Transcription
Rapid Response Radiotherapy Program (RRRP)And Bone Metastases Site Group Clinic (BMC)Annual ReportJanuary–December 2007Dr. Edward ChowChairRapid Response Radiotherapy Program and Bone Metastases Site Group1
Executive SummaryOn behalf of the Rapid Response Radiotherapy Program and the Bone Metastases Site Group(RRRP/BMC), we are pleased to send you our 2007 annual report.1.Clinicsa)b)c)2.Educationa)b)3.Newsletter - Our readers indicated they found our quarterly newsletter HOT SPOTinformative and educational.We continue to offer electives to palliative health care professionals to visit our Centreand learn about our programs.Researcha)b)4.RRRP clinics: The results indicated that we are meeting the initial goals of the RRPP toprovide timely palliative radiotherapy to patients in the terminal phase of their illness.The number of patients seen annually in the five weekly half-day clinics has reached aplateau of 500-600, eighty percent of which are new to OCC.We successfully evaluated the role of an advanced practice radiation therapist with thesupport of the Ministry of Health (MOH).Dr. Arjun Sahgal joined the palliative team.We were successful in obtaining grant support to continue our research projects.Research students from Waterloo’s co-op program have been extremely productiveand have also won numerous awards.Our Quality Assurance rounds resulted in several published case reports.This report summarizes our very successful year and the academic activities of theRRRP/BMC.2
Odette Cancer CentreRapid Response Radiotherapy Program (RRRP)December 2007The membership of the RRRP currently includes:Radiation Oncologists:Edward Chow (Chair)Toni BarnesCyril DanjouxArjun SahgalMay TsaoRadiation Therapists:Emily SinclairLori HoldenNurses:Grace ChanMichelle DavisErnest DixonMacey FarhadianRosemary IrishMatina FlorosNives KrajnovicCathy DoylePharmacist:Carlo DeAngelisClinical TrialsAdam Lam3
Odette Cancer CentreBone Metastases Site GroupDecember 2007The membership of the BMC currently includes:Radiation Oncologists:Toni BarnesEdward Chow (Chair)Cyril DanjouxAndrew Loblaw (spinal cord compression)Arjun SahgalMay TsaoOrthopedic Surgeons:Joel FinkelsteinMichael FordAlbert YeeRadiologists:Richard AvivMonique ChristakisLinda ProbynRobyn PugashJoel RubensteinSean SymonsPharmacist:Carlo DeAngelisClinical TrialsAdam LamBioengineer:Cari WhyneMedical Physicist:Parminder BasranLaboratory Medicine:David ColeReinhold ViethBasic Science:Gurmit Singh – Director of Research,(Hamilton Research Cancer Centre)Shun WongMedical Oncologists:Urban EmmeneggerYooj KoNurses:Macey FarhadianSharon LemonPalliative Care Physicians:Anita ChakrabortyJan HuxHyon KimJeff MyersGiovana SirianniDebbie SelbyAnoo TamberLesia Wynnychuk4
EDUCATIONThe RRRP organizes monthly Palliative Rounds, publishes a quarterly newsletter“HOT SPOT” and provides educational electives for students and health care professionalsinterested in palliative radiotherapy.CME Monthly RoundsThe rounds are organized by Dr. E. Barnes and held on the last Tuesday of the Month from 12 - 1p.m. in the R.D.T. Jenkin Auditorium. They are accredited for MOCERT credits.The subjects discussed during 2007 were:2007January 29February 27March 27April 24May 29September 25October 30November 27TitlePresenter“Opiods and Addiction: An Approach to RiskDr. Lawrence LibrachManagement”Cannabinoids: Panacea or Problems?Dr. Lawrence LibrachCaring for the Dying in a Multicultural Society: EthicalDr. J. A.Issues in Truth-TellingChandrakanthanPsycho-Oncology Update: Focus on Depression andDr. Eileen LaCroixAnxiety Part IIAssessing Quality of Life - From Research to Applying the Dr. Andrea BezjakFindings in Clinical PracticeManaging Symptomatic Bone Metastases: LessonsDr. Jackson WuLearned at a Regional Cancer CentreFamily Caregiver Perceptions of Quality of Dying and Death Dr. Sarah Halesin Metastatic CancerProblems of People Living with Cancer: A Psychologist’sDr. Ross GrayPerspective*Rounds cancelled: June 26, July 31, August 28, December 255
