AUGUST 2020 THE LEADING MAGAZINE FOR . - Endocrine News

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HIG H LIG HTS FROMAUGUST 2020THE LEADING MAGAZINE FORENDOCRINOLOGISTSIN A heartbeatI NTE R N ATI O N A LEndocrine-Disrupting Chemicalsand Cardiovascular HealthAs heart disease continues to kill more Americans than any otherailment each year, more endocrine research is linking endocrinedisruptors to cardiovascular health. Despite a lack of significant action toreduce EDCs, patients can take steps to avoid exposure to these compounds.CEU 2020 PREVIEW:An investigation into “thyroid imposters”SPECIAL INTEREST GROUPS:Introducing the Endocrine Society’s Transgender SIG

THE LEADING MAGAZINE FOR ENDOCRINOLOGISTS2020 – 2022 EDITORIAL ADVISORY BOARDHenry Anhalt, DOBergen County Pediatric EndocrinologySally Camper, PhDDepartment of Human GeneticsUniversity of Michigan Medical SchoolRodolfo J. Galindo, MDAssistant Professor of MedicineMount Sinai School of MedicineChristian M. Girgis, MBBS, PhD, FRACPRoyal North Shore and Westmead HospitalsUniversity of Sydney, AustraliaAndrea Gore, PhDDivision of Pharmacology and ToxicologyUniversity of TexasDaniel A. Gorelick, PhDBaylor University, Houston, TexasM. Carol Greenlee, MD, FACPWestern Slope EndocrinologyGrand Junction, Colo.(Faculty for Transforming Clinical Practice initiative [TCPi])Gary D. Hammer, MD, PhDMillie Schembechler Professor of Adrenal Cancer,Endocrine Oncology ProgramUniversity of MichiganRobert W. Lash, MDChief Professional & Clinical Officer, Endocrine SocietyKarl Nadolsky, DOAssistant Clinical Professor of Medicine,MSU College of Human MedicineSHMG EndocrinologyJoshua D. Safer, MD, FACPExecutive Director, Center for Transgender Medicine and SurgeryMount Sinai Health SystemProfessor of MedicineIcahn School of Medicine at Mount SinaiNew York, NYShehzad Topiwala, MD, FACEEndocrinology DepartmentSevenHills Hospital, Mumbai, IndiaKristen R. Vella, PhDBeth Israel Deaconess Medical CenterHarvard Medical SchoolChristina Wang, MDTUNE INTO OURNEW JOURNAL CLUBPODCAST SERIESSTAY UP-TO-DATEON MEDICAL LITERATUREUCLA Clinical and Translational Science InstituteHarbor – UCLA Medical CenterMihail “Misha” Zilbermint, MDDivision of Endocrinology, Diabetes and Metabolism,Johns Hopkins University School of Medicine;Endocrinology, Diabetes and Metabolism, Suburban Hospital;Johns Hopkins Community Physicians 2020 ENDOCRINE SOCIETY

IN THIS ISSUEAUGUST 202020 CEU Preview:Investigating Thyroid ImpostersIn a preview of his on-demand CEU 2020 session, “When It’s Not YourThyroid,” James V. Hennessey, MD, presents a series of questions aboutthyroid patients, what their symptoms mean, as well as what they don’t mean.BY KELLY HORVATH26 Introducing the Endocrine14Society’s Transgender Special InterestGroup14 Veiled Threats: NewThese newly established, member-led communities will foster both onlineinteraction and in-person collaboration on specific topics.BY JENNA SARVAIDEO, DOFindings Show More Links BetweenEDCs and Cardiovascular Health30 The ShowAs heart disease continues to kill moreAmericans than any other ailment annually,more endocrine research is linking endocrinedisruptors to cardiovascular health. Despitea lack of significant action to reduce EDCs,patients can reduce their own exposure tothese compounds.When the world was thrown into disarray earlier this year due to the COVID-19pandemic, ENDO 2020 in San Francisco was one of the many casualties.All was not lost, however, as the Endocrine Society quickly regrouped andrebounded and hosted the completely virtual ENDO Online 2020 takingplace over two weeks in June and reached thousands of endocrine scientistsand clinicians around the world.Must Go On: Highlights of ENDO Online 2020BY DEREK BAGLEYBY DEREK BAGLEY2 PRESIDENT’S VIEWPOINTMore Connected, United, andInclusive Than Ever4 FROM THE EDITORA Look Back and a Look Forwardat ENDO Online 20206 InTOUCHRemembering Robert B. Jaffe, MD;Endocrine Society urges Congressto increase NIH funding.8 TRENDS & INSIGHTSFDA approves oral somatostatinanalog for acromegaly;Long-term culture of humanpancreatic slices reveals theregeneration of insulin-producingcells in real time; and Multi-center study addresses impactof COVID-19 on people with type1 diabetes.on metabolomics to unlock themysteries of cardiometabolicdiseases.BY DEREK BAGLEYBY GLENDA FAUNTLEROY SHAW11 DASHBOARD44 PRACTICE RESOURCESHighlights from the world ofendocrinology12 ENDOCRINE ITINERARYScientific meetings of interestto endocrinologists from aroundthe world40 LABORATORY NOTESPUSHING BOUNDARIESFresh from receiving his 2020Laureate Award for OutstandingInnovation, Christopher B.Newgard, PhD, discusses howcollaboration has shaped hisresearch and why he focusesSLEEPY HEADFor residents and early-careerclinicians, a lack of sleep is anongoing health hazard. EndocrineNews looks at ways to help youcope with sleep deprivation so youcan give your patients the bestcare possible, as well as take careof your own health.BY CHERYL ALKON47 ADVOCACYAdvocacy results in rapid reversal ofvisa restrictions; Endocrine Societymembers meet with EU leaders todiscuss EDCs; and How you makeyour voice heard advocating forendocrine science and practice.50 HORMONE HEALTHNETWORKUnderstanding X-LinkedHypophosphatemeia52 CLASSIFIEDSCareer opportunitieswww.endocrine.orgFollow us on Twitter:@Endocrine NewsENDOCR INE NEWS AUGUS T 2 0 2 0 1

