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WE ARE PROUDTO BE LEADERSAFYA DAY

SAFE HARBORThis presentation contains forward-looking statementswithin the meaning of the Private Securities LitigationReform Act of 1995, which statements involve substantialrisks and uncertainties. All statements other thanstatements of historical fact, could be deemed forwardlooking, including risks and uncertainties related tostatements about our competition; our ability to attract,upsell and retain students; our ability to increase tuitionprices; our ability to anticipate and meet the evolvingneeds of student and teachers; our ability to source andsuccessfully integrate acquisitions; general market,political, economic, and business conditions; and ourfinancial targets such as revenue, share count and IFRSand non-IFRS financial measures including gross margin,operating margin, net income (loss) per diluted share,and free cash flow. Forward-looking statements by theirnature address matters that are, to different degrees,uncertain, such as statements about the potentialimpacts of the COVID-19 pandemic on our businessoperations, financial results and financial position and onthe Brazilian economy.The Company undertakes no obligation to update anyforward-looking statements made in this press release toreflect events or circumstances after the date of thispress release or to reflect new information or theoccurrence of unanticipated events, except as requiredby law. The achievement or success of the matterscovered by such forward-looking statements involvesknown and unknown risks, uncertainties andassumptions. If any such risks or uncertainties materializeor if any of the assumptions prove incorrect, our resultscould differ materially from the results expressed orimplied by the forward-looking statements we make.Readers should not rely upon forward-lookingstatements as predictions of future events.Forward-looking statements represent management’sbeliefs and assumptions only as of the date suchstatements are made. Further information on these andother factors that could affect the Company’s financialresults is included in filings made with the United StatesSecurities and Exchange Commission (SEC) from time totime, including the section titled “Risk Factors” in themost recent Rule 434(b) prospectus. These documentsare available on the SEC Filings section of the investorrelations section of our website at: https://ir.afya.com.br/.

OURMISSIONTo become the referencepartner of physicians in theirjourney, through rewardinglifelong experience and anenhanced daily practice byAfya’s digital services.

WE ARE THE ONLY PLAYER SERVING THE PHYSICIANSDURING THEIR WHOLE MEDICAL JOURNEY, FROMSCHOOL DAYS THROUGH PRACTICING MEDICINE,GENERATING HIGH LIFETIME VALUE.

WHAT MAKESAFYA UNIQUE?

UNIQUE OPERATIONAL MODEL2021202088%90%% OF NET REVENUE FROMPRODUCTS THAT AREDESTINED TO PHYSICIANSAND HEALTH COMMUNITYProductsand Services

UNIQUE OPERATIONAL MODEL2-3 YEARS6 YEARSResident PhysicianSpecialist Physician(e.g. cardiologist)Generalist PhysicianJOHNALTERNATIVE PATHPETERResident Physician4-8 YEARSMedical Student2-3 YEARSSubspecialist Physician(e.g. cardiac surgery)ANNESTEVESpecializationSpecialist Physician(e.g. cardiologist)Generalist PhysicianTOMMEDICALEDUCATION SUZYUndergradSpecializationEducation SupportPrep CoursesDIGITALHEALTHSERVICESTAMR 50.5BNSpecializationClinical Decision SoftwarePractice Management Tools & Electronic Medical RecordsTelemedicinePhysician - Patient RelationshipDigital PrescriptionContent & Technology for Medical Education

UNIQUE OPERATIONAL MODELLEADER OF MEDICALSEATS IN BRAZILLARGEST NUMBEROF PHYSICIANSAND MEDICALSTUDENTS INOUR ECOSYSTEMAFYAPLAYER 2PLAYER 3PLAYER 4PLAYER 52,7591,7421,533636473REPRESENTING 1,000OF MARKETSHARE INBRAZILHOSPITALSAND CLINICSPARTNERSHIPSALL OVER BRAZIL 33%