Hot Spot NewsletterIn response to a satisfaction survey from our referring physicians who wanted bettercommunication, we initiated a quarterly newsletter in 1999 called “HOT SPOT”.HOT SPOT is the educational newsletter of the RRRP at OCC. It is published quarterly anddistributed to oncologists, palliative care specialists, family doctors and professional health careworkers in palliative medicine. Our readership has expanded to over 2,000 per issue and wecontinue to expand our circulation to new readers. Survey results from our readers rated theeducational value of HOT SPOT as high and suggested that we add other topics of interest. Weincreased the content of our newsletter from four to six pages with additional sections andcontributors. The newsletter has regular articles on the following PC UPDATEPEDIATRICEDUCATIONAL ACTIVITIESEDUCATIONAL INSERTEach issue also has a double-sided educational insert.The Editorial Board of Hot SpotEditorAssociate EditorsConsultantAdvisersEditorial & Financial ManagersDr. E. ChowDr. C. DanjouxDr. S. WongDr. E. Barnes, Dr. R. Goldman, Dr. A. Husain, Dr. L. Librach,Dr. C. Newman, Dr. A. Sahgal, Ms. E. Sinclair, Dr. E.Szumacher, Dr. M. Tsao.Ms. S. LueThe publication of the newsletter is made possible by the financial support of pharmaceutical &radiotherapy equipment companies.The newsletter is also available electronically on the OCC web site:http://www.sunnybrook.ca/content/?page 2341.[Appendix F provides the content of previous issues and inserts of HOT SPOT from1999-2007.]6
Educational ElectivesAs part of our undergraduate teaching, students from the co-op program at the University ofWaterloo have their electives working with the RRRP-BMC. This co-operative educational elective hasbeen extremely successful. Several of our students have won numerous awards.AwardsStephanie Hadi (2006-2007), Second year undergraduate student. ISOQOL New Investigator Scholarship. 14th Annual Conference of the InternationalSociety for Quality of Life Research, October 2007, Toronto, Ontario.Amanda Hird (2006 – 2007), Second year undergraduate student. 2007 Marion J. Todd Memorial Award, Faculty of Applied Health Sciences, University ofWaterloo, November 2007, Waterloo, Ontario. 2007 Michael and Karyn Goldstein Best Cancer Research Student Travelling ScholarshipAward, Odette Cancer Centre, December 2007, Toronto, Ontario. 2007 RRRP Student of the Year Award, Odette Cancer Centre, December 2007, Toronto,Ontario. 2007 CAFCE University Co-op Student of the Year Honorable Mention Award – CanadianAssociation for Co-operative Education (CAFCE), 2007, Canada. 2007 EWO Co-op Student of the Year Nominee – Education at Work Ontario (EWO),2007, Canada.Julie Napolskikh (2006-2007), Third year undergraduate student. The Best Poster Presentation Award. 17th Annual Ontario Provincial Conference onPalliative and End-of-Life Care, April 2007, London, Ontario. 2007 Laura Talbot-Allan Award in Applied Health Sciences, University of Waterloo,Waterloo, Ontario.[Appendix G – Undergraduate Teaching–Co-op Program]Dr. Alysa Fairchild, Fellow under the supervision of Dr. Barnes. The Best Poster Award. International Patterns of Practice of Painful Bone Metastases. 11thAnnual International Symposium on Palliative Medicine, Florida, USA, March 2007. Young Investigator’s Award. Has the pattern of practice in the prescription of palliativethoracic radiotherapy for lung cancer changed between 1999 and 2006 at the RRRP?MASCC 19th International Symposium Supportive Care in Cancer, St. Gallen, Switzerland,June 2007.7
