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Source: g (04.07.2016)Source: Murphy, Kenneth: Janeway‘sImmunobiology, 8th Edition, p. 604Non-IgE-mediated allergic diseasesSummaryMarkus RudowitzFaculty of chemistry and biochemistryMolecular Immunology 2016Wed 6th of July, 2016
Non-IgE-mediated allergic diseases Type II (e.g. penicillin allergy hemolytic anemia or thrombocytopenia) type III (soluble antigens, immune complexes; e.g. Arthus reaction, serumsickness): IgG mediated Type IV: antigen specific TH1 or CD8T cells (TH2 similar to IgE-mediatedallergic diseases; e.g.tuberculin test, poison ivy, nickel,allergic contact dermatitis,celiac disease)Modified from: Murphy, Kenneth:Janeway‘s Immunobiology, 8thEdition, p. 594Non-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.20162
Non-IgE-mediated allergic diseasesArthus reaction: local type III hypersensitivityreaction Triggered in skin by contact with sensitizing antigenAlso activation of the complement: complement fragment C5aSource: Source: Murphy, Kenneth: Janeway‘sImmunobiology, 8th Edition, p. 599Non-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.20163
Non-IgE-mediated allergic diseasesTuberculin test (type IV hypersensitivity reaction)Source: Murphy, Kenneth: Janeway‘s Immunobiology, 8th Edition, p. 601Non-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.20164
Non-IgE-mediated allergic diseasesAllergic contact dermatitis and systemic allergic contact dermatitis (type IVhypersensitivity reaction)Source: Murphy, Kenneth: Janeway‘s Immunobiology, 8th Edition, p. 602Non-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.20165
Non-IgE-mediated allergic diseasesCeliac disease Mediated by gluten; α-gliadin modified by tissue transglutaminase (tTG) tobind HLA-DQ2 Strong genetic predisposition: 95% of patients express HLA-DQ2 class MHCallele loss of mature epithelial cells in upper small intestine, severe inflammation,increased number of T cells, macrophages, plasma cells in the lamina propria;increased number of lymphocytes in epithelial layerNon-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.20166
Non-IgE-mediated allergic diseasesSource: Murphy, Kenneth: Janeway‘s Immunobiology, 8th Edition, p. 605Non-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.20167
Non-IgE-mediated allergic diseasesCeliac disease has some features of autoimmunity! Autoantibodies (IgA) against tTG in all patients used as testNo tTG-specific T cells found; gluten-reactive T cells may help B cells reactiveto tTGSource: Murphy, Kenneth: Janeway‘sImmunobiology, 8th Edition, p. 605Non-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.20168
Non-IgE-mediated allergic diseasesCeliac diseaseReasons for pathology of gluten: relative resistant to digestion, gliadin-derivedpeptides stimulate innate immune system by inducing IL-15 release byintestinal epithelial cells antigen-nonspecific process that involves peptides notbound by HLA-DQ2 and not recognized by CD4 T cells IL-15: upregulation of MIC-A expression in epithelial cells MIC-A activates CD8 T cells via NKG2D receptors thatcan kill MIC-A expressing cellsNon-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.20169Source: Murphy, Kenneth: Janeway‘sImmunobiology, 8th Edition, p. 606
Janeway‘s Immunobiology, 8th Edition, p. 594. 3 Non-IgE-mediated allergic diseases Arthus reaction: local type III hypersensitivity reaction Triggered in skin by contact with sensitizing antigen Also activation of the complement: complement fragment C5a Non-IgE-mediated allergic diseases Markus Rudowitz RUB 06.07.2016 Source: Source: Murphy, Kenneth: Janeway‘s Immunobiology, 8th .
