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CURRICULUM VITAETIMOTHY M. HOFFMAN, MD, FACC, FAHAEducationPostgraduate Education:1988-92MDWest Virginia University School of Medicine1984-88BSAllegheny College (Biology)Postgraduate Training and Fellowship Appointments:1999-00Cardiac Critical Care and Thoracic Organ Transplantation Fellowship,Children’s Hospital of Philadelphia, University of Pennsylvania School ofMedicine, Philadelphia, PA1996-99Cardiology Fellowship, Children’s Hospital of Philadelphia, University ofPennsylvania School of Medicine, Philadelphia, PA1995-96Chief Resident, Pediatrics, West Virginia University Children’s Hospital,Morgantown, WV1992-95Pediatric Residency, West Virginia University Children’s Hospital, WVUSchool of Medicine, Morgantown, WVSpecialty Certifications:201320072002200019951993American Board of Pediatrics RecertificationAmerican Board of Pediatric Cardiology RecertificationAmerican Board of Pediatrics RecertificationAmerican Board of Pediatric Cardiology (1518)American Board of Pediatrics (056172)National Board of Medical ExaminersProfessional Experience –Employment History09/16-present Governors Club Distinguished Professor in Pediatric Cardiology,Department of Pediatrics, University of North Carolina, Chapel Hill,North Carolina Children’s Hospital
Timothy M. Hoffman, MD, FACC, FAHACurriculum VitaeMay 202003/15-present Division Chief, Pediatric Cardiology, Professor, Department ofPediatrics, University of North Carolina, Chapel Hill, North CarolinaChildren’s Hospital11/13-2/15Professor, Department of Pediatrics, Division of Cardiology, NationwideChildren’s Hospital, The Ohio State University College of Medicine07/10-2/15Associate Medical Director of Cardiology, Nationwide Children’sHospital, The Ohio State University College of Medicine04/09-2/15Cardiology Fellowship Director, Nationwide Children’s Hospital, TheOhio State University College of Medicine01/02-1/15Medical Director, Heart Transplant and Heart Failure Program,Nationwide Children’s Hospital, The Ohio State University College ofMedicine11/06-10/13Associate Professor of Pediatrics, Department of Pediatrics, Division ofCardiology, Nationwide Children’s Hospital, The Ohio State UniversityCollege of Medicine01/02-10/06Assistant Professor of Pediatrics, Department of Pediatrics, Division ofCardiology, Nationwide Children’s Hospital, The Ohio State UniversityCollege of Medicine; Section of Cardiac Critical Care and HeartTransplant Services01/01-12/01Interim Section Chief and Medical Director of the Thoracic OrganTransplantation Program, Department of Pediatrics, Division ofCardiology, The Children’s Hospital of Philadelphia, University ofPennsylvania School of Medicine07/00-12/01Assistant Professor, Department of Pediatrics, Division of Cardiology,The Children’s Hospital of Philadelphia, University of PennsylvaniaSchool of Medicine; Sections of Cardiac Critical Care and ThoracicOrgan Transplantation07/96-6/00Instructor, General Pediatrics (Pediatric Cardiology Fellow), TheChildren’s Hospital of Philadelphia, University of Pennsylvania Schoolof Medicine07/95-06/96Instructor, General Pediatrics, West Virginia University Children’sHospital, West Virginia University School of MedicineLicensure:2015-present North Carolina (2015-00309)2002-18Ohio (#35-08-0682-H)2
