Transcription
Rook’sTextbook ofDermatologyEDITED BYTony BurnsMB, BS, FRCP, FRCP(Edin)Emeritus Consultant Dermatologist, Leicester Royal Infirmary, LeicesterStephen BreathnachMA, MB, BChir, MD, PhD, FRCPConsultant Dermatologist and Senior Lecturer, St John’s Institute of Dermatology, St Thomas’ Hospital, London,and Consultant Dermatologist, Epsom & St Helier University Hospitals NHS Trust, Epsom, SurreyNeil CoxBSc, MB, ChB, FRCP(Lond & Edin)Consultant Dermatologist, Department of Dermatology, Cumberland Infirmary, CarlisleChristopher GriffithsBSc, MD, FRCP, FRCPathProfessor of Dermatology and Consultant Dermatologist, The Dermatology Centre, University of Manchester,Hope Hospital, Salford, ManchesterIN FOUR VOLUMESVOLUME 1SEVENTH EDITIONBlackwellScience
Rook’sTextbook ofDermatology
The Editors. From l to r, Tony Burns, Stephen Breathnach, Christopher Griffiths and Neil Cox standingin front of a portrait of Arthur Rook, the father of the Textbook of Dermatology.
Rook’sTextbook ofDermatologyEDITED BYTony BurnsMB, BS, FRCP, FRCP(Edin)Emeritus Consultant Dermatologist, Leicester Royal Infirmary, LeicesterStephen BreathnachMA, MB, BChir, MD, PhD, FRCPConsultant Dermatologist and Senior Lecturer, St John’s Institute of Dermatology, St Thomas’ Hospital, London,and Consultant Dermatologist, Epsom & St Helier University Hospitals NHS Trust, Epsom, SurreyNeil CoxBSc, MB, ChB, FRCP(Lond & Edin)Consultant Dermatologist, Department of Dermatology, Cumberland Infirmary, CarlisleChristopher GriffithsBSc, MD, FRCP, FRCPathProfessor of Dermatology and Consultant Dermatologist, The Dermatology Centre, University of Manchester,Hope Hospital, Salford, ManchesterIN FOUR VOLUMESVOLUME 1SEVENTH EDITIONBlackwellScience
1968, 1972, 1979, 1986, 1992, 1998, 2004 by Blackwell Science Ltda Blackwell Publishing companyBlackwell Publishing, Inc., 350 Main Street, Malden, Massachusetts 02148-5020, USABlackwell Publishing Ltd, 9600 Garsington Road, Oxford OX4 2DQ, UKBlackwell Publishing Asia Pty Ltd, 550 Swanston Street, Carlton, Victoria 3053, AustraliaThe right of the Authors to be identified as the Authors of this Work has been asserted inaccordance with the Copyright, Designs and Patents Act 1988.All rights reserved. No part of this publication may be reproduced, stored in a retrievalsystem, or transmitted, in any form or by any means, electronic, mechanical, photocopying,recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act1988, without the prior permission of the publisher.First published 1968Reprinted 1969Second edition 1972Reprinted 1975Third edition 1979Reprinted 1982, 1984Fourth edition 1986Reprinted 1988, 1990Fifth edition 1992Reprinted 1993, 1994Sixth edition 1998Seventh edition 2004Library of Congress Cataloging-in-Publication DataRook’s textbook of dermatology.—7th ed. / edited by Tony Burns . . . [et al.].p. ; cm.title: Textbook of dermatology.Rev. ed. of: Rook/Wilkinson/Ebling textbook of dermatology. 6th ed. / edited byR.H. Champion . . . [et al.] . c1998.Includes bibliographical references and index.ISBN 0-632-06429-31. SkinaDiseases. 2. Dermatology.[DNLM: 1. Skin Diseases. WR 140 R77711 2004] I. Title: Textbook of dermatology.II. Rook, Arthur. III. Burns, Tony, FRCP. IV. Rook/Wilkinson/Ebling textbook ofdermatology.RL71.R744 2004616.5 adc222004010343ISBN 0-632-06429-3ISBN 1-4051-2974-3 (IE)A catalogue record for this title is available from the British LibrarySet in 9.5/12pt Palatino by Graphicraft Limited, Hong KongPrinted and bound in Italy by G. Canale & C. SpA, TurinCommissioning Editor: Stuart TaylorManaging Editor: Rupal MaldeEditorial Assistant: Katrina ChandlerProduction Editor: Nick MorganProduction Controller: Chris DownsFor further information on Blackwell Publishing, visit our website:http://www.blackwellpublishing.comThe publisher’s policy is to use permanent paper from mills that operate a sustainableforestry policy, and which has been manufactured from pulp processed using acid-freeand elementary chlorine-free practices. Furthermore, the publisher ensures that the textpaper and cover board used have met acceptable environmental accreditation standards.
