What Makes Us Human? - VideoLectures

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The Music of LifeWhat makes us human?Denis Noble

The Music of LifeWhat makes us human?An insect?The „music of life‟has no conductor!orA violin?With thanks to theJapanese Paper Artist内藤英治Hideharu Naito

Selfish Genes“Now they swarm in huge colonies, safe inside giganticlumbering robots, sealed off from the outside world,communicating with it by tortuous indirect routes, manipulatingit by remote control. They are in you and me; they created us,body and mind; and their preservation is the ultimate rationalefor our existence.” Dawkins, The Selfish Gene, 1976, pp 19-20“[readers] . Should imbibe the fundamental truth that an organismis a tool of DNA rather than the other way round”Dawkins, The Extended Phenotype p 159

Genes as PrisonersNow they are trapped in huge colonies, locked inside highlyintelligent beings, moulded by the outside world, communicating withit by complex processes, through which, blindly, as if by magic,function emerges. They are in you and me; we are the system thatallows their code to be read. And their preservation is totally dependenton the joy we experience in reproducing ourselves. (Our joy not theirs!)We are the ultimate rationale for their existence.The fundamental truth is that an organism is the only tool by whichDNA can express functionality, by which the “Book of Life” can beread. DNA alone is inert - - - deadThe MUSIC of LIFE chapter 1

Selfish or Cooperative Genes?.the vision of life that I advocate is not provably morecorrect . I doubt whether there is any experiment thatcould be done to prove my claim.Richard Dawkins, The Extended Phenotype, 1982The idea of the selfish gene is metaphorical polemic,not science

The Story of the Chinese Emperor秦始皇帝and the poor farmer(The Music of Life chapter 2).和貧窮農民

16 3264 128 30,000 10003 million

Square 36:all the ricein the palace

Square 50:all the ricein China

Square 64:all the surfaceof the world

The genome and combinatorial explosionAssume each function depends on 2 genes(absurd, but still instructive)Total number of possible „functions‟ would be0.5 x 25,000 x 24,99928910 312,487,500With more realistic assumptions about # of genes in eachfunction, the figures are huge : at 100/function ( 1.5 e302);for all combinations ( 2 e166713)(The MUSIC of LIFE, chapter 2).7240310!

7240310Howis this number?Compare itwithlargethe largestobject we knowThe UNIVERSE

7240310Number of galaxies 80 billionTotal number of atoms in the universe ?

7240310Total number of atoms in the universe 1080There wouldn’t be enough materialin the whole universe for nature tohave tried out all the possible interactionseven over the long period of billions of yearsof the evolutionary process(The MUSIC of LIFE chapter 2).

Guitar soloJeux InterditsForbidden gamesNarcisso Yepes

The French bistro omeletteThe Music of Life, chapter 3

GuitarBach: Invention no 8

A novel view of DarwninismThe Silmans find some tropical islandsThe Music of Life chapter 8

The Silmans’ errorHuman spermatozoonfertilizingan egg cellWith acknowledgement:drawingby Leonardoda VinciThe Queen’s collection in Windsor Castle

Can acquired characteristics be inherited?The Guardian14 February 2007Weaver et alThe Journal of Neuroscience(2007) 27,1756 –1768

JupiteriansThe Music of Life, chapter 10

The first humans to visit this new world

They find buildings that are,to all intents and purposes,CATHEDRALS

They arebeautifulornatetreasures

There are are „priests‟dressed in colourful robes

The inhabitants practise a specialform of „prayer‟ -- meditation

There are scriptures 81,000 „books‟52 million „words‟God?“why do you ask that question?”Self/soul? “No-self – it‟s a process”Descartes: I think therefore I am? “No-‟I‟ – “Thinking – so being”

UNESCO World Heritage Site海印寺 Hae-in-sa

Non sai tu che la nostra anima è composta di armonia?No words are needed for those who understand musicDo you not know that our soul is composed of harmony?Leonardo da VinciTrattato della Pittura

