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INFANT FORMULAPREPARATION GUIDELINESAND DILUTION CHARTSFOR HEALTH CARE PROFESSIONAL USE ONLYAbbott Nutrition data on calorically dense feedings islimited. Hypocaloric and hypercaloric formulas should beused under medical supervision. 27 Cal/30 mL or more calorically dense formula may notsupply enough water for some infants. Hydration statusshould be monitored and water supplied from othersources if necessary. When using a hypo- or hypercaloric formula, monitorthe changes in vitamin and mineral status as well asgastrointestinal tolerance. For improved tolerance, it is best to increase caloricdensity slowly, by 2- to 4-Cal/30 mL increments.Ready to use cans, 235-mL and HFS bottles Do not dilute.Concentrated Liquid (40 Cal/30 mL)Standard dilution (20 Cal/30 mL) is one part concentratedliquid to one part water. See product label for detailedpreparation instructions.Caloric Density1(Cal/30 mL)ConcentratedLiquid (mL)20 (standard)2427 Water(mL)309060 FinalVolume (mL)3060306015090PowderStandard dilution (20 Cal/30 mL) is one level, unpackedscoop of powder for each 60 mL of water. See productlabel for detailed preparation instructions.Caloric Density1(Cal/30 mL)Unpacked LevelScoop(s)†20 (standard)222427 1233Water(mL) 60105150130ApproximateYield‡ (mL)60120180150Scoop Measurement and Displacement VolumesFor Infant PowdersProductGrams ofpowder perscoopDisplacementvolume perscoop‡ (mL)Displacementvolume per g ofpowder‡ 98.710.46.86.86.70.760.780.64PretermSimilac Neosure Similac Human Milk FortifierTerm InfantsSimilac Pro-Advance Step 1Similac Pro-Advance Step 2Similac Simply NurtureSimilac Alimentum Similac Advance Step 1Similac Advance Step 2Similac Step 1Similac Step 2Similac Lower IronSimilac Sensitive Lactose SensitivitySimilac Isomil Similac Total ComfortTMGo & Grow bySimilac Step 3N/A - Not applicable† Use only scoop provided in the container.‡ Values are approximate.§ Per 0.9 g packet.¶ Information was not available at the time of publication.REFERENCE:1. Adapted from Young T, Mangum B. Dilution Tables Neofax 17th ed. Raleigh NC 2004:232.12

STORAGE GUIDELINESTO ENSURE THE HIGHEST QUALITY OFUNOPENED PRODUCTSReady-to-use or concentrated liquid formats Store at room temperature.Avoid extreme temperatures. Do notfreeze. While the product would remainsterile and the nutritional quality shouldnot be affected, there could be changesto the physical consistency of the productthat could affect its appearance, flavour,and other sensory attributes.45 C40 C35 C30 C25 C20 C15 C10 C5 C0 C-5 C-10 C-15 CPowder Store in dry, cool area. Do not refrigerate.GUIDELINES FOR PREPARING ANDSTORING FORMULAHuman Milk FortificationSee individual product pages for storage instructions of: Similac Human Milk Fortifier Extensively HydrolyzedProtein Concentrated Liquid Similac Human Milk Fortifier Special Care 30 Similac Human Milk Fortifier, powder LiquiProtein Ready-to-use productsCans and bottles: after opening, cover, refrigerate, and usewithin 48 hours.Concentrated liquid products Open can (undiluted): cover, refrigerate, and use within48 hours. Prepare as per label instructions. Pour into individual feeding bottles or cups, cover, andstore in refrigerator. Use prepared formula within 48 hours.Powdered products Prepare as per label instructions. Pour into individual feeding bottles or cups, cover, andstore in refrigerator. Use within 24 hours. Cover opened container after each use. Use product within 1 month of opening container.- Similac Isomil should be used within 3 weeksof opening.If ready-to-use, undiluted, or prepared formula is leftopened at room temperature, it should be used within2 hours.1Continued on next page13