ContentsContributors, ix12 Genetics and Genodermatoses, 12.1J.I. Harper & R.C. TrembathPreface to Seventh Edition, xvii13 Prenatal Diagnosis of Genetic Skin Disease, 13.1Preface to First Edition, xviiiR.A.J. Eady & J.A. McGrath14 The Neonate, 14.1VOLUME 11 Introduction and Historical Bibliography, 1.1D.A. Burns & N.H. Cox2 Comparative Dermatology, 2.1D.A. Burns3 Anatomy and Organization of Human Skin, 3.1J.A. McGrath, R.A.J. Eady & F.M. Pope4 Functions of the Skin, 4.1C.B. Archer5 Diagnosis of Skin Disease, 5.1N.H. Cox & I.H. Coulson6 Epidemiology of Skin Disease, 6.1H.C. Williams7 Histopathology of the Skin: General Principles, 7.1R. Cerio & E. Calonje8 Molecular Biology, 8.1J.L. Rees9 Inflammation, 9.1D.J. Atherton, A.R. Gennery & A.J. Cant15 Naevi and other Developmental Defects, 15.1D.J. Atherton & C. Moss16 Pruritus, 16.1M.W. Greaves17 Eczema, Lichenification, Prurigo andErythroderma, 17.1C.A. Holden & J. Berth-Jones18 Atopic Dermatitis, 18.1P.S. Friedmann & C.A. Holden19 Contact Dermatitis: Irritant, 19.1S.M. Wilkinson & M.H. Beck20 Contact Dermatitis: Allergic, 20.1M.H. Beck & S.M. Wilkinson21 Occupational Dermatoses, 21.1J.S.C. English22 Mechanical and Thermal Injury, 22.1C.T.C. Kennedy & D.A.R. BurdIndexM. Steinhoff, C.E.M. Griffiths, M.K. Church &T.A. LugerVOLUME 210 Clinical Immunology, Allergy andPhotoimmunology, 10.1G.P. Spickett & T. Schwarz11 Wound Healing, 11.1J.A. McGrath & S.M. Breathnach23 Reactions to Cold, 23.1P.M. Dowd24 Cutaneous Photobiology, 24.1J.L.M. Hawk, A.R. Young & J. Fergusonv
viContents25 Virus Infections, 25.1VOLUME 3J.C. Sterling42 Lichen Planus and Lichenoid Disorders, 42.126 AIDS and the Skin, 26.1S.M. Breathnach & M.M. BlackC.B. Bunker & F. Gotch43 Disorders of the Sebaceous Glands, 43.127 Bacterial Infections, 27.1N.B. Simpson & W.J. CunliffeR.J. Hay & B.M. Adriaans44 Rosacea, Perioral Dermatitis and Similar Dermatoses,28 Mycobacterial Infections, 28.1V.M. Yates & G.A.W. Rook29 Leprosy, 29.1D.N.J. Lockwood30 The Treponematoses, 30.1The late R.S. Morton, G.R. Kinghorn &F. Kerdel-VegasFlushing and Flushing Syndromes, 44.1J. Berth-Jones45 Disorders of Sweat Glands, 45.1I.H. Coulson46 Disorders of Connective Tissue, 46.1N.P. Burrows & C.R. Lovell47 Urticaria and Mastocytosis, 47.131 Mycology, 31.1R.J. Hay & M.K. Moore32 Parasitic Worms and Protozoa, 32.1F. Vega-Lopez & R.J. Hay33 Diseases Caused by Arthropods and Other NoxiousAnimals, 33.1D.A. Burns34 Disorders of Keratinization, 34.1M.R. Judge, W.H.I. McLean & C.S. Munro35 Psoriasis, 35.1C.E.M. Griffiths, R.D.R. Camp & J.N.W.N. Barker36 Non-Melanoma Skin Cancer and Other EpidermalSkin Tumours, 36.1R.M. MacKie & A.G. Quinn37 Tumours of the Skin Appendages, 37.1R.M. MacKie & E. Calonje38 Disorders of the Cutaneous Melanocyte, 38.1R.M. MacKie39 Disorders of Skin Colour, 39.1S.S. Bleehen & A.V. AnsteyC.E.H. Grattan & A. Kobza Black48 Purpura and Microvascular Occlusion, 48.1N.H. Cox & W.W. Piette49 Vasculitis and Neutrophilic Vascular Reactions, 49.1K.L. Barham, J.L. Jorizzo, B. Grattan & N.H. Cox50 Diseases of the Veins and Arteries: Leg Ulcers, 50.1P.S. Mortimer & K.G. Burnand51 Disorders of Lymphatic Vessels, 51.1P.S. Mortimer52 Histiocytoses, 52.1A.C. Chu53 Soft-Tissue Tumours and Tumour-like Conditions,53.1E. Calonje & R.M. MacKie54 Cutaneous Lymphomas and Lymphocytic Infiltrates,54.1S.J. Whittaker & R.M. MacKie55 Subcutaneous Fat, 55.1M.M. Black & W.J. Cunliffe56 The ‘Connective Tissue Diseases’, 56.1M.J.D. Goodfield, S.K. Jones & D.J. Veale40 Genetic Blistering Diseases, 40.1R.A.J. Eady, J-D. Fine & S.M. Burge41 Immunobullous Diseases, 41.157 Metabolic and Nutritional Disorders, 57.1R.P.E. Sarkany, S.M. Breathnach, C.A. Seymour,K. Weismann & D.A. BurnsF. Wojnarowska, V.A. Venning & S.M. Burge58 Sarcoidosis, 58.1IndexD.J. Gawkrodger