GREAT EXECUTIONSTANDARDIZED FORMAT IN ALL HUBS,ENSURING QUALITY PROGRAM INALL CAMPUSES ANDOPERATIONAL OPTIMIZATIONOur curriculum is standardized in all of our units,ensuring the same high quality on all campuses,along with better operational performanceSince the 1st year of medical school,students have access to practical classesin real and simulated environmentsblended-learning, using tools to supportclinical decision and telemedicineThis is one of our main distinguished deliveriesStudents take a proficiency examevery semester which enablesthem to customize their learningpath with a focus on the pace ofknowledge acquisition skills,and attitudesStudent results are comparedacross campuses, another uniquedelivery focused on excellenceAccess to 5th and 6th yearstudents for AFYA’s onlinepreparatory coursesTeaching publications in congressesAll HEIS with satisfactory IGC (GENERAL INDEX FOR PROGRAMS)Satisfactory concept in on-site institutional visits(For HEIS accreditation or re-accreditation)Assistance to more than 340thousand patients per year,from municipal health departmentsand philanthropic institutions

GREAT EXECUTIONINCREASING NUMBER OF MEDICALSTUDENTS GRADUATING WHILERESIDENCY SEATS HAVE REMAINEDFLAT, INCREASING COMPETITION35,34637,346 37,82331,60623,45718,47017,41516,776 16,83625,61827,82920,52217,350 17,350 17,350 17,350 17,350 17,350 17,350 17,35016,76316,52915,145 15,9382015201620172018201920202021MEDICAL STUDENTS GRADUATING PER YEAR# OF RESIDENCY SEATS AVAILABLE20222023202420252026

GREAT EXECUTIONGEOGRAPHICALPRESENCEThere are 500k activedoctors in Brazil and 50% of them arelocated in only 14 cities2021 UNITS2022 UNITS2021 CampusesNew campusesopenings(prediction for 2022) expansion studyPorto Velho, ROMontes Claros, MG

GREAT EXECUTIONRELEVANT POINTS62% of our students has up to 35 years oldBrand well perceived by the marketPerception studies regarding our brand,shows that our referral rates has grown consistently71 NPS in 2021Partnerships with several medical associationsfor courses offeringsPortfolio continuous expansion, with offeringsthat goes from 100% online courses up togold-standard specialization courses, within-person workload equivalent to residencyModularized courses, promoting a moreefficient in take process

GREAT EXECUTIONTODAYIPO20195,550MEDICAL STUDENTS16,017 10k10,455POTENTIAL MEDICALSTUDENTS19,865 9k1,452MEDICAL SEATS2,759 1.3k9,147MAU247,543 238kNET REVENUER 1,8MN 1,0MNR 750k

GREAT EXECUTIONGROWTH WITH PROFITABILITYADJUSTEDNET REVENUE(R MM) 45.1%ADJUSTED EBITDAand EBITDA MARGIN(R MM and %)44.4%46.6%75.7% 34% 68.9%750.652.8% 5 440.4754.8563.12020100.8%99.7% 0,7% 60.9%1207.7ADJUSTED NETINCOME and EPS(R MM)43.1%1752.72019ADJUSTEDOPERATING CASHGENERATION andCASH CONVERSION(R MM and %)2020202150.5% CAGR2019-2021ADJUSTED EBITDAEBITDA MARGIN20192020202147.2% CAGR2019-2021CASH GENERATIONCASH CONVERSION20192020202132.3% CAGR2019-2021ADJUSTED NET INCOME

GREAT EXECUTIONSTRONG TEAMALIGNED WITHAFYA’S LONGTERM VIEWSTEGRESULTS&MANAGEMENTOVATIOCNAEINNN & PERFORA F YAESGMA F YAENSATIONSMPCOA F YAINCENTIVE&TARA F YASFCO & REVENUEGROWTHORGANIZATION CLIMATE 90PTSSTUDENTS ANDPHYSICIAN NPS

INNOVATION IS IN OUR DNACOVIDOUTBREAKThe Medical Communityand Patients alike haveembraced a digitalcomponent to healthcareCaused us to rethink wherebest to invest our resourcesTHE EMERGENCEOF AFYA DIGITALSERVICES STRATEGY

INNOVATION IS IN OUR DNACOVIDOUTBREAKThe Medical Communityand Patients alike haveembraced a digitalcomponent to healthcareCaused us to rethink wherebest to invest our resourcesTHE EMERGENCEOF AFYA DIGITALSERVICES STRATEGYEVOLUTIONOF OUR MISSIONTo become the referencein medical and healthcareeducation, empoweringstudents to transform theirambitions into rewardinglifelong learning experiences

WHERE AREWE HEADING?

