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29 Brain tumors diagnostic. Multidisciplinar residential managementcourse of cerebral glioma Cosenza 4-6 October 200730 Vertebroplasty in 32 European Congress of Neuroradiology – Genova21-23 September 200731 Pathological findings in Animal Study after intradiscal epidural andintraforaminal injection of Oxygen-Ozone. World congress Of Ozonetherapy . Pechino 12 September 2007 Beijing32 Etiopathogenesis of vertebrogenic pain and diagnostic problemsrelated Bergamo 23rd National Congress AINR 20-23 June 200733 Spinal interventional Radiology Itinerary course AINR NoceraInferiore 18-19 May 200734 Aspetti Neuroradiologici TC e RM della fossa cranica anteriore.Workshop sul basicranio. Approcci transuranici alla fossa cranicaanteriore. Napoli 19-21 nov 200735 Cutting Edge in Vertebroplasty. Annual meeting American SocietySpine Radiology Indian Wells 19-22 febbraio 200836 Interventional Radiology of the spine.Antalya- Key note lecture 29thnational Meeting of the Turkish Society of Radiology 1-4 November200837 Epidural and facet joint injection. Antalya- Categorial Course 29thnational Meeting of the Turkish Society of Radiology 1-4 November200838 Intradiscal treatment of HNP with oxygen-ozonotherapy – Cracow 33rdmeeting of European Society of Neuroradiology 18 -21 September200839 Spine anatomy and bio –mechanics . Rome – 43 SIRM Congress 2226 May 200840 Cutting edge in Vertebroplasty. Report at Annual Meeting AmericanSociety Spine Radiology Indian Wells 19-22 February 200841 Intradiscal ozonotherapy. USA New York -16 AIM Symposium 19-21November 200842 New device in spine augmentation .Spine Radiology joint MeetingESNR – ASSR Roma july 9-11 2009.43 Diagnostic imaging in brain tumors. Cosenza Multidisciplinary coursein managementof brain tumors 26-28 February 200944 Medical treatment of osteoporosis. Orlando 13 meeting ASSR– 19-22February 200945 ECR Wien 2010, Percutaneous spine treatment46 Congresso Nazionale SIRM 2010. Anatomia e Biomeccanica delrachide.47 ESNR Annual meeting Athens sept 2010. Percutaneous disk treatment48 Degenerative facet joints disease. ESNR Annual meeting AntwerpSept 201149 Spine disease treatment. WFTIN Meeting, Cape Town Nov 201150 ECR Wien 2011. Ozone treatment51 Percutaneous treatment of spinal disease ECR Wien 201252 New device in vertebral augmentation. ASSR Meeting Miami 201253 Overview on disk treatment. 12-16 april 2012, Milan, ESNRP.Lasjunias Course54 How to retreat spine pain. 12-16 april 2012, Milan, ESNR P.LasjuniasCourse55 Il rachide degenerative 45 Congresso Nazionali SIRM Torino giugno201256 Spine metastasis, how to treat. ESNR Annual meeting, Edimburgh, 1923 sept 201257 Advanced in spine intervention, ESNR Annual meeting, Edimburgh,19-23 sept 201258 Biomechanic of the spine- Annual Meeting SENR, Società Spagnola diNeuroradiologia 18-20 ottobre 2012, Alicante59 Overview on spine intervention, Annual Meeting SENR, SocietàSpagnola di Neuroradiologia 18-20 ottobre 2012, AlicantePage 8 - Curriculum vitae ofMuto MarioFor more information go /comm/education/index en.htmlwww.eurescv-search.com