Contents59 Systemic Disease and the Skin, 59.1R.M. Graham & N.H. Cox60 The Skin and the Nervous System, 60.1C.B. Archer & D.J. EedyIndex69 Racial Influences on Skin Disease, 69.1D.J. Gawkrodger70 The Ages of Man and their Dermatoses, 70.1R.A.C. Graham-Brown71 General Aspects of Treatment, 71.1J.A. Cotterill & A.Y. FinlayVOLUME 461 Psychocutaneous Disorders, 61.172 Systemic Therapy, 72.1S.M. Breathnach, C.E.M. Griffiths, R.J.G. Chalmers &R.J. HayL.G. Millard & J.A. Cotterill73 Drug Reactions, 73.162 Disorders of Nails, 62.1S.M. BreathnachD.A.R. de Berker, R. Baran & R.P.R. Dawber74 Erythema Multiforme, Stevens–Johnson Syndrome63 Disorders of Hair, 63.1D.A.R. de Berker, A.G. Messenger & R.D. Sinclair64 The Skin and the Eyes, 64.1J.N. Leonard & J.K.G. Dart65 The External Ear, 65.1C.T.C. Kennedyand Toxic Epidermal Necrolysis, 74.1S.M. Breathnach75 Topical Therapy, 75.1J. Berth-Jones76 Radiotherapy and Reactions to Ionizing Radiation,76.1M.F. Spittle & C.G. Kelly66 The Oral Cavity and Lips, 66.1Crispian Scully77 Physical and Laser Therapies, 77.1N.P.J. Walker, C.M. Lawrence & R.J. Barlow67 The Breast, 67.1D.A. Burns78 Dermatological Surgery, 78.1C.M. Lawrence, N.P.J. Walker & N.R. Telfer68 The Genital, Perianal and Umbilical Regions, 68.1C.B. Bunker & S.M. NeillIndexvii
ContributorsADRIAANS, Beverley M.BARKER, Jonathan N.W.N.MD, FRCPConsultant Dermatologist, Department of Dermatology,Gloucestershire Royal Hospital, Great Western Road, GloucesterGL1 3NNCo-author ofChapter 27: Bacterial InfectionsBSc, MD, FRCP, FRCPathProfessor of Clinical Dermatology, St John’s Institute ofDermatology, St Thomas’ Hospital, Lambeth Palace Road,London SE1 7EHCo-author ofChapter 35: PsoriasisANSTEY, Alexander V.BARLOW, Richard J.MB, BS, FRCPConsultant Dermatologist, Royal Gwent Hospital, Cardiff Road,Newport NP20 2UB, and Honorary Senior Lecturer, AcademicDepartment of Dermatology, University of Wales College ofMedicine, Heath Park, Cardiff CF14 4XNCo-author ofChapter 39: Disorders of Skin ColourMD, FRCPConsultant Dermatologist and Senior Lecturer, DermatologicalSurgery and Laser Unit, St John’s Institute of Dermatology, StThomas’ Hospital, Lambeth Palace Road, London SE1 7EHCo-author ofChapter 77: Physical and Laser TherapiesARCHER, Clive B.MB, ChB, FRCPConsultant Dermatologist and Director of Contact DermatitisInvestigation Unit, Dermatology Centre, University ofManchester, Hope Hospital, Stott Lane, Salford, Manchester M68HDCo-author ofChapter 19: Contact Dermatitis: IrritantChapter 20: Contact Dermatitis: AllergicBSc, MB, BS, MD, PhD(Lond), FRCP(Lond & Edin)Consultant Dermatologist and Clinical Senior Lecturer, BristolDermatology Centre, Bristol Royal Infirmary, Marlborough Street,Bristol BS2 8HWAuthor ofChapter 4: Functions of the SkinCo-author ofChapter 60: The Skin and the Nervous SystemATHERTON, David J.MA, MB, BChir, FRCPConsultant in Paediatric Dermatology, Department of Dermatology,Great Ormond Street Hospital for Children, Great Ormond Street,London WC1N 3JHCo-author ofChapter 14: The NeonateChapter 15: Naevi and other Developmental DefectsBARAN, RobertMDHead of Nail Disease Centre, Le Grand Palais, 42 rue des Serbes,06400 Cannes, FranceCo-author ofChapter 62: Disorders of NailsBARHAM, Kelly L.MDResident Physician, Department of Dermatology, Wake ForestUniversity School of Medicine, Medical Center Boulevard,Winston-Salem, NC 27157-1071, USACo-author ofChapter 49: Vasculitis and Neutrophilic Vascular ReactionsBECK, Michael H.BERTH-JONES, JohnFRCPConsultant Dermatologist, University Hospitals Coventry andWarwickshire NHS Trust, Department of Dermatology,Walsgrave Hospital, Clifford