EXPANDING THE COREMEDICAL SCHOOLSAVERAGE TICKETand IPCA (R and%Chg 12 months)STUDENTSAPPROVEDSEATS2,75919,865 6.8%16,017MATURATION5,550IPO ckets above inflation repricingaggregating value (digitalsolutions included for students)AVERAGE TICKETIPCA1,452IPO 1,3072021Additional seats

EXPANDING THE COREMEDICAL SCHOOLSUNDERGRAD GROSSMARGIN (%)110BPS970BPS61.9%63.0%52.2%IPO20202021

EXPANDING THE COREMEDICAL SCHOOLSORGANICMaturation of current units - organic growth and margin expansionPricing power100% historical occupancyIntegration of Unifipmoc and Unigranrio - margin expansionUp to 1.2k potential additional seatsINORGANIC 200 seats per year starting in 2022Strong M&A pipeline: 4,500 seats

EXPANDING THE CORECONTINUING 2021GROWTHDRIVERS3,1891111Recovery after pandemicimpacts on practical classesRamp up of new campusesNew courses being launched

BUILDINGTHE FUTUREExpansion of our marketWE WANT TO HELP PHYSICIANSTO BE MORE ASSERTIVEAND EFFICIENT TO IMPROVETHEIR RELATIONSHIP WITHTHE HEALTH INDUSTRY

HOW AREWE BUILDINGTHE FUTURE?

AFYA’S BUSINESS MODEL B2PCore PHYSICIAN JOURNEYFrom Education to RetirementMarketSegments& e Value - Health B2B MarketPROFESSIONAL PHYSICIANPrep CoursesSpecializationPHARMADigital Services forPhysicians’ ProfessionalActivities (B2P)PROVIDERSPAYORSDigital Services to supportPhysicians’ Relations with theHealth Industry B2P2B

AFYA’S BUSINESS MODEL B2PDigital Services for Health PhysiciansDIGITALPLATFORMSAfya’s UniqueDifferentiator& ShareholderValue CreationIN CONSTRUCTION OR M&AMATURE SOLUTIONPhysician Services – B2PTelemedicineClinical DecisionSoftwareDigitalPrescriptionPractice ManagementTools & ElectronicMedical RecordsPhysician-patientRealtionship

AFYA’S BUSINESS MODEL B2PDigital Education B2P (Business to Physician)DIGITALPLATFORMSAfya’s UniqueDifferentiator& ShareholderValue CreationIN CONSTRUCTION OR M&AMATURE SOLUTIONStation (Digital to extentMedcel Content toUndergraduate Students)Medcel (Digital Platformfor Preparing Physiciansto Residency Practice)Persona (Digital Platformfor Undergraduate andPost Graduate Education)Medical Harbour(Digital Human Atlas)

AFYA’S BUSINESS MODEL B2PContent & Technologyfor Medical EducationPhysician - PatientRelationshipClinical Decision SoftwarePractice Management Tools &Electronic Medical RecordsDigital PrescriptionTelemedicine

AFYA’S BUSINESS MODEL B2PMEDCEL BY THE NUMBERS LARGEST RESIDENCYPREP DIGITAL PLATFORM IN BRAZIL, DRIVENBY STRONG GROWTH IN USERS AND 3MMCONTENT CONSUMPTIONEVOLUTION PER QUARTER IN M20202021VIDEOSPODCASTSE-BOOKSMOCK 24.9KQ45.3MM198.8K1.1MM7.9MM79.2K37.1K

AFYA’S BUSINESS MODEL B2PMEDCEL WITH GREAT FIGURES, SHOWING GROWTH ANDINCREASE IN STUDENTS ENGAGEMENT AND IT CONSOLIDATESAS THE BIGGER RESIDENCY PREP DIGITAL PLATFORM IN BRAZILLOGINSMONTHLYACTIVE 01920202021