STORAGE GUIDELINESGUIDELINES FOR PREPARINGAND STORING FORMULA (continued) Once feeding begins (first time the baby’s mouthcomes into contact with the nipple), use within 1 houror discard. Do not reuse plastic bottles.If a product is consumed directly from the originalcontainer (includes use of a straw):† Use or refrigerate within 1 hour. If refrigerated, use product within 24 hours.RECOMMENDED HANG TIMESReady to use (commercially sterile) 4 hours for neonates and immunocompromisedinfants/children.2 8 hours for non-immunocompromised infants( 30 days of age) and children.2Reconstituted formulasIncludes: Concentrated liquid, powder, any formula towhich a modular product has been added, or fortifiedhuman milk. Prepare using aseptic technique. 4-hour hang times are recommended for human milkand facility-prepared formulas.2It is recommended that feeding bags, containers, andtubing be replaced with each new hang time.2Health care facilities should have guidelines in place forusing safe techniques in the preparation and administrationof feedings and should also have established qualityassurance protocols for monitoring purposes.EXPIRATION DATES To ensure the highest quality, use the product by thedate indicated. The vitamin content and the physical stability of theproduct cannot be guaranteed beyond the expiry datebecause both may degrade with time.WARNINGS Never use a microwave oven to warm formula;serious burns can result. Abbott Nutrition products are not intended forparenteral use.† This practice exposes the product to significant amounts of bacteria.REFERENCES:1. Government of Canada. Preparing and handling powdered infant formula. Last modified on 201104-12. [Accessed online on 2020-08-19]. 2. Steele C, Collins E (editors). Infant and Pediatric Feedings:Guidelines for Preparation of Human Milk and Formula in Health Care Facilities, 3rd Ed. Academy ofNutrition and Dietetics. 2019.14

IN THIS SECTIONSimilac Mom Pregnant Women andBreastfeeding MomsPREGNANT WOMEN ANDBREASTFEEDING MOMS

Pregnant Women andBreastfeeding MomsPREGNANT WOMEN ANDBREASTFEEDING MOMS

HEALTHY BABIES BEGINWITH HEALTHY MOMSPREGNANT WOMEN AND BREASTFEEDINGMOMS HAVE UNIQUE NUTRITIONAL NEEDSHealthy eating plays an important role in a healthypregnancy. A balanced diet helps support both the momand the baby’s health – and provides specific nutrientsthat are particularly important during pregnancy, includingprotein, iron, calcium, vitamin D, vitamin B12, and folicacid.Breast milk is the ideal food for babies,1 and breastfeedingmoms require optimal nutrition to ensure they haveenough energy to give their baby their best.Similac Mom is the first and only nutritional beverage forpregnant women and breastfeeding moms, to help themmeet their nutritional needs.For information on the complete Abbott Nutrition adultproduct line, visit abbottnutrition.ca.REFERENCE:1. Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee forCanada (2015). Nutrition for healthy term infants: Recommendations from birth to six months.17

SIMILAC MOM Complete, balanced nutritionFor pregnant women and breastfeeding momsINDICATIONS FOR USE For pregnant or breastfeeding women:- Who would benefit from a nutritious snack.- With increased caloric needs.- Who require increased protein, vitamins and minerals. To be used as part of an overall healthy diet that includes followingdoctor’s recommendations for using prenatal vitamins. For use with or between meals or, in appropriate amounts, as ameal replacement. Recommended intake: 1 serving per day along with the use ofprenatal vitamins. For oral feeding only.Safety precautions: Not for parenteral use. Not intended for use in infants or children.FEATURES AND BENEFITS Complete, balanced nutrition.Provides 26 vitamins and minerals.Convenient source of protein and energy to help meet theincreased needs of pregnant women and breastfeeding moms.Convenient, reclosable bottle.2 delicious flavours: Vanilla and Chocolate.TECHNICAL DATAReady to useCaloric density (Cal/mL)Protein (% of total energy)Fat (% of total energy)Carbohydrate (% of total energy)Total Cal:g nitrogen ratioNon-protein Cal:g nitrogen ratio0.96212455122:196:1Water (g/L)Osmolality (mOsm/kg water)Renal solute load (mOsm/L)Minimum tube size for gravity/pump feeding (French)837546417N/ALow ITYReady to use565838485658484818Similac Mom , VanillaSimilac Mom , Chocolate235-mL bottles235-mL bottles4 x 6/case4 x 6/case