Health Care Professionals ElectivesThe RRRP provides an orientation for other health care professionals to experience the activities ofthe RRRP clinics. Professor O. Bruland from Norway and Dr. D. Rheaume from Nova Scotia spent acouple of days with us as they plan to start a similar project in their Centre. They found theexperience valuable and recommend it for others planning to start a similar program.RESEARCHThe RRRP-BMC team objective is to provide palliative radiotherapy in an academic environment.We participate in local, national and international clinical trials, have regular research rounds andhave been successful in securing grants to fund our research projects.Clinical TrialsWe participate in several clinical trials. The research students have been an essential resource inhelping us to enroll, follow-up, analyze and publish our studies. Without the dedication of ourresearch students, it would have been difficult to successfully complete our research studies.[Appendix H - A list of ongoing research studies in the RRRP and BMC]PROG-O (Palliative Radiation Oncology Group Ontario)Our collaboration with Princess Margaret Hospital (PMH) and the Hamilton Regional Cancer CentrePalliation Radiation Oncology Group, led to the formation of the Palliative Radiotherapy OncologyGroup Ontario (PROG-O) in 2000. Since then PROG-O has expanded to include Cancer Centresfrom the Maritimes, Manitoba, Calgary and British Columbia. Currently, this group meets monthlythrough videoconference. This has improved communication between the staff involved in thepalliative radiotherapy program in those Centres and offered the opportunity for collaboration inresearch. At the last CARO meeting, more Cancer Centres expressed enthusiasm in participating inPROG-O rounds.PROG-O offers a national forum for monthly research discussion in palliative radiotherapy. Over thepast years the coordinators for the PROG-O rounds have been Drs. J. Wu, A. Bezjak, R. Wong andT. Barnes. The rounds are scheduled for the first Tuesday of every month held from 12 - 1 p.m.To represent the change in participation from Ontario to Cancer Centres across Canada werenamed the group as Canadian Palliative Radiation Oncology Group (CPROG)8
Videoconference Rounds (PROG-O)2007January 2The subjects discussed during 2007 were:TitleUpdate on BC Palliative RT studiesFebruary 6Rapid access clinicMarch 6Technology developments and outcomesApril 3New studiesMay 1Rapid access clinic, re-treatmentJune 5Symptom control advisory group initiativesSeptember 4Development of a National Curriculum in SymptomControl for Radiation Oncology Residency TrainingProgramsResults of a prospective study of Dexamethasone doseand tapering in patients with brain metastasisundergoing WBRTEarly integration of Zoledronic acid with radiotherapy inthe treatment of painful bone metastases in prostatecancerQuality of Life Instruments in palliative careOctober 2November 6December 4Presenter(s)Dr. G. Duncan, BCCAVancouver CancerDr. Rajiv Samant,ORCCDr. Rebecca Wong,PMHDr. Edward Chow,OCCDr. D. Severin, CCI,EdmontonDr. Jackson Wu,TBCC, CalgaryDr. Jackson Wu,TBCC CalgaryDr. Alina Sturdza,PMHDr. UrbanEmmenegger, OCCAmanda Hird, OCC*Rounds cancelled: July 3, August 7RRRP and BMC Monthly MeetingsOur research rounds are scheduled on the second Tuesday of every month.2007TitleChair(s)January 16Business MeetingFebruary 20Quality Assurance RoundDrs. Edward Chow &Cyril DanjouxDr. Cyril DanjouxApril 17Research/Education RoundDr. Toni BarnesJune 19Quality Assurance RoundSeptember 18Annual General MeetingDr. Edward ChowOctober 16Quality Assurance RoundDr. May TsaoNovember 20Research/Educational RoundDr. Toni BarnesDecember 18Business MeetingDr. Edward ChowDr. Danjoux*Rounds cancelled: March 20, May 15, July 17, and August 219