AFYA’S BUSINESS MODEL B2PMONTHLYACTIVE ‘213Q‘214Q‘21

AFYA’S BUSINESS MODEL B2PWE ARE LEADERS INPROVIDING DIGITALSOLUTIONS#1 PLAYERIN THE MARKETSTRONGLEADERSHIPThe most used content platformand medical tools for decision making 422K of consumed content per day 9.5K topics 4.2K of updated topics500 new topics54 published calculators in 2021500 medical images published in 2021125K in 2021 vs 105K in 2020active subscribers 194K in 2021 vs 160K in 2020monthly active users61 million in 2021 vs 54 million in 2020Whitebook Consultations37 million in 2021 vs 30 million in 2020patients impacted

AFYA’S BUSINESS MODEL B2PWE ARE LEADERS INPROVIDING DIGITALSOLUTIONS# OF 106.9 .0185.3198.7155.3173.6166.2164.7161.8173.9181.1MAU (K) 151.9125.34Q‘21194.0 194.3

AFYA’S BUSINESS MODEL B2P#1 PLAYERIN THE MARKET18.0K in 2021 vs 13.1Kin 2020 doctors 2.3 million in 2021vs 850K in 2020 medicalconsultations per month 5.1 million in 2021vs 4 million in 2020medical prescriptions8.5K telemedicineconsultations per monthas of December 202151 in 2021 vs 44 in 2020medical specialities 1.6k in 2021 vs 1.3k in 2020cities across Brazil - nationwidepenetration35 million in 2021 vs 19 millionregistered patientsSERVICESLEADERHIGH CUSTOMERSATISFACTIONMost complete solutionfor physicians’ management:calendar, medical records,finance, marketing and billingFast and resolutivecustomer supportIntegrated tebook376K visitors per month;iClinic brand has 1.4x moresearches than the 2ndlargest player in industry58 NPS as ofDecember 2021Only 1.3%monthly churn98% CSAT

AFYA’S BUSINESS MODEL B2PIMPRESSIVE TRACK RECORDOF PHYSICIAN USER GROWTHAND ENGAGEMENTMONTHLYACTIVE 0.2K4Q‘201Q‘212Q‘213Q‘214Q‘21

AFYA’S BUSINESS MODEL B2P

AFYA’S BUSINESS MODEL B2PMain featuresProduct DifferentialsHealth product baseFluid prescription through a simple andintuitive interfaceMemorization of dosageDigital signature Sending theprescription by WhatsappReuse of previous prescriptionsAutomated suggestion ofprescription typeby drug andsubstance prescription templatesPDF print and downloadMore than 21 thousandprescriptions in 2022,6 months after launchFree shipping by whatsappGreater flexibility and autonomy for theuser vis-a-vis the main competitorGreater reliability of the drug baseConstruction based on active andconstant listening to users throughsurveys, tests and other dynamics.More than 27 thousandregistered items

AFYA’S BUSINESS MODEL B2PPresence in 25 of the 27 states of BrazilTrack record of 4 new referrals per customer (without financial incentive)78% of the base coming from user recommendationMVP Base iClinic (CRM channel) with 19.11% average conversionMore than R 67.8 million processed in 2021Product DifferentialsUX and features developed together with physicians, integrating financial services into the journeyof Scheduling, Attending, Prescribing Patients and Office/Clinic Management (One Stop Shop thesis)Exclusive features such as online payment integrated into the medical agenda, sales simulator,reconciliation of receivables, integration with operators without the need for manual inputs,exclusive financial anels and anticipation of health plan receivables (a pioneering solutionin the market).Trained and specific service for the health segment.

AFYA’S BUSINESS MODEL B2PGROWTHMorePhysiciansPMoreDATAA,Mo( PH rAR eMlatSiogiluDttiosyshicPniearns sB foMorePtsienatBDI2ROVre PhysiciaMonltuastionConsBsre)SROffYAPOERS,

AFYA’S BUSINESS MODEL B2BB2B RAMP-UPTHE NEW VIEW ON HOW WE CREATEVALUE FOR THE HEALTHCARE CHAINHealthcareMarketValueCreationPhysicianDay to dayPHARMAPROVIDERSPAYORSACCESSTAM R 6.7BNDEMANDTAM R 5.6BNEFFICIENCYTAM R 12.1BNKnowledge& RefreshingVisibility &ReputationService &ManagementDiagnosis &Decision SupportConductFollow-upB2B ADDRESSABLE MARKETTAM R 24.4 BN

