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P R O V E N R E S U LT SAUBAGIO REDUCED RELAPSES OVER TIME1,10AUBAGIO 14 mg maintained its impact on relapses for up to 7.5 years,in the original and the extension study of Clinical Trial 1.1,10CLINICAL TRIAL 1EXTENSION STUDYORIGINAL CLINICAL TRIAL 1ANNUALIZED RELAPSE RATE (ARR)( 95% CI)0.60.4AUBAGIO 14 mg31%Relative RiskReduction1This line shows that the rate ofrelapses decreased over time0.2Transitionto ExtensionStudy0.0ABOUT 2 YEARSABOUT 5.5 YEARSTOTAL DURATION: ABOUT 7.5 YEARSPEOPLE EXPERIENCED ABOUT 1 RELAPSE OVER 6 YEARSIN THE EXTENSION STUDY10IMPORTANT SAFETY INFORMATIONDo not take AUBAGIO if you have had an allergic reaction to AUBAGIOor a medicine called leflunomide.10Please see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.An extension study follows participantsafter the original trial has ended and looksat their long-term experience with themedication.7 riginal clinical study: 1 relapse over 2 yearsOfor patients taking placebo1 xtension study: 1 relapse over 6 years forEpatients taking AUBAGIO 14 mg10 I n the original clinical study 1: 31% reductionin relapse rate with AUBAGIO 14 mg and with7 mg vs. placebo1 I n the original clinical study 2, there was 36%reduction in relapse rate with AUBAGIO 14 mgand 22% with AUBAGIO 7 mg vs. placebo1Kyra- On AUBAGIO for1 year- Results-oriented- 24/7 momA HELPFUL TIP:Symptoms of relapses may not always bevisible. This is why it’s important to partnerclosely with your healthcare provider.Watch stories ofpeople who takeAUBAGIOPatient Portrayal

P R O V E N R E S U LT STAKE NEW LESIONS INTOACCOUNTAUBAGIO DECREASED THENUMBER OF NEW LESIONS1,9New lesions can be a “silent” sign that relapsing MS isgetting worse. You may not have symptoms but yourdisease may still be active.One clinical trial looked at brain lesions as a keymeasure of disease activity. People taking AUBAGIOhad fewer new brain lesions vs. placebo.CLINICAL TRIALA HELPFUL TIP:It’s recommended that people living withrelapsing MS have regular MRIs. Use your firstMRI as a baseline and then compare to anyMRIs performed after that.1Fewer New Lesions*with AUBAGIO 14 mg vs. placebo57% fewer new lesions withAUBAGIO 7 mg vs. placebo* Average contrast-enhancinglesions per scan.The MSAA MRI Access Fund may be able to helpeligible patients cover the cost of regular MRIs.Watch stories ofpeople who takeAUBAGIOVISIT MYMSAA.ORG TO LEARN MORE.IMPORTANT SAFETY INFORMATIONDo not take AUBAGIO if you take a medicinecalled leflunomide for rheumatoid arthritis.11Please see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.Patient Portrayal

P R O V E N R E S U LT SWHY IS IT IMPORTANT TOSLOW DISABILITY PROGRESSION?Disability progression* can affect functions of the body, such as motor,sensory, bowel and bladder, visual and mood.12A HELPFUL TIP:It’s never too early to think about slowing disability progression. If you’renewly diagnosed, talk to your healthcare provider about making this a goal.AUBAGIO 14 mgSIGNIFICANTLY SLOWEDDISABILITY PROGRESSION1AUBAGIO 14 mg was shown to help keeppeople free of disability progression.AUBAGIO 7 mg did not achieve a statistically significantreduction in risk of sustained disability progression ineither trial.CLINICAL TRIAL1Showed no disabilityprogressionwith AUBAGIO 14 mg vs. 73% with placebo78% remained free of disability progressionwith AUBAGIO 7 mg vs. 73% with placebo*Watch people answer thequestion “why AUBAGIO?"IMPORTANT SAFETY INFORMATIONAUBAGIO may stay in your blood for up to 2 years after you stop taking it. Your healthcareprovider can prescribe a medicine that can remove AUBAGIO from your blood quickly.* Healthcare providers measure disability progression using a test called the Expanded Disability StatusScale, or EDSS. Your first score—or your “baseline”—will determine how your disability is gauged movingforward. If your baseline score is 5.5, you’re considered to have sustained disability progression if thatscore goes up by 1 point (lasting at least 12 weeks). If your baseline score is 5.5, you’re considered tohave sustained disability progression if that score goes up by at least 0.5 points (lasting at least 12 weeks).The mean EDSS at baseline was 2.7 in both Clinical Trial 1 and Clinical Trial 2.112Please see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.CLINICAL TRIAL2Showed no disabilityprogressionwith AUBAGIO 14 mg vs. 80% with placebo79% remained free of disability progressionwith AUBAGIO 7 mg vs. 80% with placebo*Patient Portrayal