Timothy M. Hoffman, MD, FACC, FAHACurriculum Vitae1996-101994-96May 2020Pennsylvania (MD-057980-L)West Virginia 971996199519941993199219921991198819871987Best Doctors in AmericaCastle Connolly Top DoctorPediatric Cardiac Intensive Care Society Presidential DistinguishedService AwardNorth Hills High School Distinguished Alumni AwardGold Citation Award, Allegheny CollegeKeynote Commencement Speaker, North Hills High School (Alma Mater),Pittsburgh, PAAaron Morton Endowed Fellowship, Children’s Hospital of Philadelphia,University of Pennsylvania School of MedicineAnn Newman Fellowship, Outstanding Clinical Cardiology Fellow,Children’s Hospital of Philadelphia, University of Pennsylvania School ofMedicineOutstanding Resident Research Award, Department of Pediatrics, WVUSchool of MedicineOutstanding Resident Teaching Award, Department of Pediatrics, WVUSchool of MedicineOutstanding Resident in Ambulatory Medicine, Department of Pediatrics,WVU School of MedicineOutstanding Intern, Department of Pediatrics, WVU School of MedicineEdward G. Stuart Memorial Award, WVU School of MedicineAlpha Omega AlphaE.B. Flink Award for Excellence, Department of Internal Medicine, WVUSchool of MedicinePhi Beta KappaNational Dean’s ListWho’s Who Among American Colleges and Universities3
Timothy M. Hoffman, MD, FACC, FAHACurriculum VitaeMay 2020Bibliography and Products of ScholarshipBooks and Chapters:1. Hoffman TM. Phosphodiesterase Inhibitors. Heart Failure in the Child and YoungAdult: From Bench to Bedside, edited by Jeffries JL, Chang AC, Rossano JW, ShaddyRE, and Towbin JA. Elsevier Inc, London 2018; 517-522.2. Hoffman TM, Welty S. Physiology of the pre-term and term infant. Moss and Adams’Heart Disease in Infants, Children, and Adolescents, 9th edition, edited by Allen HD,Shaddy RE, Penny DJ, Feltes TF, and Cetta F. Wolters Kluwer, Philadelphia 2016; 655664.3. Thrush PT, Mendell JR, Flanigan KM, Hoffman TM, Allen HD. The heart in musculardystrophies. Moss and Adams’ Heart Disease in Infants, Children, and Adolescents, 9thedition, edited by Allen HD, Shaddy RE, Penny DJ, Feltes TF, and Cetta F. WoltersKluwer, Philadelphia 2016; 1343-1354.4. Contributing author. Chapter 11: Acute heart failure. ISHLT Monograph Series Vol. 8:ISHLT Guidelines for the Management of Pediatric Heart Failure, edited by Kirk R,Dipchand AI, Rosenthal DN, and Kirklin JK. UAB Printing, Birmingham 2014; 201229.5. Allen HD, Mendell JR, Flanigan KM, Hoffman TM. The heart in muscular dystrophies.In Moss and Adams’ Heart Disease in Infants, Children, and Adolescents, 8th edition,edited by Allen HD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams andWilkins, Philadelphia 2013; 1277-1286.6. Hoffman TM, Welty S. Physiology of the pre-term and term infant. In Moss andAdams’ Heart Disease in Infants, Children, and Adolescents, 8th edition, edited by AllenHD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins,Philadelphia 2013; 473-482.7. Hoffman TM. The Cardiology laboratory. In Clinical Handbook of Pediatrics, 5e,Schwartz and Zorc, Williams and Wilkins, Philadelphia, PA 2013; 883-899.8. Tsai SF, Stines JR, Hoffman TM. Syncope. In Child Neurology Manual, 1e, Weisleder,World Scientific Publishing Co. Pte. Ltd, Singapore 2012; 163-174.9. Hoffman TM. The Cardiology laboratory. In Clinical Handbook of Pediatrics, 4e,Schwartz and Zorc, Williams and Wilkins, Philadelphia, PA 2009; 959-974.10. Allen HD, Hoffman TM Mendell JR. The heart in muscular dystrophies. In Moss andAdams’ Heart Disease in Infants, Children, and Adolescents, 7th edition edited by AllenHD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins,Philadelphia 2008; 1234-1241.4