AFYA’S BUSINESS MODEL B2BACCESSDEMANDEFFICIENCYInnovative and efficient groupdigital solution to boost the healthindustry's Access to physiciansin the ADS ecosystemDigital solution to promoteDemand for the healthindustry fromphysician practicesDigital solution to improveEfficiency throughout thehealth value chainPhysician RecruitmentEncourage the purchase of prescribedmedications and procedures by patients,generating demand for the Pharmaindustry, including Distributorsand ProvidersHealth Market IntelligenceResearch / ReportsClinic IntelligenceHealth Industry (mostly Pharmas)Educational Content Distribution& Medication e-detailingFacilitate patients’ adherence to thetreatment of chronic diseases, generatingdemand for the Pharma industry,including Distributors and ProvidersEletronic Opt-inMarket IntelligencePHASE 1

AFYA’S BUSINESS MODEL B2B

AFYA’S BUSINESS MODEL B2BACCESS OFFERINGS TO PHARMA INDUSTRYARE STARTING TO DELIVER OUR B2B VALUEIN A LAND AND EXPAND STRATEGY23 contracts closed with 18 different health companiesand more 43 proposals being worked13x more efficient than the traditional social network performance,in a 10x shorter time, in a campaign to access physicianfor a specific medical content

AFYA’S BUSINESS MODEL B2BOUR MISSION IS TO WORK ON DIGITAL TRANSFORMATION,ACCESS MORE PHYSICIANS AND BRING KNOWLEDGEON RARE DISEASES, AND AFYA IS A RELEVANT PARTOF THIS PROJECT WILLING TO DISSEMINATEKNOWLEDGE TO PHYSICIANS IN BRAZILElisabete MathiasCountry Brand Lead - Pfizer

AFYA’S BUSINESS MODEL B2BDIGITAL TRANSFORMATION IN HEALTHCARE INDUSTRYIS ALREADY A REALITY AND AN IRREVERSIBLE PROCESS.AFYA HAS ACTIVELY PARTICIPATED IN THIS PROCESS,WITH A TALENTED TEAM AND EXCELLENT TOOLSCleiton MarquesCEO - Biolab

AFYA’S BUSINESS MODEL B2BDIGITAL EVENTS ARE STILL CHALLENGING, ANDWE ALWAYS ASK OURSELVES WHAT CAN WE DOTO INNOVATE AND IMPACT MORE PHYSICIANS.THROUGH PEBMED PLATFORM, AFYA, IN AN AGILEAND EFFICIENT WAY, WAS FUNDAMENTAL FOR USTO REACH THE RANGE WE WERE LOOKING FORNathalia MazzaBrand Manager - Boehringer

AFYA’S BUSINESS MODEL B2BSTRONGLY BELIEVE IN THE NETWORKING EFFECT AND IN THEPOWER OF STRATEGIC ALLIANCES FOR THE EXPONENTIALDEVELOPMENT OF THE HEALTH AREA. PARTNERSHIPS BETWEENPHYSICIANS, HOSPITALS, PHARMACEUTICALS AND HEALTHCAREECOSYSTEMS LIKE AFYA ARE REDEFINING THE WAY IN WHICHWE CAN, TOGETHER, POSITIVELY IMPACT THE HEALTHCAREPROFESSIONAL’S JOURNEY AND THE QUALITY OF TREATMENTSALONG THE PATIENT’S JOURNEYMirian RodriguesPharma Tech Director - Brazil

AFYA’S BUSINESS MODEL B2BDIGITAL TRANSFORMATION IN THE HEALTHCAREECOSYSTEM STILL REPRESENTS A MAJORCHALLENGE IN THE EVOLUTION OF PRODUCTS,SYSTEMS AND PROCESSES. WE ARE SIGNIFICANTLYBEHIND THE MUCH TALKED-ABOUT FARMA 4.0, ANDTHIS DIRECTLY IMPACTS THE EFFICIENCY OFTREATMENTS AND THE LIVES OF THOUSANDS OFPATIENTS. THE ADOPTION OF AFYA TECHNOLOGIESIMPROVES CHANGES AND ENGAGES THESTAKEHOLDERS, EFFECTIVELY CONTRIBUTING TOTHE TRANSFORMATION OF THIS ECOSYSTEM NOTONLY IN BRAZIL BUT WORLDWIDEPedro AlmeidaDigital Patient Journey Manager - Roche

