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Research Day Programon October 5, 2018 from 8am-2pmat The Carolina Club, Alumni Hall III150 Stadium Dr., Chapel Hill, NC 275147:45amBreakfast in Alumni Hall III8:20amWelcome Remarks by:Dr. Richard Loeser, TARC Center DirectorDr. Beth Jonas, Division Chief, Rheumatology, Allergy and ImmunologyShort TalksModerators: Lara Longobardi, PhD, Assistant Professor of Medicine, TARCLeigh F. Callahan, PhD, Distinguished Professor of Medicine, Associate Director, TARC8:30amTroy Blackburn, Brian Pietrosimone, Darin Padua, Chris Johnston. Effectsof vibratory stimuli on gait biomechanics and somatosensory functionin individuals with anterior cruciate ligament reconstruction.(Poster #17, Session 1)8:45amTabish Khan, Charles Park, and Peng Liu. NR4A1 contributes toautoimmune arthritis by regulating Treg and Th1/Th17 cells.(Poster #22, Session 2)9:00amAmanda E. Nelson, Yvonne M. Golightly, Rebecca J. Cleveland, W.Patrick Gale, Tessa Walker, Leigh F. Callahan, Joanne M. Jordan. TheJohnston County Osteoarthritis Project and Johnston County HealthStudy: Opportunities for Collaboration.9:15amShailesh K. Choudhary S, Onyinye I. Iweala, C. Traci Addison, GrayCrispell, Shahid Karim, Scott P. Commins. Tick salivary extract inducesalpha-gal allergy in alpha-gal deficient mice. (Poster #29, Session 2)9:30am-11:00amPoster Presentation Session #11. Amanda E. Nelson; Matthew Fuller; Rebecca J. Cleveland; Todd A.Schwartz; Joanne M. Jordan; Leigh F. Callahan; J. S. Marron; RichardF. Loeser. A Machine Learning Approach to Knee OA Phenotyping:The Johnston County Osteoarthritis Project.2. Alvarez C, Cleveland RJ, Schwartz TA, Renner JB, Murphy LB, JordanJM, Callahan LF, Golightly YM, Nelson AE. Comorbid conditions and

the transition among states of hip osteoarthritis and symptoms ina community-based study: A multi-state time-to-event modelapproach.3. Ayesha Jaleel, Jeffrey R. Curtis, Rui Chen, Huifeng Yun, Tarun Arora,Suzanne M. Cadarette, Nicole C. Wright, Amy Mudano, JefferyFoster, Kenneth Saag. Defining Alendronate Drug Holidays and Reinitiation in US Medicare Data.4. Rebecca J. Cleveland, Carolina Alvarez, Todd A. Schwartz, Jordan B.Renner, Joanne M. Jordan, Leigh F. Callahan. Association of HipPain With or Without Radiographic Osteoarthritis on ExcessMortality.5. Matthew J. Rich, Susan D’Costa, Noah Pieper, Brian Diekman.Engineered cartilage from genome-edited chondrocytes for thestudy and treatment of osteoarthritis.6. Garrett A. Sessions, Jie-Yu Liu, Brian O. Diekman. Characterizing theSenescent Phenotype of Chondrocytes With High p16INK4a GeneExpression.7. Caitlin V. Johnson, Kathleen S. Metz, and Douglas H. Phanstiel.Fibronectin fragments induce global transcriptional changes inprimary human chondrocytes.8. Douglas H. Phanstiel. The role of DNA looping in humandevelopment and disease.9. Morika D. Williams, Rachel C. Meyers, B. Duncan X. Lascelles. LongTerm Impacts of Early Life Injury on Monoiodoacetate InducedOsteoarthritis in Adult Rats.10. King Wa Chiu, Jon Hash, Rachel C. Meyers, B. Duncan X. Lascelles.The Effect of Naturally Occuring Osteoarthritis on ConditioningPain Modulation in the Canine Model.11. Lauryn Braxton, Morika Williams, Stephanie Cone, Duncan X.Lascelles, Matthew B Fisher. Comparing Pain and SeverityOutcomes of Two Induced Models of Osteoarthritis in Young andMature Rats.12. Derek Adrian , Jo Murrell, John Harris, Rachel Meyers, AndreaThomson, B. Duncan X. Lascelles. Feasability And Repeatability OfMeasuring Nociceptive Withdrawal Reflexes In Healthy Cats.