60 Oxygen ozone therapy in the treatment of disk disease, CongressoNazionale Società Francese di Radiologia Paris 18-23 ottobre 201261 The vessel wall: angiogenesis and vascular repair. European Courseof diagnostic and interventional neuroradiology ESNR. 2-6 nov Antalya2012 , Turkey62 Anatomy and imaging technique of the extracranial neck vessels.European Course of diagnostic and interventional neuroradiologyESNR. 2-6 nov Antalya, 2012 Turkey63 Spinal cord vasculariuzation. Anatomy and imaging. European Courseof diagnostic and interventional neuroradiology ESNR. 2-6 nov 2012Antalya, Turkey64 American Society Spine Radiology Annual Meeting Phonenix ArizonaFebruary 2013. Update on assisted technique65 European Congress of radiology Vienna 4-7 march 2013. Overview onhead trauma66 European Congress of radiology Vienna 4-7 march 2013Percutaneous Spine Interventions67 European Course of diagnostic and interventional neuroradiologyESNR. Cerebral vasoconstriction syndrome 3-7 nov Antalya, 2013Turkey68 European Course of diagnostic and interventional neuroradiologyESNR.Workshop on Spinal MRA and CTA: how, when and why. 3-7nov 2013 Antalya, Turkey69 Tecniche assistite per il rachide. Congresso nazionale AINR , L’Aquila,19-21 settembre 201370 I trauma vertebrali. Congresso Nazionale Sezione RadiologiaInterventistica della SIRM Catania 17-19 ottobre 201371 World Federation Intervention and Therapeutic Neuroradiology BuenosAires 9-13 nov 2013. Spine metastases: how I do it.72 Spine course of the ESNR. Geneve 9-12 dec 2013.73 Convegno annual della sezione di Neuroradiologia della SIRM. MilanoOspedale S. Raffaele 13 dicembre 2013PATENTPCT PATENT APLLICATION IB2004/003706APPARATUS AND METHOD FOR ADMINISTERING ATHERAPEUTICAGENT INTO TISSUEPage 9 - Curriculum vitae ofMuto MarioFor more information go /comm/education/index en.htmlwww.eurescv-search.com

ADDITIONAL INFORMATIONIndexed publications:1)Rubinstein-Taybi syndrome. Description of a case].Muto R, Bozzi V, Muto M, Di Giulio P, Lembo G.Radiol Med. 1986 Jul-Aug;72(7-8):584-5.2) A bilateral mixed laryngocele: CT findings.Muto R, Muto M, Cirillo LC, Bozzi V, Fondacaro R, Muto M, Belfiore G, Muto P,Porta E.Rays. 1986 May-Aug;11(2):69-71.3) La Risonanza Magnetica nei trauma vertebrali recenti .M.Muto, H. Wang, Rivista di Neuroradiologia 5, 55-63, 19924) 4) Macroentesopathy ossificans of rotuleous tendon. N. Pappone, R. Meoli,M.Muto. Radiol Med 87, 506-508, 19945) 5) MR in intramedullary pathology. M.Muto, R. Izzo, A. Palmieri, Rivista diNeuroradiologia, 7, 605-615, 19946) Spondilolisi e spondilolistesi. Stato dell’arte.R. Izzo, M.Muto, G.Fucci, Rivista di Neuroradiologia, 8, 693-707, 19957) Le stenosi del canale lombare. Stato dell’arte.R. Izzo, M.Muto, G. Fucci, S. Simpatico, Rivista di Neuroradiologia, 8,557-567,1995.8) Associazione di multipli emangiomi cavernosi sovratentoriali condisplasia venosa in fossa cranica posteriore.M.Muto, G.Fucci, R.Izzo, F.A. De Falco, L.MajelloRivista di Neuroradiologia 9, 233-238, 19969) Diagnostic imaging of the disk-root fightM.Muto, E Meary, JF MederRivista di Neuroradiologia 10:519-522,199710) Intraosseous pneumocyst of the ileum: CT findings in two cases andliterature reviewO. Catalano, F De