Per 235 mLPer 100 mLENERGY (Cal [kJ])225 (945)96 (402)PROTEIN (g)125.02% of total energy21Arginine (mg)Taurine (mg)Carnitine (mg)SourceSodium and calcium caseinates, soy protein isolateFAT (g)6.02.55% of total energy24Polyunsaturated fatty acids (g)1.20.5Linoleic acid (g)1.00.43Arachidonic acid (ARA) (g)Linolenic acid (g)0.180.08Docosahexaenoic acid (DHA) (g)Omega-6:Omega-3 ratio7.4:1Monounsaturated fatty acids (g)2.31.0Saturated fatty acids (g)0.50.2SourceHigh oleic safflower oil, canola oil, corn oil, soy lecithinMCT oil (% of total fats)0CARBOHYDRATE (g)3113.2% of total energy55Total dietary fibre (g)Short-chain fructooligosaccharides (scFOS) (g)Galactooligosaccharides (GOS) (g)SourceSucrose, corn maltodextrinAcesulfame-potassium (mg)Sucralose (mg)-VITAMINSVitamin A (RE [IU])Vitamin D3 (mcg [IU])Vitamin E (IU)Vitamin K1 (mg)Vitamin C (mg)Thiamine (mg)Riboflavin (mg)Niacin (mg)Vitamin B6 (mg)Folic acid (mg)Vitamin B12 (mg)Pantothenic acid (mg)Biotin (mg)Choline (mg)350 (1166)1.25 5-149 (496)0.53 0510.00430.0119MINERALSSodium (mg)Potassium (mg)Chloride (mg)Calcium (mg)Phosphorus (mg)Magnesium (mg)Iron (mg)Zinc (mg)Iodide (mg)Copper (mg)Manganese (mg)Selenium (mg)Chromium (mg)Molybdenum (mg)Nutritional information for Similac Mom , Vanilla, 235 mL.INGREDIENTSSimilac Mom , Vanilla:Water, sugar, sodium and calcium caseinate, corn maltodextrin, high oleic safflower oil, canola oil,soy protein isolate, corn oil, natural and artificial flavours, soy lecithin, carrageenan, MINERALS(potassium citrate, sodium citrate, calcium phosphate, magnesium phosphate, magnesiumchloride, salt, potassium phosphate, zinc sulphate, ferrous sulphate, manganese sulphate, cupricsulphate, potassium iodide, sodium molybdate, sodium selenate, chromium chloride), VITAMINS(ascorbic acid, niacinamide, dl-α-tocopheryl acetate, calcium d-pantothenate, vitamin A palmitate,pyridoxine hydrochloride, thiamine chloride hydrochloride, riboflavin, folic acid, biotin, vitamin D3,cyanocobalamin).Contains: Milk, soy.Additional ingredients for Chocolate: Cocoa powder, colour.Values listed are subject to change. Please refer to the productlabel or packaging for the most current ingredient, allergenand nutrient profile information.SIMILAC MOM Complete, balanced nutritionFor pregnant women and breastfeeding momsNUTRITIONAL INFORMATIONENERGY

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PRETERM INFANTSPreterm InfantsIN THIS SECTIONSimilac Human Milk Fortifier Extensively HydrolyzedProtein Concentrated LiquidSimilac Human Milk Fortifier, powderSimilac Human Milk Fortifier Special Care 30 (HFS)LiquiProtein Similac Special Care 20 (HFS)Similac Special Care 24 (HFS)Similac Special Care 24 High Protein (HFS)Similac Neosure Similac Neosure (HFS)

