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CHRISTINE M. HEIMPage 5 of 34PROFESSIONAL SOCIETY SERVICES2001Contributions to development of a “Brain Briefing” on Child Abuse (web-basededucational materials), Society for Neuroscience, USA2002Contributions to development a “Brain Briefing” on Depression and StressHormones (web-based educational material; newsletter), Society forNeuroscience, USA2003Membership Committee, International Society for Psychoneuroendocrinology2003-2005Development of a “Behavioral Health Curriculum” for the education ofBehavioral Health Care Providers regarding the etiology, diagnosis, andtreatment of Chronic Fatigue Syndrome (paper brochures, webpage and onlinecourse), Continuing Medical Education (CME), American Chronic Fatigue andImmune Dysfunction Syndrome (CFIDS) Association, Charlotte, NC, USA2004-2005Contribution to a “Public Awareness Campaign” on Chronic Fatigue Syndrome,a project of the Centers for Disease Control & Prevention (CDC), Atlanta, GA,with a contractual agreement with the American Chronic Fatigue and ImmuneDysfunction Syndrome (CFIDS) Association, Charlotte, NC, USA2005Deputy Chair for Medical and Biological Sciences, 21st Annual Meeting of theInternational Society for Traumatic Stress Studies (ISTSS), Toronto, Canada.2006Program Committee, Neurobiology, 22nd Annual Meeting of the InternationalSociety for Traumatic Stress Studies (ISTSS), Hollywood, CA.2007Program Committee, Neurobiology, 23rd Annual Meeting of the InternationalSociety for Traumatic Stress Studies (ISTSS), Baltimore, MD.2009Awards Committee, International Society for Traumatic Stress Studies (ISTSS)2010Fundraising lecture for NARSAD, Atlanta, GA, USA2012-2014Service on Training & Education Committee, ACNP2012-2014Travel Awardee Selection, ACNP2012Public Advocacy Forum (The Developing Brain: How Research and Advocacy isShaping Public Policy), Neuroscience 2012, Annual Meeting, New Orleans, LA,USARESEARCHRESEARCH FOCUS Psychobiological consequences of early adverse experience, i.e. child maltreatment andother developmental stressors Neurobiology of stress, depression & anxiety disorders, including posttraumatic stressdisorder Psychoneuroendocrinology of functional somatic syndromes Neural correlates of stress and emotion Interactions between neural and endocrine systems in stress-related disorders Interactions of stress and dispositional factors across development Prevention/treatment of stress-related disorders Methods of psychoneuroendocrinology Differential treatment response as a function of early traumaGRANT SUPPORT Principal Investigator/Coordinator: Christine Heim; BMBF; 07/01/2013-06/30/2016;Research Network Project: Immediate Biological Embedding of Maltreatment in Children:Berlin Longitudinal Children Study (BerlinLCS); 2.2 Million Principal Investigator: Christine Heim; NeuroCure Innovation Funds; 04/01/201303/21/2014; Validation of Intranasal Oxytocin for Human Neuromaging Studies; 15.000

CHRISTINE M. HEIM Page 6 of 34Investigator within NeuroCure Excellence Cluster (Coordinators: Schmitz/Rosenmund);Deutsche Forschungsgemeinschaft (DFG); 11/01/2008-10/31/2012; 40 Million; Renewal11/01/2012-10/31/2016: 25 MillionPrincipal Investigator: Christine Heim; K01 MH073698-01; NIMH; 07/01/200604/15/2011; Neural Substrates of Depression Risk after Child Abuse; 641.736Principal Investigator: Christine Heim; Junior Faculty Research Grant; Anxiety DisordersAssociation of America (ADAA); Mitgefördert durch Novartis Pharmaceuticals; 04/01/200609/30/2010 (nce); Regulation of Human Fear Responses by Cortisol Status: ANeuroendocrine fMRI Study; 30.000Principal Investigator: Christine Heim; Young Investigator Award; National Alliance forResearch in Schizophrenia and Depression (NARSAD); 07/01/2005-06/30/2010 (nce);Imaging Neural Substrates of Depression Risk after Child Abuse: Processing of MaskedEmotional Faces; 60.000Co-Investigator (Principal