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Anhydro Spray DryingF O R T H E P H A R M AC E U T I CA L I N D U S T RY

SPX Flow Technology Danmark A/S is aninternational engineering company with aAnhydro Spray Drying Technologiesconsistent goal to provide our customers withthe optimal processing technology and thehighest plant performance standards. We haveBased on a four-tier model incorporating the most com prehensive rangespecialised in supplying the optimal designof continuous spray drying solutions available, SPX FLOW customisesand engineering with respect to productionhigh-performance, cost -effective processing solutions to individualperformance, flexibility, energy efficiency andenvironmental protection.pharmaceutical needs.SPX FLOW offers a wide range of Anhydrospray drying technologies for handling numerousapplications for the pharmaceutical industryAsepticthat give high-quality end-products in the mostefficient and economical way.A-ClassGMPSPX FLOW, Inc. (NYSE:FLOW) is a leadingMicraSpray Standard Plantsmanufacturer of innovative flow technologies,many of which help define the industry standardin the market segments they serve. From itsheadquarters in Charlotte, North Carolina, itoperates a sales and support network, centersof manufacturing excellence, and advancedengineering facilities, throughout the world. ItsWith thousands of spray drying plants sold worldwide, SPX FLOW offerscutting-edge flow components and processdecisive competitive edge in pharma ceutical spray drying:equipment portfolio includes a wide rangeof pumps, valves, heat exchangers, mixers,homogenisers, separators, filters, UHT, and dryingtechnology that meet many application needs.Its expert engineering capability also makes it apremium supplier of customized solutions andcomplete, turn-key packages to meet the mostexacting of installation demands.Incorporating many leading brands, SPX FLOWhas a long history of serving the food and The most comprehensive spray drying solution range available today Compact processing of more drug products than with other processingtechnologies Dedicated customisation based on world-leading experience and expertise Multiple processes including API processing, spray encapsulation, sprayagglomeration and spray cooling Scalable design space Predictable path forward and control spacebeverage, power and energy, and industrial market Complete control over particle size distributionsectors. Its designs and engineered solutions Consistent precision and performancehelp customers drive efficiency and productivity, Maximum uptime with straightforward cleaning and maintenance.increase quality and reliability, and meet the latestregulatory demands. In-depth understandingof applications and processes, state-of-the-artInnovation Centers, and advanced pilot/testingtechnology further assist in optimizing processesand reducing timescales to reliably meetproduction targets.To learn more about SPX FLOW capabilities,its latest technology innovations and completeservice offerings, please visit www.spxflow.com.2B E N E F I T S T H AT M A K E A D I F F E R E N C E

Precision, Control and ScalabilityTypical Product ApplicationsAnhydro spray drying solutions enable cost-effective production ofpowders with tailored particle engineering in a controlled environmentand under scalable conditions.Pharmaceutical companies across the world use Anhydrospray drying solutions for a wide range of applications inWith the Anhydro spray drying equipment youcan produce a wide range of pharmaceuticalpowders.the fields of: Pharmaceuticals Nutraceuticals Biopharmaceuticals and biotherapeutics Aseptic applications and processingFree Flowing PowdersContinuous single-stage spraydrying of APIs, excipients andfinal formulations into freeflowing powders.VA L I DAT I O NAnhydro spray drying solutions for the pharmaceutical industryfeature FDA 21 CFR Part 11-compliant process control and dataacquisition to accommodate individual customer requirements.Anhydro supplies the necessary process control and data acquisitionsolutions to facilitate successful validation.Agglomerated PowdersSpray bed drying combiningspray drying with fluidized bedtechnology for single-stepproduction of agglomeratedpowders.EncapsulationFor various formulationsenabling special propertiessuch as microencapsulation forvarious compounds enablingtaste masking or controlledrelease functional coatings.Fine PowdersIsolation of amorpouscompounds, improvedbioavailability through theproduction of amorphouspowders by forming soliddispersions, molecule or powderstabilisation.Spray CoolingFor various compounds enablingtaste masking or controlledrelease.3

Anhydro MicraSpray - Customizable, Adaptable and ScalableThe Anhydro MicraSpray series is the result of more than 65A N H Y D R O M I C R A S P R AY G M P S E R I E Syears of spray drying experience and expertise gained fromAnhydro MicraSpray-GMP dryers are typically used for primarythousands of installed spray dryers and innumerable drying testspharma applications including APIs, excipients and someconducted on a huge variety of different products.antibiotics. The MicraSpray GMP dryer quality standards complyAnhydro MicraSpray dryers feature a series of cutting-edgetechnology developments within key process components,with FDA guidelines and the dryers are used in R&D work aswell as in actual API production.opening new doors for particle engineering and plant sanitation.Anhydro MicraSpray dryers can be customized and scaled toF E AT U R E B E N E F I T Svirtually any requirement within primary as well as secondary Enhanced plant surface finishpharmaceuticals. Material certificates eCustomized automationA N H Y D R O M I C R A S P R AY S TA N DA R D S E R I E SMicraSpray Standard dryers follow a design concept based on abasic dryer with a wide range of optional modules. This enablesthe customer to configure the dryer for special application andprocessing needs.The standard MicraSpray is available in six differentsizes with gas rates of:35 - 150 - 400 - 750 - 1,250 - 2,500 kg/h(77 - 331 - 882 - 1,653 - 2,756 - 5,512 lb/h)An h y d r o M i c r a S p r a y 1 5 04 CIP (Clean-In-Place) and sanitation in place capability Process gas filtration Supply of documentation enabling equipment qualification.

