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Oral, Head and Neck Oncologyand Reconstructive SurgeryR. Bryan Bell, MD, DDS, FACS, FACDMedical DirectorProvidence Oral, Head and Neck Program and Clinic;Fellowship DirectorHead and Neck Oncologic and Microvascular Reconstructive SurgeryProvidence Cancer Center at Providence Portland Medical Center;Assistant MemberRobert W. Franz Cancer Research Center in the Earle A. Chiles Research Institute at Providence Cancer Center;Clinical ProfessorOregon Health and Science University;Director of ResearchThe Head and Neck InstituteHead and Neck Surgical AssociatesPortland, OregonRui P. Fernandes, MD, DMD, FACSAssociate ProfessorDepartments of Oral and Maxillofacial Surgery and Neurosurgery;Chief, Division of Head Neck SurgeryDirector of Head and Neck Oncologic Surgery and Microvascular Reconstructive FellowshipUniversity of Florida College of Medicine JacksonvilleJacksonville, FloridaPeter E. Andersen, MDProfessorDepartment of Otolaryngology–Head and Neck Surgery;ProfessorDepartment of Neurological SurgeryOregon Health and Science UniversityPortland, Oregon
To all whose lives are inexorably touched bythe capriciousness of head and neck cancer:your grace and tenacity inspire us to do better.RBBRPFPEAv
3251 Riverport LaneSt. Louis, Missouri 63043ORAL, HEAD AND NECK ONCOLOGY AND RECONSTRUCTIVE SURGERYISBN: 978-0-323-26568-3Copyright 2018 by Elsevier, Inc. All rights reserved.No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical,including photocopying, recording, or any information storage and retrieval system, without permission in writingfrom the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright LicensingAgency, can be found at our website: www.elsevier.com/permissions.This book and the individual contributions contained in it are protected under copyright by the Publisher (other thanas may be noted herein).NoticesPractitioners and researchers must always rely on their own experience and knowledge in evaluating and using anyinformation, methods, compounds or experiments described herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extentof the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any injury and/or damageto persons or property as a matter of products liability, negligence or otherwise, or from any use or operation ofany methods, products, instructions, or ideas contained in the material herein.Library of Congress Cataloging-in-Publication DataNames: Bell, R. Bryan, editor. Fernandes, Rui P., editor. Andersen, Peter E., editor.Title: Oral, head and neck oncology and reconstructive surgery /[edited by]R. Bryan Bell, Rui P. Fernandes, Peter E. Andersen.Description: St. Louis, Missouri : Elsevier, [2018] Includesbibliographical references and index.Identifiers: LCCN 2017023583 ISBN 9780323265683 (hardcover :alk. paper)Subjects: MESH: Head and Neck Neoplasms--surgery MouthNeoplasms--surgery Reconstructive Surgical Procedures--methodsClassification: LCC RF51 NLM WE 707 DDC 617.5/1059--dc23 LCrecord available at https://lccn.loc.gov/2017023583Director, Content Development: Teri Hines-BurnhamSenior Content Strategist: Jennifer Flynn-BriggsPublishing Services Manager: Julie EddySenior Project Manager: Mary StueckDesign Direction: Miles HitchenPrinted in ChinaLast digit is the print number: 987654321
