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Sysmex Webinars Available On-DemandSpring 2010Spring 2010Missed the latest series ofSysmex webinars? It's nottoo late! You can view thewebinars on-demand atwww.sysmex.com/webinars.Recently added topics include: Automation and the Need for Lavender Top TubeManagement in Hemoglobin A1C Testing (5/5/2010)Michael Spiekerman, Ph.D., Professor of Pathologyand Laboratory Medicines, Texas A&M HealthScience Center College of Medicine, Chief, Sectionof Chemistry Clinical Pathology, Scott & WhiteHealthcare, Temple, TXSYSMEX AMERICA, INC.ONE NELSON C. WHITE PKWYMUNDELEIN, IL 60060Managing Reagent Inventory without the HassleSysmex customers to realize reagent replenishment with minimal customer interventionSysmex America recently developed a system designed to streamlinethe reagent ordering process, manage customer on-site inventory, andreduce the costs and errors associated with expedited reagentshipments. The system, known as e-Supply, is a software solution thatprovides automatic reagent delivery, automatic reagent monitoring,reagent tracking alert notification, order approval, on-demand inventoryadjustment and management reporting. A practical guide to implementing Sysmex XE-5000Immature Granulocyte count (4/7/2010)Linda M. Sandhaus, MD, MS - Associate Professorof Pathology, Director, Hematology Laboratory andPoint-of-Care Testing, University Hospitals CaseMedical CenterMobile Infirmary Medical Center,a not-for-profit 704-licensed bedacute-care hospital located in MobileAlabama, served as a beta site fore-Supply. According to Sandy Lozano,MT, ASCP, Core Laboratory Managerand primary person responsible forhematology and chemistry reagents’purchasing for Mobile Infirmary,e-Supply has made her job easier. The Power of the RBC Indices Letting Go of theRules of Three (3/3/2010)Jeri Walters SH (ASCP) - Technical Supervisor,Esoteric Testing, ACL Laboratories Sysmex XT-4000i TMAutomated HematologyAnalyzer Cleared by FDA Managing Reagent Inventory without the Hassle –Sysmex Introduces e-SupplyCheck Out These Articles and Many More Inside.Many of these complimentary webinars on currentclinical laboratory topics are accredited for 1.0continuing education credits through PACE and theState of Florida. They areavailable 24/7. Check outwww.sysmex.com/webinarsto view the webinars listedabove and many others! Sysmex America Two-time “Company That Cares”Award Winner Managing by Fact: Using Metrics in the ClinicalLaboratory (2/3/2010)Sandy Hood, MT(ASCP) SBB, AdministrativeDirector of Lab and Pathology Medicine,Riverside Methodist Hospital, Columbus, OH“I was looking for a way to automateand simplify the reagent orderingprocess so that my co-workers couldalso assist with reagentreplenishment. While MobileInfirmary is still in the process offine-tuning its e-Supply initiative,overall we are pleased with thee-Supply system. I especiallyappreciate the way in which Sysmexis watching over us,” said Sandy.“What we like most about e-Supply are the electronic alerts.(continued on page 2)Published by: 2010 Sysmex America, Inc. All rights reservedPresident’sMessageThe recentlyapproved U.S.Health Reformpackage includesprovisions that increaseemphasis on prevention,positive health outcomes, bettercoordination of care and comparativeeffectiveness research, including personalizedmedicine. What does this mean for theclinical laboratory and how does Sysmex'sproduct offering fit into this new landscape?Clear evidence suggests that we will see ashift from the traditional paradigm of chronicdisease diagnosis and management to one ofdisease prevention, early treatment, tailoredtherapy, and genome/proteome/cellulomeguided disease management. Examples ofthis transition are well-defined in breastcancer, leukemia and cardiovascular disease.A test for the HER2 protein in breast cancerpatients has permitted better targeting oftherapies— resulting in a 50 percentreduction in recurrence and a 30 percentreduction in death for such patients. Teststhat read the DNA structure in acutelymphocytic leukemia, the most commonform of leukemia in children, have helpedboost the 10-year survival rate from fourpercent in the 1960s to more than 80 percenttoday. A test that identifies whether a patientis especially sensitive to Warfarin, whichprevents blood clots, could eliminate as manyas 17,000 strokes and 85,000 serious bleedingepisodes per year.For some time, Sysmex has pursued researchand development projects which support theabove paradigm shift with focus given to thecompany's technology “bank”. For example,using Sysmex's proprietary "One Step NucleicAcid Amplification" (OSNA) technology,President’s Message(continued on page 2)

