetics ResearchDivision of Human Genomics, Dept. of Molecular Physiology & BiophysicsDepartment of Biomedical InformaticsVanderbilt University, Nashville, TN1
Tricia A. Thornton-Wells, Ph.D.2013-PresDecember 2014Core DirectorCore C, Statistical and Methodological ServicesThe Eunice Kennedy Shriver Intellectual and Developmental DisabilitiesResearch Center; Vanderbilt Kennedy CenterVanderbilt University, Nashville, TNNON-ACADEMIC:1996-2000Quality Improvement CoordinatorPatient Outcomes Research; Database Development & AdministrationDirect Supervisor: Raymond M. Hakim, M.D. (Chief Medical Officer)Renal Care Group, Inc. (now Fresenius Medical Care), Nashville, TNPROFESSIONAL ORGANIZATIONS2000 - PresSociety for Neuroscience (SFN)2001 - PresAmerican Society for Human Genetics (ASHG)2001 - PresInternational Genetic Epidemiology Society (IGES)PROFESSIONAL ACTIVITIESINTRAMURAL ACTIVITIES:2001-2002President, Graduate Student Council2002-2003Outreach Coordinator, Neuroscience Student Organization2003-2005Student Editorial Board, J Am Med Informatics Assoc2005-2007Assistant Editor, Vanderbilt University Editors' Club2007-2008Editor-In-Chief, Vanderbilt University Editors' Club2010-2011Pre-Review Committee Member for Genotyping and Statistical AnalysisPlans, Vanderbilt’s DNA Repository (BioVU), Vanderbilt Institute for Clinicaland Translational Research2010Chair, 11th Annual Genetics Symposium, Vanderbilt Center for HumanGenetics Research, October 13, 20102011-PresScientific Review Committee Member for Vanderbilt’s DNA Repository(BioVU), Vanderbilt Institute for Clinical and Translational Research2012Chair of Systems Neuroscience Poster Session for the Vanderbilt KennedyCenter Science Day, February 28, 2012EXTRAMURAL ACTIVITIES:2003-PresAd-hoc Reviewer for the following peer-reviewed journals:Alzheimer’s & Dementia, American Journal of Intellectual and DevelopmentalDisabilities, Annals of Human Genetics, BioData Mining, Bioinformatics, BMCGenetics, European Conference on Evolutionary Computation, GeneticEpidemiology, Genomics, Human Brain Mapping, Human Genetics, HumanHeredity, Journal of Alzheimer Disease, Journal of Artificial Evolution and2
Tricia A. Thornton-Wells, Ph.D.December 2014Applications, Journal of Neurodevelopmental Disorders, Journal ofNeuroscience, Machine Learning and Data Mining in Bioinformatics,Magnetic Resonance Imaging, Molecular Genetics and Metabolism,Molecular Psychiatry, Neurobiology of Aging, NeuroImage, NeuropsychiatricGenetics, Pacific Symposium on Biocomputing, Pharmacogenetics andGenomics, PLoS Genetics, PLoS ONE, Psychiatric Research - Neuroimaging2010Grant Reviewer, Israel Science Foundation2010Ad-Hoc Study Section Member / Grant Reviewer, Neurological, Aging andMusculoskeletal Epidemiology (NAME) Study Section, National Institutes ofHealth2010Reviewer, ASHG/GEON Genetics Concepts in State Science Standards2011-PresReview Editor, Frontiers in Statistical Genetics and Epidemiology2011-PresEditorial Board Member, Academic Editor, PLoS ONE2012-2013Grant Reviewer, Qatar National Research Fund2012-2014Grant Reviewer, Alzheimer’s Association Intl Research Grant Program2013-PresCommittee Member, Down Syndrome Biomarker Initiative (DSBI)2014-PresAssociate Editor, Journal of Alzheimer’s DiseaseOTHER PROFESSIONAL ACTIVITIES:2012Scientific Program Committee Member, American Society for HumanGenetics Annual Meeting, San Francisco, CA, November 6-10, 2012.2013Scientific Program Committee Member, Alzheimer’s AssociationInternational