GrantsA novel delivery system for BMP-2 to enhance ACL graft integration. Physician's ServicesIncorporated 80,000 (2007 - 2008). Richards RR (PI), Robertson C (MSc Candidate), Yee AJ(collaborator).A Phase II Study of Early Integration of Zoledronic Acid with Radiotherapy to Bone in theTreatment of Painful Bone Metastases in Prostate Cancer. Novartis Pharmaceuticals CanadaInc. 60,000 (2007 – present). Chow E (PI), Ko Y (PI), Emmenegger U, Danjoux C, Barnes E,Barbera L, Tsao M, Sinclair E, Lemon S, Vieth R.A Phase II Study of Maintenance Therapy with Temsirolimus in Androgen-IndependentProstate Cancer After First-Line Chemotherapy with Docetaxel. Wyeth PharmaceuticalsCanada Inc. 315,000 (2007 – 2009). Ko Y (PI), Emmenegger U, Berry S, Kerbel R.Biomechanical Implications of metastatic disease in the spine: Evaluation of stability andtumor burden in a pre-clinical model. CIHR (Canadian Institutes of Health Research) 239,460 (2004 - 2007). Whyne C, Yee AJ (Co-PI), Finkelstein J (Co-Applicant).Biomechanical Implications of metastatic disease in the spine: Evaluation of stability andtumor burden in a pre-clinical model - funding extension. CIHR (Canadian Institutes of HealthResearch) 40,096 (2007 - 2008). Whyne C, Yee AJ (Co-Principal Investigator), Finkelstein J(Co-Applicant).Development of a Canadian-led international bone metastases module to accompanyEuropean Organization for Research and Treatment of Cancer Quality of Life Group corequestionnaire (the EORTC QLQ-C30) for future clinical trials in patients with bone metastases.National Cancer Institute of Canada 271,483 (2005-2008). Chow E (PI), Clemons M, Wu JBezjak A, Brundage M, Yee A, Bottomley A, Velikova G, and Hoskin P.Imiquimod for patients with positive surgical margins following surgical excision of basal cellcarcinoma or squamous cell carcinoma in-situ of the skin. 3M Pharmaceuticals 108,000(2005 – 2007). Barnes E (PI), Choo R, Assaad D, Antonyshyn O, Fialkov J, Kamra J, Balogh J.Large Aggregating Proteoglycans and Therapeutic Strategies in Intervertebral Disc CellMetabolism. Zimmer Grant 8,300 (2006 - 2007). Yee AJ, Yang B, Whyne C.Metastatic breast cancer genome anatomy. Canadian Breast Cancer Research Alliance,Special Competition in New Approaches to Metastatic Disease in Breast Cancer Research 750,000 (2005 - 2010). Seth A, Aubin J (Co-applicant), Kahn H (Co-Applicant), LyonsWeiler J (Collaborator), Yee AJ (Collaborator), Narod S (Collaborator).Modeling thin bone structures of the human skeleton. Natural Sciences and EngineeringResearch Council (NSERC) 165,000 (2006 - 2011). Whyne, C.Photodynamic therapy for the treatment of metastatic breast carcinoma to the spine:development and validation in a preclinical model. Canadian Breast Cancer Foundation Ontario Chapter 300,000 (2004 - 2007). Yee A, Whyne C, Finkelstein J, Wilson B.Prospective PET study in glioblastoma multiforme patients. OCC Intramural Fund 31,000(2005 – 2008). Tsao MN (PI), Perry J, Reznik A, Lui B.Recombinant elastin-like polypeptide based materials for use in artificial spinal discs.10
Emerging Materials Network Collaborative Grant, Ontario Centres of Excellence 211,400(2006 - 2008). Woodhouse K, Whyne C (Co-Investigator), Yee A (Co-Investigator).Recombinant large aggregating proteoglycans and therapeutic strategies in intervertebral discmetabolism. U of T Zimmer Orthopaedic Research 10,000 (2006 - 2007). Whyne C, Yee A,Yang B, Akens M, Finkelstein JA.The efficacy of risedronate in protecting bone mineral density for men with locally advancedprostate cancer receiving radiotherapy and neoadjuvant/adjuvant hormone therapy for 2 or 3years. Phase III, Double-Blinded, Placebo-Controlled Study. Aventis-Sanofi Pharma Ltd. 250,000 (2004 - 2007). Danjoux C (PI), Choo R, Malone S, Bowen J, Lukka H, BrionesUrbina R, Ehrlich L, Vieth R.11