72President’s Message (continued)Sysmex has developed and plans to launch agene amplification method which extracts andamplifies genes, enabling the detection oflymph-node metastasis in approximately 30minutes. Sysmex also has developed the world'sfirst protein chip that can simultaneouslymeasure twenty types of proteins for use inpredicting the effects of anticancer drugs.Clearly, a manufacturer's research anddevelopment efforts will remain critical to aclinical laboratory's survival in this new era. Assuch, we at Sysmex will continue to view ourcustomers' needs from a forward-lookingperspective. In other words, how is the clinicallaboratory going to evolve over the years tocome and what can we do to shape and supportthat development? This is a guiding principle of“The Sysmex Way” – the principles by which weoperate and challenge our employees toinnovate.In this issue of Sysmex News, you will learn ofour recent FDA clearance for the SysmexXT-4000i which literally puts our company inthe unique position of servicing the hematologyneeds of small clinics to high-volume clinicallaboratories in every sized hospital or IDN in thenation. You also will read about our company'sinnovative e-Supply program that we recentlydeveloped to streamline the reagent orderingprocess, manage customer on-site inventory, andto reduce the costs and errors associated withexpedited reagent shipments.Both of these milestones demonstrate Sysmex'scontinued commitment to innovation,technology excellence and research. It is thiscommitment that will make Sysmex a key playerin the advancement of healthcare and is thereason why our customers will not only survivein a new healthcare environment, but thrive.John KershawPresident & CEO, Sysmex America, Inc.(continued from cover)Once we receive an alert, we do a quick inventory and adjust,approve or reject the order automatically via the e-Supply web site,eliminating the need to call in our order to customer service.It's easier than handling the reagent ordering process through astanding order, which often requires adjustments on our part andmakes the process more difficult,” she added. Eventually Sandywould like to see e-Supply include the consumables, QC and/orreagents for the SP-1000i (Slide Maker Stainer) as well as theflexibility to create a reagent order without receiving an alert, sheadded. Currently Mobile Infirmary processes 350 – 400 samplesdaily.Here is how e-Supply works.Prior to e-Supply start-up, each customer is asked to provide acompleted information sheet and a pre-determination of theminimum level of stock inventory or “safety stock” for each product.Recommended inventory level will consider reagent usage based oninstrumentation, volume and ordering pattern. This baseline will becompared with the customer's actual usage to ultimately determinestock level and reagent delivery.Stock level also considers factors such as maximum adjust days(How close to an existing order can this reagent be ordered?), maximumsupply days (How many days maximum supply should the customerhave on hand?) and minimum supply quantity (How many daysminimum supply should the customer have on hand?). If the safetystock is reached, an automatic e-mail will be generated at least fivedays before re-order point to notify the customer. If the customerdoesn't accept or reject the initial order notification, a second emailnotification will be sent; followed by a call from the SysmexCustomer Service Center if necessary.Once a customer has reviewed and approved an order throughSysmex's Customer Resource Center (CRC), the order will beshipped from Sysmex to the customer within the site's delivery timeframe.Delivery timelines consider factors such as minimum days betweenorder alerts, consolidation adjustment window, customer orderapproval window, estimated shipping time and the customer'sminimum stock levels. Customers can track orders through theSysmex CRC e-Supply page under the REPORTS tab.Sysmex America Two-time “Company That Cares” Award WinnerSysmex America has been selected by the Center for Companies That Care for a second consecutive year as an employerdemonstrating consistent practice of “10 Characteristics of a Company That Cares”. These characteristics include:developing employees and leaders, supporting the pursuit of work/life balance, sustaining a work environment foundedon dignity and respect for all employees, providing competitive compensation and benefits, and volunteering in thecommunity. The 2010 Companies That Care Honor Roll is selected by an independent panel of seasoned professionals ina variety of industries.“We are honored that Sysmex America has beenRoll. We understand that our employees arerole as an employer committed to thebeing of our employees,” said KarenResources, Sysmex America, Inc.included in the 2010 Companies That Care Honorour greatest asset and, as such, embrace ourprofessional development and personal wellStoneman, Vice President of HumanCenter for Companies That Care is a nationalnot-for-profit 501(c) (3) organization dedicatedto recognizing employers whose values andpractices enhance employee well-being andsupport the needs of society as well as theprofitability of their businesses. Those namedto the 2010 list feature U.S. organizations that arelarge, medium and small, public and private, forprofit and not-for-profit, in diverse industries headquartered in 18 states.“We are extremely impressed that during a tough economy the Honor Roll employers – such as Sysmex America, Inc. – aredoing whatever they can to sustain individuals, families, and communities. Not increasing employees' benefits costs,decreasing expenses in other areas to keep providing merit increases and recognition programs, and continuing to engageemployees in community service are just a few actions these employers have taken,” said Marci Koblenz, Co-founder andPresident of Center for Companies That Care.The Honor Roll is announced annually in conjunction with the annual launch of CAREDAYS, a month-long nationalinitiative to engage individuals and employers in activities addressing a significant societal issue.More Information onSysmex Fall Webinar Serieswill be available soon.A list will be posted onthe Sysmex CustomerResource Center when itbecomes available.