AFYA’S BUSINESS MODEL B2BDIGITAL SOLUTIONS HAVE STARTED TO FULFILLRELEVANT GAPS IN THE PATIENT'S JOURNEY,BOOSTING THE SUPPLY AND COVERAGEOF INFORMATION, DIAGNOSIS, AND TREATMENTOPTIONS IN THE PHARMACEUTICAL INDUSTRY.THEY SURPASS A PERSON AS JUST A PATIENT,STARTING TO IMPACT THEIR ENTIRE LIFEMirella VieiraPharmaceutical Division Innovation Manager - Bayer

WHATSUSTAINS AFYASTRATEGY?

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?VERY ATTRACTIVE DYNAMICS FORMEDICAL ECOSYSTEM IN BRAZILAExceptional Rewardsfor Medical CareerEBInequality of MedicalDistribution in BrazilCIncreasing Demand forMedical ProfessionalsDRegulatory and OtherBarriers of Entry in theMedical UndergradExcess Demand for Life-longMedical Education

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?AExceptional Rewardsfor Medical CareerOCCUPATION RATE FORMEDICAL DEGREE (%)B C D EAVERAGE SALARY(R gh EmployabilityHigher Wages 100% employability3x higher income than lawSource: IPEASource: CAGED / eSocial / Empregador Web

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?AB C D EExceptional Rewardsfor Medical CareerCUMULATIVE INCOME FORMEDICAL STUDENT (R 0600PERIOD (Years)Outstanding Financial ReturnsAvarage payback in 5 years after graduation

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?A BC D EInequality of MedicalDistribution in BrazilPHYSICIANS /1000 INHABITANTS5.15.14.33.93.5Avarage of Selected OECD Countres3.52.82.62.52.41.81.5 (Ex-capitals)1.1Brazil is still well behind other countriesWhile the largest cities in Brazil are close to European in medical density,the smaller ones (most representative) are still lacking physiciansSource: Demografia Médica

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?A BC D EInequality of MedicalDistribution in BrazilCITIES STRATIFIED BY POPULATION SIZE(% OF TOTAL POPULATION)5,260 Cities2%4%9%310 Cities16%11%26%(PHYSICIAN / 1000 INHABITANTS)32%4.892.271.360.370.38UP TO 5K5-10K0.470.7910-20K20-50K50-100K100-500K500K Most cities do not have enough physiciansApproximately 95% of all cities belong to a stratum with an average of less than 1.5 physicanper 1,000 inhabitants, which accounts for almost 50% of the total populationSource: Demografia Médica

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?A BInequality of MedicalDistribution in BrazilC D EREGIONS AND STATES WHERE AFYA IS MaranhãoPiauíBahiaParaíbaPernambucoParanáMinas GeraisRio de JaneiroNorth EastSouthSouth EastSource: Demografia médicaSTATE RATIOREGION .701.301.692.683.15

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?A B CD EIncreasing Demand forMedical ProfessionalsYEARS FOR ELDERLY POPULATION (65 )TO INCREASE FROM 7% TO 14%CLAIMS PERBENEFICIARY / YEAR12-17 51938201119442013193019751947199219701996Source: The United States Census Bureau, Accenture232000202621201220332017. Results in an increasein per capita utilizationof medical servicesIn addition to the aging process,consumers are changing behaviorand demanding more healthcareservices as they gain accessto medical professionals

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?A B CD EIncreasing Demand forMedical ProfessionalsHEALTH EXPENDITURE(%) 1199999999999999999999888889991010. Results in an increase in per capita utilization of medical servicesIn addition to the aging process, consumers are changing behaviorand demanding more healthcare services as they gain accessto medical professionalsSource: BofA Global Research, World Health Organization, IBGE, OECD