13. Laura Minnema , Joshua Wheeler , Saumitra Pitake , Santosh Mishra ,B. Duncan X. Lascelles. Reverse translation to discover relevanttargets for chronic pain: GFRα3/artemin.14. Kelli D. Allen, PhD, Tamara J. Somers, PhD , Lisa C. Campbell, LiubovArbeeva , Cynthia J. Coffman, Crystal W. Cené, MPH, Eugene Z.Oddone, Francis J. Keefe. Title: Pain Coping Skills Training forAfrican Americans with Osteoarthritis (STAART): Results of aRandomized Controlled Trial.15. Helen H. Willcockson, Amaya Esterellas, Chris Jowdy, HuseyinOzkan, Richard F. Loeser and Lara Longobardi. CCL2/CCR2 signalingin chondrocyte degeneration.16. Natalia Favoreto, Leigh Callahan. Successes and challenges of acommunity-based clinical trial in a rural NC county.17. Troy Blackburn, Brian Pietrosimone, Darin Padua, Chris Johnston.Effects of vibratory stimuli on gait biomechanics andsomatosensory function in individuals with anterior cruciateligament reconstruction.18. Brian Pietrosimone, Matthew K. Seeley, Christopher JohnstonSteven J. Pfeiffer, Jeffery T. Spang, J. Troy Blackburn. MechanicalLoading During Gait following Anterior Cruciate LigamentReconstruction: An Analysis of Symptomatic vs AsymptomaticIndividuals.11:00am-12:00pmKeynote speaker, Daniel Hal Solomon, MD, MPHProfessor, Harvard Medical SchoolBrigham and Women’s HospitalTalk Title: “Cardiovascular Disease in Rheumatoid Arthritis: From“Bench” to Bedside”Dr. Solomon is a Rheumatologist with clinical interests in arthritis,disease management strategies, osteoporosis, outcome analysis,rheumatic diseases, rheumatoid arthritis, systemic lupuserythematosus, and vasculitis. Dr. Solomon is a population scientistfocusing on the epidemiology and health services of rheumaticdisease. He serves as the Chief of the Section of Clinical Sciences in theDivision of Rheumatology at BWH. His research work is primarily fundedby the NIH, AHRQ, and foundations. He has served major roles at theAmerican College of Rheumatology and within the osteoporosiscommunity as well.12:00pm-12:45pmLunch in Dowd Harris Room