Conference (AAIC), Boston, MA, July 13-18, 2013.SPECIAL HONORS, AWARDS AND RECOGNITIONS:2001-2002NIMH Neuroscience Training Grant Fellowship (T32 MH64913)2001Vanderbilt University Graduate School Travel Grant2002-2006NLM Informatics Training Grant Fellowship (LMO7450-01)2002Vanderbilt University Graduate School Travel Grant2003Roger Williams Predoctoral Award Finalist, International GeneticEpidemiology Society2006-2008NIH Roadmap for Medical Research Postdoctoral Fellowship, BiobehavioralIntervention Training Program (T32 MH75883)2008Vanderbilt Kennedy Center Travel Award2009Featured Postdoc Presentation, Vanderbilt Kennedy Center Science Day2010Genome Technology Magazine 5th Annual Young Investigators Award2011Featured Scientist, Vanderbilt Brain Institute (November 2011)2012Invited “Rising Star” Guest, Institute of Medicine Meeting, April 23, 2012,Nashville, TN3
Tricia A. Thornton-Wells, Ph.D.December 2014TEACHING ACTIVITIESMEDICAL SCHOOL COURSES:2002Teaching Assistant, Biostatistics (IGP 300B), Interdisciplinary GraduateProgram, Vanderbilt University, Nashville, TN.2002Lecturer, Biostatistics (IGP 300B), Interdisciplinary Graduate Program,Vanderbilt University, Nashville, TN.2002Lecturer, Biostatistics (IGP 300B), Interdisciplinary Graduate Program,Vanderbilt University, Nashville, TN.2005-2006Lecturer, Research Methodology, Department of Cancer Biology, VanderbiltUniversity, Nashville, TN2007Adjunct Teacher, School for Science and Math at Vanderbilt, Nashville, TN2007-2009Lecturer, Scientific Outreach Program, Vanderbilt University Institute ofImaging Science, Nashville, TN2010-PresLecturer, Human Genetics II (HGEN 341), Graduate Program in HumanGenetics, Vanderbilt University, Nashville, TN. (2 lectures; offered eachSpring semester)2011-PresLecturer, Systems Biology (BMIF 310), Department of BiomedicalInformatics, Vanderbilt University, Nashville, TN (2 lectures; offered everyother Spring semester)2011-PresCourse Director and Lecturer, Genetics of Neurodevelopmental Disorders,Interdisciplinary Graduate Program, Vanderbilt University, Nashville, TN. (5lectures, 5 class discussions; offered each Spring semester)2013-PresCourse Co-Director, Special Topics in Human Genetics (HGEN 330),Graduate Program in Human Genetics, Vanderbilt University, Nashville, TN.(3 lectures, 8 class discussions, offered every other Spring semester)2013-PresLecturer, Brain and Behavior, Vanderbilt Medical School, VanderbiltUniversity, Nashville, TN (1 lecture; offered each Fall semester)GRADUATE SCHOOL COURSES:2008Guest Lecturer, Issues in Developmental Disabilities (PSY2100-1),Vanderbilt University, Nashville, TN2013Guest Lecturer, “Imaging Genetics of Sociability in Williams Syndrome,”Psychology Graduate Seminar, Vanderbilt University, Nashville, TN2014Guest Lecturer, “Williams Syndrome: Genetics & Cognitive Science,”Educational & Cognitive Neuroscience (PSY3690), Vanderbilt University,Nashville, TNUNDERGRADUATE SCHOOL COURSES:2014Guest Lecturer, “Experienced Reality and Concept of Self in Individuals withNeurodevelopmental Disorders,” Psychology Undergraduate HonorsSeminar, Vanderbilt University, Nashville, TN4