P R O V E N R E S U LT SAUBAGIO CONTINUED TO SLOW DISABILITYPROGRESSION OVER TIME10LEARN ON YOUR SCHEDULEIn the original and extension study of Clinical Trial 1, the majority of people takingAUBAGIO 14 mg remained free of disability progression for up to 7.5 years.8,10Stream our relapsing MS On Demand webinars anytime. Watch in-depth discussionswith MS experts designed to help you keep learning about your condition — andonce-daily AUBAGIO. You’ll also get to hear from someone living with relapsing MSwho takes AUBAGIO.EDSS SCORE CHANGE FROM BASELINE(MEAN SE)ORIGINAL CLINICAL TRIAL 1CLINICAL TRIAL 1 EXTENSION STUDY1.5Transitionto ExtensionStudy1.0AUBAGIO 14 mgPatients increased an average of less than 0.5 on the EDSS scale,which means their level of disability remained relatively stableWatch On DemandAUBAGIO webinars0.50.0-0.5IMPORTANT SAFETY INFORMATIONABOUT 2 YEARSABOUT 5.5 YEARSTOTAL DURATION: ABOUT 7.5 YEARS61% of people on AUBAGIO 14 mg remained free of disabilityprogression for up to 7.5 years in the original and extension studyof Clinical Trial 1.1013Never miss the chance to know more.Please see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.Before taking AUBAGIO, talk with your healthcare provider if you have: liver or kidneyproblems; a fever or infection, or if you are unable to fight infections; numbness or tingling inyour hands or feet that is different from your MS symptoms; diabetes; serious skin problemswhen taking other medicines; breathing problems; or high blood pressure. Your healthcareprovider will check your blood cell count and TB test before you start AUBAGIO. Talk with yourhealthcare provider if you take or are planning to take other medicines (especially medicinesfor treating cancer or controlling your immune system), over-the-counter medicines, vitaminsor herbal supplements.