PRESIDENT’S VIEWPOINTMore Connected,United, andInclusive ThanEverThis year has dealt us many challenges. During times like these, we leanon our professional communities for strength, encouragement, andguidance. Despite our inability to gather, socialize, and learn in person,I’m immeasurably proud that our global endocrine community is now all themore connected, united, and inclusive.This is no coincidence — we’re a resilient group of change-makers and gamechangers who are committed to advancing the science of endocrinology andimproving the health and well-being of those we serve. In that spirit, our diversecommunity has embraced digital learning as one alternative form of connecting,and in doing so, obviated traditional barriers such as time and distance. This newnormal has propelled us forward and already demonstrated meaningful benefitsfor our expanding community.ENDO Online 2020 by the Numbers“We’re a resilientgroup of change-makersand game-changerswho are committedto advancing the scienceof endocrinology andimproving the healthand well-being ofthose we serve.”2 AUGUS T 2 0 2 0 ENDOCR INENEWS.ORGENDO Online 2020, our inaugural online conference, attracted more than27,500 registrants, the largest event in our longstanding history! Here are a fewstats that will surely pique your interest: 19 international societies endorsedthe event; upwards of 3,000 learners tuned-in for ancillary symposia sessions;2,381 individuals actively participated in Basic Science Day; 171% increase inmemberships processed during an ENDO conference; and, 30 exhibit booths,seven product theaters, and generous support from five sponsors.United, we hosted an Anti-Racism Vigil to acknowledge those who have sufferedfrom racial injustice and reaffirm our commitment to a more just and equitablesociety — 600 individuals reflected together in solidarity on June 16 at 10:00 a.m.Thanks to our member leaders, organizers, faculty, attendees, sponsors, and stafffor rapidly transforming the bold concept of ENDO Online 2020 into a recordbreaking reality! If you want to view and/or re-watch any sessions, all content willremain accessible to members at no cost.CEU/EBRMark your calendars for Clinical Endocrinology Update (endocrine.org/ceu2020) and Endocrine Board Review (endocrine.org/ebr2020), September 10– 12 and September 16 – 18, respectively.These programs feature content curated by experts and led by world-class faculty,in a convenient (and safe) online environment. You’ll enjoy a blend of virtual ondemand and live programming designed to maximize your learning experienceand accommodate your busy schedule. Plus, you’ll have access to the recordingsfor a minimum of 12 months. I hope you’ll take advantage of this year’s exclusivediscounted rates and join us at CEU and/or EBR!

Continued Investment in Digital LearningIn time, we will once again be able to gather in person formeetings, conferences, and networking events. Nothingcan replace those essential human-to-human interactions.That said, we have witnessed the undeniable value of digitallearning within our community. Albeit a different format,“Our diverse community hasembraced digital learning as onealternative form of connecting,and in doing so, obviatedtraditional barriers such as timeand distance. This new normal haspropelled us forward and alreadydemonstrated meaningful benefitsfor our expanding community.”we continue to lead the way with promulgating the latestendocrine science and clinical education for our learners,with the advantage of bypassing physical and travel barriers.To this end, the Endocrine Society will continue investingin digital learning, as well as in-person programs, to expandand amplify our reach in this beautifully diverse, globalcommunity.ABSTRACTSAlthough ENDO 2020 was canceledbecause of the COVID-19 pandemic, morethan 2,300 accepted abstracts are nowavailable online in a special supplementalissue of the Journal of the EndocrineSociety (JES).B I T. LY / E N D O 2 0 2 0 A B S T R A C T SUntil we can see each other in person, I look forward togiving you a virtual elbow bump at one of our upcomingonline programs.Learn more about JES,our Open Access journalat academic.oup.com/jesThank you, each of you, for all you do to serve the EndocrineSociety, and society. The world is a better place because ofyour service, talent, and contributions.Gary D. Hammer, MD, PhDPresident, Endocrine Society 2020 ENDOCRINE SOCIETYENDOCR INE NEWS AUGUS T 2 0 2 0 3