Preterm InfantsPRETERM INFANTS

CARING FOR THE TINIESTPATIENTSABBOTT NUTRITION – GIVING HEALTH CAREPROVIDERS THE POWER TO DO MOREWithout the chance to develop fully in utero, infants bornprematurely are physiologically different from term infants.Early nutrition is a key factor in their survival. Each pretermbaby has individual needs, and these needs vary over timeafter birth.Human milk is the feeding of choice for preterm infants.However, neither human milk nor term infant formulasprovide preterm and low-birth-weight babies with thenecessary amounts of nutrients required for catch-up growthand optimal development. Human milk, once supplementedwith human milk fortifier, provides adequate amounts ofenergy and most nutrients, with the exception of protein,which may require additional supplementation.1Abbott Nutrition has developed a wide range of infantnutritional products to help you meet the unique andvaried nutritional needs of your preterm patients:1) The most comprehensive line of human milkfortification options Similac Human Milk Fortifier, powderUnique to Abbott Nutrition Similac Human Milk Fortifier Extensively HydrolyzedProtein Concentrated Liquid Similac Human Milk Fortifier Special Care 30 LiquiProtein 2) Preterm formulas, available in various caloricand protein densities Similac Special Care 20 Similac Special Care 24 Similac Special Care 24 High ProteinUnique to Abbott Nutrition – The Similac Liqui-MixTMSystem allows health care professionals the flexibilityto create a variety of calorically dense feedings usingSimilac Special Care formulas and Similac HumanMilk Fortifier Special Care 30.3) Preterm, post-discharge formula Similac Neosure REFERENCE:1. Koletzko B, Poindexter B, Uauy R (eds). Nutritional Care of Preterm Infants: Scientific Basis and PracticalGuidelines. World Rev Nutr Diet, Basel, Karger, 2014;110:215-27.23

SIMILAC HUMAN MILK FORTIFIEREXTENSIVELY HYDROLYZED PROTEINCONCENTRATED LIQUIDFor preterm or low-birth-weight infantsThe FIRST and ONLYsterile human milk fortifierwith extensivelyhydrolyzed protein.INDICATIONS FOR USE For preterm or low-birth-weight infants nourished with human milkthat requires fortification to meet elevated nutrient requirements. Intended as nutritional supplement to add to human milk. For oral or tube feeding use. Use under medical supervision.Safety precautions: Add only to human milk do not add water. This product is nutritionally incomplete by itself and is designedto be added to human milk. Additional iron may be necessary. Tolerance to enteral feedings should be confirmed by offeringsmall volumes of unfortified human milk. Once enteral feeding is well established, Similac Human MilkFortifier Extensively Hydrolyzed Protein Concentrated Liquid canbe added to human milk. Not intended for feeding low-birth-weight infants after they reacha weight of 3600 g (approximately 8 lb) or as directed by a healthcare professional. Not for parenteral use.FEATURES AND BENEFITS Commercially sterile liquid:- a safer choice for preterm and low-birth-weight infants;1-3- preferred for even distribution during mixing;3- heat treated for sterility (non-acidified).Concentrated to minimize displacement; each packetdisplaces 5 mL.†Extensively hydrolyzed protein for easy digestion and absorption.When added to human milk, meets expert recommendations forprotein4,5† and other nutrients for the preterm infant.4Clinically proven to support weight, length and head circumferencegains in preterm babies.6-8Safe and well tolerated by preterm infants.6-8Contains an exclusive blend of DHA, lutein and natural vitamin E,‡all found in the infant brain and eyes.9-12Low iron level provides flexibility to add iron as needed.TECHNICAL DATAReady to mixCaloric density (Cal/mL)Protein (% of total energy)Fat (% of total energy)Carbohydrate (% of total energy)Total Cal:g nitrogen ratioNon-protein Cal:g nitrogen ratioWater (g/30 mL)Osmolality (mOsm/kg water)Renal solute load (mOsm/L)Minimal tube size for gravity/pump feeding (Fr)Low rated Liquid63010A14Similac Human Milk FortifierExtensively Hydrolyzed ProteinConcentrated Liquid24 x 5-mLpackets/innercarton6 innercartons/case† One packet mixed with 25 mL of human milk yields a total volume of 30 mL.‡ RRR-α-tocopherol provided as d-α-tocopheryl acetate, the most bioactive formof vitamin E.§ Value based on 25 mL of Preterm Human Milk 1 packet of Similac Human Milk FortifierExtensively Hydrolyzed Protein Concentrated Liquid.24

The health of the infant depends on carefully following the directions for preparationand use. Proper hygiene, handl

PEDIATRIC NUTRITIONALS. This product guide provides a detailed nutritional overview of our products intended for infants and children. Our goal . is to help you provide the best care for your patient by helping you with product selecti