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?A B C DRegulatory and Other Barriersof Entry in the Medical UndergradINDUSTRY GUARDED BYBARRIERS TO ENTRYUndergraduate degrees regulated by the Ministry of Educationand the Ministry of HealthStrong influence and oversight from industry associationssuch as CFM and AMBSpecialist titles governed by 50 specialty associationsOnly Higher Educations Institutions with health-relatedUndergraduate degrees can offer Medical Specialization degreesIn April 2018, MEC effectively froze the number of medicalschools for the next 5 years (Normative 328/2018)E

WHAT SUSTAINS AFYA’S EDUCATION STRATEGY?A B C D EExcess Demand for Life-longMedical EducationMEDICAL ECOSYSTEMMEDICAL SCHOOLMEDICAL RESIDENCYApplicants per seat inUndergraduate Medical SchoolApplicants per seat inMedical Residency ProgramsCONTINUINGMEDICAL EDUCATION7.65.15.24.32016 2017 2018 2019 2020 2021 2022 20232016 2017 2018 2019 2020 2021 2022 2023Increase of 200 thousandphysicians from 2018 to 2028Potencial growth well sustainedby excess demand

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?B2P PERSPECTIVEPandemic deeply influenced the usageof technology of Brazilian physiciansAdvantages of digital health services:It facilitates access to health services allowing more directcommunication with the patientStorage and full access to information and sharing and sendingreports to patients or other professionals. This allows the physicianto follow the patient more entirely and make clinical decisionsmore quicklyGreater adherence to treatmentBetter management of the scheduled patient plan, since notas much time, is wasted as in face-to-face farewells and welcomes

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?PHYSICIANS AND MARKET OPENTO TECH SERVICES AND PRODUCTSTelemedicine monthlyaverage services 1.4MM30MMServicesExpectedin 2022 850KTelemedicine mainbenefits for physicianMOBILITYLOWER RISKBIGGER SERVICESCOPE 400K50%Cost of ServicesReduction202020212022Sources: (1) Saúde Digital Brasil 2022; (2) Portal Hospitaos Brasil 2021; (3) Brasil Telemedicina 2021; (4) Fortune Business Insights 2021;(5) Portal Telemedicina 2021; (6) Panorama das Clínicas e Hospitais 2022; (7) CETIC Saúde 2021

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?PHYSICIANS AND MARKET OPENTO TECH SERVICES AND PRODUCTS50% of physicians alreadyusing telemedicine70% of health institutionsusing telemedicineDigital improvements in 2022priority for health centers94% of physicians satisfiedwith digital prescriptions method93% of pharmaceutical industry satisfiedwith the digital prescriptions methodSources: (1) Saúde Digital Brasil 2022; (2) Portal Hospitaos Brasil 2021; (3) Brasil Telemedicina 2021; (4) Fortune Business Insights 2021;(5) Portal Telemedicina 2021; (6) Panorama das Clínicas e Hospitais 2022; (7) CETIC Saúde 2021

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?PHYSICIANS AND MARKET OPENTO TECH SERVICES AND PRODUCTSDigital Services andProducts Availability (in %)60DIGITAL EVOLUTIONOF HEALTH CENTERSREGISTERED IN THE CNES64524442(NATIONAL HEALTH FACILITIES cineSIX PILLAR DIGITAL STRATEGY SYNERGYSources: (1) Saúde Digital Brasil 2022; (2) Portal Hospitaos Brasil 2021; (3) Brasil Telemedicina 2021; (4) Fortune Business Insights 2021;(5) Portal Telemedicina 2021; (6) Panorama das Clínicas e Hospitais 2022; (7) CETIC Saúde 2021

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?PHYSICIANS AND MARKET OPENTO TECH SERVICES AND PRODUCTSGrowth trend in marketing Investments by the Pharmaceutical industryPharma RX Co invest 28% of sales in marketing 58.2% of Total Investment5.1%8.0% 15.914.6%32.5%9.1% 2.58.7%89.9%16.1.%11.4%63.1% 17.8 10.863.7%63.7%6.0%9.9% 0.221.0%77.8%18.0%68.4%8.0% 2.163.7%22.3% RTISINGDTCMAILLINGOTHERSDIGITAL35.3%WorldwideTotal Invest BNUSASource: IQVIA ChannelDynamics 2018JapanChinaEU5MexicoColombiaBrazil