Rosa, M.Muto, European Radiology 7, 1449-1451, 199711) Non discal lumbar radiculopathy: combined diagnostic approach by CT andMRM.Muto,G. De Maria, R Izzo, G. Fucci, I AprileRivista di Neuroradiologia 10:165-173,199712) Magnetic Resonance Imaging with fluid attenuated pulse sequences inevaluation of craniospinal lesions A. Palmieri, M.Muto, R.Izzo, C.GirardiRivista di Neuroradiologia 10, 223-234, 199713) Compressive Vertebral Angioma. Case report and literature reviewR.Izzo, M.Muto, G.Fucci, G. Cantatore, S Simpatico, F. AvellaRivista di Neuroradiologia 11, 103-112,199814) 14) Percutaneous treatment of herniated lumbar disc by intradiscal oxygenozone injection. Muto M, Avella F.Interv Neuroradiol. 1998 Dec 20;4(4):279-86.15) 15) CTA and DSA evaluation of patients with subarachnoid haemorrhage.M.Muto, R Bonsignore, G. Ambrosanio, G. Esposito, L. Cesaro, U. Di Furia,A.Palmieri. Rivista di Neuroradiologia, 12: 399-408, 1999Page 10 - Curriculum vitae ofMuto MarioFor more information go /comm/education/index en.htmlwww.eurescv-search.com

16) CTA and DSA in the evaluation of patients with subarachnoidhaemorrhage.M.Muto, R Bonsignore, G. Ambrosanio, G. Esposito, L. Cesaro, U. Di Furia, A.Palmieri. Rivista di Neuroradiologia, 12: 399-408, 199917) Gunshot wounds of the cranium studied with computerized tomography.Personal experience in 23 cases].Salzano A, De Rosa A, Scialpi M, Rossi E, Carbone M, Brunese L, Nocera V,Muto M.Radiol Med. 2000 Jan-Feb;99(1-2):26-30.18)The role of computed tomography in gunshot lesions of the chest. Theauthors' personal experience].Salzano A, De Rosa A, Carbone M, Rossi E, Muto M, Tuccillo M, Nunziata A,Brunese L.Radiol Med. 1999 Nov;98(5):356-6219)The role of computed tomography in assessing subphrenic abscesses afterposttraumatic splenectomy.Salzano A, Rossi E, De Rosa A, Carbone M, Amodio F, Muto M, Accattatis V,Brunese L. Radiol Med. 1999 Sep;98(3):173-7.20) Defecography and treatment of essential anal painSalzano A, Carbone M, Rossi E, De Rosa A, Muto M, Amodio F, Rea G, GinolfiF.Radiol Med. 1999 Jul-Aug;98(1-2):48-52.21) Defecography in rectal wall prolapse conditions.Salzano A, Muto M, De Rosa A, Ginolfi F, Tuccillo M, Carbone M, Amodio F,Rossi E.Radiol Med. 1999 Jun;97(6):486-90.22)Dilatation of the ventriculus terminalis of the conus medullaris: MR findingsin two patients. M.Muto, A PalmieriRivista di Neuroradiologia 13, 755-758,200023)Duplicazione isolata del peduncolo ipofisario: ultimo stadio di uno spettromalformativo ? A.A. Diano, M.Muto, L.Galasso, G. Rossi, A PalmieriRivista di Neuroradiologia 14, 437 443, 200124) Treatment of herniated lumbar disc by intradiscal and intraforaminaloxygen-ozone injection. M.Muto . C. Andreula, M. Leonardi. J. Neuroradiol, 31,183-189, 200025) Malattia da deposito di cristalli di – idrato pirofosfato di calcio alocalizzazione peri-odontoidea ed associazione con os-odontoideumM.Muto, A.A. Diano, L.Galasso , A Crispino, E. Muto, A PalmieriRivista di neuroradiologia 14, 471 478 , 200126) Interventional CT guided neuroradiology in pain syndrome managementM.Muto, A Palmieri. Functional Neurology 370, (16) 4 200127) La vertebroplastica nel trattamento delle