Timothy M. Hoffman, MD, FACC, FAHACurriculum VitaeMay 202011. Olson TM, Hoffman TM, Chan DP. Dilated cardiomyopathy. In Moss and Adams’Heart Disease in Infants, Children, and Adolescents, 7th edition edited by Allen HD,Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins, Philadelphia2008; 1195-1206.12. Hoffman TM, Welty S. Physiology of the pre-term and term infant. In Moss andAdams’ Heart Disease in Infants, Children, and Adolescents, 7th edition edited by AllenHD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins,Philadelphia 2008; 440-447.13. Luce WA, Joshi MS, Hoffman TM, Feltes TF, Bauer JA. Immune mechanisms inpediatric cardiovascular disease. In Immune Dysfunction and Immunotherapy in HeartDisease, edited by Ronald R. Watson and Douglas F. Larson, Chapter 2, 2007; 6-16.14. Hoffman TM. The Cardiology laboratory. In Clinical Handbook of Pediatrics, 3eSchwartz, Williams and Wilkins, Philadelphia, PA 2003; 920-924.15. Hoffman TM, Spray TL. Infant Heart Transplantation. In Hypoplastic Left HeartSyndrome, Rychik J and Wernovsky G (eds), Kluwer Academic Publishers, Norwell, MA2003; 241-250.16. Hoffman TM. The Cardiology laboratory. In The 5 minute Pediatric Consult, 3eSchwartz, Williams and Wilkins, Philadelphia, PA 2003; 899-906.17. Hoffman TM. Cardiomyopathy. In The 5 minute Pediatric Consult, 3e Schwartz,Williams and Wilkins, Philadelphia, PA 2003; 216-217.18. Hoffman TM. Rheumatic fever. In The 5 minute Pediatric Consult, 3e Schwartz,Williams and Wilkins, Philadelphia, PA 2003; 716-717.19. Hoffman TM, Spray TL. Transplantation for Hypoplastic Left Heart Syndrome. InHypoplastic Left Heart Syndrome, Hennein HA and Bove EL (eds), Chapter 18, FuturaPublishing, Armonk, NY 2002; 289-300.20. Hoffman TM. The Cardiology laboratory. In The 5 minute Pediatric Consult, 2eSchwartz, Williams and Wilkins, Philadelphia, PA 2000; 891-897.21. Hoffman TM. Cardiomyopathy. In The 5 minute Pediatric Consult, 2e Schwartz,Williams and Wilkins, Philadelphia, PA 2000; 222-223.22. Hoffman TM. Rheumatic fever. In The 5 minute Pediatric Consult, 2e Schwartz,Williams and Wilkins, Philadelphia, PA 2000; 710-711.23. Hoffman TM. The Cardiology laboratory. In Clinical Handbook of Pediatrics, 2eSchwartz, Williams and Wilkins, Philadelphia, PA 1998; 892-899.5
Timothy M. Hoffman, MD, FACC, FAHACurriculum VitaeMay 2020Books and Chapters (In Press/Submitted):1. Phelps C, Simic J, Hoffman TM. Low Cardiac Output Syndrome. Second Edition ofPediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care edited by daCruz EM, Ivy, D, and Jaggers J. Springer (submitted July 2018).2. Hoffman TM, Welty S. Physiology of the pre-term and term infant. Moss and Adams’Heart Disease in Infants, Children, and Adolescents, 10th edition, edited by Allen HD,Shaddy RE, Penny DJ, Feltes TF, and Cetta F. Wolters Kluwer (submitted October 2019).3. Thrush PT, Mendell JR, Flanigan KM, Hoffman TM, Allen HD. The heart in musculardystrophies. Moss and Adams’ Heart Disease in Infants, Children, and Adolescents, 10thedition, edited by Allen HD, Shaddy RE, Penny DJ, Feltes TF, and Cetta F. Wolters Kluwer(submitted November 2019).Refereed Papers/Articles:1. Smith CL, Hoffman TM, Dori Y, Rome JJ. Decompression of the Thoracic Duct: ANovel Transcatheter Approach. Catheter Cardiovasc Interv. 