PublicationsAhn H, Mousavi P, Chin L, Roth S, Finkelstein J, Vitken A, Whyne C. The effect ofprevertebroplasty tumor ablation using laser induced thermo-therapy on biomechanical stabilityand cement fill in the metastatic spine. European Spine Journal [Epub ahead of print] 16: 117178, 2007.Akens M, Yee AJ, Wilson BC, Burch S, Johnson C, Lilge L, Bisland SK. Photodynamic therapy ofvertebral metastasis: Evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in amurine model of metastatic human breast carcinoma. Photochemistry and Photobiology 83:1-6,2007.Barnes E, Fan G, Harris K, Doyle M, Librach L, Chow E, Barbera L, Tsao M, Lam K, Danjoux C.Involvement of family physicians in the care of cancer patients seen in the Palliative RapidResponse Radiotherapy Program. Journal of Clinical Oncology 25 (36): 5758-5762, 2007.Bethune A, Houlden D, Smith T, Yee A, Midha R, Singrakhia M. Generalized peripheral nervefailure during thoracic spinal surgery; a case report. Journal of Clinical Monitoring andComputing 21(1): 41-47, 2007.Bradley N, Husted J, Sey M, Husain A, Sinclair E, Harris K, Chow E. Review of patterns of practiceand patients’ preferences in the treatment of bone metastases with palliative radiotherapy.Supportive Care in Cancer 15 (4): 373-385, 2007.Braybrooke J, Ahn H, Gallant A, Bronstein Y, Ford M, Finkelstein JA, Yee AJ. The Impact ofSurgical Wait Time on Patient-based Outcomes in Posterior Lumbar Spinal Surgery. EuropeanSpine Journal 16(11): 1832, 2007.Burch S, Bisland SK, Wilson BC, Whyne C, Yee AJ. Multimodality imaging for vertebralmetastases in a rat osteolytic model. Clinical Orthopaedics and Related Research 454: 230-236,2007.Chow E, Chiu H, Doyle M, Hruby G, Holden L, Barnes E, Tsao M, Mallia G, Harris K, Danjoux C.Patient expectation of the partial response and response shift in pain score. Supportive CancerTherapy 4 (2): 110-118, 2007.Chow E, Fan G, Hadi S, Filipczak L. Symptom clusters in cancer patients with bone metastases.Supportive Care in Cancer 15 (9): 1035-1043, 2007.Chow E, Harris K, Fan G, Tsao M, Sze WM. Palliative radiotherapy trials for bone metastases: asystematic review. Journal of Clinical Oncology 25(11): 1423-1436, 2007.Chow E, Loblaw A, Harris K, Doyle M, Goh P, Chiu H, Panzarella T, Tsao M, Barnes E, Sinclair E,Farhadian M, Danjoux C. Dexamethasone for the prophylaxis of radiation-induced pain flarefollowing palliative radiotherapy for bone metastases: A pilot study. Supportive Care in Cancer15 (6): 643-647, 2007.Chuang C, Sahgal A, Lee L, Larson D, Huang K, Petti P, Verhey L, Ma L. Effects of residual targetmotion for image-tracked spine radiosurgery. Medical Physics 34 (11): 4484-4490, 2007.Doyle M, Bradley N, Li K, Sinclair E, Lam K, Chan G, Chow E, Barnes E, Danjoux C, Tsao M.Quality of life in patients with brain metastases treated with a palliative course of whole brainradiotherapy. Journal of Palliative Medicine 10 (2): 367-374, 2007.12
Fan G, Filipczak L, Chow E. Symptom cluster in cancer patients: a review of the literature.Current Oncology 14 (5): 173-179, 2007.Fan G, Hadi S, Chow E. Symptom clusters in patients with advanced-stage cancer referred forpalliative radiation therapy in an outpatient setting. Supportive Cancer Therapy 4 (3): 157-162,2007.Goh P, Harris K, Napolskikh J, Chow E, Sinclair S, Emmenegger U, Lemon S, Yee A, WynnychukL, Myers J, Danjoux C, Ko Y. New multidisciplinary prostate bone metastases clinic---first of itskind in Canada. Current Oncology 14 (1): 9-12, 2007.Hardisty M, Gordon L, Agarwal P, Skrinskas T, Whyne C. Quantitative characterization ofmetastatic disease in the spine: Part 1 Semi-automated segmentation of the