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Copyright 2001-2012 Synergix Ltd. All rights reserved.Molecular Conceptor 2Installation GuideStandalone version

September 2012Copyright Synergix Ltd. 2001-2012. All rights reserved. No part of this publicationmay be reproduced, transmitted, transcribed, stored in a retrieval system, ortranslated into any language in any form by any means without the writtenpermission of Synergix Ltd.Software License NoticeYour license agreement that is included with the product specifies thepermitted and prohibited uses of the product. Any unauthorized duplication oruse of the software in whole or in part, in print, or in any other storage andretrieval system is forbidden.Licenses and TrademarksMolecular Conceptor 2 is a trademark of Synergix Ltd.Windows 98, Windows 2000, Windows ME, Windows XP, Windows Server2003, Windows Vista, Windows Server 2008, Windows 7 are registeredtrademarks of Microsoft Corporation.Novell is a registered trademark of Novell, Inc.Viewer ActiveX Control is a registered trademark of Accelrys, IncHASP is registered trademarks of Aladdin Knowledge System Ltd.All other trademarks, brands, and product names used in this guide aretrademarks of their respective owners.Page 2

A. Table of ContentsA.B.C.Table of Contents .3Molecular Conceptor 2 License .4Introduction .9C.1System Requirements .9C.2Contents of the Standalone Package .9C.3Viewer ActiveX Control .10C.4The HASP Key.10D. Software Installation .11D.1Installation of Molecular Conceptor .11E. Running Molecular Conceptor .15F. Uninstall procedure .19F.1Uninstall Molecular Conceptor .19F.2Uninstall HASP key Driver.19G. Questions or Problems .19Page 3

B. Molecular Conceptor 2 LicenseSynergix Synergix Electronic End-User Software License AgreementTHIS AGREEMENT IS A LEGAL DOCUMENT. READ IT CAREFULLYBEFORE COMPLETING THE INSTALLATION PROCESS AND USINGTHE SOFTWARE. IT PROVIDES A LICENSE TO USE THE SOFTWAREAND CONTAINS WARRANTY INFORMATION AND LIABILITYDISCLAIMERS. BY INSTALLING AND USING THE SOFTWARE, YOUARE CONFIRMING ACCEPTANCE OF THE SOFTWARE ANDAGREEING TO BECOME BOUND BY THE TERMS OF THISAGREEMENT. IF YOU DO NOT WISH TO DO SO, DO NOT COMPLETETHE INSTALLATION PROCESS. PROMPTLY RETURN THE ENTIREPACKAGE TO THE PLACE WHERE YOU OBTAINED IT, FOR A FULLREFUND.1.Definitions(a) "Synergix" means Synergix Ltd. and its licensors, if any.(b) "Software" means the programs which may also include documentation,associated media (e.g.:text(s), Molecule(s), 3D visualization(s), picture(s),animation(s)), printed materials, voice(s), and online and electronicdocumentation, supplied by Synergix herewith, and any and all updates thereto.(c) "Network License" means a multi users license of the Software accessibleacross a network controled by Aladdin License Manager. License terms allowfor example 50, 100 (or more) users to access the software concurrently.2.LicenseThis Agreement allows you to:(a) Install and use the Software on a single computer and make one copy ofthe Software in machine-readable form solely for backup purposes. You mustreproduce on any such copy all copyright notices and any other proprietarylegends on the original copy of the Software.Page 4

(b)If you have purchased a Network License for the Software product, youmay install the Software on a storage device, such as a network server, and runthe Software on an internal network only, provided the number of concurrentusers does not exceed the number authorized by the Network License.(c)If you have the evaluation version or the demo version of the Software,you may use it for internal testing and evaluation purposes only.3.License RestrictionsOther than as set in Section 2, you may not install the Software on a storagedevice, such as a network server, and run the Software on an internal network,you may not use the Software without the supplied protection key, you may notmake or distribute copies of the Software, or electronically transfer theSoftware from one computer to another or over a network. You may notdecompile, reverse engineer, disassemble, or otherwise reduce the Software toa human-perceivable form. You may not lend, rent, lease, sublicense, ortransfer for value the Software. You may not modify the Software or createderivative works based upon the Software. You may not copy or post any partof it on any network computer or broadcast it in any media. You may not giveaccess to the software from a computer outside your institution, (e.g. accessfrom a web page). You may not transfer the software or any part of it, into anyother application, media, or viewer (e.g. PowerPoint, html page). You may notcreate hard-copy of the software or any part of it.4.OwnershipThe foregoing license gives you limited rights to use the Software. Althoughyou own the media on which the Software is recorded, you do not become theowner of, and Synergix Ltd. retains title to, the Software, and all copiesthereof. All rights not specifically granted in this Agreement, including Federaland International Copyrights, are reserved by Synergix.5.Limited Warranties(a) Synergix warrants that, for a period of ninety (90) days from the date ofdelivery (as evidenced by a copy of your receipt): (i) when used with arecommended hardware configuration, the Software and the protection key willperform in substantial conformance with the documentation supplied with theSoftware; and (ii) that the media on which the Software is furnished will befree from defects in materials and workmanship under normal use. EXCEPTPage 5