Bridge Road, Coventry CV2 2DX,and Coventry and George Eliot Hospital NHS Trust, NuneatonAuthor ofChapter 44: Rosacea, Perioral Dermatitis and Similar Dermatoses,Flushing and Flushing SyndromesChapter 75: Topical TherapyCo-author ofChapter 17: Eczema, Lichenification, Prurigo and ErythrodermaBLACK, Martin M.MD, FRCP, FRCPathConsultant Dermatologist, St John’s Institute of Dermatology, StThomas’ Hospital, Lambeth Palace Road, London SE1 7EHCo-author ofChapter 42: Lichen Planus and Lichenoid DisordersChapter 55: Subcutaneous FatBLEEHEN, Stanley S.MA, MB, BChir, FRCPEmeritus Professor of Dermatology, University of Sheffield,Sheffield, and Honorary Consultant Dermatologist, St John’six
xContributorsInstitute of Dermatology, St Thomas’ Hospital, Lambeth PalaceRoad, London SE1 7EHCo-author ofChapter 39: Disorders of Skin ColourAnimalsChapter 67: The BreastCo-author ofChapter 1: Introduction and Historical BibliographyChapter 57: Metabolic and Nutritional DisordersBREATHNACH, Stephen M.MA, MB, BChir, MD, PhD, FRCPConsultant Dermatologist and Senior Lecturer, St John’s Instituteof Dermatology, St Thomas’ Hospital, Lambeth Palace Road,London SE1 7EH, and Consultant Dermatologist, Epsom andSt Helier University NHS Trust, Dorking Road, Epsom, SurreyKT18 7EGEditorAuthor ofChapter 73: Drug ReactionsChapter 74: Erythema Multiforme, Stevens–Johnson Syndromeand Toxic Epidermal NecrolysisCo-author ofChapter 11: Wound HealingChapter 42: Lichen Planus and Lichenoid DisordersChapter 57: Metabolic and Nutritional DisordersChapter 72: Systemic TherapyBUNKER, Christopher B.MA, MD, FRCPConsultant Dermatologist, Chelsea & Westminster Hospital,Fulham Road, London SW10 9NH, and the Royal MarsdenHospital, Fulham Road, London SW3 6JJ, London, and HonorarySenior Lecturer, Imperial College School of Medicine, LondonCo-author ofChapter 26: AIDS and the SkinChapter 68: The Genital, Perianal and Umbilical RegionsBURD, D. Andrew R.MD, FRCSEd, FHKAMChief of Division of Plastic and Reconstructive Surgery, Departmentof Surgery, Chinese University of Hong Kong, Prince of WalesHospital, Shatin, Hong KongCo-author ofChapter 22: Mechanical and Thermal InjuryBURGE, Susan M.BSc, DM, FRCPConsultant Dermatologist, Department of Dermatology, ChurchillHospital, Old Road, Headington, Oxford OX3 7LJCo-author ofChapter 40: Genetic Blistering DiseasesChapter 41: Immunobullous DiseasesBURNAND, Kevin G.MB, BS, FRCS, MSProfessor of Vascular Surgery, Head of Academic Department ofSurgery, UMDS, St Thomas’ Campus, Lambeth Palace Road,London SE1 7EHCo-author ofChapter 50: Diseases of the Veins and Arteries: Leg UlcersBURNS, David AnthonyMB, BS, FRCP, FRCP(Edin)Emeritus Consultant Dermatologist, Leicester Royal Infirmary,Leicester LE1 5WWEditorAuthor ofChapter 2: Comparative DermatologyChapter 33: Diseases Caused by Arthropods and Other NoxiousBURROWS, Nigel P.MD, FRCPConsultant Dermatologist and Associate Lecturer, Department ofDermatology, Addenbrooke’s Hospital, Hills Road, CambridgeCB2 2QQCo-author ofChapter 46: Disorders of Connective TissueCALONJE, EduardoMD, DipRCPathDirector of Diagnostic Dermatopathology, and Consultant andHonorary Senior Lecturer in Dermatology, St John’s Institute ofDermatology, St Thomas’ Hospital, Lambeth Palace Road,London SE1 7EHCo-author ofChapter 7: Histopathology of the Skin: General PrinciplesChapter 37: Tumours of the Skin AppendagesChapter 53: Soft-Tissue Tumours and Tumour-like ConditionsCAMP, Richard D.R.PhD, FRCPProfessor of Dermatology, Department of Infection, Immunity andInflammation, Maurice Shock Medical Sciences Building,University of Leicester, University Road, Leicester LE1 9HNCo-author ofChapter 35: PsoriasisCANT, Andrew J.BSc, MRCP, MD, FRCP, FRCPCHConsultant