AcknowledgmentsI am fortunate to have been surrounded by individuals ofmuch higher quality than myself ever since boyhood. Athome, at school, and in my current profession—I am deeplyindebted to God, my family, friends, teachers, and colleagueswho have provided me the license, opportunity, and mentorship necessary for a successful surgical career and a fulfilling life. I am especially grateful to E. Craig Nemec, BruceBordeleon, Don A. Hay, Gene R. Huebner, Wayne W. Barkmeier, Lawrence J. Sutton, Sean M. Cerone, Timothy A. Turvey, Raymond P. White, George H. Blakey, John R. Zuniga,Ramon L. Ruiz, Tinerfe J. Tejera, Shawn M. Conrad, StevenA. Bankston, Todd E. Zeigler, Eric J. Dierks, Bryce E. Potter,William B. Long, Leon A. Assael, Robert W. T. Myall, Jason K. Potter, Kevin Arce, Joshua E. Lubek, Brian L. Schmidt, DavidL. Hirsch, Shahrokh C. Bagheri, Andrew Christensen, TuanG. Bui, Allen C. Cheng, Ashish A. Patel, Melissa S. Amudson, Michael R. Markiewicz, Walter J. Urba, Rom S. Leidner,Bernard A. Fox, Andrew Weinberg, Marka R. Crittenden,Michael J. Gough, Brendan D. Curti, Steven K. Seung, andSteven B. Bader for their tutelage, support, and unwaveringfriendship; as well as the physicians, scientists, residents, fellows, nurses, surgical technicians, and administrators at thexxRobert W. Franz Cancer Research Center in the Earle A.Chiles Research Institute at Providence Cancer Center; theTrauma Service at Legacy Emanuel Medical Center; and theDepartment of Oral and Maxillofacial Surgery at OregonHealth and Science University.To my parents, William and Sherry Bell, brother Adam Bell,sisters Christine Foreman and Elizabeth Atkins, and parentsin-law Franklin and Karen Halvorsen—thank you for yourunconditional love. To my wife and children whom I adoreand whose patience, gentleness, and love illuminate my pathhome at the end of a long day—Heidi, Harrison, and Caroline.Thank you for my wonderful life.R. Bryan BellTo Candace, Gabriela, and Alessandro with love andappreciation.Rui P. FernandesTo Susan, Molly, Katherine, and Matthew, my teachers andespecially to my patients for allowing me to be part of theirlives.Peter E. Andersen
ContributorsLaith Al-Qamachi, BDS, MFDSRCSEd, MBChB, FRCSEdDepartment of Oral and Maxillofacial SurgeryUniversity Hospital–Birmingham NHS Foundation TrustBirmingham, United KingdomChapter 36: Soft Palate CancerHemantha K. Amarasinghe, BDS, MSc, MDConsultant, Community DentistryHead of Research and Surveillance UnitInstitute of Oral HealthMaharagama, Sri LankaChapter 1: EpidemiologyPeter E. Andersen, MDProfessorDepartment of Otolaryngology–Head and Neck Surgery;ProfessorDepartment of Neurological SurgeryOregon Health and Science UniversityPortland, OregonChapter 9: Management of the NeckChapter 41: Subglottic Larynx CancerKevin Arce, DMD, MD, MCRAssistant Professor of SurgeryDepartment of SurgeryDivision of Oral and Maxillofacial SurgeryMayo ClinicRochester, MinnesotaChapter 23: Early Oromandibular CancerVarun Arya, DMD, BDSChief ResidentOral and Maxillofacial SurgeryBoston University Henry M. Goldman School of DentalMedicineBoston Medical CenterBoston, MassachusettsChapter 22: Advanced Floor of Mouth CancerTomer Avraham, MDAssistant ProfessorPlastic and Reconstructive SurgeryMount Sinai Health SystemNew York, New YorkChapter 7: Virtual Surgical PlanningviRichard L. Bakst, MDAssistant ProfessorRadiation OncologyIchan School of Medicine at Mount SinaiMount Sinai Medical CenterNew York, New YorkChapter 34: Advanced HPV-Related Oropharynx CancerLauren E. Basile, DMDChief ResidentDepartment of Oral and Maxillofacial SurgeryUniversity of WashingtonSeattle, WashingtonChapter 27: Early Palatomaxillary CancerAndrew D. Beckler, MDCenter for Advanced Facial Plastic, Reconstructive, andCosmetic SurgeryENT SpecialistsBoynton Beach, FloridaChapter 10: Microvascular SurgeryR. Bryan Bell, MD, DDS, FACS, FACDMedical DirectorProvidence Oral, Head and Neck Program and Clinic;Fellowship DirectorHead and Neck Oncologic and Microvascular ReconstructiveSurgeryProvidence Cancer Center at Providence Portland MedicalCenter;Assistant MemberRobert W. Franz Cancer Research Center in the Earle A.Chiles Research Institute at Providence Cancer Center;Clinical ProfessorOregon Health and Science University;Director of ResearchThe Head and Neck InstituteHead and Neck Surgical AssociatesPortland, OregonChapter 12: Maxillofacial Reconstruction and ProstheticRehabilitationChapter 15: ImmunotherapyChapter 24: Advanced Oromandibular CancerChapter 33: Early HPV-Related Base of Tongue CancerChapter 35: Advanced HPV-Unrelated Pharynx Cancer