FinaleA l’Ora de l’AubadaAt the hour of dawnNadau

A l’ora de l’aubadaAt the break of dawnQue t’vieneri cercarI will come to find youConneissi ua istoriaI know a storyTe la podi contarI will tell youSi l’aiga shebitejaWhen the water shimmersQuand n’i aura pas na bruch When there is no soundA l’ora de las hadasAt the witching hourT’estuparei las lutzI’ll turn off the lightA l’ora dau silenciQue saurei descobrirQuand pots estar beroiaE ou sont tos caminsA la punta dau diaQue t’preneri la manPagera dins la miaTornarem comencarAt the hour of silenceI know how to findWhen you are beautifuland where you goat the break of dayI’ll take your handput it in minewe’ll start together

Sens pietat ni cadenaComa un heuc dins la nueitComa un heuc dins ma vidaEnta virat lo hredQue t’aimera ma miaSei pas quand des matinsAura luseich l’eslamaLheu qu’es va amortirWithout pity or chainslife a fire in the nightlike a fire in my lifeto chase the coldI’ll love you, my lovehow many morningsnow the light shinesperhaps it will dieSi as los uelhs a la luaQu’aniram pasejansConeissi las estelasQui hen virat los capsSi as los uelhs a la brumaT’inventarei sorelhsEt ton cos sera primaLa pausa d’un sauneiif you look at the moonwe’ll go togetherI know starsthat will turn your headif you look at the darkI will invent suns for youyour body will shinelike a dream

Thank you

Arron d’aimar -- after loveOccitan love song (Nadau)

Arron d‟aimar -- after making lovequauque còp que sauneji -- sometimes I dreama mars-grana de nèu -- of oceans of snowe aus navius negats -- of drowning shipsaus arrisers gaujós -- of laughter of childrenau dia que punteja -- of the break of dayau dessús d‟un camin -- over a roadque non s‟acaba pas -- that never endsQue t‟aime -- how I love youpr‟amor dau temps qu‟acaças -- for the time you dispelque t‟aimeper la nèu e lo huec -- for snow and fireque t‟aimecaminaram amassas -- we‟ll go togetherque t‟aimeper l‟aiga o l‟eslambrec -- for water and lightening

La hièstra que obèrta -- the window is openla lua que t‟bailina -- moonlight caresses youe tu qui vas dromir -- and you who go to sleepton cap s‟ei amagat -- your face is hiddenper delà lo plaser -- beyond pleasurela tendressa engalina -- beyond tendernessio qu‟espii ton còs -- on seeing your bodye‟u gausi pas tocar -- I dare not touchQue t‟aime -- how I love youpr‟amor dau temps qu‟acaças -- for the time you dispelque t‟aimeper la nèu e lo huec -- for snow and fireque t‟aimecaminaram amassas -- we‟ll go togetherque t‟aimeper l‟aiga o l‟eslambrec -- for water and lightening

Arron d‟aimar -- after making lovequauque còp que sauneji -- sometimes I dreamque lo vent nos a miats -- that the wind has put uscap sús los crums negrós -- above the black cloudsen un pais sens fin -- in a distant countryont dab tu me passeji -- where we go togetheront lo monde es perdonan -- where people forgiveaus qui s‟aiman, urós -- those who love, and are happyQue t‟aime -- how I love youpr‟amor dau temps qu‟acaças -- for the time you dispelque t‟aimeper la nèu e lo huec -- for snow and fireque t‟aimecaminaram amassas -- we‟ll go togetherque t‟aimeper l‟aiga o l‟eslambrec -- for water and lightening

La hièstra que obèrta -- the window is openla lua que t‟bailina -- moonlight caresses youe tu qui vas dromir -- and you who go to sleepton cap s‟ei amagat -- your face is hiddenper delà lo plaser -- beyond pleasurela tendressa engalina -- beyond tendernessio qu‟espii ton còs -- on seeing your bodye‟u gausi pas tocar -- I dare not touchQue t‟aime -- how I love youpr‟amor dau temps qu‟acaças -- for the time you dispelque t‟aimeper la nèu e lo huec -- for snow and fireque t‟aimecaminaram amassas -- we‟ll go togetherque t‟aimeper l‟aiga o l‟eslambrec -- for water and lightening

A l'ora de las hadas At the witching hour T'estuparei las lutz I'll turn off the light A l'ora dau silenci At the hour of silence Que saurei descobrir I know how to find Quand pots estar beroia When you are beautiful E ou sont tos camins and where you go A la punta dau dia at the break of day Que t'preneri la man I'll take your hand