in Paediatric Immunology and Infectious Diseases, andHonorary Clinical Senior Lecturer in Child Health, NewcastleGeneral Hospital, Westgate Road, Newcastle upon Tyne NE4 6BECo-author ofChapter 14: The NeonateCERIO, RinoBSc, MB, BS, FRCP, FRCP(Edin), FRCPathConsultant Dermatologist and Reader in Dermatopathology,Department of Dermatology and Institute of Pathology (QMUL),Bart’s and Royal London Medical Schools, Whitechapel Road,London E1 1BBCo-author ofChapter 7: Histopathology of the Skin: General PrinciplesCHALMERS, Robert J.G.MB, FRCPConsultant Dermatologist, University of Manchester, DermatologyCentre, Hope Hospital, Stott Lane, Salford, Manchester, M6 8HDCo-authorChapter 72: Systemic TherapyCHU, Anthony C.FRCPSenior Lecturer/Honorary Consultant Dermatologist, ImperialCollege, Hammersmith Campus, Hammersmith Hospital, DuCane Road, London W12 0HSAuthor ofChapter 52: Histiocytoses
ContributorsCHURCH, Martin K.MPharm, PhD, DScProfessor of Immunopharmacology, Allergy and InflammationResearch, Southampton General Hospital, Tremona Road,Southampton SO16 6YDCo-authorChapter 9: InflammationCOTTERILL, John A.BSc, MD, FRCPFormerly Consultant Dermatologist, Department of Dermatology,Leeds General Infirmary, LeedsCo-authorChapter 61: Psychocutaneous DisordersChapter 71: General Aspects of TreatmentCOULSON, Ian H.BSc, MB, BS, FRCPConsultant Dermatologist, Dermatology Unit, Burnley GeneralHospital, Casterton Avenue, Burnley, Lancashire BB10 2PQAuthor ofChapter 45: Disorders of Sweat GlandsCo-authorChapter 5: Diagnosis of Skin DiseaseCOX, Neil H.BSc, MB, ChB, FRCP(Lond & Edin)Consultant Dermatologist, Department of Dermatology,Cumberland Infirmary, Carlisle CA2 7HYEditorCo-author ofChapter 1: Introduction and Historical BibliographyChapter 5: Diagnosis of Skin DiseaseChapter 48: Purpura and Microvascular OcclusionChapter 49: Vasculitis and Neutrophilic Vascular ReactionsChapter 59: Systemic Disease and the SkinCUNLIFFE, William J.MD, FRCPProfessor of Dermatology, Department of Dermatology, LeedsGeneral Infirmary, Great George Street, Leeds LS1 3EXCo-authorChapter 43: Disorders of the Sebaceous GlandsChapter 55: Subcutaneous FatDART, John K.G.MA, DM, FRCS, FRCOphthConsultant Ophthalmologist, Corneal External Disease and CataractServices, Moorfields Eye Hospital, City Road, London EC1V 2PDCo-authorChapter 64: The Skin and the EyesDAWBER, Rodney P.R.MA, FRCPConsultant Dermatologist, Department of Dermatology, ChurchillHospital, Old Road, Headington, Oxford OX2 7LJCo-authorChapter 62: Disorders of Nailsde BERKER, David A.R.BA, MRCPConsultant Dermatologist and Clinical Senior Lecturer, BristolDermatology Centre, Bristol Royal Infirmary, Marlborough Street,Bristol BS2 8HWxiCo-authorChapter 62: Disorders of NailsChapter 63: Disorders of HairDOWD, Pauline M.BSc, MD, FRCPProfessor of Dermatology, Department of Dermatology, TheMiddlesex Hospital, Tottenham Street, London W1T 4NJAuthor ofChapter 23: Reactions to ColdEADY, Robin A.J.DSc, FRCP, FMedSciEmeritus Professor of Experimental Dermatopathology, Division ofSkin Sciences, Guy’s, King’s and St Thomas’ School of Medicine,King’s College London, and Honorary Consultant Dermatologist,St John’s Institute of Dermatology, St Thomas’ Hospital, LambethPalace Road, London SE1 7EHCo-author ofChapter 3: Anatomy and Organization of Human SkinChapter 13: Prenatal Diagnosis of Genetic Skin DiseaseChapter 40: Genetic Blistering DiseasesEEDY, David J.MD, FRCPConsultant Dermatologist, Department of Dermatology, CraigavonArea Hospital Group Trust, 68 Lurgan Road, Portadown, Co.Armagh, Northern Ireland BT63 5QQCo-author ofChapter 60: The Skin and the Nervous SystemENGLISH, John S.C.MB, BS, FRCPConsultant