ContributorsSandeep Bhuta, MBBS, DMRD, DNB, FRANZCRNeuroradiologistChief of Neuroradiology and Head and Neck ImagingDepartment of Medical ImagingGold Coast University HospitalSouthport, Queensland, AustraliaChapter 44: Aggressive Non-melanoma Skin CancerCarlo B. Bifulco, MDMedical Director of Oncologic Molecular Pathology andPathology InformaticsDirector of Translational Molecular PathologyRobert W. Franz Cancer Research Center in the Earle A.Chiles Research Institute at Providence Cancer CenterProvidence Health and ServicesPortland, OregonChapter 2: Cellular and Molecular PathologyChapter 15: ImmunotherapyGido Bittermann, MD, DMDSenior PhysicianCenter of Dental MedicineDepartment of Oral and Maxillofacial Surgery and RegionalPlastic SurgeryUniversity Medical CenterFreiburg, GermanyChapter 8: Intraoperative NavigationKeith E. Blackwell, MDProfessorSection Chief of Facial Plastic and Reconstructive SurgeryDepartment of Head and Neck SurgeryDavid Geffen School of Medicine at University ofCalifornia–Los AngelesLos Angeles, CaliforniaChapter 10: Microvascular SurgeryAngel Blanco, MDDirector of Radiation OncologyMemorial Hermann Cancer Center TMCHouston, TexasChapter 25: Early Buccal Mucosa CancerAlexander M. Bobinskas, BSc, MBBS, B Oral Health(Dental Science), Grad Dip Dentistry, MPhil,FRACDS(OMS), FRCS(OMFS)Oral and Maxillofacial SurgeonMaxillofacial Surgery DepartmentGold Coast University HospitalSouthport, Queensland, AustraliaChapter 44: Aggressive Non-melanoma Skin CancerCaroline Brammer, MBChB(Sheff), MRCP, FRCRConsultant, Clinical OncologyThe Clatterbridge Cancer Centre–AintreeLiverpool, United KingdomChapter 29: Advanced Palatomaxillary Cancer (SpecialConsiderations Related to Reconstruction)Lawrence E. Brecht, DDSDirector of Maxillofacial ProstheticsJonathan and Maxine Ferencz Postgraduate Program inProsthodonticsCollege of DentistryNew York University;Director of Dental Services and Craniofacial ProstheticsHanjörg Wyss Department of Plastic SurgeryLangone Medical CenterNew York University;Institute of Reconstructive Plastic SurgeryNew York, New YorkChapter 7: Virtual Surgical PlanningJames Brown, MD, FRCs, FDSRCSConsultant, Maxillofacial and Head and Neck SurgeonHead and Neck DirectorateAintree University Hospital;Consultant, Oral and Maxillofacial SurgeonAintree University Hospital and Warrington HospitalProfessor of Head and Neck SurgeryLiverpool UniversityLiverpool, United KingdomChapter 29: Advanced Palatomaxillary Cancer (SpecialConsiderations Related to Reconstruction)Chris J. Butterworth, BDS(Hons), MPhil, FDSRCS,FDS(Rest), RCSConsultant, Oral Rehabilitation and MaxillofacialProsthodonticsHead and Neck DirectorateAintree University Hospital;Hon Senior Lecturer in Maxillofacial ProsthodonticsDepartment of Molecular and Clinical Cancer MedicineUniversity of LiverpoolLiverpool, United KingdomChapter 29: Advanced Palatomaxillary Cancer (SpecialConsiderations Related to Reconstruction)Eric R. Carlson, DMD, MD, FACSProfessor and Kelly L. Krahwinkel ChairDirector of Oral and Maxillofacial Surgery ResidencyProgramDepartment of Oral and Maxillofacial SurgeryUniversity of Tennessee Medical Center;Director of Oral/Head and Neck Oncologic SurgeryFellowship ProgramUniversity of Tennessee Cancer InstituteKnoxville, TennesseeChapter 31: Lip CancerKeith A. Chadwick, MDResident PhysicianDepartment of Otolaryngology–Head and Neck SurgeryOregon Health and Science UniversityPortland, OregonChapter 39: Early Glottic Larynx Cancervii