AS SET FORTH IN THE FOREGOING LIMITED WARRANTY, SynergixDISCLAIMS ALL OTHER WARRANTIES OR CONDITIONS, EITHEREXPRESS OR IMPLIED, INCLUDING THE WARRANTIES ORCONDITIONS OF MERCHANTABILITY, FITNESS FOR A PARTICULARPURPOSE AND NONINFRINGEMENT. IF APPLICABLE LAW IMPLIESANY WARRANTIES WITH RESPECT TO THE SOFTWARE AND THEPROTECTION KEY, ALL SUCH WARRANTIES ARE LIMITED INDURATION TO NINETY (90) DAYS FROM THE DATE OF DELIVERY.No oral or written information or advice given by Synergix, its dealers,distributors, agents or employees shall create a warranty or in any way increasethe scope of this warranty.(b) (USA only)SOME STATES DO NOT ALLOW THE EXCLUSIONOF IMPLIED WARRANTIES, SO THE ABOVE EXCLUSION MAY NOTAPPLY TO YOU. THIS WARRANTY GIVES YOU SPECIFIC LEGALRIGHTS AND YOU MAY ALSO HAVE OTHER LEGAL RIGHTS WHICHVARY FROM STATE TO STATE.6.Exclusive RemedyYour exclusive remedy under Section 5 is to return the Software and theprotection key to the place you acquired it, with a copy of your receipt and adescription of the problem. Synergix will use reasonable commercial efforts tosupply you with a replacement copy of the Software and/or the protection keythat substantially conforms to the documentation, provide a replacement fordefective media, or refund to you your purchase price for the Software, at itsoption. Synergix shall have no responsibility if the Software has been altered inany way, if the media has been damaged by accident, abuse or misapplication,or if the failure arises out of use of the Software with other than arecommended hardware configuration. After 90 days, basic cost may apply forreplacement of the software and/or protection key.7.Limitation of Liability.IN NO EVENT WILL SYNERGIX OR ITS SUPPLIERS BE LIABLE TOYOU FOR ANY CONSEQUENTIAL, INDIRECT, INCIDENTAL,PUNITIVE OR SPECIAL DAMAGES, INCLUDING ANY LOST PROFITSOR LOST SAVINGS, EVEN IF A REPRESENTATIVE OF SYNERGIX ORANY SUPPLIER HAS BEEN ADVISED OF THE POSSIBILITY OF SUCHDAMAGES, OR FOR ANY CLAIM BY ANY THIRD PARTY. SOMEPage 6