Dermatologist, Department of Dermatology, Queen’sMedical Centre, University Hospital, Clifton Boulevard,Nottingham NG7 2UHCo-author ofChapter 21: Occupational DermatosesFERGUSON, JamesMD, FRCPConsultant Dermatologist, Photobiology Unit, Departmentof Dermatology, Ninewells Hospital and Medical School,Dundee DD1 9SYCo-author ofChapter 24: Cutaneous PhotobiologyFINE, Jo-DavidMD, MPH, FACPProfessor of Medicine, University of Kentucky College of Medicine,and Dermatology Associates of Kentucky, PSC, 250 FountainCourt, Lexington, KY 40509, USACo-author ofChapter 40: Genetic Blistering DiseasesFINLAY, Andrew Y.FRCP(Lond & Glasg)Professor of Dermatology and Honorary Consultant Dermatologist,Department of Dermatology, University of Wales College ofMedicine, Heath Park, Cardiff CF14 4XNCo-author ofChapter 71: General Aspects of Treatment
xiiContributorsFRIEDMANN, Peter S.GRATTAN, Clive E.H.MD, FRCP, FMedSciProfessor of Dermatology, Dermatopharmacology Unit,Southampton General Hospital, Tremona Road, SouthamptonSO16 6YDCo-author ofChapter 18: Atopic DermatitisMA, MD, FRCPConsultant Dermatologist, Department of Dermatology, Norfolkand Norwich University Hospital, Colney, Norfolk NR4 7UZCo-author ofChapter 47: Urticaria and MastocytosisGREAVES, Malcolm W.GAWKRODGER, David J.MD, FRCP, FRCPEConsultant Dermatologist and Honorary Senior Clinical Lecturer,Department of Dermatology, Royal Hallamshire Hospital,Glossop Road, Sheffield S10 2JFAuthor ofChapter 58: SarcoidosisChapter 69: Racial Influences on Skin DiseaseGENNERY, Andrew R.MD, MRCP, MRCPCH, DCH, DipMedSciWatson Clinical Senior Lecturer/Honorary Consultant in PaediatricImmunology and Bone Marrow Transplantation, NewcastleGeneral Hospital, Westgate Road, Newcastle upon Tyne NE4 6BECo-author ofChapter 14: The NeonateGOODFIELD, Mark J.D.MD, FRCPConsultant Dermatologist, Department of Dermatology, LeedsGeneral Infirmary, Great George Street, Leeds LS1 3EXCo-author ofChapter 56: The ‘Connective Tissue Diseases’GOTCH, FrancesPhD, FRCPathProfessor of Immunology, Head of Department, Department ofImmunology, Imperial College School of Medicine, Chelsea &Westminster Campus, Fulham Road, London SW10 9NHCo-author ofChapter 26: AIDS and the SkinGRAHAM, Robert M.MB, FRCPConsultant Dermatologist, Department of Dermatology, JamesPaget Healthcare NHS Trust, Lowestoft Road, Gorleston, GreatYarmouth, Norfolk NR31 6LACo-author ofChapter 59: Systemic Disease and the SkinGRAHAM-BROWN, Robin A.C.BSc, MB, BS, FRCPConsultant and Honorary Senior Lecturer in Dermatology,Department of Dermatology, Leicester Royal Infirmary, LeicesterLE1 5WWAuthor ofChapter 70: The Ages of Man and their DermatosesGRATTAN, BethMDResident Physician, Department of Dermatology, MedicalUniversity of South Carolina, Charleston, SC 29425, Carolina,USACo-author ofChapter 49: Vasculitis and Neutrophilic Vascular ReactionsMD, PhD, FRCPProfessor of Dermatology, Department of Dermatology, SingaporeGeneral Hospital, Outram Road, Singapore 169608Author ofChapter 16: PruritusGRIFFITHS, Christopher E.M.BSc, MD, FRCP, FRCPathProfessor of Dermatology and Consultant Dermatologist, TheDermatology Centre, University of Manchester, Irving Building,Hope Hospital, Salford, Manchester M6 8HDEditorCo-author ofChapter 9: InflammationChapter 35: PsoriasisChapter 72: Systemic TherapyHARPER, John I.MD, FRCP, FRCPCHProfessor of Paediatric Dermatology, Great Ormond Street Hospitalfor Children, Great Ormond Street, London WC1N 3JHCo-author ofChapter 12: Genetics and GenodermatosesHAWK, John L.M.BSc, MD, FRACP, FRCPConsultant Dermatologist and Head, Department of EnvironmentalDermatology, St John’s Institute of Dermatology, St Thomas’Hospital, Lambeth Palace Road, London SE1 7EHCo-author