Transcription
Radioisotopes and radiopharmaceuticals for nuclearmedicine in GeorgiaMedea Abramishvili (TSU-Masters program: Nuclear physics and nuclear safety)Supervisor: prof. Revaz ShanidzeAug 23, 2018Page 1
Contents: Introduction Radioisotopes used in Georgia Radioisotope production and import in Georgia Example:Aversi clinic Summary and outlookPage 2
IntroductionRadio-isotopes for nuclear medicine:- Diagnostic (nuclear / molecular imaging):Biologically active elements (H, C, O.), Short life-time, . . .- Therapy/treatment60Co(radiation therapy),192Ir– brachytherapy- Calibration sources:57Co, 68Ge, 137CsPage 3
Physical properties of radionuclides used in nuclear medicine studiesSource:Radionuclide andradiopharmaceutical productionPage 4
Radioisotope productionNuclear reactorCyclotronUsed to produce radioactive very short livedtracers such as fluorine-18Page 5
Neutron-activated radionuclides of importance in biology and medicinePage 6
Medical facilities that use radio-isotopes fordiagnosis/treatmentAversi- Center of nuclearmedicine.Radioisotopes:99mTc, 131IClinical medicinescientific-researchinstitute- ToduaRadioisotopes: 99mTc,131I, 18F, 192Ir, 68Ge, 57Co,137CsRadiation medicine centerRadioisotopes: 99mTc, 131I,60CoPage 7
Radio-isotopes used in GeorgiaIsotopeT1/2Eγ(kev)Nuc. Med.Production18F(β )109.78 m511ImagingCyclotron99mTc6.01 h140ImagingReactor(99Mo/99mTcGenerator)8.02 d364ImagingTreatmentReactor131I(γ)(β-)ClinicRMC, HIMCAversi, RMC, RICMAversi, RMC, RICM60Co(γ)5.2714 y1173TreatmentReactorRMC192Ir(β )73.8 d180TreatmentAcceleratorRMC57Co272 d14.4CyclotronRMC68Ge270.8 d10630.08 y1170137Cs(β-)– Research Institute of Clinical Medicine (Medical Center ofAcad. Todua)2RMC - Radiation Medicine CenterFor calibrationFor calibrationFor calibration76GeRMCReactorRMC1RICMPage 8
Import ofradioisotopesin ge 7
Radio-isotopes also can be produced bygenerators. For example, isotope 99mTc isproduced from 99Mo, which is imported inGeorgia from Iran by company called“Parstek”, also from turkish company “Monrol”.
Example: Aversi- center of nuclear medicineGamma-camera used in AversiUsed for 2 radioisotopes:99mTc, 131IPage 8
Example from Aversi nuclear medicine center:Full body scan with 99mTc (bone scintigraphy)Page 9
Nuclear medicine treatmentBasically, Radioactive Iodine (131I) is the onlyisotope used for treatment of thyrotoxicosis.Therapeutic effect depends on emission of β rays.Isotope is Imported from Hungary.Page 12
Example from Aversi nuclear medicine center:Thyroid scan with 99mTcPage 10
Summary and Outlook Radio-isotopes in Georgia are imported from different countries Research nuclear reactor (Mtskheta) – was decommissioned in 1990. PET scan require short lived radio-isotope (18F) –! limiting factor for the PET-technique in Georgia Cyclotron for radio-isotope production in Georgia is under considerationPage 13
Thank you for attention!Page 14
Medea Abramishvili (TSU-Masters program: Nuclear physics and nuclear safety) Supervisor: prof. Revaz Shanidze Aug 23, 2018 Page 1. Contents: Introduction Radioisotopes used in Georgia Radioisotope production and import in Georgia Example: Aversi clinic Summary and outlook
