CHRISTINA L. GOLDSTEIN BS MD, FRCSC

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CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTE4040-1100 VIRGINIA AVENUEGOLDSTEINCL@HEALTH.MISSOURI.EDUOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 1ClinicalAppointmentsAttending SurgeonUniversity of Missouri Health SystemMissouri Orthopaedic InstituteNovember 2014 PresentAcademicAppointmentsAssistant ProfessorUniversity of Missouri School of MedicineDepartment of Orthopaedic SurgeryJuly 2014 - PresentDirector of Spine ResearchUniversity of Missouri School of MedicineDepartment of Orthopaedic SurgeryJuly 2016 - PresentUniversity of Missouri Graduate FacultyUniversity of MissouriDepartment of Veterinary PathobiologyMarch 2017 - PresentAssociate Residency Program DirectorUniversity of MissouriDepartment of Orthopaedic SurgeryNovember 2017 – PresentMaster of Public Health (candidate)Johns Hopkins UniversityBloomberg School of Public HealthJanuary 2014 – PresentClinical FellowshipToronto Western Hospital Spine ProgramUniversity of TorontoJuly 2012 – June 2014Clinical FellowshipCombined Spine ProgramUniversity of CalgaryJuly 2011 – June 2012Orthopedic Surgery Residency Training ProgramMcMaster UniversityJuly 2006 – June 2011Undergraduate MD ProgramMcMaster University2003 - 2006Bachelor of Science HonoursMcMaster University1999 - 2003Missouri State Board of Registration for the Healing ArtsLicence #2014021822July 2014 – PresentEducationMedical LicensesJanuary 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 2QualificationsandCertificationsScholarships andAwardsCollege of Physicians and Surgeons of OntarioLicense #84997June 2012 - PresentCollege of Physicians and Surgeons of AlbertaLicense #017887July 2011 – December2014United States Medical Licensing Examination Step 2 –Clinical KnowledgeJune 2014United States Medical Licensing Examination Step 1December 2013Royal College of Physicians and Surgeons of CanadaOrthopaedic Surgery CertificationJune 2011Licentiate Certificate of the Medical Council of CanadaDecember 2007Medical Council of Canada Qualifying Examination Part IIDecember 2007Medical Council of Canada Qualifying Examination Part IJune 2006University of Missouri Department of Orthopaedic SurgeryMOI Clinical Research Team of the Quarter Q1 (Spine)2017University of MissouriMU Top Faculty Achiever2017American Orthopaedic Association –2017 North American Traveling Fellowship (NATF)2017Alpha Omega Alpha Honor Medical SocietyUniversity of Missouri Columbia Chapter - Member2017Columbia’s Favorite DoctorsOrthopaedic Spine Surgery201726th Annual Caring for the Frail Elderly Conference2nd Place Poster Award“Know the risks: An investigation of reoperation rates followingsurgical fusion in adult spinal deformity”2016Society for Minimally Invasive Spine Surgery 2014 Global ForumBest Paper Award“Comparative clinical and economic outcomes of minimally invasivesurgery for posterior lumbar fusion: A systematic review and metaanalysis”2014January 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 3IV World Congress of Minimally Invasive Spine Surgery andTechniquesBest Paper Award“Comparative clinical and economic outcomes of minimally invasivesurgery for posterior lumbar fusion: A systematic review and metaanalysis”2014Canadian Spine Society 13th Annual Scientific Conference –Fellows’ Best Paper Award“Symptomatic spinal epidural hematoma after posterior cervicalsurgery: Incidence and risk factors”20135th Annual Fellows’ Research Symposium –University of Calgary Division of Orthopaedics2nd Place Presenter“Symptomatic Spinal Epidural Hematoma After Posterior CervicalSurgery: Incidence and Risk Factors”201210th Annual AOSpine North America Fellows’ Forum –1st Prize Poster Presentation“Evidence and Current Practice in the