Tricia A. Thornton-Wells, Ph.D.December 20142014-PresCourse Director & Lecturer, Neurogenetics: Special Topics in Neuroscience(NSC 285), Interdisciplinary Program in Neuroscience, College of Arts &Science, Vanderbilt University, Nashville, TN. (41 lecture hours; offered eachFall semester)2014-PresGuest Lecturer, “Genomics and Personalized Medicine,” Biological Sciences105, Vanderbilt University, Nashville, TN (1 lecture; offered each Fallsemester)RESEARCH SUPERVISION:Mentor/Advisor Roles2007-2009Laura Keppley – currently Undergraduate at Eastern Mennonite UniversityMentor, High School Science Fair ProjectsRegional Science Fair Award Winner & Penn State Scholarship RecipientChristopher Dock High School, Lansdale, PA2007-2009Liam Solus – currently PhD Student in Mathematics at University of KentuckyCo-Mentor, Summer Research Assistant, Vanderbilt Kennedy CenterUndergraduate, Oberlin College, Oberlin, OH2009-2013Jennifer Pryweller, Ph.D. – currently Postdoctoral Fellow at St. JudeChildren’s Research HopsitalMentor, Interdisciplinary Ph.D. Program on Neuroimaging ofNeurodevelopmental DisordersVanderbilt University, Nashville, TN2010-2012Tracy Porchak, M.S. – currently Program Manager at Vanderbilt UniversityInstitute of Imaging ScienceCo-Mentor, M.S. Student, Master of Laboratory Investigation ProgramVanderbilt University School of Medicine, Nashville, TN2010-2014Mary Ellen I. Koran, Ph.D. – currently MSTP student at Vanderbilt UniversityMentor, Human Genetics Ph.D. ProgramM.D./Ph.D. Medical Scientist Training Program (MSTP)Vanderbilt University School of Medicine, Nashville, TN2011-2013Jennifer N. Vega – currently Ph.D. candidate at Vanderbilt UniversityMentor, Ph.D. Candidate, Systems Neuroscience Graduate ProgramVanderbilt University, Nashville, TN2012-2013Mike Sivley – currently Ph.D. student in Biomedical Informatics at VanderbiltCo-Mentor, M.S. Thesis Student, Computer Science Graduate ProgramVanderbilt University, Nashville, TN2012-2014Timothy J. Hohman, Ph.D. – currently Research Instructor, Department ofNeurology, Vanderbilt University Medical CenterMentor, Postdoctoral Research Fellow, NIMH Neurogenomics TrainingProgram; PhRMA Found. Postdoc in Translational Medicine & TherapeuticsVanderbilt University, Nashville, TN2012-2014Laura D’Aoust, Ph.D. – currently MSTP student at Vanderbilt UniversityCo-Mentor, Human Genetics Ph.D. ProgramM.D./Ph.D. Candidate, Medical Scientist Training Program (MSTP)Vanderbilt University, Nashville, TN5
Tricia A. Thornton-Wells, Ph.D.December 20142013Courtney M. Edwards – currently undergraduate student, Hampton UniversityMentor, Vascular Biology Short-Term Training ProgramVanderbilt University, Nashville, TN2013-2014Jordan Plaxico, B.A. – currently Graduate Student at Vanderbilt UniversitySchool of NursingCo-Mentor, Undergraduate Honors Thesis Student in PsychologyVanderbilt University Summer Research ProgramVanderbilt University, Nashville, TN2013-2014Uzoamaka Ugochukwu, B.S. – currently Medical student at Vanderbilt Univ.Mentor, Medical Student Biomedical Research ProjectVanderbilt University, Nashville, TN2014Jarryd Rigby – currently undergraduate student, University of MelbourneMentor, Vanderbilt International Scholars ProgramVanderbilt University, Nashville, TN2014-PresJacob Hall, B.S. (Co-Mentor)Ph.D. Student in Human Genetics Ph.D. ProgramVanderbilt University, Nashville, TN2014-PresNicole Restrepo, B.S. (Co-Mentor)Ph.D. Student in Human Genetics Ph.D. ProgramM.S. Student in Interdisciplinary Biostatistics Graduate ProgramVanderbilt University, Nashville, TN2014Matt Oetjens, Ph.D. – currently postdoctoral fellow at University of MichiganCo-Mentor, M.S. Student in Interdisciplinary Biostatistics Graduate ProgramVanderbilt University, Nashville, TNThesis/Dissertation Committees2010-2011Vishal Gandi, Ph.D.Dissertation Committee