lombalgie su base porotica e dellelesioni secondary vertebrali M.Muto, R Bonsignore, A Palmieri. Rivista diNeuroradiologia 14 , 287 290, 200128)Interventional spinal procedures. C. Andreula, M. Leonardi, M.Muto.European Journal of Radiology 50,2, 112-119 May 200429)Alterazioni indotte da infiltrazioni intradiscali ed intramuscolari di ossigenoozono. Studio anatomo patologico. M.Muto , G. De Dominicis. Rivista italianadi Ossigeno Ozonoterapia 3,7-13,2004Page 11 - Curriculum vitae ofMuto MarioFor more information go /comm/education/index en.htmlwww.eurescv-search.com

30)Metastasi intraperitoneali da medulloblastoma. Presentazione di un caso erevisione della letteratura. M.Muto , R. Izzo, A. Palmieri. Rivista diNeuroradiologia 2004.31)La vertebroplastica nel trattamento delle sindromi algiche del rachide.M.Muto , Muto E, Izzo R, Diano A, Lavanga A, Di Furia U, Radiol Med109:208-219, 2005.32) Biomechanics of the Spine II. The loss of Integrity and Stability of thespine. R. Izzo, A.A. Diano, M.Muto . Rivista di Neuroradiologia 18: 592-605,2005.33) Vertebroplasty in the Treatment of Spine Disease. Ambrosanio G, LavangaA, Vassallo P, Izzo R, Diano AA, M.Muto. Interventional Neuroradiology 11:309-323, 200534)Percutaneous vertebroplasty: indications, contra-indications, technique andcomplications . C. Andreula, G. Guglielmi, M.Muto L. Giloula Acta Radiologica46(3), 256-68, 200535)Biomechanics of the Cervical Spine. Izzo R, Diano A, M.Muto RivistaMedica Vol. 12 n 3-4 Settembre- Dicembre 2006.36)Neuropsycological assessment , quantitative MRI and ApoE genepolymorphism in a series of MS patients treated with IFN beta 1b. Lanzillo R,Prinster A, Scarano V, Liuzzi R, Coppola G, Florio C, Salvatore E, SchiavoneV, Brunetti A, Muto M, Orefice G, Alfano B, Bonavita V, Brescia Morra V. JNeurol Sci, Jun 15,245,141-145, 200637)La RM nello studio dei pazienti talassemici affetti da eritropoiesi extramidollare spinale: diagnosi e follow-up a distanza dopo trattamentospecifico. Diano AA, Izzo R, Prossomariti L, Vassallo P, Zeccolini F, Muto M.Rivista di Neuroradiologia 19:50-56, ottobre 200638) Spettroscopia RM Single-Voxel nello studio dei glomi cerebrali: correlazioniisto-patologiche negli astrocitomi ad alto grado operati e follow-up nei lowgrade non-trattati. Diano AA, Misciasci T, Di Gaeta A, Capobianco E, LavangaA, Muto M.Rivista di Neuroradiologia 19:50-56, ottobre 200639)Posterior Fossa Arteriovenous Pial Fistula: Diagnostic and EndovascularTherapeutic Features. A Case Report. Izzo R., Diano A M.MutoRivista di Neuroradiologia 19: 783-786, 2006.40)Biomechanics of the Spine III. The Cranio-Cervical Junction. R. Izzo, ADiano, M.Muto. The Neuroradiology Journal 20: 209-217, 200741)Stenting intracranico. Guarnieri G, Izzo R, M.Muto. Rivista Medica.Vol.14.n.4.77-83, dicembre 200842) Low back pain and sciatica: treatment with intradiscal intraforaminal 02 03injection.Our Experience. M.Muto ,Ambrosanio G, Guarnieri G, Capobianco E,Piccolo G, Annunziata G, Rotondo A Radiol Med 113:695-706, 200843)Vertebroplasty and kyphoplasty: friends or foes? Muto M, Perrotta V,Guarnieri G, Lavanga A, Vassallo P, Reginelli R, Rotondo A. Radiol Med113,1171-1184, 200844) NeuroImaging: le nuove tecniche per una diagnosi più precisa. M.Muto , ADiano, R. Izzo, 3-23,Tumori Cerebrali, anno 2, vol 2., 200845) Ruptured, dissecting posterior inferior cerebellar artery aneurysms:endovascular treatment without parent vessel occlusion. Cellerini M,Page 12 - Curriculum vitae ofMuto MarioFor more information go /comm/education/index en.htmlwww.eurescv-search.com