Investigator: Kerry Ressler); R01 MH071537-01A1; NIMH;09/01/2005-08/31/2010; Genetic and Trauma-Related Risk Factors for PTSD; ; 405.683/yearCo-Investigator (Principal Investigator: Clinton Kilts); R01 DA019999-01; NIDA;09/01/2006-08/31/2011; An fMRI Study of the Impact of Stress on Drug Addiction; 125,000/yearPrincipal Investigator: Christine Heim; Institutional Personnel Agreement (IPA); Centers forDisease Control & Prevention; 12/15/2009-11/30/2010; Epidemiological and ClinicalStudies of Chronic Fatigue Syndrome; 30.000Co-Investigator (Principal Investigator Viola Vaccarino, M.D., Ph.D.); R21 HL093665-01; NIH;04/01/2009-03/31/2011; Sex Differences in Myocardial Ischemia Triggered by EmotionalFactors after MI; 250.000Co-Investigator (Principal Investigator Charles Raison); R01 MH070553-01A1; NIMH;01/13/2005-12/31/2009; Risk Factors for Interferon-Induced Depression in Patients withHepatitis C; 202.500/yearSubproject Principal Investigator (Center PI: Clinton Kilts); 2P50 MH-58922; NIMH;09/16/2004-09/15/2009; Emory Conte Center for the Neuroscience of Mental Disorders;Subproject Title: Clinical Psychobiology of Early Life Trauma; Subproject: 150.000/year;total center: 1.9 Mio/year.Principal Investigator: Christine Heim; IPA; Centers for Disease Control & Prevention;04/01/2005-03/31/2007; IPA with Centers for Disease Control & Prevention (CDC)Principal Investigator: Christine Heim; Young Investigator Award; National Alliance forResearch in Schizophrenia and Depression; 7/1/2002-3/31/2007 (nce); Neurobiologicaland Hematological Correlates of Child Abuse in Adult Men: Relevance for Major Depressionand Cardiovascular Disease; 59.800Co-Principal Investigator (Principal Investigator William C. Reeves); CDC IntramuralFunding; 09/30/2004-12/31/2005; Survey of Chronic Fatigue Syndrome and ChronicUnwellness in Georgia; 4 MillionPrincipal Investigator: Christine Heim; IPA; Centers for Disease Control and Prevention;09/28/2001-09/16/2005; IPA with Centers for Disease Controls & Prevention (CDC); 247.590Co-Investigator (Principal Investigator William C. Reeves). CDC Clinical Studies of ChronicFatigue in Wichita, KS. Intramural Funding; 7 MillionSubproject Principal Investigator (Principal Investigator: Dirk H. Hellhammer); DFGResearch Group (FOR 255); DFG; 01/01/2000-12/31/2002; Prj. D: Mechanisms ofHypocortisolism in PTSD, Pelvic Pain and Fibromyalgia; Prj. F: Mechanisms of Stress

CHRISTINE M. HEIM Page 7 of 34Sensitization after Early Adversity; Subprojects D/F: 460.000; total research group: 2.1Million.Principal Investigator: Christine Heim; B1Y-MC-X176; Eli Lilly Company; 09/01/199906/30/2006; Does Fluoxetine Reverse Neurobiological & Behavioral Effects of EarlyAdversity?Co-Investigator (Principal Investigator: Charles B. Nemeroff); P50 MH-58922; NIMH;09/20/1999-08/31/2004; Emory Conte Center for the Neuroscience of Mental Disorders;Subproject 100.000/year, total center 1.8 Mio/year.Postdoctoral stipend: Christine Heim, Ph.D.; DFG; 01/01/1997-06/30/1998Predoctoral stipend: Christine Heim; Rheinland-Pfalz, State Ministry for Education andResearch; 01/01/1994-12/31/1996OTHER RESEARCH ACTIVITIES AND COLLABORATIONS Early stress and cardiovascular risk (Collaboration with Dominique Musselman, M.D., M.S.,Associate Professor, Department of Psychiatry & Behavioral Sciences, University of Miami,Miami, FL) Psychoneuroimmunology of early adverse experience (Collaboration with Andrew H. Miller,M.D, William P. Timmie Professor, und Thaddeus Pace, Ph.D., Assistant Professor,Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine,Atlanta, GA, USA) Psychobiology of endometriosis (Collaboration with Friedrich Wieser, M.D., AssistantProfessor, Department of Obstetrics & Gynecology, Emory University School of Medicine,Atlanta, GA, USA) Structural and functional neuroimaging studies in relation early-life trauma (Collaborationwith Helen S. Mayberg, M.D, Professor of Psychiatry and Neurology