2020 Feb;95(2):E56-E61.2. Hollander SA, Pruitt E, Sutherland SM, Cantor RS, Kirklinj J, Ravekes WJ, Ameduri R,Chrisant M, Hoffman TM, Lytriyi I, Conway J. Renal Injury and Recovery in PediatricPatients After Ventricular Assist Device Implantation and Cardiac Transplant. PediatrTransplant 2019 Aug;23(5):e13477.3. Hayes, D Jr., Wilson KC, Krivchenia K, Hawkins SM, Balfour-Lynn IM, Gozal D,Panitch HB, Splaingard ML, Rhein LM, Kurland G, Abman SH, Hoffman TM, CarrollCL, Cataletto ME, Tumin D, Oren E, Martin RJ, Baker J, Porta GR, Kaley D, Gettys A;Deterding R, MD on behalf of the American Thoracic Society Assembly on Pediatrics.Home Oxygen Therapy for Children: An Official ATS Clinical Practice Guideline. Am JRespir Crit Care Med 2019 Feb;199(3): e5–e23.4. Rostad CA, Wehrheim K, Kirklin JK, Naftel D, Pruittt E, Hoffman TM, L’Ecuyer T,Berkowitz K, Mahle WT, Scheel JN. Bacterial Infections in Pediatric Heart TransplantRecipients: Epidemiology, Risk Factors, and Outcomes. J Heart Lung Transplant 2017Sep; 36(9):996-1003.5. Peura JL, Colvin-Adams M, Francis GS, Grady KL, Hoffman TM, Jessup M, Ranjit J,Kiernan MS, Mitchell JE, O’Connell JB, Pagani FD, Petty M, Ravichandran P, RogersJG, Semigran MJ, Toole MJ. Recommendations for the Use of Mechanical CirculatorySupport: Ambulatory and Community Patient Care: A Consensus Statement from theAmerican Heart Association. Circulation, 2017 Jun; 20;135(25):e1145-e1158.6. Marino BS, Goldberg DJ, Dorfman AL, King E, Kalkward H, Zemel BS, Smith M, PrattJ, Fogel MA, Shillingford AJ, Deal BJ, John AS, Goldberg CS, Hoffman TM, Jacobs6
Timothy M. Hoffman, MD, FACC, FAHACurriculum VitaeMay 2020ML, Lisec A, Finan S, Kochilas LK, Pawlowski TW, Campbell K, Joiner C, Goldstein S,Stephens P, Chin AJ. Abnormalities in serum biomarkers correlate with lower cardiacindex in the Fontan population. Cardiol Young 2017 Jan;27(1):59-68.7. Thrush, PT, Pahl E, Naftel DC, Pruitt E, Everitt MD, Missler H, Zangwill SD, Burch M,Hoffman TM, Butts RJ, Mahle WT. A Multi-institutional Evaluation of AntibodyMediated Rejection Utilizing the PHTS Database: Incidence, Therapies, and Outcomes JHeart Lung Transplant 2016 Dec;35(12):1497-1504.8. Mills KI, Vincent JA, Zuckerman WA, Hoffman TM, Canter CE, Marshall AC, BlumeED, Bergersen L, Daly KP. "Is endomyocardial biopsy a safe and useful procedure inchildren with suspected cardiomyopathy?" Pediatr Cardiol 2016 Oct;37(7):1200-10.9. Hoffman TM. Chronic Heart Failure. Pediatr Crit Care Med 2016 Aug:17 (8 Suppl1):S119-S123.10. Hoffman TM. Quality Improvement in Pediatric Heart Failure. Progress in PediatricCardiology Mar 2016 40:9-11.11. Rossano JW, Hoffman TM, Jefferies JL, Lorts A, Kirsch RE, Thiagarajan RR. Clinicalissues and controversies in heart failure and transplantation. World J Pediatr CongenitHeart Surg 2016 Jan;7(1):63-71.12. Backes CH, Huang H, Cua CL, Garg V, Smith CV, Yin H, Galantowicz M, Bauer JA,Hoffman TM. Early versus Delayed Umbilical Cord Clamping in Infants withCongenital Heart Disease: A Pilot, Randomized, Controlled Trial. J Perinatol 2015Oct;35(10):826-31.13. Rossano JW, Dipchand AI, Hoffman TM, Singh TP, Jefferies JL. Advances in pediatricheart