12:45pm-2:00pmPoster Presentation Session #219. Liubov Arbeeva, Braxton Mitchell, Rebecca Jackson, Michelle Yau,Kathleen Ryan, Yvonne Golightly, Marian Hannan, Amanda Nelson,Joanne M. Jordan, Marc Hochberg. Genome-wide meta-analysisidentified two novel variants associated with Hallux Valgus.20. Liubov Arbeeva, Rebecca J. Cleveland, Carolina Alvarez, Todd A.Schwartz, Lauren M. Abbate, Amanda E. Nelson, Yvonne M.Golightly, Jordan B. Renner, Joanne M. Jordan, Leigh F. Callahan.The Effect of Body Mass Index Change on Increased KellgrenLawrence Grade in the Knee: A Joint Modeling Approach.21. Charles Park, Mengyao Jin, Michael Weeks, and Peng Liu. Dendriticcells but not macrophages stimulate T cell responses in earlyatherosclerosis.22. Tabish Khan, Charles Park, and Peng Liu. NR4A1 contributes toautoimmune arthritis by regulating Treg and Th1/Th17 cells.23. Michael Miao, John Collins, Maryna Kapustina, Richard Loeser. Roleof NADPH Oxidases in the Development of Osteoarthritis.24. Collins, J.A., DeFoor. M.T., Diekman, B.O., Wood, S., Bolduc, J.A.,Nelson, K., Chubinskaya, S., Poole, L.B., Furdui, C., Loeser, R.F.Oxidative Stress-Induced Sulfenylation of SIRT6 is Associated withEnhanced NF-kB Signaling in Human Chrondrocytes.25. Rachel Romero, Carolina Alvarez, Shruti Saxena Beem, ToddSchwartz, Rumey C. Ishizawar. Immune Related Adverse Eventsfrom Immune Checkpoint Inhibitors: A Retrospective Analysis from2004-2017 at the University of North Carolina at Chapel Hill.26. Sandra Soto, Leigh F. Callahan, Stephanie Bahorski, Mary Altpeter,Ashley Phillips, Dana Carthron, Christine Rini. Dyadic influences onspousal companionship support for physical activity given to andreceived by individuals with osteoarthritis.27. Onyinye I. Iweala, Paul B. Savage, Scott P. Commins. A Role forCD1d-restricted Invariant Natural Killer T Cells and Glycolipids inAlpha-Gal Allergy.28. Choudhary S, Bresch D, Jerath M, Choudhary S, Commins SP. Venomallergy is increased in alpha-gal allergy: shared environmental orimmunologic factors?

29. Choudhary S, Iweala OI, Addison CT, Crispell G, Karim S, ComminsSP. Tick salivary extract induces alpha-gal allergy in alpha-galdeficient mice.30. Chaitali Basole, Pamelia Fraungruber, Branimir Popovic, SairaSheikh, Shanmugam Nagarajan. Fcgamma Receptor MediatedNeutrophil Activation Promotes Macrophage InflammatoryResponses and Foam Cells: Possible Mechanism Contributing toLupus-Induced Atherosclerosis.31. Edward G.A. Iglesia, Mildred Kwan, Saira Sheikh. Perceptions of aContinuing Medical Education Activity to Increase Knowledge ofVaccination in Adults with Chronic Inflammatory ConditionsAmong Clinicians.32. Enid Y. Sun, Carolina Alvarez, Saira Z. Sheikh. Class III LupusNephritis is Independently Associated with Increased Risk forCoronary Artery Disease.33. Brittaney-Belle E. Gordon, Katherine Kaufman, Sean T. Hicks,Rebecca J. Cleveland, Julie A. Norfleet, Leigh F. Callahan, Saira Z.Sheikh. Walk SLE – End of study results of a pilot study exploringWalk with Ease, a self-directed walking program, in Lupuspatients.34. Yvonne M. Golightly. Association of Knee Ligament and/orMeniscal Injury with Radiographic Knee Osteoarthritis in MilitaryOfficers.35. Yvonne M. Golightly, Carolina Alvarez, Liubiv Arbeeva, Rebecca J.Cleveland, Todd A. Schwartz, Jordan B. Renner, Leigh F. Callahan,Joanne M. Jordan, Amanda E. Nelson. Knee Injury and TransitionsAmong States of Knee Osteoarthritis in the Johnston CountyOsteoarthritis Project: A Multi-state Time-to-event ModelingApproach.36. Kirsten Ambrose, Allison Napier, Serena Weisner, Yvonne GoLightly,Haley Hudson, Leigh Callahan. The Osteoarthritis Action Alliance(OAAA). Addressing the National Burden of Osteoarthritis ThroughStrategic Partnerships and Collaborations.

Leigh F. Callahan, PhD, Distinguished Professor of Medicine, Associate Director, TARC 8:30am Troy Blackburn, Brian Pietrosimone, Darin Padua, Chris Johnston. Effects of vibratory stimuli on gait biomechanics and somatosensory function in individuals with anterior