FROM THE EDITORAUGUST 2020THE LEADING MAGAZINE FOR ENDOCRINOLOGISTSA Look Back and a Look Forwardat ENDO Online 2020The Endocrine Society has been one of the strongest rallyingvoices in the world regarding the dangers of endocrinedisrupting chemicals (EDCs). The Society not only continuouslypublishes cutting-edge research on the effects of these substances onhuman health in its journals, but it is also one of the most forceful voiceswhen it comes to advocating policy makers both here in the U.S. andaround the world regarding the importance of regulating the productionand dissemination of these compounds in everyday products.“The Society is also one of the mostforceful voices when it comes to advocatingpolicy makers both here in the U.S. andaround the world regarding the importance ofregulating the production and dissemination ofthese compounds in everyday products.”This month’s cover story by senior editor Derek Bagley examines theimpacts EDCs have on cardiovascular health in “Veiled Threats” on page28. Bagley looks at two studies from the Journal of the Endocrine Society:One paper looks at a rodent study that suggests how bisphenol Asubstitutes can affect the developing fetus and cause hypertension inlater life. The other study is the first human study that links blood levelsof “forever” chemicals known as PFAS in pregnant women with the riskof obesity in their granddaughters. Both of these studies were originallygoing to be featured at ENDO 2020 in San Francisco but were insteadpresented as a virtual press conference.Even though we all missed out on a trip to San Francisco in March, Junesaw the first ever, all virtual ENDO Online 2020 that presented theEditor: Mark A. Newmanmnewman@endocrine.orgSenior Editor: Derek Bagleydbagley@endocrine.orgArt Director/Production: Anthony S. PiccoArt Director/Design: Catherine C. Neill,CNJ Creative, LLCwww.cnjcreative.comPrepress & Printing: The Sheridan Groupwww.sheridan.comEndocrine News is a registered trademark owned by theEndocrine Society.Endocrine News informs and engages the global endocrinecommunity by delivering timely, accurate, and trustedcontent covering the practice, research, and profession ofendocrinology.President: Gary D. Hammer, MD, PhDpresident@endocrine.orgPresident-Elect: Carol H. Wysham, MDchwysham@comcast.netPast-President: E. Dale Abel, MD, PhDdale-abel@uiowa.eduSecretary-Treasurer: Dolores M. Shoback, MDdolores.shoback@ucsf.eduChief Communications Officer: Aaron Lohralohr@endocrine.orgThe mission of the Endocrine Society is to advance excellencein endocrinology and promote its essential and integrative rolein scientific discovery, medical practice, and human health.Endocrine News is published 12 times a yearby the Endocrine Society, 2055 L Street, NW,Suite 600, Washington, DC 20036Phone 202-971-3636 Fax 202-736-9708www.endocrine.org.Print ISSN 2157-2089 Online ISSN 2157-2097Copyright 2020 by the Endocrine Society.All rights reserved. Please send letters to the editor, comments, and suggestions for EndocrineNews to mnewman@endocrine.org. Product print and product online display advertising,by Pharmaceutical Media, Inc., contact Joe Schuldner,jschuldner@pminy.com, or John Alberto, jalberto@pminy.com. For classified print advertising by Pharmaceutical Media, Inc.,Dan Simone, dsimone@pminy.com For classified online advertising by endocareers@endocrine.orgThe statements and opinions expressed in Endocrine News are those of individual authors and do not necessarily reflectthe views of the Endocrine Society.Advertising appearing in this publication does not constitute endorsementof its content by Endocrine News or the Endocrine Society.4 AUGUS T 2 0 2 0 ENDOCR INENEWS.ORG

latest endocrine research to an audience of almost 18,000,easily the largest Endocrine Society meeting ever held. Onpage 44 is a look at just a portion of the research presentedat this online expo. In “The Show Must Go On,” Bagleydiscusses some of the studies that were presented either liveor on-demand in June, in a format that was embraced bythe attendees and participants alike. “All the presenters inthe session were able to see each other before the start ofthe sessi

Thyroid,” James V. Hennessey, MD, presents a series of questions about thyroid patients, what their symptoms mean, as well as what they don’t mean. BY KELLY HORVATH 26 Introducing the Endocrine Society’s Transgender Special Interest Group These newly established, member-led communities will foster both online interaction and in-person collaboration on specific topics. BY