metastatic spineusing atlas-based deformable registration and the level set method. Medical Physics 34: 312734, 2007.Harris K, Li K, Flynn C, Chow E. Worst, average or current pain in brief pain inventory: whichshould be used to calculate response to palliative radiotherapy in patients with bone metastases?Clinical Oncology 19: 523-527, 2007.Harris K, Pugash R, David E, Yee A, Sinclair E, Myers J, Chow E. Percutaneous cementoplasty ofthe lytic metastasis in left acetabulum. Current Oncology 14(1): 4-8, 2007.Khoury A, Whyne C, Daly M, Moseley D, Bootsma, G, Skrinskas T, Siewerdsen JH and Jaffray D.Intraoperative cone-beam CT for measurement and correction of periaxial malrotation of thefemoral shaft: A surface-matching approach. Medical Physics 34(4): 1380-7, 2007.Khoury A., Siewerdsen J.H., Whyne C.M., Daly M.J., Kreder H.J., Moseley D.J., Jaffray D.Intraoperative cone-beam CT for image-guided tibial plateau fracture reduction. ComputerAssisted Surgery 12: 195-207, 2007.Li K, Harris K, Hadi S, Chow E. What should be the optimal cutpoints for mild, moderate andsevere pain? Journal of Palliative Medicine 10 (6): 1338-1346, 2007.Lutz S, Chow E, Hartsell W, Konski A. A review of hypofractionated palliative radiotherapy.Cancer 109 (8): 1462-1470, 2007.Pugash R, Sinclair E, David E, Myers J, Yee AJ, David E, Chow E. Percutaneous cementoplasty ofa lytic metastasis of the left acetabulum. Current Oncology 14(1): 4-8, 2007.Sinclair E, Li K, Pope J, Farhadian M, Harris K, Yee A, Librach L, Wynnchuk L, Danjoux C, Chow E.A Multidisciplinary Bone Metastases Clinic at Toronto Sunnybrook Regional Cancer Centre -- AReview of the Experience from 1999 to 2005. Clinical Oncology 19(3): S45, 2007.Szumacher E, Barbera L, Barnes E A, Keighley-Clarke T, Pressnail B, Matyas Y, Danjoux C, ZhangL, Nyhof-Young J. Improving access to radiotherapy services in the Simcoe-Muskoka region ofOntario – Needs assessment study. CMRTJ 38 (3): 7-16, 2007.Tschirhart CE, Finkelstein JA, Whyne CM. Biomechanics of vertebral level, geometry, andtranscortical tumors in the metastatic spine. Journal of Biomechanics 40(1): 46-54, 2007.Wang Y, Chow E, Piliotis E, Tsao M. Initial presentation as sclerotic bone metastases is a patientwith acute myelogenous leukemia. Journal of Palliative Medicine 10 (1): 256-259, 2007.13
Whyne CM, Wu F, Skrinskas T, Gordon L, Hardisty M, Basran P. Quantitative characterization ofmetastatic disease in the spine: Part 2 histogram based analyses. Medical Physics 34: 3279-85,2007.Yang W, Lam P, Kitching R, Kahn H, Yee A, Aubin JE, Seth A. Breast Cancer Metastasis in aHuman Bone NOD/SCID mouse model. Cancer Biol Ther 6(8), 2007.Yee AJ, Akens M, Yang BL, Finkelstein JA, Zheng PS, Deng Z, Hardisty M, Yang BB. The effect ofversican G3 domain on local breast cancer invasiveness and bony metastasis. Breast CancerResearch 9(4): R47, 2007.14
In PressBederman SS, Kreder HJ, Weller I, Finkelstein JA, Ford M, Yee AJ. The who, what, and when ofsurgery for the degenerative lumbar spine. A population-based study of surgeon factors, surgicalprocedures, recent trends and reoperation rates. Canadian Journal of Surgery.Chow E, Abdolell M, Panzarella T, Harris K, Bezjak A, Warde P, Tannock I. Validation of apredictive model for survival in metastatic cancer patients attending an outpatient palliativeradiotherapy clinic. International Journal of Radiation Oncology, Biology and Physics.Chow E, Abdolell M, Panzarella T, Harris K, Bezjak A, Warde P, Tannock I. Recursive partitioninganalysis of prognostic factors for survival in patients with advanced cancer. International Journalof Radiation Oncology, Biology and Physics.Culleton S, de Sa E, Christakis M, Ford M, Zbieranowski I, Sinclair E, Cheung P, Campos S, GohP, Chow E. Rare bone metastases