failure and treatments. Progress in Pediatric Cardiology July 2015, 39(1):33–36.14. Schumacher K, Almond C, Singh TP, Kirk R, Spicer R, Hoffman TM, Hsu D, NaftelDC, Pruitt E, Zamberlan M, Canter CE, Gajarski RJ. Predicting Graft Loss by 1-Year inPediatric Heart Transplant Candidates: An Analysis of the PHTS Database. Circulation2015 Mar 10;131(10):890-8.15. Naguib AN, Winch PD, Tobias JD, Yeates KO, Miao Y, Galantowicz M, and HoffmanTM. Neurodevelopmental outcome after cardiac surgery utilizing cardiopulmonarybypass in children. Saudi J Anaesth. 2015 Jan;9(1):12-8.16. Thrush PT, Hoffman TM. Pediatric heart transplantation – Indications and outcomes inthe current era. J Thorac Dis 2014 Aug;6(8):1080-96.17. Pennell DJ, Udelson JE, Arai AE, Bozkurt B, Cohen AR, Galanello R, Hoffman TM,Kiernan MS, Lerakis S, Piga A, Porter JB, Walker JM, Wood J. Cardiovascular Function7
Timothy M. Hoffman, MD, FACC, FAHACurriculum VitaeMay 2020and Treatment in β-Thalassemia Major: A Consensus Statement from the American HeartAssociation. Circulation 2013 Jul 16;128(3):281-308.18. Naguib AN, Tobias JD, Hall MW, Cismowski MJ, Miao Y, Barry N, Preston T,Galantowicz M, Hoffman TM. The role of different anesthetic techniques in altering thestress response during cardiac surgery in children: A prospective, double-blinded, andrandomized study. Pediatr Crit Care Med. 2013 Jun;14(5):481-90.19. Hayes D, Baker PB, Preston TJ, Kirkby S, Galantowicz M, Hoffman TM. Aggressivecoronary artery vasculopathy after combined heart-lung transplantation. Congenit HeartDis 2013 May-Jun;8(3):E88-91.20. Hayes D, Galantowicz M, Hoffman TM. Combined heart-lung transplantation: Aperspective on the past and future. Pediatr Cardiol 2013 Feb;34(2):207-12.21. Allen HD, Thrush PT, Hoffman TM, Flanigan KM, Mendell JR. Cardiac managementin neuromuscular diseases. Phys Med Rehabil Clin N Am 2012 Nov;23(4):855-68.22. Peura JL, Colvin-Adams M, Francis GS, Grady KL, Hoffman TM, Jessup M, Ranjit J,Kierman MS, Mitchell JE, O’Connell JB, Pagani FD, Petty M, Ravichandran P, RogersJG, Semigran JM, and Toole JM. Recommendations for the Use of MechanicalCirculatory Support: Device Strategies and Patient Selection: A Scientific Statement fromthe American Heart Association. Circulation 2012 Nov 27;126(22):2648-2667.23. Ameduri R, Zheng, Schectman, Hoffman TM, Gajarski R, Chinnock R, Fricker J, NaftelD, Kirklin, Dichand A, Canter C. Has Late Rejection Decreased in Pediatric HeartTransplantation in the Current Era? A Multi-institutional Study. J Heart LungTransplant 2012 Sep;31(9):980-6.24. Daly KP, Marshall AC, Vincent JA, Zuckerman WA, Hoffman TM, Canter C, BlumeED, Bergensen L. Endomyocardial biopsy is a safe and effective procedure in children:Results of a multi-center experience. J Heart Lung Transplant 2012 Apr;31(4):398-409.25. Feingold B, Zheng J, Law Y, Morrow WR, Hoffman TM, Schechtman KB, DipchandAI, Canter C. Risk factors for late renal dysfunction in pediatric heart transplantation: Amulti-institutional study. Pediatr Transplantation 2011;15:699-705.26. Hoffman TM. Impact of Evolution of the Fontan Operation on the Early and LateMortality A Single Center Experience of 405 Patients over 3 Decades (InvitedCommentary). Ann Thorac Surg 2011 Oct;92(4):1466-7.27. Yates AR, Hoffman TM, Shepherd E, Boettner B, McBride K., Pediatric Sub-specialistcontroversies in the treatment of congenital heart disease in Trisomy 13 or 18. J GenetCouns 2011 Oct;20(5):495-509.8