Chair, Human Genetics Ph.D. ProgramVanderbilt University School of Medicine, Nashville, TN2010-2013Olivia Veatch – currently Postdoctoral Fellow at Vanderbilt UniversityDissertation Committee Chair, Human Genetics Ph.D. ProgramVanderbilt University School of Medicine, Nashville, TN2012Ryan Urbanowicz – currently Postdoctoral Fellow at Dartmouth CollegeExternal Examiner, Graduate Program in Genetics; Neukom Institute FellowDartmouth Medical School, Hanover, NH2012-2014Joshua HoffmanDissertation Committee Member, Human Genetics Ph.D. ProgramVanderbilt University School of Medicine, Nashville, TN2012-2014Matt Oetjens, Ph.D.Dissertation Committee Member, Human Genetics Ph.D. ProgramVanderbilt University School of Medicine, Nashville, TN2012-2013Carrie Buchanan Moore, Ph.D. – currently MSTP Student at Vanderbilt Univ.Dissertation Committee Member, Human Genetics Ph.D. Program, MedicalScientist Training ProgramVanderbilt University School of Medicine, Nashville, TN6
Tricia A. Thornton-Wells, Ph.D.December 20142012-2014Laura D’Aoust, Ph.D. – currently MSTP Student at Vanderbilt Univ.Dissertation Committee Chair, Human Genetics Ph.D. Program, MedicalScientist Training Program (MSTP)Vanderbilt University, Nashville, TN2013-PresLaura WileyDissertation Committee Member, Human Genetics Ph.D. Program,Biomedical Informatics M.S. ProgramVanderbilt University, Nashville, TN2014-PresBrittany HollisterDissertation Committee Member, Human Genetics Ph.D. ProgramVanderbilt University, Nashville, TNRESEARCH PROGRAMActive Funding2011-2014Vanderbilt Kennedy Center Hobbs Discovery Award 27,840“Novel MRI biomarkers for early detection of Alzheimer pathology in Downsyndrome”Role: Principal Investigator2013-2014National Institute for Child Health & Human Development P30 HD015052Eunice Kennedy Shriver Intellectual and Developmental Disability ResearchCenter, Core C: Statistics & Methodology ServicesPI: Elisabeth M. Dykens, Ph.D. (VU Psychology/Pediatrics/Psychiatry)Role: Director, Statistical & Methodology Services Core2014-PresNational Institute of Mental Health R01 MH095621“Iron and Mitochondrial Genomics in Neuro-Inflammation and HIV-AssociatedNeurocognitive Disorders (HAND): A CHARTER Study”PI: Todd Hulgan, M.D., M.P.H. (VU Medicine)Role: Co-Investigator (Statistical Genetics)2014-PresAmercian Heart Association“Characterization of variants in PTGER3 genes as novel markers ofcardiovascular risk”PI: Olivier Boutaud, Ph.D. (VU Pharmacology)Role: Co-Investigator (Statistical Genetics)2013-PresNational Institute of Mental Health R01 MH064735-08“1/4-Prevention of Depression: Impact on the Transition to Early Adulthood”PI: Judy Garber, Ph.D. (VU Psychology/Psychiatry)Role: Co-Investigator (Statistical Genetics)2014 –PresDepartment of Defense Investigator Initiated Grant“VIPER II: Chronic Pain after Amputation: Inflammatory mechanisms, novelanalgesic pathways and improved patient safety”PI: Andrew D. Shaw, M.D. (VU Anesthesiology)Role: Co-Investigator (Statistical Genetics)7