viiiContributorsSrinivasa R. Chandra, MD, BDS, FDSRCSAssistant ProfessorDepartment of Maxillofacial–Head and Neck Oncologic andReconstructive Microvascular SurgeryUniversity of WashingtonSeattle, WashingtonChapter 27: Early Palatomaxillary CancerAllen Cheng, MD, DDSMedical DirectorOral, Head and Neck Cancer ProgramLegacy Good Samaritan Medical CenterLegacy Health;Section ChairOral and Maxillofacial SurgeryLegacy Emanuel Medical Center;Attending SurgeonProvidence Oral, Head and Neck Cancer ProgramProvidence Portland Medical Center;ConsultantThe Head and Neck InstituteHead and Neck Surgical AssociatesPortland, OregonChapter 12: Maxillofacial Reconstruction and ProstheticRehabilitationChapter 24: Advanced Oromandibular CancerChapter 33: Early HPV-Related Base of Tongue CancerChapter 35: Advanced HPV-Unrelated Pharynx CancerScott Claiborne, DDS, MDFellow in Oral/Head and Neck Oncology and ReconstructiveSurgeryNorth Memorial Medical CenterMinneapolis, MinnesotaChapter 21: Early Floor of Mouth CancerDaniel R. Clayburgh, MD, PhD, FACSAssistant ProfessorOtolaryngology–Head and Neck SurgeryOregon Health and Science UniversityPortland, OregonChapter 3: Molecular BiologyChapter 40: Advanced Larynx CancerChapter 41: Subglottic Larynx CancerMarka R. Crittenden, MD, PhDRadiation OncologistDirector of Translational Radiation ResearchProvidence Health and ServicesRobert W. Franz Cancer Research Center in the Earle A.Chiles Research Institute at Providence Cancer CenterPortland, OregonChapter 33: Early HPV-Related Base of Tongue CancerBrendan D. Curti, MDDirector of Biotherapy and Genitourinary Oncology ResearchEarle A. Chiles Research InstituteProvidence Cancer CenterPortland, OregonChapter 43: MelanomaDerfel ap Dafydd, BSc, MBBCh, MRCP, FRCRConsultant, RadiologistImaging DepartmentThe Royal Marsden NHS Foundation TrustLondon, EnglandChapter 42: Major Salivary Gland CancerRoi Dagan, MD, MSAssistant ProfessorDepartment of Radiation OncologyUniversity of Florida College of MedicineUniversity of Florida Health Proton Therapy InstituteJacksonville, FloridaChapter 20: Advanced Tongue Cancer (Special ConsiderationsRequiring Total Glossectomy)Chapter 30: Advanced Palatomaxillary Cancer (SpecialConsiderations Related to Nasal Involvement)Camilla Dawson, BSC (Hons), MRCSLT, HCPCClinical Lead Speech and Language TherapistQueen Elizabeth Hospital BirminghamBirmingham, United KingdomChapter 36: Soft Palate CancerEric J. Dierks, MD, DMDDirector of Fellowship in Head and Neck Oncologic andMicrovascular Reconstructive SurgeryThe Head and Neck InstituteHead and Neck Surgical Associates;Attending SurgeonOral, Head and Neck Cancer ProgramLegacy Good Samaritan Medical CenterLegacy Health;Attending SurgeonProvidence Oral, Head and Neck Cancer Program;Affiliate ProfessorOral and Maxillofacial SurgeryOregon Health and Science UniversityPortland, OregonChapter 12: Maxillofacial Reconstruction and ProstheticRehabilitationChapter 35: Advanced HPV-Unrelated Pharynx CancerJasjit K. Dillon, DDs, MBBS, FDSRCS, FACSClinical Associate Professor and Program DirectorOral and Maxillofacial SurgeryUniversity of WashingtonSeattle, WashingtonChapter 27: Early Palatomaxillary Cancer