and Dorothy Fuqua Chairof Psychiatric Neuroimaging and Therapeutics, Depts. of Psychiatry & Behavioral Sciencesand Neurology, Emory University School of Medicine, Atlanta, GA, USA) Cortical thickness mapping in childhood trauma (Collaboration with Jens C. Pruessner, Ph.D.,McGill University, Montreal, Canada) Gene-environment interactions after early trauma (Collaboration with Elisabeth B. Binder,M.D., Ph.D., Max Planck Institut für Psychiatrie, München, Germany & Assistant Professor,Dept. of Psychiatry & Behaviroal Sciences, Emory University School of Medicine, Atlanta, GA,USA) Metabolic effects of early trauma (Collaboration with Charles Gillespie, Assistant Professor,Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA, USA)TEACHINGCURRICULUM DEVELOPMENT1. Model Curriculum in Human Medicine, Charité University Medicine Berlin, Member ofLeadership Committee for the development of the module “Psyche and Pain”, 2011-present2. Development of seminars and lectures for the Model Curriculum in Human Medicine, CharitéUniversity Medicine Berlin, 2011-present3. Development of seminars for the curriculum „Medical and Nursing Education“, CharitéUniversity Medicine Berlin, 2011-present4. Model Curriculum in Human Medicine, Charité University Medicine Berlin, Member ofLeadership Committee for the development of the module “Psychiatric Disorders”, 2013present

CHRISTINE M. HEIMPage 8 of 34FORMAL TEACHING1. Hellhammer D, Heim C, et al. 1993-1996. Symptomatik, Ätiologie und Verlauf psychischerStörungen: Psychosomatische Störungen. Seminar, 2 hours weekly for Masters students inpsychology. University of Trier, Trier, Germany2. Heim C. 1999-2001. Biopsychologie (A and B). Lecture, 2 hours weekly for undergraduatesin psychology. University of Trier, Trier, Germany3. Heim C. 1999-2001. Empirie-Praktikum (I and II). Practice, 2-4 hours weekly forundergraduates in psychology. University of Trier, Trier, Germany4. Hellhammer D, Heim C, et al. 1999-2001. Forschungsorientierte Vertiefung.Gesundheitspsychologie und Psychosomatik (A and B): Psychosomatische Störungen. Seminar,2 hours weekly for Masters students in psychology. University of Trier, Trier, Germany5. Heim C, 2002. Translational Research Seminar in Developmental Psychopathology, EmoryUniversity School of Medicine and Psychology Department, Atlanta, GA, USA6. Heim C, 2005. Seminar for doctoral students in neuroscience and psychology, Center forBehavioral Neuroscience, Georgia State University, Atlanta, GA, USA7. Heim C, 2006. Journal Club. Emory University School of Medicine, Department of Psychiatry& Behavioral Sciences, Atlanta, GA, USA8. Heim C, 2009. Block seminar for doctoral students (5 days). Dept. of Clinical Psychology,University of Zurich, Zurich, Switzerland9. Heim C, 2011-present. Modellstudiengang, Biopsychosoziale Aspekte in der Medizin, Lecture,Module 1; Charité University Medicine, Berlin, Germany10. Heim C, 2011-present. Modellstudiengang, Stress und Stressverarbeitung; Seminar, Module6; Charité University Medicine, Berlin, Germany11. Heim C, 2011-2012. Modellstudiengang, Wissenschaftliches Arbeiten; Practice, Module 8;Charité University Medicine, Berlin, Germany12. mierungderKrankheitsvulnerabilität; Seminar, Module 20; Charité University Medicine, Berlin, Germany13. Heim C, 2012-present; Modellstudiengang, Das gestresste Gehirn; Seminar, Module 20;Charité University Medicine, Berlin, Germany14. Heim C, 2013-present; Modellstudiengang, Neurobiologie von Partnerschaft; Seminar,Module 22; Charité University Medicine, Berlin, GermanyEXAMINATIONS1. Heim C, 1999-2011. Written exam for undergraduates in biopsychology (2 exam cycles peryear). University of Trier, Trier, Germany2. Heim C, 1999-2001. Oral exam in psychology (M.S.), co-examiner, 2 exam cycles per year.University of Trier, Trier, Germany3. Heim C, 1999-2005. Defense of theses (Ph.D.), co-examiner, University of Trier, Trier,Germany4. Heim C, 2011. Dissertation committee, Emory University School of Medicine, Atlanta, GA,USA.5. Heim C, 2011-present. Responsible for exams in Medical Psychology in Reform CurriculumHuman Medicine, Model Curriculum Human Medicine, and Medical and Nursing Education,Charité University Medicine Berlin, Berlin, Germany.6. Heim C, 2011. Interviews for selection of medical students from applicants. CharitéUniversity Medicine Berlin, Germany.7. Heim, C, 2012-present. Defense of theses for MD degrees and habilitations, CharitéUniversity Medicine Berlin, Germany