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?PHYSICIANS AND MARKET OPENTO TECH SERVICES AND PRODUCTSGlobal Top 10 countries ranking andinvoice spending relative to the United StatesRANK2016%OF U.S.INVOICESPENDINGRANK202112 13 -145678910 2United StatesChinaJapanGermanyFranceItalyUnited .0%4.7%Brazil4.0%12345678910Sources: IQVIA Market Prognosis, Sep 2021 1-1 2-1% OF U.S.RANK2026United StatesChinaJapanGermanyFranceUnited KingdomItaly100%27.6%19.2%10.5%7.9%6.9%6.0%United 10United ING 1-1 2-1-1 2-1% OF U.S.INVOICESPENDING

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?SUCCESSFULLBENCHMARKSAFYADOXIMITY39.7% CHG47.6% CAGRM329.7% CAGR 1.8MM248K 6MM177K80K20202021248K represents33% of mkt share of Physiciansand Medical Students201343K2021 1,8MM users contemplates 80% U.S Physicians, nurses,medical students andheathcare practitioners20022021 6MM users contemplates 90% of Japna Physiciansand Physicians overseas

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?PARTNERS & CLIENTS

WHAT SUSTAINS AFYA’S DIGITAL SERVICES STRATEGY?SOLUTIONSAFYAPhysician - patient relationshipContent & technologyfor medical educationClinical decision softwarePractice management tools& electronic medical recordsTelemedicineDigital prescriptionDOXIMITYM3Docnews - Newsfeed that allowshospitals to reach physicians to achievetheir brand awareness and patientacquisitions goalsPharma - Dr communicationsDeliver promotional andeducational content to physicianssponsored by pharmaceuticalsColleague connect - Physician tophysician messaging platform allowshospitals marketers to leverage themost powerful search in healthcareto pinpoint their ideal audienceMarket research, physiciansanalytics - Data-based servicesusing physicians activities andsurvey response on our plataformPatient connect - Drives high value,specialty patient traffic from doximityand U.S News & World report directlyinto your preffered scheduling channelsCareer services - Careerchange support for physiciansand nursesDialer enterprise - Secure telehealthsolution, enables hospitals and healthsystems to grow their telehealth offeringthrough a full feature set deliveredacross mobile, desktop and tabletClinical trials - Faster, cheaperclinical trials by recruiting ourphysicians through our website

WHAT SUSTAINS AFYA’S DIGITAL STRATEGY?ALL OF THAT WITHTAM EXPANSIONR BNCOMPANYB2B TAM24.4 BNR 28.4 BNEFFICIENCYDEMANDACCESSB2P TAM4.0 BNB2PSegment

BUILDING ABETTER FUTURE

byCye rgEnanCleerSuceytirgenahCC l i m a teBUILDING A BETTER GlaecnSocial ImpactSODivers&ityCocenanverGol t u reG Cu& ESALCI&matsighnRywith themunitRelationshipComplencyCo mparHuansTrCuAgrpltuorreenatedaiance

SomanRightsCultureAudit, Risks and Ethics StatutoryCommittee supervises the Integrity Programand inspects Internal ControlsHuacilImptcandegAaitysreDiva teropro&CBUILDING A BETTER FUTURE?leRSOCIALitasnopihthiwCCode of Ethics and Conduct human rights,repudiation of slave-like and child labor,prohibition of bribery, among other issuesthmmoeitnuyGoveE nv i lCleaVNE& C o m p l i a n ceatengeXSOCy b erSecuritChaGove&rnESanGceCultureEthics Channel available to employees andthird parties, managed by an independentcompanyAfya’s Policies Related party transactionsand conflicts of interestAnti-corruption and anti-fraud policyStatement of Policy Concerning TradingMandatory Trainings at UCA (AfyaCorporate University) adherence of morethan 90%Ethics and Conduct CodeyCom

Specialist Physician (e.g. cardiologist) 4-8 YEARS ALTERNATIVE PATH 6 YEARS Specialization 2-3 YEARS 2-3 YEARS Undergrad Education Support Prep Courses Specialization Specialization Clinical Decision Software Physician - Patient Relationship Digital Prescription Content & Technology for Medical Education Practice Management Tools & Electronic .