ContributorsDonita Dyalram, DDS, MD, FACSAssistant ProfessorAssociate Program Director/Associate Fellowship DirectorDepartment of Oral and Maxillofacial SurgeryUniversity of Maryland Medical CenterBaltimore, MarylandChapter 18: Early Tongue CancerSean P. Edwards, DDS, MDClinical Associate ProfessorDirector, Residency ProgramChief, Pediatric Oral and Maxillofacial SurgeryDepartment of Oral and Maxillofacial Surgery/HospitalDentistryUniversity of Michigan Health SystemAnn Arbor, MichiganChapter 28: Advanced Palatomaxillary CancerDavid A. Elliott, MDAssistant ProfessorRadiation OncologyUniversity of Toledo Medical CenterToledo, OhioChapter 13: Radiation TherapyChapter 40: Advanced Larynx CancerChapter 41: Subglottic Larynx CancerMererid Evans, PhD, FRCRConsultant, Clinical OncologistVelindre Cancer CentreCardiff, Wales, United KingdomChapter 38: Advanced Supraglottic Larynx CancerAdam P. Fagin, DMD, MDResidentDepartment of Oral and Maxillofacial SurgeryOregon Health and Science UniversityPortland, OregonChapter 26: Advanced Buccal Mucosa CancerCarole Fakhry, MD, MPHAssociate Professor of Otolaryngology-Head and Neck SurgeryJohns Hopkins University School of MedicineBaltimore, MarylandChapter 1: EpidemiologyMark B. Faries, MD, FACSProfessor of SurgeryDirector of Donald L. Morton Melanoma Research ProgramJohn Wayne Cancer InstituteSanta Monica, CaliforniaChapter 43: MelanomaZipei Feng, PhDDepartment of Cell, Developmental and Cancer BiologyOregon Health and Science UniversityPortland, OregonChapter 15: ImmunotherapyixRui P. Fernandes, MD, DMD, FACSAssociate ProfessorDepartments of Oral and Maxillofacial Surgery andNeurosurgery;Chief, Division of Head Neck SurgeryDirector of Head and Neck Oncologic Surgery andMicrovascular Reconstructive FellowshipUniversity of Florida College of Medicine JacksonvilleJacksonville, FloridaChapter 20: Advanced Tongue Cancer (Special ConsiderationsRequiring Total Glossectomy)Chapter 30: Advanced Palatomaxillary Cancer (SpecialConsiderations Related to Nasal Involvement)Jay K. Ferrell, MDResident PhysicianOtorhinolaryngology—Head and Neck SurgeryUniversity of Texas Health Science Center at Houston Schoolof MedicineHouston, TexasChapter 32: Early HPV-Related Tonsil CancerBernard A. Fox, PhDHarder Family Endowed Chair for Cancer ResearchChief of Laboratory of Molecular and Tumor ImmunologyRobert W. Franz Cancer Research CenterEarle A. Chiles Research InstituteProvidence Cancer Center, Knight Cancer InstituteDepartment of Molecular and ImmunologyOregon Health and Science UniversityPortland, OregonChapter 15: ImmunotherapyClifton D. Fuller, MD, PhDAssistant ProfessorDepartment of Radiation OncologyDivision of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHouston, TexasChapter 32: Early HPV-Related Tonsil CancerG.E. Ghali, DDS, MD, FACS, FRCS(Ed)Gamble Professor and ChairmanDepartment of Oral and Maxillofacial SurgeryLouisiana State University Health Sciences CenterShreveport, LouisianaChapter 19: Advanced Tongue CancerJohn P. Gleysteen, MDAssistant ProfessorDepartment of OtolaryngologyUniversity of Tennessee Health Science CenterMemphis, TennesseeChapter 40: Advanced Larynx Cancer
xContributorsKathryn A. Gold, MDAssociate ProfessorMoores Cancer CenterUniversity of California San DiegoLa Jolla, CaliforniaChapter 32: Early HPV Related Tonsil CancerJames Good, MSc, MD, PhDConsultant, OncologistQueen Elizabeth HospitalBirmingham, United KingdomChapter 36: Soft Palate CancerJennifer R. Grandis, MDAmerican Cancer Society ProfessorAssociate Vice ChancellorClinical and Translational Research DirectorProfessorOtolaryngology—Head and Neck SurgeryUniversity of CaliforniaSan Francisco, CaliforniaChapter 3: Molecular BiologyDonna J. Graville, PhD, CCC-SLPAssociate ProfessorDirector of NW Center for Voice and SwallowingOtolaryngology/Head and Neck SurgeryOregon Health and Science UniversityPortland, OregonChapter 17: Speech Pathology and RehabilitationNeil D. Gross, MD, FACSAssociate ProfessorDirector of Clinical ResearchHead and Neck SurgeryUniversity of Texas MD Anderson Cancer CenterHouston, TexasChapter 32: Early HPV-Related Tonsil