Radiologic Assessment ofLumbar Spine Fusion”2012Hamilton Health Sciences Medical Staff Association –Outstanding Senior Resident2011McMaster University Neuroscience Residents Research Day –1st Place Presenter2010McMaster University Division of Orthopaedic Surgery –3rd Place Research Prize2010McMaster University Division of Orthopaedic Surgery –Robert Lofthouse Senior Resident Research Award2009McMaster University Division of Orthopaedic Surgery –Derek Kirkpatrick Clinical Research Award2008McMaster University Department of Surgery –2nd Place Presenter Core Program Research Day2006McMaster University Anatomy Prize2003The Esther McCandless Memorial Prize2003Ontario Graduate Scholarship (declined)2003January 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 4Grant FundingThe John D. Schultz Science Student Scholarship2002 & 2003The Dr. Harry Lyman Hooker ScholarshipMcMaster University Dean’s Honour List20012000, 2001 & 2003The George and Nora Elwin Merit Award1999Spine Cadaver Skills Lab for PGY 4-5 Training on TLIF/ALIF TechniquesPrincipal Investigator: Christina L. GoldsteinAmount: 2,571Granting Agency: DePuy SynthesDate Awarded: December 2017CelluloGel for Vertebral Compression Fracture RepairClinical Principal Investigator: Christina L. GoldsteinEngineering Co-Principal Investigators: Bret Ulery, Ellen WanAmount: 100,000Granting Agency: University of Missouri Coulter Translational PartnershipDate Awarded: January 2017Injectable Osteomodulatory Hydrogels for Vertebral Compression Fracture RepairClinical Principal Investigator: Christina L. GoldsteinEngineering Principal Investigator: Bret UleryAmount: 26,750Granting Agency: University of Missouri Coulter Translational PartnershipDate Awarded: April 2016Dispersal Pattern of Injectate After Cervical Epidural Steroid Evaluated with MagneticResonance ImagingPrincipal Investigator: Joel Jeffries (Christina L. Goldstein assumed role of PI May 2015)Amount: 10,010.00Granting Agency: University of Missouri Orthopaedic AssociationDate Awarded: 2015Correlation of Health Outcome Measure Scores in Foot and Ankle TraumaPrincipal Investigator: Christina L. GoldsteinSenior Colleagues: Brad A. Petrisor, Mohit BhandariAmount: 10,000Granting Agency: OTA/Foundation for Orthopaedic TraumaDate Awarded: March 2007January 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 5Publications andPresentationsPublications:Peer Reviewed 1.Goldstein CL, Pashuck TD, Ingalls K, Billings L, Agha M, Drymalski M, Choma TJ,Joeffries JT. Dispersal pattern of injectate after cervical epidural steroid injectionevaluated with magnetic resonance imaging. Global Spine J. 2017. [Submitted forPublication].2.Bateman AH, Larouche J, Goldstein CL, Sciubba DM, Choma TJ, Lawrence B, Cheng J,Fehlings MG, Paquette SJ, Yee AJM. The importance of determining trainee perspectiveson procedural competencies during spine surgery clinical fellowship. Global Spine J.2017. [Accepted for Publication].3.Makler V, Goldstein CL, Hoernschemeyer D, Tanaka T. Chiari I malformation andsyringomyelia in mucopolysaccharidosis type I (Hurler Syndrome) treated with posteriorfossa decompression: Case report and review of the literature. Surg Neuro Int. 2017;8:80.4.Hsu WK, Goldstein CL, Shamji MF, Cho SK, Arnold PM, Fehlings MG, Mroz TE. Novelosteobiologics and biomaterials in the treatment of spinal disorders. Neurosurgery. 2017.80;3S:S100-S107.5.Choma TJ, Mroz TE, Goldstein CL, Arnold P, Shamji MF. Emerging techniques indegenerative thoracolumbar surgery. Neurosurgery. 2017. 80;3S:S55-S60.6.Sheshadri V, Moga R, Manninen P, Goldstein CL, Rampersaud YR, Massicotte EM,Fehlings MG, Venkatraghavan L. Airway adverse events following posterior occipitocervical spinal fusion. J Clin Neurosci. 