of the olecranon. Journal of Palliative Medicine.de Almeida J, Morris A, Whyne C, James A. Testing Biomechanical Strength of in vitro CSF LeakRepairs. Journal of Otolaryngology.Fairchild A, Harris K, Barnes E, Wong R, Lutz S, Bezjak A, Cheung P, Chow E. Palliative thoracicradiotherapy for lung cancer. A systematic review. Journal of Clinical Oncology.Flynn C, Danjoux C, Wong J, Christakis M, Rubenstein J, Yee A, Yip D, Chow E. Two cases ofacrometastases to the hands and review of the literature. Current Oncology.Hadi S, Zhang L, Hird A, de Sa E, Chow E. Validation of symptom clusters in patients withmetastatic bone pain. Current Oncology.Hird A, Chow E, Ehrlich L, Probyn L, Sinclair E, Yip D, Ko Y. Rapid improvement in pain andfunctional level in a patient with metastatic renal cell carcinoma (mRCC): a case report andreview of the literature. Journal of Palliative Medicine.Hird A, Chow E, Yip D, Davis M, Hadi S, Flynn C, Sinclair E, Ko Y. Do bone metastases fromgastrointestinal cancers produce similar response rates following radiotherapy when compared tobone metastases from other primary cancers? Current Oncology.Kirou-Mauro, Hird A, Wong J, Sinclair E, Barnes E, Tsao M, Danjoux C, Chow E. Is response toradiotherapy in patients related to the severity of pre-treatment pain? International Journal ofRadiation Oncology, Biology and Physics.Li K, Sinclair E, Pope J, Farhadian M, Harris K, Napolskikh J, Yee A, Librach S, Wynnychuk L,Danjoux C, Chow E. A multidisciplinary bone metastases clinic at Toronto Sunnybrook RegionalCancer Centre - a review of the experience from 1999 to 2005. Journal of Cancer Pain &Symptom Palliation.O'Reilly M, Whyne CM. Comparison of CT Based Parametric and Patient Specific Finite ElementModels of the Healthy and Metastatic Spine Using a Mesh-Morphing Algorithm. Spine.Razmjou H, Yee AJ, Ford M, Holtby R, Vidmar M, Finkelstein JA. Relationship betweenpreoperative patient characteristics and expectations in candidates for Total Knee Arthroplasty.Physiotherapy Canada.15
Sahgal A, Chuang C, Huang K, Petti P, Weinstein P, Larson D, Ma L. Split-volume planning ofmultiple consecutive vertebral body metastases for CyberKnife body radiotherapy. MedicalDosimetry.Sahgal A, Ma L, Chuang C, Hossain S, Petti P, Larson D, Shrieve D. Comparisons of Novalis andCyberknife spinal stereotactic body radiotherapy treatment planning based on physical andbiologic modelling parameters. Radiosurgery.Salvo N, Christakis M, Rubeinstein J, de Sa E, Napolskikh J, Sinclair E, Ford M, Goh P, Chow E.The role of plain radiographs (x-rays) in management of bone metastases. Journal of PalliativeMedicine.Tharmalingam S, Chow E, Harris K, Hird A, Sinclair E. Quality of life measurement in bonemetastases: a literature review. Journal of Cancer Pain & Symptom Palliation.Wong J, Chow E, De Sa E, Rowsell C, Probyn L, Christakis M, Sinclair E, Law C, Finkelstein J.Immediate pain relief and improved structural stability following percutaneous vertebroplasty fora severely destructive vertebral compression fracture. Journal of Palliative Medicine.Yee AJ, Yoo JU, Marsolais B, Carlson G, Poe-Kochert C, Bohlman HH, Emery SE. A prospectiverandomized trial on the use of postoperative bracing in lumbar spinal fusion for degenerativeconditions of the spine. Journal of Bone and Joint Surgery (American).16