STATES OR JURISDICTIONS DO NOT ALLOW THE EXCLUSION ORLIMITATION OF INCIDENTAL OR CONSEQUENTIAL DAMAGES, SOTHE ABOVE LIMITATIONS MAY NOT APPLY TO YOU.8.TerminationWithout prejudice to any other rights, Synergix may terminate this LA if youfail to comply with the terms and conditions of this LA. In such event, youmust uninstall and destroy all your copies of Molecular Conceptor .9.General Disclaimer.ALL CONTENT OF THE SOFTWARE IS PROVIDED "AS IS" ANDWITHOUT WARRANTIES OR REPRESENTATIONS OF ANY KIND,EITHER EXPRESSED OR IMPLIED. TO THE FULLEST EXTENTPERMISSIBLE UNDER APPLICABLE LAW, SYNERGIX DISCLAIMSALL WARRANTIES AND REPRESENTATIONS, EXPRESSED ORIMPLIED, RELATING TO SUCH CONTENT, INCLUDING BUT NOTLIMITED TO ANY WARRANTIES AND REPRESENTATIONS OFNONINFRINGEMENT OF THIRD PARTY INTELLECTUAL PROPERTYRIGHTS, TITLE, MERCHANTABILITY, AND FITNESS FOR APARTICULAR PURPOSE.ALTHOUGH SYNERGIX WISHES THECONTENT OF THE SOFTWARE TO BE ACCURATE, COMPLETE, ANDCURRENT, SYNERGIX DOES NOT WARRANT OR REPRESENT THATANY CONTENT OF THE SOFTWARE IS ERROR-FREE, COMPLETE, ORCURRENT, THAT USE OF SUCH CONTENT WILL BEUNINTERRUPTED, THAT DEFECTS WILL BE CORRECTED.APPLICABLE LAW MAY NOT ALLOW THE EXCLUSION OF CERTAINWARRANTIES, SO THESE EXCLUSIONS MAY NOT APPLY TO YOU INWHOLE OR IN PART.10. (USA only)Government End UsersRESTRICTED RIGHTS LEGEND This software is "Restricted ComputerSoftware." Use, duplication, or disclosure by the U.S. Government is subjectto restrictions as set forth in this Agreement and as provided in DFARS227.7202-1(a) and 227.7202-3(a) (1995), DFARS 252.227-7013 (OCT 1988),FAR 12.212(a)(1995), FAR 52.227-19, or FAR 52.227-14, as applicable.Manufacturer: Synergix Ltd., Hataassiya 8, Jerusalem ISRAELPage 7

11. (Outside of the USA only)Consumer End UsersThe limitations or exclusions of warranties and liability contained in thisagreement do not affect or prejudice the statutory rights of a consumer; i.e., aperson acquiring goods otherwise than in the course of a business.12. GeneralThis Agreement shall be governed by the internal laws of Israel. ThisAgreement contains the complete agreement between the parties with respectto the subject matter hereof, and supersedes all prior or contemporaneousagreements or understandings, whether oral or written. All questionsconcerning this Agreement shall be directed to: Synergix Ltd, Hataassiya 8, Sh.Cohen Building. Office 316, 93420 Jerusalem ISRAEL Attention: LegalDepartment.Page 8

C. IntroductionThank you for purchasing Molecular Conceptor, the unique molecularmodeling and drug design courseware.C.1System RequirementsThe minimum system requirements to install and run Molecular Conceptorare as follows: C.2 350 MHz Intel Pentium processorWindows 7 / Vista / XP / 200390 MB of free available system RAM800 MB of available disk space24-bit color monitorDVD-ROM driveSound card with speakers (optional for audio support)One available standard USB port for hardware protection deviceMicrosoft .Net Framework version 2.0or Microsoft .Net Framework version 3.5 SP1Internet Explorer 5.5 or higherContents of the Standalone PackageHASP key (Hardware protection device, See section C.4)Molecular Conceptor DVD-ROMInstallation GuideQuick Installation CardPage 9

C.3Viewer ActiveX ControlThe 3D visualization of molecules in Molecular Conceptor 2 is based on"Viewer ActiveX Control" from Accelrys IncFor more information about the Accelrys Viewer products visit http://www.accelrys.comC.4The HASP KeyNote: MC team began to introduce a new version of Molecular Conceptor,which does not depend on a hardware key. Detailed instructions for using thisversion can be found on our website –http://www.drugdesign.com/web/support/license activationThe HASP key is a small hardware device (sometimes called a dongle) thatprotects Molecular Conceptor against piracy. You must insert the key intoyour computer USB port only AFTER the completion of the installationprocedure.Page 10

D. Software InstallationD.1Installation of Molecular ConceptorNote: Molecular Conceptor must be installed by a user with administratorprivileges.To Install:1. Close all Windows applications.2. Insert the Molecular Conceptor DVD into your DVD-ROM drive. If the"Molecular Conceptor Installation Setup" doesn't automatically run, doubleclick the 'mc2 setup.exe' program in the root directory of the DVD.3. Click Next.Page 11

4. Read carefully the License Agreement.5. If you accept all the terms, click I accept the agreement and press Next.Page 12