2017 Jan 16. [Epub ahead of print]. doi:10.1016/j.jpcn.2016.12.036.7.Goldstein CL, Rampersaud YR, Phillips FM. Comparative effectiveness and economicevaluations of open versus minimally invasive transforaminal lumbar interbody fusion: Asystematic review. Spine. 2016 Jan 19. [Epub ahead of print].8.Goldstein CL, Macwan K, Sundararajan K, Rampersaud YR. Perioperative outcomes andadverse events of minimally invasive versus open posterior lumbar fusion: A systematicreview and meta-analysis. J Neurosurg Spine. Published online November 13, 2015; DOI:10.3171/2015.2.SPINE14973.9.Goldstein CL, Chutkan NB, Choma TJ, Orr RD. Management of the elderly with vertebralcompression fractures. Neurosurgery. 2015 Oct;77 Suppl 4:S33-45.10. Tetreault L, Goldstein CL, Harrop J, Hilibrand A, Nouri A, Fehlings MG. Degenerativecervical myelopathy: A spectrum of related disorders affecting the aging spine.Neurosurgery. 2015 Oct;77 Suppl 4:S51-67.11. Goldstein CL, Brodke DS, Choma TJ. Surgical management of spinal conditions in theelderly osteoporotic spine. Neurosurgery. 2015 Oct;77 Suppl 4:S98-107.January 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 612. Shamji MF, Goldstein CL, Wang M, Uribe J, Fehlings MG. Minimally invasive spinalsurgery in the elderly: Does it make sense? Neurosurgery. 2015 Oct;77 Suppl 4:S108-15.13. Samuel N, Goldstein CL, Santaguida C, Fehlings MG. Spontaneous resolution ofidiopathic thoracic spinal cord herniation: case report. J Neurosurg Spine. 2015;May 29:13 [Epub ahead of print].14. Goldstein CL, Varga PP, Gokaslan ZL, Boriani S, Luzzati A, Rhines L, Fisher CG,Chou D, Williams RP, Dekutoski MB, Quraishi NA, Bettegowda C, Kawahara N,Fehlings MG. Hemangiomas of the spine: Results of surgical management and mortality ina multicenter study. Spine. 2015;40(9):656-64.15. White AN, Wong DT, Goldstein CL, Wong J. Cervical spine over-flexion in a haloorthosis contributing to complete upper airway obstruction during awake bronchoscopicintubation. Can J Anaesth. 2015;62:289-293.16. Goldstein CL, Bains I, Hurlbert RJ. Symptomatic spinal epidural hematoma after posteriorcervical surgery: Incidence and risk factors. Spine J. 2015;15(6):1179-87.17. Westwick HJ, Goldstein CL, Shamji MF. Acute spontaneous cervical disc herniationcausing rapidly progressive myelopathy in a patient with comorbid ossified posteriorlongitudinal ligament: Case report and literature review. Surg Neurol Int. 2014;4(5):S368S372.18. Goldstein CL. Success in academic spine surgery: The role of mentoring. Evid BasedSpine Care J. 2013;4:90-95.19. Goldstein CL, Schemitsch E, Bhandari M, Mathew G, Petrisor BA. Comparison ofdifferent outcome instruments following foot and ankle trauma. Foot and AnkleInternational. 2010;31(12):1075-1080.Invited Submissions:20. Goldstein CL, Tintle SM, Hogan MV, Ravi B, Waterman BR. The 2017 North AmericanTraveling Fellowship. J Bone Joint Surg. [Submitted for publication].21. Cowan RS, Goldstein CL, NASS Coverage Committee. NASS Coverage PolicyRecommendations. Allograft and Demineralized Bone Matrix for Spinal Fusion. 2017 2. NASS Coverage Committee. NASS Coverage Policy Recommendations. Spinal CordStimulation. 2017 3. White AN, Wong DT, Goldstein CL, Wong J. In reply: Airway management strategies inpatients with halo vest fixation devices. Can J Anaesth. 2015. DOI 10.1007/s12630-0150396-x.January 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 724. Lewis SJ, Zamorano JJ, Goldstein CL. Treatment of severe pediatric spinal deformities. JPediatr Orthop. 2014 Oct-Nov; 34 Suppl 1:S1-S5.25. Goldstein CL, Macwan K, Sundararajan K, Rampersaud YR. Comparative Outcomes ofMinimally Invasive Surgery for Posterior Lumbar Fusion: A Systematic Review. ClinOrthop Rel Res. 2014;Jan 25 [Epub ahead of print].26. Goldstein C. Defining and evaluating success in spinal fusion. Spinal Columns.2012;12(2):16-17.27. Goldstein C, Drew B. When is a Spine Fused? Injury. Int. J. Care Injured. 