ofChapter 24: Cutaneous PhotobiologyHAY, Roderick J.DM, FRCP, FRCPathDean, Faculty of Medicine and Health Sciences, Queen’s UniversityBelfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT97BLCo-author ofChapter 27: Bacterial InfectionsChapter 31: MycologyChapter 32: Parasitic Worms and ProtozoaChapter 72: Systemic TherapyHOLDEN, Colin A.BSc, MD, FRCPConsultant Dermatologist, Epsom and St Helier UniversityHospitals NHS Trust, St Helier Hospital, Wrythe Lane,Carshalton, Surrey SM5 1AACo-author ofChapter 17: Eczema, Lichenification, Prurigo and ErythrodermaChapter 18: Atopic DermatitisJONES, Stephen K.BMedSci, BM, BS, MD, FRCP(Lond & Edin)Consultant Dermatologist, Department of Dermatology,Clatterbridge Hospital, Bebington, Wirral CH63 4JY
ContributorsCo-author ofChapter 56: The ‘Connective Tissue Diseases’JORIZZO, Joseph L.MDProfessor and Former (Founding) Chair, Department ofDermatology, Wake Forest University School of Medicine,Medical Centre Boulevard, Winston-Salem, NC 27157-1071, USACo-author ofChapter 49: Vasculitis and Neutrophilic Vascular ReactionsJUDGE, Mary R.MD, FRCP, DCHConsultant Dermatologist, Department of Dermatology, RoyalBolton Hospital, Minerva Road, Farnworth, Bolton BL4 0JR, andConsultant Paediatric Dermatologist, Dermatology Centre, HopeHospital, Stott Lane, Salford, Manchester M6 8HDCo-author ofChapter 34: Disorders of KeratinizationKELLY, Charles G.xiiiConsultant Dermatologist, Department of Dermatology, RoyalVictoria Infirmary, Queen Victoria Road, Newcastle upon TyneNE1 4LPCo-author ofChapter 77: Physical and Laser TherapiesChapter 78: Dermatological SurgeryLEONARD, Jonathan N.BSc, MD, FRCPConsultant Dermatologist, Department of Dermatology, St Mary’sHospital, Praed Street, London W2 1NYCo-author ofChapter 64: The Skin and the EyesLOCKWOOD, Diana N.J.MD, FRCPConsultant Physician and Leprologist, The Hospital for TropicalDiseases, Capper Street, London WC1E 6AUAuthor ofChapter 29: LeprosyMSc, FRCP, FRCRConsultant Clinical Oncologist, Northern Centre for CancerTreatment, Newcastle General Hospital, Westgate Road,Newcastle upon Tyne NE4 6BECo-author ofChapter 76: Radiotherapy and Reactions to Ionizing RadiationLOVELL, Christopher R.KENNEDY, Cameron T.C.LUGER, Thomas A.MA, MB, BChir, FRCPConsultant Dermatologist and Clinical Senior Lecturer, BristolDermatology Centre, Bristol Royal Infirmary, Marlborough Street,Bristol BS2 8HWAuthor ofChapter 65: The External EarCo-author ofChapter 22: Mechanical and Thermal InjuryMDProfessor and Chairman, Department of Dermatology, University ofMünster, Von-Esmarch-Strasse 58, D-48149 Münster, GermanyCo-author ofChapter 9: InflammationMD, FRCPDepartment of Dermatology, Royal United Hospital, Coombe Park,Bath BA1 3NGCo-author ofChapter 46: Disorders of Connective TissueM A C KIE, Rona M.CBE, MD, MSc, DSc, FACPFormer Professor of Dermatology, Universidad Central deVenezuela, Caracas, and Fellow of the National Academy ofMedicine and the Academy of Sciences of Venezuela, CentralUniversity of Venezuela, Apartado 60391, Caracas 1060-A,VenezuelaCo-author ofChapter 30: The TreponematosesCBE, FRSE, MD, DSc, FRCP, FRCPathSenior Research Fellow, Public Health and Health Policy, Universityof Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZAuthor ofChapter 38: Disorders of the Cutaneous MelanocyteCo-author ofChapter 36: Non-Melanoma Skin Cancer and Other EpidermalSkin TumoursChapter 37: Tumours of the Skin AppendagesChapter 53: Soft-Tissue Tumours and Tumour-like ConditionsChapter 54: Cutaneous Lymphomas and Lymphocytic InfiltratesKINGHORN, George R.McGRATH, John A.KERDEL-VEGAS, FranciscoMB, ChB, MD, FRCPClinical Director, Department of Genitourinary Medicine, RoyalHallamshire Hospital, Glossop