Books, Book ChaptersBraybrooke J, Yee A, Chow E. Palliative orthopedic surgery. Palliative Medicine. Editor-in-Chief:Declan Walsh. Elsevier (in press).Brown J. Chow E. Bone markers in research and clinical practice. Bone metastases: atranslational and clinical approach. Editors: Dimitrios Kardamakis, Vassilios Vassiliou and EdwardChow. Springer (in press).Bruland O, Hird A, Chow E. Radiotherapy of skeletal metastases. ASBMR Primer 7th edition of theprimer on the metabolic bone diseases and disorders of mineral metabolism (in press).Chow E. Update on radiation treatment for cancer pain. Current opinion in supportive & palliativecare. Pain: cancer section. Section Editors: Sam Ahmedzai and Anthony Dickenson. LippincottWilliams & Wilkins 1: 11-15, 2007.Fairchild A, Chow E. Role of radiation therapy and radiopharmaceuticals in bone metastases.Current opinion in supportive & palliative care. Renal and urological problems. Section Editor:Fred Saad. Lippincott Williams & Wilkins 1: 169-173, 2007.Fairchild A, Chow E. Palliative radiation therapy. Palliative Medicine. Editor-in-Chief: DeclanWalsh. Elsevier (in press).Fairchild A, Chow E. Palliative radiotherapy. Cancer pain: assessment and management. 2ndedition. Editors: Eduardo Bruera and Russell Portenoy. Cambridge University Press (in press).Fairchild A, Hird A, Chow E. Pain control with palliative radiotherapy in bone metastases. Recentadvances in bone cancer progression and therapeutic approaches. Editor: Dominique Heymann.Research Signpost (in press).Freedman O, Clemons M, Vassiliou V, Kardamakis D, Simmons C, Trinkaus M, Chow E.Assessment of therapeutic response. Bone metastases: a translational and clinical approach.Editors: Dimitrios Kardamakis, Vassilios Vassiliou and Edward Chow. Springer (in press).Janjan N, Krishnan S, Das P, Gould MS, Zampieri J, Crane C, Delclos M, Cleeland C, Lutz ST andChow E. Palliative radiation therapy techniques. Chapter 20 Pages 271-296. Cancer painmanagement. Editors: Michael J Fisch and Allen W Burton. McGraw Hill 2007.Nousianen M, Whyne CM, Yee AJ, Ford M. Surgical Management of Bone Metastases. Bonemetastases: A translational and clinical approach. Editors: Kardamakis, Ed Chow and Vassiliou,eds. Springer, Berlin Heidelberg New York (in press).Sahgal A, van der Kogel AJ, Wong CS. Spinal cord radiobiology. Spine Radiosurgery (in press).Vassiliou V, Chow E, Kardamakis D. Clinical features and complications of metastatic bonedisease. Bone metastases: a translational and clinical approach. Editors: Dimitrios Kardamakis,Vassilios Vassiliou and Edward Chow. Springer (in press).Whyne CM and Hardisty M. Biomechanics of metastatic disease in the spine. The Pathomechanicsof Tissue Injury and Disease, and the Mechanophysiology of Healing. Part IV: Cancer andMetastatic Diseases. Editors: Gefen A, ed. Research Signpost (in press).Yee AJ, Chow E. Prognosis in Patients with Bone Secondaries. Prognosis in Advanced Cancer.Editors: Paul Glare and Christakis, ed. Oxford University Press, Oxford (in press).17
Posters, Presentations and Published Abstracts4th UK Radiation Oncology Conference. Edinburgh, UK, March 2007. E. Chow. Meta-analysis of palliative radiotherapy trials for bone metastases. E. Chow. Early phase in the development of a bone metastases quality of life module.Department of Radiation Oncology, Mount Vernon Hospital. Middlesex, UK, March2007. E. Chow. Bone metastases research.Bonus 2 - Breast cancer and bone disease new updates. Toronto, Ontario, March2007. E. Chow. Radiotherapy research.4th Annual Toronto Radiation Medicine Conference. King City, Ontario, April 2007. EA. Barnes. Exploring interprofessional and collaborative roles for patient-centered care.17th Annual Ontario Provincial Conference on Palliative and End-of-Life Care.London, Ontario, April 2007. E. Chow. Symptom cluster management. EA. Barnes. Exploring interprofessional and co
Control for Radiation Oncology Residency Training Programs Dr. Jackson Wu, TBCC Calgary October 2 Results of a prospective study of Dexamethasone dose and tapering in patients with brain metastasis undergoing WBRT Dr. Alina Sturdza, PMH November 6 Early integration of Zoledronic acid with radiotherapy in