CancerAaron Grossberg, MD, PhDClinical ResidentDepartment of Radiation OncologyUniversity of Texas MD Anderson Cancer CenterHouston, TexasChapter 32: Early HPV-Related Tonsil CancerShan Guo, MDAssistant ProfessorDivision of OncologyDepartment of Internal MedicineUniversity of Texas Health Science Center at HoustonHouston, TexasChapter 25: Early Buccal Mucosa CancerBronwyn Hamilton, MDAssociate Professor of RadiologyRadiology DepartmentOregon Health and Science UniversityPortland, Oregon;Adjunct Assistant Professor of RadiologyRadiology DepartmentUniversity of UtahSalt Lake City, UtahChapter 5: Diagnostic ImagingEric K. Hansen, MDRadiation OncologyOregon ClinicProvidence St. Vincent Medical CenterPortland, OregonChapter 13: Radiation TherapyHeidi J. Hansen, DMD, DABOMAssistant Professor of SurgeryDivision of Dentistry, Oral and Maxillofacial SurgeryWeill Cornell MedicineNew York, New YorkChapter 16: Oral/Dental OncologyBruce H. Haughey, MD, FACSOtolaryngologyFlorida ENT Surgical SpecialistsCelebration, FloridaChapter 4: OncovirusesRichard E. Hayden, MD, FACS, FRCS(C)ProfessorDepartment of Otolaryngology–Head and Neck SurgeryMayo Clinic ArizonaPhoenix, ArizonaChapter 37: Early Supraglottic Larynx CancerJoseph I. Helman, DMDC.J. Lyons Endowed ProfessorOral and Maxillofacial SurgeryUniversity of MichiganAnn Arbor, MichiganChapter 28: Advanced Palatomaxillary CancerDavid L. Hirsch, MD, DDS, FACSClinical Assistant ProfessorOral and Maxillofacial SurgeryCollege of DentistryNew York UniversityNew York, New YorkChapter 7: Virtual Surgical Planning
ContributorsJohn M. Holland, MDAssociate ProfessorRadiation OncologyOregon Health and Science UniversityPortland, OregonChapter 13: Radiation TherapyChapter 41: Subglottic Larynx CancerKatherine A. Hutcheson, PhDAssociate ProfessorDepartment of Head and Neck SurgerySection of Speech Pathology and AudiologyUniversity of Texas MD Anderson Cancer CenterHouston, TexasChapter 32: Early HPV-Related Tonsil CancerMegan J. Hyers, MS, CCC-SLP, BCS-SSpeech-Language PathologistProvidence Health and ServicesPortland, OregonChapter 24: Advanced Oromandibular CancerChapter 33: Early HPV-Related Base of Tongue CancerChapter 35: Advanced HPV-Unrelated Pharynx CancerMatthew Idle, MDSpecialist RegistrarOral and Maxillofacial SurgeryWest Midlands Deanery and Queen Elizabeth HospitalBirmingham, United KingdomChapter 36: Soft Palate CancerJames E. Jackson, MBBS, FRANZCRRadiation OncologistRadiation Oncology CentresGold Coast University HospitalSouthport, Queensland, AustraliaChapter 44: Aggressive Non-melanoma Skin CancerScharukh Jalisi, MD, FACS, MAAssociate ProfessorDirector of Head and Neck Cancer Center of ExcellenceDepartment of Otolaryngology–Head and Neck SurgeryDepartment of NeurosurgeryDirector of Division of Head and Neck Surgical Oncologyand Skullbase SurgeryBoston UniversityBoston Medical CenterBoston, MassachusettsChapter 22: Advanced Floor of Mouth CancerNewell W. Johnson, PhD, MDSc, FDSRCS, FRCPath,FMedSciProfessor EmeritusMenzies Health Institute–QueenslandGriffith UniversityGold Coast, Queensland, AustraliaChapter 1: EpidemiologyxiTerry M. Jones, BSc, FRCSEd, FRCS(ORL-HNS), MD,SFHEA, FASE(RCS)Professor of Head and Neck SurgeryCancer Lead, NIHR CRN NWCEditor-in-Chief of Clinical OtolaryngologyNWCR CentreDepartment of Molecular and Clinical Cancer MedicineUniversity of Liverpool;Honorary Consultant, Otolaryngologist/Head and NeckSurgeonAintree University Hospitals NHS Foundation TrustLiverpool, United KingdomChapter 38: Advanced Supraglottic Larynx CancerDeepak Kademani, DMD, MD, FACSAssociate ProfessorOral and Maxillofacial SurgeryUniversity of Minnesota;Chief of SurgeryNorth Memorial Medical CenterMinneapolis, MinnesotaChapter 21: Early Floor of Mouth