Mangiafico S, Ammannati F, Ambrosanio G, Muto M, Galasso L, MennonnaP.M.Muto Neuroradiology, 315-320, Vol. 50, 200846) Vertebroplasty in the treatment of osteoangioma. Guarnieri G, AmbrosanioG, Vassallo P, Pezzullo MG, Galasso R, Lavanga A, Izzo R, Muto M.Neuroradiology July 51, 7, 471-476 200947) Management of vertebral re-fractures after vertebroplasty in osteoporoticpatients. Guarnieri G, Izzo R, Zeccolini, M.Muto Interventional Neuroradiology15,153-157,200948) A meta-analisys of the effectveness and safety of ozone treatments forherniated lumbar discs. J. Steppan, K. Murphy, M.Muto J Vasc Interv Radiolfeb 24, 2010.49) Percutaneous VP or KP. Anselmetti GC, M.Muto. G. Guglielmi, S. Masala,Radiol Clin North Am 48 (3): 641/9, 201050) Modifications or damage induced by intradiscal, epidural, intraforaminaland intramuscular gelified ethanol diffusion (Discogel)M.Muto , G. De Dominicis. The Neuroradiology Journal 201051) Percutaneous VP relieves pain metastatic cervical fractures. Masala S,Anselmetti GC, M.Muto, Mammuccari M, Volpe G, Simonetti Clin Ortop RelatRes 469:715-22, 201152) Vertebral augmentation: 7 years experience. Anselmetti GC, Bonaldi G,Carpegiani P, Manfrè L, Masala S, M.Muto Acta Neurochirurgica sup, 108:14761, 2011.53) Facet Joint Disease. M.Muto. Neuoradiology oct 2011 Sep;53 Suppl1:S167-854) Vertebral Body Stenting System for the Treatment of OsteoporoticVertebral Compression Fracture: Follow-up at 12 Months in 20 Cases.Muto M, Greco B, Setola F, Vassallo P, Ambrosanio G, Guarnieri G.Neuroradiol J. 2011 Aug 31;24(4):610-9.55) Osteoporotic vertebral compression fractures augmentation by injectablepartly resorbable ceramic bone substitute : a prospective nonrandomizedstudy. Masala S, Nano G, Marcia S, Muto M, Fucci FP, Simonetti GNeuroradiology aug 11, 201156) Italian multicenter experience with flow-diverter devices for intracranialunruptured aneurysm treatment with periprocedural complications-aretrospective data analysis.Briganti F, Napoli M, Tortora F, Solari D, Bergui M, Boccardi E, Cagliari E,Castellan L, Causin F, Ciceri E, Cirillo L, De Blasi R, Delehaye L, Di Paola F,Fontana A, Gasparotti R, Guidetti G, Divenuto I, Iannucci G, Isalberti M,Leonardi M, Lupo F, Mangiafico S, Manto A, Menozzi R, Muto M, Nuzzi NP,Papa R, Petralia B, Piano M, Resta M, Padolecchia R, Saletti A, Sirabella G,Bolgè LP.Neuroradiology. 2012 May 957) PERCUTANEOUS VERTEBROPLASTY: MULTI-CENTRIC RESULTSFROM EVEREST EXPERIENCE IN LARGE COHORT OF PATIENTSG. Anselmetti, M.Muto, S. Marcia, S. Masala, G. Bonaldi, L. Manfrè,European Journal of Radiology 16-AUG-201258) Role of computed tomography in the assessment of intraorbital foreignbodies.Page 13 - Curriculum vitae ofMuto MarioFor more information go /comm/education/index en.htmlwww.eurescv-search.com