Tricia A. Thornton-Wells, Ph.D.December 2014Funding Applications In ProgressPendingPhase I Small Business Innovation Research Grant”Whole-genome analysis methods for accurate Alzheimer’s risk prediction”PI: Ellen McRae, Ph.D. (Parabon Nanolabs, Inc.)Role: Alzheimer’s Disease Statistical Genetics ConsultantDec 2014 SubmResubmission of BC140860 (scored 2.3 out of 5 in first submission)CDMRP-Breast Cancer Research Program Breakthrough Award (Level 1)“Personalized Cognitive Intervention for Breast Cancer Survivors”Role: Principal InvestigatorJan 2015 SubmRFA-AG-15-011 – NIA/NICHD“Biomarkers of Alzheimer’s Disease in Down Syndrome”Role: Co-Principal Investigator (Co-PI: Paul Newhouse)Jan 2015 SubmNIA/NICHD U54 for Eunice Kennedy Shriver Intellectual and DevelopmentalDisability Research Center, Core C: Biostatistics & Bioinformatics CorePI: Elisabeth M. Dykens, Ph.D. (VU Psychology/Pediatrics/Psychiatry)Role: Associate Director, Biostatistics & Bioinformatics CoreCompleted Funding2007-2008Vanderbilt Kennedy Center Hobbs Discovery Grant, 24,262“Williams Syndrome Paradox: Genetic and Neural Bases of Hypersociabilityand Nonsocial Fears” PI: Jennifer BlackfordRole: Co-Investigator2008Vanderbilt Institute of Imaging Science Pilot Funding, 3,375Vanderbilt Inst. for Clinical and Translational Research, 8,623Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH“Williams Syndrome Paradox: Genetic and Neural Bases of Hypersociabilityand Nonsocial Fears” PI: Elisabeth DykensRole: Co-Investigator2009Vanderbilt Inst. for Clinical and Translational Research 3,970Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH“fMRI Study of Auditory Mirror Neuron System in Williams Syndrome”Role: Principal Investigator2009-2010Vanderbilt Inst. for Clinical and Translational Research 2000Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH“Genetics of Aging in Down Syndrome” 2,000.Role: Principal Investigator2009-2011National Library of Medicine R01 LM010040-01“Analysis Tool for Heritable and Environmental Network Associations”PI: Marylyn RitchieRole: Co-Investigator (Statistical Genetics)2009-2013National Human Genome Research Institute 5U01 HG004798-02“Epidemiologic Architecture for Genes Linked to Environment (EAGLE)”PI: Dana CrawfordRole: Co-Investigator (Statistical Genetics)8
Tricia A. Thornton-Wells, Ph.D.December 20142009-2014National Institute of Mental Health Mentored Clinical Scientist ResearchCareer Development Award, K08 MH085810-01“A Computational Analysis of Psychiatric Genetics Data: Pathways andArchitecture”PI: Kathleen AsklandRole: Statistical Genetics Consultant2010-2012National Institute on Aging 1P30AG036445-01“Recruitment of Faculty for Genetic Aging Research”PI: Jonathan HainesRole: Faculty Recruitment Recipient2010-2011National Human Genome Research Institute 5U01HG004608-04“Genome-wide Study of Cataract and Low HDL”PI: Marylyn RitchieRole: Statistical Geneticist2011Vanderbilt Inst. for Clinical and Translational Research 2000Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH“Novel 3T MRI Scans for Detection of Alzheimer Disease” 2,000.Role: Principal Investigator2011Vanderbilt Inst. for Clinical and Translational ResearchVanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH“MRI studies in Williams syndrome: Structure, function and physiology”Role: Co-Investigator2011-2012Vanderbilt Inst. for Clinical and Translational Research 1,872Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH“Exome Genotyping in Caucasians with Alzheimer’s Disease from BioVU”Role: Principal Investigator2011-2012Vanderbilt Inst. for Clinical and Translational Research 1,684Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH“Exome Genotyping in African Americans and Hispanics with Alzheimer’sDisease from BioVU”Role: Principal InvestigatorVanderbilt Inst. for Clinical and Translational ResearchInvestigator-Initiated (Type A) Resource Request VR1982, 23,090“Genetic Polymorphisms and Pain”PI: Stephen BruehlRole: Co-Investigator2011-20122011-2013National Institute on Aging 5RC2AG036528-03“Genome Wide Associate Analysis of Alzheimer’s Disease”PI: Gerard SchellenbergRole: Statistical Geneticist2012-2013Vanderbilt Inst. for Clinical and Translational ResearchInvestigator-Initiated (Type A) Resource Request VR4752, 2,000“A neural basis for atypical auditory processing in Williams syndrome”Role: Co-Investigator (PI’s Mentor)9