CancerJoseph R. Kelley, MD, PhDRadiation OncologyUniversity of Tennessee Medical CenterKnoxville, TennesseeChapter 31: Lip CancerCyrus Kerawala, BDS, MBBS, FDSRCS, FRCSConsultant, Maxillofacial/Head and Neck SurgeonThe Royal Marsden HospitalLondon, United KingdomChapter 42: Major Salivary Gland CancerDongsoo David Kim, DMD, MD, FACSAssociate ProfessorEdward and Freda Green Endowed ProfessorChief of Division of Head and Neck Oncology andReconstructive SurgeryDepartment of Oral and Maxillofacial/Head and NeckSurgeryLouisiana State University Health Sciences Center–ShreveportShreveport, LouisianaChapter 19: Advanced Tongue CancerTamar A. Kotz, MS, CCC-SLPSenior Head and Neck Speech and Swallow PathologistDepartment of Otolaryngology–Head and Neck SurgeryIcahn School of Medicine at Mount SinaiMount Sinai Medical CenterNew York, New YorkChapter 34: Advanced HPV-Related Oropharynx Cancer
xiiContributorsHirofumi Kuno, MD, PhDRadiologyBoston University School of MedicineBoston Medical CenterBoston, MassachusettsChapter 22: Advanced Floor of Mouth CancerJoshua E. Lubek, MD, DDS, FACSAssociate Professor and Fellowship DirectorOral and Maxillofacial SurgeryUniversity of MarylandBaltimore, MarylandChapter 18: Early Tongue CancerMoni Abraham Kuriakose, MD, FRCSProfessor and Director, Surgical OncologyChief, Head and Neck OncologyMazumdar Shaw Cancer Center;Director, Mazumdar Shaw Center for Translational ResearchNarayana Health CenterBangalore, IndiaChapter 9: Management of the NeckAndrew J. Lyons, MS, FDS, FRCSConsultant, Oral and Maxillofacial SurgeonHead and Neck UnitGuy’s and St. Thomas’ NHS Foundation TrustLondon, United KingdomChapter 45: OsteoradionecrosisSusan E. Langmore, PhD, CCC-SLP, BCS-SProfessorDepartment of Otolaryngology;Clinical ProfessorDepartment of Speech Language Hearing ScienceBoston University School of MedicineBoston, MassachusettsChapter 22: Advanced Floor of Mouth CancerRom Leidner, MDCo-DirectorProvidence Oral, Head and Neck Cancer ProgramProvidence Portland Medical Center;Assistant MemberRobert W. Franz Cancer Research Center in the Earle A.Chiles Research Institute at Providence Cancer CenterPortland, OregonChapter 15: ImmunotherapyChapter 24: Advanced Oromandibular CancerChapter 33: Early HPV-Related Base of Tongue CancerChapter 35: Advanced HPV-Unrelated Pharynx CancerJamie P. Levine, MDAssociate ProfessorPlastic SurgeryNew York University Langone Medical CenterNew York, New YorkChapter 7: Virtual Surgical PlanningChristopher Loh, MBBS, DOHNS, FRCS(ORL-HNS)Head and Neck FellowAintree University Hospitals NHS Foundation TrustLiverpool, United KingdomChapter 38: Advanced Supraglottic Larynx CancerSapna Lohiya, BS, DDSChief ResidentDepartment of Oral and Maxillofacial SurgeryUniversity of WashingtonSeattle, WashingtonChapter 27: Early Palatomaxillary CancerJoann Marruffo, DDS, MSAdjunct Clinical Assistant ProfessorDepartment of Restorative Dentistry and ProsthodonticsUniversity of Texas Health Science Center at HoustonHouston, TexasChapter 25: Early Buccal Mucosa CancerRobert E. Marx, DDSProfessor of SurgeryChief of Division of Oral and Maxillofacial SurgeryMiller School of MedicineUniversity of Miami;Chief of SurgerySouth Medical CenterMiami, FloridaChapter 11: Tissue EngineeringMarco Matos, MDMedical OncologistGold Coast Cancer CareSouthport, Queensland, AustraliaChapter 44: Aggressive Non-melanoma Skin CancerAustin Mattox, MD, PhDLudwig Center for Cancer Genetics and TherapeuticsJohns Hopkins University School of MedicineJohns Hopkins University School of Public HealthBaltimore, MarylandChapter 4: OncovirusesAvanti Mehrotra, MDHumphrey Cancer CenterNorth Memorial Medical CenterRobbinsdale, MinnesotaChapter 21: Early Floor of Mouth CancerJames C. Melville, DDS, FACSAssistant ProfessorDepartment of Oral and Maxillofacial SurgeryUniversity of Texas Health Science Center at HoustonHouston, TexasChapter 25: Early Buccal Mucosa Cancer