A N H Y D R O M I C R A S P R AY A - C L A S S S E R I E SA N H Y D R O M I C R A S P R AY A S E P T I C S E R I E SAnhydro MicraSpray A-Class dryers are designed for secondaryThe Anhydro MicraSpray aseptic series is the first and only trulypharmaceuticals, typically final formulation, spray congealingaseptic spray dryer series available. Anhydro MicraSpray asepticfor taste masking, increased bio-availability drugs, micro-dryers are designed for peptides, proteins, vaccines and otherencapsulation, and powders for inhalation.biopharmaceutical products requiring aseptic processes.The Anhydro MicraSpray A-Class series eliminates inspectionThe MicraSpray aseptic series is based on the same equipmentdoors and unnecessary flange connections in the processstandard as the MicraSpray A-class series together with a rangevessels in order to provide optimum surfaces and even vesselof special features to ensure a truly aseptic process.surface temperatures.F E AT U R E B E N E F I T S Cutting-edge technology air distribution systems Atomization systems Powder separation systems Mirror-polished surfaces Comprehensively documented qualification services Special verification systems enabling tracking anddocumenting complex parameters in order to verify processconsistency over time.An h y d r o M i c r a S p r a y 1 5 0 A s e p t i c5

Anhydro MicraSpray dryers are available in different sizes, classes and configurations.M I C R A S P R AY D RY E R M O D E L SM S 35M S 15 0M S 400M S 75 0M S 12 5 0M S 2500S I N G L E S TAG EYESYESYESYESYESYESM U LT I - S TAG ENOYESYESYESYESYESST R A N DA R DGMPA - C L AS SAS E P T I CAt m o s p h e r i cSingle passClosed cycleAn h y d r o M i c r a S p r a y 7 5 0 G M PAn h y d r o M i c r a S p r a y 1 5 0 c l o s e d c y c l e G M P6An h y d r o M i c r a S p r a y 3 5 G M P

Other Anhydro Spray DryerOptionsGlobal Services for IndividualNeedsA N H Y D R O AT M O S P H E R I C A I R D RY E R SSPX FLOW is committed to helping our customers all over theApplications: Aqueous based products to be dried under non-world to optimise product quality and plant availability, and toaseptic conditions.minimise operating costs on their Anhydro spray bed dryingConfigurations: Single-stage execution (producing fineparticles) and multi-stage execution (for agglomerated powders,typically applied for direct compressible powders).plants. Our solutions range from feasibility studies to full scaleturnkey projects.PR OCE S S D EVE LOPM E NTSPX FLOW helps you to find the best solution for your long-A N H Y D R O I N E R T G A S S I N G L E - PA S Sterm needs. We offer a close partnership based on personalD RY E R Scommitment and documented Best Practice from the initialApplications: Sterile conditions, when spent gas compositionneeds analysis and planning stage until the end of the serviceand product contact are incompatible R&D work on a verylife of your Anhydro spray bed dryer many years later.infrequent basis for either solvent-based products or potentcompounds.Together with you we analyse the available options based onyour product and through put requirements. If required, we canConfiguration: Single pass employing inert gas as the dryingrun pilot tests at our test facilities to ensure that the process willmedium without recirculation of the spent drying gas.meet your expectations on a production scale.3D computer design, global sourcing of equipment, and localA N H Y D R O I N E R T G A S C L O S E D CYC L Emanufacture, where appropriate, are part of our standard projectD RY E R Sexecution.Applications: Solvent-based (water, ethanol, acetone andmethylene chloride) pharmaceuticals.S PX F L O W I N N O VAT I O N C E N T E RConfiguration: Additional powder recovery and solventSPX FLOW’s state-of-the-art test facility close to Copenhagenrecovery systems, as well as explosion proof electrical controls.in Denmark enables customers to test new products and toevaluate process conditions to secure precise synergy betweenS M A L L - S CA L E P L A N T Soptimisation of the plant concept ad reproducible product quality.Anhydro small-scale plants are designed for scientific test work,Alternatively, we can install small-scale test plants at your siteindustrial research and development, as well as for small-scalefor a limited period for demonstration purposes or pilot-scaleproduction. Anhydro small-scale plants offer high uptime andpro duction.yield, adaptability, repeatability, full process control, scalability,and compliance with the strictest factory standards.7

Anhydro SprayDrying for thePharmaceuticalIndustryGlobal locationsUSAA PACS PX F LOWS PX F LOW C H I N AGetzville, NY 14068Shanghai 2000052USAPeoples Republic of ChinaP: 1 716 692 3000 or 800 828 7391P: 86 21 2208 5888F: 1 716 692 6416E: anhydro.china@spxflow.comE: anhydro.americas@spxflow.comBased in Charlotte, North Carolina, SPX FLOW, Inc. (NYSE: FLOW) is a multi-industry manufacturing leader. For more information, pleasevisit www.spxflow.comS P X F L OW T E C H N O LO GY DA N M A R K A / SOestmarken 72860 SoeborgDenmarkP: 45 7027 8222F: 45 7027 8223E: ft.dk.soeborg@spxflow.comSPX FLOW, Inc. reserves the right to incorporate our latest design and material changes without notice or obligation.Design features, materials of construction and dimensional data, as described in this bulletin, are provided for your information only and should not be relied upon unless confirmedin writing. Please contact your local sales representative for product availability in your region. For more information visit www.spxflow.com.The green “ ” and “ ” are trademarks of SPX FLOW, Inc.ANH-116-GBVERSION 02/2017ISSUED 12/2017COPYRIGHT 2017 SPX FLOW, Inc.

Anhydro MicraSpray - Customizable, Adaptable and Scalable The Anhydro MicraSpray series is the result of more than 65 years of spray drying experience and expertise gained from thousands of installed spray dryers and innumerable drying tests conducted on a huge variety of different products. Anhydro MicraSpray dryers feature a series of cutting .