CHRISTINE M. HEIMPage 9 of 34SUPERVISORY TEACHINGSupervision of Masters Students1. Tanja Mletzko, Mentor, University of Trier, Trier, Germany, 1999-2000; Thesis:Psychological and Endocrine Features of Pelvic Pain2. Veronika Engert, Mentor, University of Trier, Trier, Germany, 2000-2002; Thesis: StressReactivity in Institutionalized Children3. Tanja Schad, Mentor, University of Trier, Trier, Germany, 2000-2002; Thesis: MRIMeasurement of Adrenal Cortex Volume in Patients with Hypocortisolism4. Silke Welter, Mentor, University of Trier, Trier, Germany, 2000-2003; Thesis:Psychoendocrine-immune interactions after Childhood TraumaSupervision of Ph.D. Students1. Iris Schmidt, Mentor, University of Trier, Trier, Germany, 1999-2004; Dissertation: FearPotentiated Startle reactivity and Discrimination Learning of Safety Cues after ChildhoodAbuse (funded through DFG grant to CH; Summa cum laude; Dissertation Award of TheUniversity of Trier)2. Katja Wingenfeld, Mentor, University of Trier, Trier, Germany, 1999-2004; Dissertation:Mechanisms of Hypocortisolism in PTSD, Pelvic Pain and Fibromyalgia (funded through DFGgrant to CH; Magna cum laude); was awarded a Heisenberg W2 Professorship in 2013.3. Gunther Meinlschmidt, Mentor, University of Trier, Trier, Germany, 2000-2005;Dissertation: Psychobiology of Childhood Trauma (funded through stipend fromCusanuswerk; Summa cum laude)4. Andrea Liatis, Member of Dissertation Committee, Emory University, Atlanta, GA, USA 20072011; Dissertation: Norepinephrine Regulation of Inflammatory Responses during MonocyteActivation and Differentiation and during Acute Stress in Patients with Major Depression5. Juliane Wissmann; Institute of Medical Psychology, Charité University Medicine, Berlin,Germany, 2011-present.6. Noemie Jacoby, Institute of Medical Psychology, Charité University Medicine, Berlin,Germany, 2012-present.7. Judith Overfeld, Institute of Medical Psychology, Charité University Medicine, Berlin,Germany, 2012-present.8. Laurel Raffington, Berlin School of Mind and Brain, Berlin, Germany, 2013-present.9. Nora Moog, Berlin School of Mind and Brain, Berlin, Germany, 2013-present.Supervision of Postdoctoral Fellows1. Kristin Penza, Ph.D. (University of Oregon), Emory University, Atlanta GA, USA, 2002-2004;Psychobiology of Childhood Trauma2. Dieter Wagner, Ph.D. (University of Trier), Centers for Disease Control & Prevention, Atlanta,GA, USA, 2003-2004; Psychobiology of Chronic Fatigue Syndrome3. Mathias Majer, Ph.D. (Max Planck Institute of Psychiatry), Emory University, Atlanta GA, USA,2004-2006; Cognitive Dysfunction after Childhood Trauma; Cognition in CFS4. Thaddeus Pace, Ph.D. (University of Colorado Boulder), Emory University, Atlanta GA, USA,2005-2006 (Collaboration, post-doc of Dr. Andrew H. Miller); Neuroendocrine-ImmuneInteractions in Depression5. Urs Nater, Ph.D. (University of Zurich), Emory University, Atlanta GA, USA, 2005-2007(funded through Swiss National Science Foundation); Psychobiology of CFS (Dr. Naterreceived the following awards related to his work during his postdoc: Irmela-Florin Award,German Society of Behavioral Medicine, 2007; Early Career Award, International Society forBehavioral Medicine, 2006; Scholar Award, American Psychosomatic Society; He wasselected for a Lichtenberg Professorship in 2010; in 2012 he was awarded the Charlotte andKarl Bühler Award of the German Society for Psychology)