Pinto A, Brunese L, Daniele S, Faggian A, Guarnieri G, Muto M, Romano L.Semin Ultrasound CT MR. 2012 Oct;33(5):392-5.59)Future trials of endovascular mechanical recanalisation therapy in acuteischemic stroke patients - A position paper endorsed by ESMINT and ESNR :Part II: methodology of future trials.Fiehler J, Söderman M, Turjman F, White PM, Bakke SJ, Mangiafico S, vonKummer R, Muto M, Cognard C, Gralla J.Neuroradiology. 2012 Sep 560)Future trials of endovascular mechanical recanalisation therapy in acuteischemic stroke patients: a position paper endorsed by ESMINT and ESNR :Part I: Current situation and major research questions.Fiehler J, Söderman M, Turjman F, White PM, Bakke SJ, Mangiafico S, vonKummer R, Muto M, Cognard C, Gralla J.Neuroradiology. 2012 Sep 5.61) Biomechanics of the spine. Part I: Spinal stability.Izzo R, Guarnieri G, Guglielmi G, Muto M.Eur J Radiol. 2012 Oct 19.62)Biomechanics of the spine. Part II: Spinal instability.Izzo R, Guarnieri G, Guglielmi G, Muto M.Eur J Radiol. 2012 Oct 19.63) Editorial: «Interventional Neuroradiology: a Neuroscience sub-specialty?».Rodesch G, Picard L, Berenstein A, Biondi A, Bracard S, Choi IS, Feng L,Hyogo T, Lefeuvre D, Leonardi M, Mayer T, Miyashi S, Muto M, Piske R,Pongpech S, Reul J, Soderman M, Chuh DS, Tampieri D, Taylor A, TerbruggeK, Valavanis A, van den Berg R.Interv Neuroradiol. 2013 Sep;19(3):263-70. Epub 2013 Sep 26.64).Endovascular strategy for unruptured cerebral aneurysms.Mangiafico S, Guarnieri G, Consoli A, Ambrosanio G, Muto M.Eur J Radiol. 2013 Oct;82(10):1638-45.65) Epidemiology and genetics of intracranial aneurysms.Caranci F, Briganti F, Cirillo L, Leonardi M, Muto M.Eur J Radiol. 2013 Oct;82(10):1598-605.66) Percutaneous treatment of symptomatic aneurysmalbone cyst of L5 by percutaneous injectionof osteoconductive material (Cerament)G Guarnieri P Vassallo, M Muto, M MutoJNIS 2013 in pressBook1) La TC e la RM nelle radicolopatie lombari. Fucci G., Muto MIdelson ED, 19962)Interventional Neuroradiology of the Spine, M.Muto Editor, Springer 2012Book ChapterPage 14 - Curriculum vitae ofMuto MarioFor more information go /comm/education/index en.htmlwww.eurescv-search.com

1) Intradiscal intraforaminal oxygen ozone therapy. In Miniinvasive spine procedure. Mathis J Editor, Springer, 20072) Periradicular therapy in Image guided Interventions ,Mauro, Murphy Thomson, Venbreux, Zollikofer Editors,Saunders Elsevier 20083) Percutaneous disk intervention in Image guidedInterventions , Mauro, Murphy Thomson, Venbreux,Zollikofer Editors, Saunders Elsevier 20084) Neuroradiologia Interventistica endovascolare inNeuroradiologia Testo – Atlante CIC EdizioniInternazionali 2010. Bastianello S, e coll5) Neuroradiologia Interventistica spinale in NeuroradiologiaTesto – Atlante CIC Edizioni Internazionali 2010.Bastianello S, e coll6) Ra

subjects/occupational skills covered Training Dates (from - to) 1996 April - May Name and type of organisation providing education and training Ospedale S.Maria della Misericordia - Udine - Servizio di Radiologia Title of qualification awarded Training Dates (from - to) 1990 July . therapy . Pechino 12 September 2007 .