ContributorsMarc C. Metzger, MD, DMD, PhDChief Senior PhysicianCenter of Dental MedicineDepartment of Oral and Maxillofacial Surgery and RegionalPlastic SurgeryUniversity Medical CenterFreiburg, GermanyChapter 8: Intraoperative NavigationBrett A. Miles, DDS, MD, FACSAssociate ProfessorOtolaryngology/Head and Neck SurgeryMount Sinai School of MedicineNew York, New YorkChapter 34: Advanced HPV-Related Oropharynx CancerKrzysztof J. Misiukiewicz, MDAssociate ProfessorMedicine, Hematology and Medical Oncology;Assistant ProfessorOtolaryngologyIcahn School of Medicine at Mount SinaiMount Sinai Medical CenterNew York, New YorkChapter 34: Advanced HPV-Related Oropharynx CancerAbdallah S. R. Mohamed, MD, MScResearch ScientistDepartment of Radiation OncologyUniversity of Texas MD Anderson Cancer CenterHouston, Texas;Assistant LecturerDepartment of Clinical Oncology and Nuclear MedicineFaculty of MedicineUniversity of AlexandriaAlexandria, EgyptChapter 32: Early HPV-Related Tonsil CancerCasian Monaco, MDChief ResidentHansjörg Wyss Department of Plastic SurgeryNew York University Langone Medical CenterNew York, New YorkChapter 7: Virtual Surgical PlanningJames Murphy, BDS, MB, BCh, MFDS, MRCS, FFDAttending PhysicianDivision of Oral and Maxillofacial SurgeryJohn H. Stroger, Jr. Hospital of Cook CountyChicago, IllinoisChapter 28: Advanced Palatomaxillary CancerNima Nabavizadeh, MDClinical Instructor and Chief ResidentRadiation MedicineOregon Health and Science UniversityPortland, OregonChapter 13: Radiation TherapyxiiiMohammed Nadershah, MD, BDS, MScAssistant ProfessorOral and Maxillofacial SurgeryKing Abdulaziz University—Faculty of DentistryJeddah, Saudi ArabiaChapter 22: Advanced Floor of Mouth CancerThomas H. Nagel, MDAssistant ProfessorDepartment of Otolaryngology–Head and Neck SurgeryMayo Clinic ArizonaPhoenix, ArizonaChapter 37: Early Supraglottic Larynx CancerKate Newbold, MB, ChB, MRCP, FRCR, FRCPEConsultant, Clinical OncologistThe Royal Marsden NHS Foundation TrustLondon, EnglandChapter 42: Major Salivary Gland CancerDimitrios Nikolarakos, MBBS, BDSc, FRCS Eng, FRACDSMedical Director Maxillofacial UnitGold Coast University HospitalSouthport, Queensland, AustraliaChapter 44: Aggressive Non-Melanoma Skin CancerKurt Nisi, MD, MBADirectorNorth Radiation Therapy CenterRobbinsdale, MinnesotaChapter 21: Early Floor of Mouth CancerRobert A. Ord, BDS, MB, BCh(Hons), FRCS, FACS,MS, MBAProfessor and ChairmanDepartment of Oral and Maxillofacial Surgery;Professor Oncology Program Greenbaum Cancer CenterUniversity of MarylandBaltimore, MarylandChapter 18: Early Tongue CancerLarry M. Over, DMD, MSD, LLCPrivate PracticeEugene, OregonChapter 12: Maxillofacial Reconstruction and ProstheticRehabilitationChapter 24: Advanced Oromandibular CancerSara I. Pai, MD, PhD, FACSAssociate ProfessorMassachusetts General Hospital Cancer CenterHarvard Medical SchoolBoston, MassachusettsChapter 4: Oncoviruses
xivContributorsAndrew D. Palmer, PhD, CCC-SLPAssistant Professor, Speech PathologistNW Center for Voice and SwallowingOtolaryngology, Head and Neck SurgeryOregon Health and Science UniversityPortland, OregonChapter 17: Speech Pathology and RehabilitationSat Parmar, BChD, BMBS, BMedSci, FDSRCS, FRC
Department of Oral and Maxillofacial Surgery and Regional Plastic Surgery University Medical Center Freiburg, Germany Chapter 8: Intraoperative Navigation Keith E. Blackwell, MD Professor Section Chief of Facial Plastic and Reconstructive Surgery Department of Head and Neck Surgery David Geffen School of Medicine at University of California .