Tricia A. Thornton-Wells, Ph.D.December 20142012-2013Vanderbilt Inst. for Clinical and Translational ResearchInvestigator-Initiated (Type A) Resource Request VR4752, 5,000“Neuroimaging of Alzheimer Disease in African Americans”Role: Principal Investigator2012-2014Vanderbilt Inst. for Clinical and Translational ResearchInvestigator-Initiated (Type A) Resource Request VR2610, 48,400“MRI Biomarkers and Genetic Risk Factors for Alzheimer Disease”Role: Principal InvestigatorPUBLICATIONS AND PRESENTATIONSPUBLICATIONS:Articles in Refereed Journals (in Chronological Order):1.Thornton TA, Hakim RM. Meaningful Rehabilitation of the End-Stage Renal DiseasePatient. Seminars in Nephrology. 17: 246-252, 1997. PMID: 91656542.Thornton TA, Hakim RM. The Relationship Between Quality of Care and FinancialPerformance in Dialysis: “Doing Well by Doing Good”. Advances in Renal ReplacementTherapy. 4: 350-358, 1997. PMID: 93566873.Hagan MC, Thornton TA, Zald DH, Pardo JV. Somatosensory processing in the humaninterior prefrontal cortex. Journal of Neurophysiology 88: 1400-1406, 2002. PMID:122051614.Moore JH, Hahn LW, Ritchie MD, Thornton TA, White BC. Application of GeneticAlgorithms to the Discovery of Complex Models for Simulation Studies in HumanGenetics. In Langdon WB, Cantu-Paz E, Mathias K, Roy R, Davis D, Poli R,Balakrishnan K, Honavar V, Rudolph G, Wegener J, Bull L, Potter MA, Schultz AC, MillerJF, Burke E, Jonoska N (eds): Proceedings of the Genetic and EvolutionaryComputation Conference. New York, Morgan Kaufmann, 1150-1155, 2002. PMID:23413413, PMC35698495.Thornton TA, Haines JL. PowerTrim: An Automated Decision Support Algorithm forPreprocessing Family-Based Genetic Data. American Journal of Human Genetics 72:1280-1281, 2003. PMID: 12677557, PMC11802796.Moore JH, Hahn LW, Ritchie MD, Thornton TA, White BC. Routine discovery of highorder epistasis models for computational studies in human genetics. Applied SoftComputing 4: 79-86, 2004. PMID: 20948983, PMC29529577.Thornton-Wells TA, Moore JH, Haines JL. Genetics, statistics and human disease:analytical retooling for complexity. Trends in Genetics 20: 640-647, 2004. PMID:155224608.Thornton-Wells TA, Moore JH, Haines JL. Dissecting trait heterogeneity: Acomparison of clustering methodologies applied to genotypic data. BMC Bioinformatics7: 204, 2006. PMID: 16611359, PMC15252099.Bush WS, Thornton-Wells TA, and Ritchie MD. Association Rule Discovery has theability to Model Complex Genetic Effects. Proceedings of the 2007 IEEE Symposium onComputational Intelligence and Data Mining: 624-629, 2007. PMID: 20953276,PMC295459410