2011;42:306313.28. Faruggia P, Goldstein C, Petrisor BA. Measuring foot and ankle injury outcomes:Common scales and checklists. Injury. Int. J. Care Injured. 2011;42:276-280.29. Goldstein C, Sprague S, Petrisor B. Electrical stimulation for fracture healing: Currentevidence. J Orthop Trauma. 2010;24:S62-S65.30. Goldstein C, Petrisor BA. Design issues in a non-regulatory trial. J Long Term Eff MedImplants. 2009;19(3):223-233.31. Goldstein C, Petrisor BA, Ferguson T, Bhandari M. Evidence-based medicine: Implantsfor fixation of femoral neck fractures. Techniques in Orthopaedics. 2008;23(4):301-3Textbook Chapters:32. Goldstein CL, Lewis SJ. Chapter 23: Results of surgical treatment of adult isthmicspondylolisthesis. In Wollowick AD, Sarwahi V (Ed). Spondylolisthesis: Diagnosis, NonSurgical Management, and Surgical Techniques. New York; Springer. 2015.33. Goldstein C, Rampersaud YR. Clinical research in MIS surgery: Current state and futurechallenges. In Wang MY, Mummaneni P, Anderson G (Ed). Minimally Invasive SpinalDeformity Surgery: An Evolution of Modern Techniques. New York; Springer. 2014.34. Goldstein C, Bhandari M. Femoral Neck Fractures – ORIF. In Schemitsch E, McKee MD(Ed), Operative Techniques: Orthopaedic Trauma Surgery. Philadelphia; Elsevier,Saunders. 2010. Pages 283-303.35. Goldstein C, Petrisor B. The Confidence Interval Defined. In. Bhandari M, Joensson A(Eds), Clinical Research for Surgeons. New York; Thieme Publishers. 2008.36. Goldstein C, Petrisor B. The P-value Defined. In. Bhandari M, Joensson A (Eds), ClinicalResearch for Surgeons. New York; Thieme Publishers. 2008.January 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 8Peer-Reviewed Presentations:International –1.Racial Disparities in Perioperative Outcomes Following Cervical Spine Fusion: AnAnalysis of the 2015 NSQIP DatabaseJulia Matera, Emily Leary, Kaiyi Chen, Theodore J. Choma, Christina L. Goldstein2018 Global Spine Congress (Accepted for Podium)SingaporeMay 2-5, 20182.Racial Disparities in Perioperative Outcomes Following Lumbar Fusion forSpondylolisthesis: An Analysis of the 2011-2015 NSQIP DatabasesVictoria Buescher, Emily Leary, Yinghua Cui, Theodore J. Choma, Christina L. Goldstein2018 Global Spine Congress (Accepted for Podium)SingaporeMay 2-5, 20183.Racial Disparities in Perioperative Outcomes Following Lumbar Spine Fusion: AnAnalysis of the 2015 NSQIP DatabaseAbigale Berry, Emily Leary, Ruiqing Feng, Theodore J. Choma, Christina L. Goldstein2018 Global Spine Congress (Accepted for Podium)SingaporeMay 2-5, 20184.Spine Surgery Fellowship Education in North America: Trainee Perspectives on theRelative Importance of Specific Procedural CompetenciesAntony H. Bateman, Jeremie Larouche, Christina L. Goldstein, Daniel M. Sciubba,Theodore J. Choma, Brandon Lawrence, Joseph Cheng, Michael G, Fehlings, Scott J.Paquette, Albert J. M. Yee8th International Society of Orthopaedic Centers ConferenceSydney, AustraliaNovember 15-18, 20175.Clinical Outcomes and Complications Following Surgical Treatment ofSpondylolisthesis: Impact of Socioeconomic StatusRachel Honig, Caleb Smith, Emily Leary, Christina L. GoldsteinNorth American Spine Society 32nd Annual Meeting (e-Poster with Podium)Orlando, FLOctober 25-28, 20176.Dispersal Pattern of Injectate After Cervical Epidural Steroid Injection Evaluatedwith Magnetic Resonance ImagingChristina L. Goldstein, Troy Pashuck, Kevin Ingalls, Christopher James, Laura Billings,Mohammed Agha, Mark Drymalski, Theodore J. Choma, Joel Jeffries2017 Global Spine CongressMilan, ItalyMay 3-6, 2017January 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 97.Airway Adverse Events After Posterior Occipitocervical