Road, Sheffield S10 2JFCo-author ofChapter 30: The TreponematosesKOBZA BLACK, AnneMD, FRCPConsultant Dermatologist, St John’s Institute of Dermatology, StThomas’ Hospital, Lambeth Palace Road, London SE1 7EHCo-author ofChapter 47: Urticaria and MastocytosisLAWRENCE, Clifford M.MD, FRCPMD, FRCPProfessor of Molecular Dermatology, St John’s Institute ofDermatology, St Thomas’ Hospital, Lambeth Palace Road,London SE1 7EHCo-author ofChapter 3: Anatomy and Organization of Human SkinChapter 11: Wound HealingChapter 13: Prenatal Diagnosis of Genetic Skin DiseaseMcLEAN, W.H. IrwinPhD, DScWellcome Trust Senior Research Fellow and Professor of HumanGenetics, Human Genetics Unit, Division of Pathology andNeuroscience, Ninewells Hospital and Medical School, Universityof Dundee, Dundee DD1 9SY
xivContributorsCo-author ofChapter 34: Disorders of KeratinizationMESSENGER, Andrew G.MD, FRCPConsultant Dermatologist, Department of Dermatology, RoyalHallamshire Hospital, Glossop Road, Sheffield S10 2JFCo-author ofChapter 63: Disorders of HairMILLARD, Leslie G.MD, FRCP(Lond & Edin)Consultant in Dermatology and Cutaneous Surgery, Department ofDermatology and Dermatological Surgery, Queen’s MedicalCentre, University Hospital NHS Trust, Clifton Boulevard,Nottingham NG7 2UHCo-author ofChapter 61: Psychocutaneous DisordersMOORE, Mary K.MA, PhDLecturer, Mycology Department, St John’s Institute of Dermatology,St Thomas’ Hospital, Lambeth Palace Road, London SE1 7EHCo-author ofChapter 31: MycologyMORTIMER, Peter S.MD, FRCPProfessor of Dermatological Medicine, Dermatology Unit, StGeorge’s Hospital Medical School, Cranmer Terrace, LondonSW17 0REAuthor ofChapter 51: Disorders of Lymphatic VesselsCo-author ofChapter 50: Diseases of the Veins and Arteries: Leg UlcersMORTON, Robert S. [Deceased]MBE, MD, FRCP(Edin), DHMSAFormerly Honorary Lecturer in History of Medicine, University ofSheffieldCo-author ofChapter 30: The TreponematosesMOSS, CeliaSW10 9NH and Ashford & St Peter’s NHS Trust, Guildford Road,Chertsey, Surrey KT16 0PZCo-author ofChapter 68: The Genital, Perianal and Umbilical RegionsPIETTE, Warren W.MDProfessor and Vice-Chair, Department of Dermatology, Universityof Iowa Roy J. and Lucille A. Carver College of Medicine,University of Iowa Hospitals and Clinics, 200 Hawkins Drive,Iowa City, IA 52242-1090, USACo-author ofChapter 48: Purpura and Microvascular OcclusionPOPE, F. MichaelMD, FRCP(Lond, Edin & Glasg)Consultant Dermatologist, West Middlesex University Hospital,Twickenham Road, Isleworth, Middlesex TW7 6AF, and theChelsea & Westminster Hospital, Fulham Road, London SW109NH, Professor of Medical Genetics and Honorary ConsultantClinical Geneticist, Institute of Medical Genetics, University ofWales College of Medicine and University Hospital of Wales,Heath Park, Cardiff CF14 4XNCo-author ofChapter 3: Anatomy and Organization of Human SkinQUINN, Anthony G.BMSc, MB, ChB, PhD, FRCPDirector/Senior Principal Scientist, Experimental Medicine,AstraZeneca R&D Charnwood, Bakewell Road, Loughborough,Leicestershire LE11 5RHCo-author ofChapter 36: Non-Melanoma Skin Cancer and Other EpidermalSkin TumoursREES, Jonathan L.BMedSci, MB, BS, FRCP, FMedSciGrant Chair of Dermatology, Department of Dermatology, TheUniversity of Edinburgh, Lauriston Building, Lauriston Place,Edinburgh EH3 9HAAuthor ofChapter 8: Molecular BiologyROOK, Graham A.W.DM, FRCP, MRCPCHConsultant Dermatologist, Department of Dermatology,Birmingham Children’s Hospital, Steelhouse Lane, BirminghamB4 6NLCo-author ofChapter 15: Naevi and other Developmental DefectsBA, MB, BChir, M
The Editors. From l to r, Tony Burns, Stephen Breathnach, Christopher Griffiths and Neil Cox standing in front of a portrait o