Tricia A. Thornton-Wells, Ph.D.December 201410.Thornton-Wells TA, Moore JH, Martin ER, Pericak-Vance MA, Haines JL. ConfrontingComplexity in Late-Onset Alzheimer Disease: Application of Two-Stage AnalysisApproach Addressing Heterogeneity and Epistasis. Genetic Epidemiology 32: 187-203,2008. PMID: 18076107, PMC280486811.Thornton-Wells TA, Kim CY, Cannistraci CJ, Eapen M, Anderson A, Gore JC, BlakeRR, Dykens EM. Auditory Attraction: Activation of visual cortex to music and sound inWilliams syndrome. Am J Intellect Dev Disabil 115: 172-189, 2010. PMID: 20440382,PMC286200712.Thornton-Wells TA, Avery SN, Blackford JU. Using novel control groups to dissect theamygdala’s role in Williams syndrome. DevCogn Neurosci 1: 295-304, 2011. PMID:21731599, PMC312485213.Tang B, Thornton-Wells TA, Askland K. Comparative linkage meta-analysis revealsregionally-distinct, disparate genetic architectures: application to biopolar disorder andschizophrenia. PLoS ONE 6(4): e19073, 2011. PMID: 21559500, PMC308473914.Arlinghaus LR, Thornton-Wells TA, Dykens EM, Anderson AW. Alterations in diffusionproperties of white matter in Williams syndrome phenotype. Magn Reson Imaging 29:1165-1174, 2011. PMID: 21907520, PMC319933515.Avery SN, Thornton-Wells TA, Blackford JU. White matter integrity deficits inprefrontal-amygdala pathways in Williams Syndrome. Neuroimage 59: 887-894, 2012.PMID: 22008369, PMC325405816.Han Z, Thornton-Wells TA, Gore JC, Dawant BM. Effect of non-rigid registrationalgorithms on deformation based morphometry: a comparative study with control andWilliams syndrome samples. Magn Reson Imaging 2012. PMID: 2245943917.Meda SA, Pryweller JR, Thornton-Wells TA. Regional brain differences in corticalthickness, surface area and subcortical volume in individuals with Williams syndrome.PLoS ONE 7(2):e31913, 2012. PMID: 22355403, PMC328021218.Pryweller JR, Avery SN, Blackford JU, Dykens EM, Thornton-Wells TA. The effect ofintellectual ability on functional activation in a neurodevelopmental disorder: preliminaryevidence from multiple fMRI studies in Williams syndrome. Journal ofNeurodevelopmental Disorders 4: 24, 2012. PMID: 23102261, PMC350260819.Meda SA, Koran MEI, Pryweller JR, Vega JN, Thornton-Wells TA. Genetic interactionsassociated with 12-month atrophy in hippocampus and entorhinal cortex in ADNI.Neurobiology of Aging 34(5): 1518.e9-1518.518, 2013. PMID: 23107432, PMC257074820.Rane S, Ally BA, Hussey EP, Wilson TL, Thornton-Wells TA, Gore JC, Donahue MJ.Inverse correspondence between hippocampal perfusion and verbal memoryperformance in older adults. Hippocampus 23(3): 213-220, 2013. PMID: 23109214,PMC387807821.Koran ME, Hohman TJ, Thornton-Wells TA, for ADNI. Genetic interactions foundbetween calcium channel genes modulate amyloid load measured by positron emissiontomography. Human Genetics 133:85-93, 2014. PMID:24026422, PMC381551922.Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, BushWS, Mishra P, Thornton-Wells TA. Associations between KCNJ6 (GIRK2) genepolymorphisms and pain-related phenotypes. PAIN 154(12): 2853-2859, 2013. PMID:23994450, PMC384534811
Tricia A. Thornton-Wells, Ph.D.December 201423.Koran ME, Hohman TJ, Meda SA, Thornton-Wells TA, for ADNI. Genetic interactionswithin inositol-related pathways are associated with longitudinal changes in ventriclesize. Journal of Alzheimer’s Disease 38(1):145-54, 2014. PMID: 24077433,PMC381551924.Hohman TJ, Koran ME, Thornton-Wells TA, for ADNI. Interactions between GSK3βand amyloid genes explain variance in amyloid burden. Neurobiology of Aging 35:460465, 2014. PMID:24112793, PMC386462625.Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G,Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA,Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN,Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT,Choi SH, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL,Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C,Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, EvansD, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K,Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, BarbergerGateau P, McGuinness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D,Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A,Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S,Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C,Galimberti D, Mancuso M, Matthews F; European Alzheimer's Disease Initiative (EADI);Genetic and Environmental Risk in Alzheimer's Disease (GERAD); Alzheimer's DiseaseGenetic Consortium (ADGC); Cohorts for Heart and Aging Research in GenomicEpidemiology (CHARGE), Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H,Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannfelt L,Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F,Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P,Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB,Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L,Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, MorganK, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL,Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER,Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A,Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, PericakVance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V,Seshadri S, Williams J, Schellenberg GD, Amouyel P. Meta-analysis of 74,046individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nature Genetics45(12): 1452-8, 2013. PMID: 24162737, PMC389625926.Samuels DC, Li C, Li B, Song Z, Torstenson E, Clay HB, Rokas A, Thornton-Wells TA,Moore JH, Hughes TM, Hoffman RD, Haines JL, Murdock DG, Mortlock DP, WilliamsSM. Recurrent tissue-specific mtDNA mutations are common in humans. PLOSGenetics 9: e1003929, 2013. PMID:24244193, PMC382076927.Hohman TJ, Koran MEI, Thornton-Wells TA, for ADNI. Epistatic effects amongAlzheimer’s Candidate Genes. PLoS ONE 8(11): e80839, 2013. PMID: 24260488,PMC383248828.Hohman TJ, Koran MEI, Thornton-Wells TA, for ADNI. Genetic modification of therelationship between phosphorylated tau and neurodegeneration. Alzheimer’s &Dementia 2014 Mar 20. pii: S1552-5260(14)00013-2. PMID:24656848, PMC416976212
Tricia A. Thornton-Wells, Ph.D.December 201429.Koran ME, Hohman TJ, Vega JN, Pryweller JR, Slosky LE, Crockett G, Villa de Rey L,Edwards CM, Meda SA, Avery SN, Blackford JU, Dykens EM, Thornton-Wells TA.Differences in age-related effects on brain volume in Down syndrome as compared toWilliams syndrome and typical-development. Journal of Neurodevelopmental Disorders6(1): 8, 2014. PMID:24713364, PMC4022321.30.Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P,Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA,Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, ThorntonWells TA, Denning N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D,Vardarajan BN, Kamatani Y, Lin CF, Schmidt H, Kunkle B, Dunstan ML, Vronskaya M1;United Kingdom Brain Expression Consortium, Johnson AD, Ruiz A, Bihoreau MT, ReitzC, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D,Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C,Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Love
Christopher Dock High School, Lansdale, PA 2007-2009 Liam Solus - currently PhD Student in Mathematics at University of Kentucky Co-Mentor, Summer Research Assistant, Vanderbilt Kennedy Center Undergraduate, Oberlin College, Oberlin, OH 2009-2013 Jennifer Pryweller, Ph.D. - currently Postdoctoral Fellow at St. Jude