FusionVeena Sheshadri, Rebecca Moga, Pirjo Manninen, Christina L. Goldstein, Y. RajaRampersaud, Eric M. Massicotte, Michael G. Fehlings, Lashmi Venkatraghavan2017 Global Spine CongressMilan, ItalyMay 3-6, 20178.Spondylolisthesis Reduction in One- and Two-level Lumbar Fusion Has No Impacton Complication RatesChristina L. Goldstein, Nathan Beckett, Caleb Smith, Theodore J. Choma2017 Global Spine CongressMilan, ItalyMay 3-6, 20179.Adverse Events Following Lumbar Spine Fusion: The Combined Effect of Age,Smoking and Vitamin DChristina L. Goldstein, Preston Wolfe, Theodore J. Choma, Justin M. HallNorth American Spine Society 31st Annual MeetingBoston, MassachusettsOctober 25, 201610. Mentoring in Spine Surgery Training: Attitudes and Experiences of AOSpine NorthAmerica FellowsChristina L. Goldstein, Theodore J. Choma, Brandon D. Lawrence, Robert W. Molinari,Daniel M. Sciubba, Michael G. FehlingsNorth American Spine Society 30th Annual MeetingChicago, IllinoisOctober 16, 201511. Reoperation Rates Following Surgical Management of Adult Spinal Deformity:Incidence and Risk Factors at a Single Academic CenterChristina L. Goldstein, Caleb Smith, Mark T. Barron, Theodore J. ChomaNorth American Spine Society 30th Annual MeetingChicago, IllinoisOctober 16, 201512. Outcomes of Surgical Management and Risks of Recurrence of Symptomatic SpinalHemangiomas: A Multicenter Series of 68 CasesChristina L. Goldstein, Peter Pal Varga, Ziya L. Gokaslan, Stefano Boriani, AlessandroLuzzati, Laurence Rhines, Charles G. Fisher, Dean Chou, Richard P. Williams, Mark B.Dekutoski, Nasir A. Quraishi, Chetan Bettegowda, Norio Kawahara, Michael G. Fehlings.Global Spine Congress 2015Buenos Aires, ArgentinaMay 21, 2015January 2, 2018

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSCMISSOURI ORTHOPAEDIC INSTITUTEGOLDSTEINCL@HEALTH.MISSOURI.EDU4040-1100 VIRGINIA AVENUEOFFICE (573) 884-9022COLUMBIA, MISSOURI65212FAX (573) 882-5847PAGE 1013. Perioperative Outcomes and Adverse Events of Minimally Invasive Versus OpenPosterior Lumbar Fusion: A Meta-analysisChristina L. Goldstein, Kevin Macwan, Kala Sundararajan, Y. Raja RampersaudGlobal Spine Congress 2015Buenos Aires, ArgentinaMay 21, 201514. Outcomes of Management and Risks of Recurrence of Symptomatic SpinalHemangiomas: A Multicenter Series of 68 Cases.Christina L. Goldstein, Peter Pal Varga, Ziya L. Gokaslan, Stefano Boriani, AlessandroLuzzati, Laurence Rhines, Charles G. Fisher, Dean Chou, Richard P. Williams, Mark B.Dekutoski, Nasir A. Quraishi, Chetan Bettegowda, Norio Kawahara, Michael G. Fehlings.North American Spine Society 29th Annual Meeting – Poster PresentationSan Francisco, CaliforniaNovember 12-15, 201415. Hemangiomas of the Spine: Results of Surgical Management and PrognosticVariables for Local Recurrence and Mortality in a Multicenter StudyChristina L. Goldstein, Peter Pal Varga, Ziya L. Gokaslan, Stefano Boriani, AlessandroLuzzati, Laurence Rhines, Charles G. Fisher, Dean Chou, Richard P. Williams, Mark B.Dekutoski, Nasir A. Quraishi, Chetan Bettegowda, Norio Kawahara, Michael G. FehlingsEuroSpine 2014Lyon, FranceOctober 1-3, 201416. Comparative Clinical and Economic Outcomes of Minimally Invasive Surgery forPosterior Lumbar Fusion: A Systematic Review and Meta-analysisChristina L. Goldstein, Kevin Macwan, Kala Sundararajan, Y. Raja RampersaudSociety for Minimally Invasive Spine Surgery 2014 Global ForumMiami, FloridaSeptember 19-21, 201417. Comparative Clinical and Economic Outcomes of Minimally Invasive Surgery forPosterior Lumbar Fusion: A Systema

CHRISTINA L. GOLDSTEIN BSC, MD, FRCSC MISSOURI ORTHOPAEDIC INSTITUTE 4040-1100 VIRGINIA AVENUE COLUMBIA, MISSOURI 65212 GOLDSTEINCL@HEALTH.MISSOURI.EDU OFFICE (573) 884-9022 FAX (573) 882-5847 PAGE 3 January 2, 2018 IV World Congress of M