CHRISTINE M. HEIM6.7.Page 10 of 34Beate Ditzen, Ph.D. (University of Zurich), Emory University, Atlanta GA, USA, 2005-2007(funded through Swiss National Science Foundation); Psychobiology of FunctionalGynecological DisordersOrla Hornung, Ph.D., Institute of Medical Psychology, Charité University Medicine, Berlin,Germany, 2011-present.OTHER TEACHING ACTIVITIES1. “Brain Briefing” on Child Abuse and the Brain (web-based educational materials,newsletter), Society for Neuroscience, USA, 20012. “Brain Briefing” on Depression and Stress hormones (web-based educational materials,newsletter), Society for Neuroscience, USA, 20023. Trier Social Stress Test training for peers from other institutions, pharmaceuticalcompanies, etc. (preparation of a TSST Manual in English, educational slides, GCRC nursetraining), 2001-20054. Training/courses in Diagnostic Interview Schedule (DIS), Structured Clinical Interview forDSM-IV (SCID), and various psychometric testing instruments for CDC and subcontractors(educational slides, courses, practice, selection of staff; organized trainings together with Dr.Michael First and Abt Associates; 10 training sessions held in Wichita, Macon, Atlanta,Chicago), 2001-20055. CANTAB training and quality control for CDC and contractors (practice; training sessions inWichita, Macon, Atlanta), 2003-20056. Student Advisor, Psychoneuroimmunology Research Society (PNIRS), Amelia Island, FL,USA, 20037. Faculty, Anxiety Disorders Association of America (ADAA), Continuing Medical Education,Seminar on Anxiety Disorders, Toronto, Canada, 20038. Faculty, American Psychiatric Association (APA), Continuing Medical Education, Seminar onAnxiety Disorders, San Francisco, CA, USA, 20039. Faculty, American Psychiatric Association (APA), Continuing Medical Education, Seminar onMood Disorders, San Francisco, CA, USA, 200310. Faculty, Short Course on Mood Disorders, Psychoneuroimmunology Research Society(PNIRS), Amelia Island, FL, USA, 200311. Training in childhood trauma interviews and translation of US interviews for variousGerman research groups, 2003-200812. Provider Education, Behavioral Health Curriculum, CDC and American Chronic Fatigue andImmune Dysfunction Syndrome (CFIDS) Association, Development of Continuing MedicalEducation materials (brochures, texts, website, online CME course) for mental healthprofessionals, 2003-200513. Provider Education, Rehabilitation Health Curriculum, CDC and American Chronic Fatigueand Immune Dysfunction Syndrome (CFIDS) Association, Development of ContinuingMedical Education materials (brochures, texts, website, online CME course) on CFS forrehabilitation health professionals, 2004-200514. Public Awareness Campaign on Chronic Fatigue Syndrome, a public education project of theCenters for Disease Control & Prevention (CDC) with a contractual agreement with theAmerican Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) Association(brochures, ads, etc.).15. Faculty, Workshop for graduate students in Psychology, Neuroscience, and Medicine, LeidenUniversity Medical Center, Leiden, The Netherlands, 200616. Faculty, Seminar for Honors-Class, Department of Psychology, University of Leiden, TheNetherlands, 200617. Summer School, Visiting Scholar, Doctoral Student Program, 3 day seminar on “Early-LifeStress”, Institute for Psychology, University of Zurich, Switzerland, 2009.

CHRISTINE M. HEIMPage 11 of 3418. Visiting Professor, Graduate School for Psychology and Graduate School for Neuroscience,University of Helsinki, Helsinki, Finland. Block Seminar on Early Life Stress: Human Studies,201119. Textbook chapters, 30 chapters (see below)20. Invited speaker, keynote/plenary speaker, and Grand Rounds speaker ( 70) at institutes orconferences (see

CHRISTINE M. HEIM Page 1 of 34 CHRISTINE MARCELLE HEIM Curriculum Vitae . OFFICE ADDRESS. Institute of Medical Psychology . Charité Center for Health and Human Sciences . Charit