Timothy M. Hoffman, MD, FACC, FAHACurriculum VitaeMay 202028. Hoffman TM. Newer inotropes in pediatric heart failure. J Cardiovasc Pharmacol 2011Aug;58(2):121-5.29. Yates AR, Hoffman TM, Hashiguchi B, Feltes TF, Cua CL. Initial counseling prior topalliation for hypoplastic left heart syndrome. Congenit Heart Dis 2011 Jul;6(4):347-58.30. Hoffman TM. More than 30 years experience with surgical correction ofatrioventricular septal defects (Invited Commentary). Ann Thorac Surg 2010 Nov;90(5):1561-2.31. Jeffries JL, Hoffman TM, Nelson DP. Heart Failure Treatment in the Intensive Care Unitin Children. Heart Fail Clin 2010 Oct;6(4):531-58.32. Kaltman JR, Andropoulos DB, Checchia PA, Gaynor JW, Hoffman TM, Laussen P,Ohye R, Pearson G, Pigula F, Tweddell J, Wernovsky G, del Nido P. Report of thePediatric Heart Network and National Heart, Lung, and Blood Institute Working Groupon the Perioperative management of congenital heart disease. Circulation2010;121(25);2766-2772.33. Fitzgerald-Butt SM, Byrne L, Gerhardt CA, Vannatta K, Hoffman TM, McBride KL.Parental knowledge and attitudes toward hypertrophic cardiomyopathy genetic testing.Pediatr Cardiol 2010 Feb;31(2):195-202.34. Kirk R, Naftel D, Hoffman TM, Almond C, Boyle G, Caldwell RL, Kirklin JK, WhiteK, Dipchand AI. Outcome of pediatric patients with dilated cardiomyopathy listed fortransplant: A Multi-Institutional study. J Heart Lung Transplant 2009 Dec;28(12):13228.35. Moiduddin N, Cheatham JP, Hoffman TM, Phillips A, Kovalchin JP. Amplatzer septaloccluder associated with late pulmonary venous obstruction and aorta to left atrial fistula.Am J Cardiol 2009;103:1039-1040.36. Dyke PC 2nd, Konczal L, Bartholomew D, McBride KL, Hoffman TM. Acute dilatedcardiomyopathy in a patient with deficiency of long-chain 3-hydroxyacyl-CoAdehydrogenase. Pediatr Cardiol 2009 May; 30(4):523-6.37. Hoffman TM. Risks and predictors of blood transfusion in pediatric patients undergoingopen heart surgery (Invited Commentary). Ann Thorac Surg 2009 Jan;87(1):197.38. Galantowicz M, Cheatham JP, Phillips A, Cua CL, Hoffman TM, Hill SL, Rodeman R.The hybrid approach for hypoplastic left heart syndrome intermediate results after thelearning curve. Ann Thorac Surg 2008 Jun;85(6):2063-71.39. Garg R, Raman SV, Hoffman TM, Hayes J, Daniels CJ. Serum markers of systemicright ventricular function and exercise performance. Pediatr Cardiol 2008May;29(3):641-648.9
Timothy M. Hoffman, MD, FACC, FAHACurriculum VitaeMay 202040. Giannone PJ, Luce WA, Nankervis CA, Hoffman TM, Wold LE. Necrotizingenterocolitis in neonates with congenital heart disease. Life Sci 2008; 82(7-8):341-7.41. Luce WA, Hoffman TM, Bauer JA. Bench to Bedside review: Developmentalinfluences on the mechanisms, treatment and outcomes of cardiovascular dysfunction inneonatal versus adult sepsis. Critical Care 2007;11:228-237.42. Astor TL, Galantowicz M, Phillips A, Davis JT, Hoffman TM. Domino hearttransplantation involving infants. Am J Transplant 2007;7:2626-29.43.
2000 American Board of Pediatric Cardiology (1518) 1995 American Board of Pediatrics (056172) 1993 National Board of Medical Examiners Professional Experience –Employment History 09/16-present Governors Club Distinguished Professor in Pediatric Cardiology, Department