HOW IT WORKSHOW AUBAGIO WORKSExploring the science behind AUBAGIO.MS is thought to occur when a distinct set of immune cells becomes destructive and attacks thecentral nervous system, specifically targeting the outer covering of the nerves known as the myelinsheath. When you take AUBAGIO it blocks an enzyme that’s needed for these cells to multiply.Blocking this enzyme is like a dimmer switch that dials down the cell’s ability to multiply. While wedon’t fully understand how AUBAGIO works in relapsing MS, we do know that it works differentlyfrom other relapsing MS medicines.1,13Patient PortrayalPatient veimmune cellimmune cellNormalimmuneNormal cellNormalimmune cellimmune munecellsdestructivedestructiveimmune cellsimmune cellsWhen you have relapsing MS,certain immune cells in your bodybecome destructive and multiply.1,13Blocked DHODHBlocked DHODHBlocked DHODHDHODHDHODHDHODHAUBAGIOAUBAGIOAUBAGIOAUBAGIO blocks an enzymecalled DHODH that thesedestructive cells need tokeep multiplying.1,13For illustrative purposes only.14Fewer destructiveimmunecellsFewer destructiveFewerdestructiveimmunecellsimmune cellsPlease see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.Taken daily, AUBAGIO is thought toreduce the number of immune cells,including destructive immune cells thatare thought to cause MS flare-ups,while still allowing normalimmune cell activity to occur.1,13IMPORTANT SAFETY INFORMATIONAUBAGIO may cause serious side effects. Tell your doctor if you have any of the following:o decreases in white blood cell count — this may cause you to have more infections. Symptomsinclude fever, tiredness, body aches, chills, nausea, or vomiting. Patients with low white bloodcell count should not receive certain vaccinations during AUBAGIO treatment and 6 monthsafter.o allergic reactions such as difficulty breathing, itching, or swelling on any part of your bodyincluding lips, eyes, throat, or tongue. Stop taking AUBAGIO and call your doctor right away.o serious skin reactions that may lead to death. Stop taking AUBAGIO if you have rash or rednessand peeling, mouth sores or blisters.o other allergic reactions that may affect different parts of the body. If you have a fever or rashin combination with severe muscle pain, swollen lymph glands, swelling of your face, unusualbruising or bleeding, weakness or tiredness, or yellowing of your skin or the whites of your eyes,stop taking AUBAGIO and call your doctor right away.o numbness or tingling in your hands or feet that is different from your MS symptomso high blood pressureo breathing problems (new or worsening) — these may be seriousand lead to death

HOW IT WORKSPOSSIBLE SERIOUS SIDE EFFECTS OF AUBAGIO1Different treatments have different side effects. It’s important to know the serious risksof any medication you take.14In addition to the risk of liver problems, including liver failure that can be life-threatening and may requirea liver transplant, and the risk of harm to an unborn baby, other possible serious side effects include: Decreasesin white blood cell count — this maycause you to have more infections Certainvaccinations should be avoidedduring treatment with AUBAGIO and for atleast 6 months after discontinuationallergic reactions that may affectdifferent parts of the body such as your liver,kidneys, heart, or blood cellsTHE MOST COMMON SIDE EFFECTS ASSOCIATEDWITH AUBAGIO1Here are some of the most common side effects reported in clinical trials.These are not all the side effects.Side effects14 mg(1002 people)7 mg(1045 people)(997 people)Headache16%18%15%Abnormal liver test results15%13%9%Diarrhea14%13%8%Hair thinning or loss13%10%5%Nausea11%8%7% Other Numbnessor tingling in your hands or feetthat is different from your MS symptoms Allergicreactions Highblood pressure Seriousskin reactions that may lead to death Breathingproblems (new or worsening) thatmay be serious and lead to deathTell your HCP ifyou have any sideeffect that bothersyou or does notgo away.Patient PortrayalTHE NUMBER OF PEOPLE WHO STOPPED TAKINGAUBAGIO DUE TO COMMON SIDE EFFECTS8,15Here are the discontinuation rates due to common side effects in clinical trials.Side effects15PlaceboAUBAGIO14 mg(1002 people)7 mg(1045 people)(997 people)Diarrhea0.4% 4 people0.5% 5 people0.1% 1 personNausea0.3% 3 people0.1% 1 person0% 0 peopleHair thinning or loss1.3% 13 people0.2% 2 people0.1% 1 personAbnormal liver test results2.6% 26 people3.3% 34 people2.3% 23 people0% 0 people0% 0 people0.3% 3 peopleHeadachePlease see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.PlaceboAUBAGIO

HOW IT WORKSPOSSIBLE HAIR THINNING OR LOSS —IT’S USUALLY TEMPORARY8You want to look your best. So, you’ll want to know what hair thinning with AUBAGIO is, and whatit isn’t. Hair thinning associated with AUBAGIO is similar to hair thinning that may happen withchildbirth, stress, or iron deficiency.16 Some people may worry that their hair thinning with AUBAGIOis similar to what may happen with chemotherapy. That is not the case.With AUBAGIO, hair thinning or loss is usually temporary and may occur around 3 months afterstarting treatment.1DosageAUBAGIO 14 mgAUBAGIO 7 mgPlaceboOutcomePercentageReported hair loss13%Did not report hair loss87%Reported hair loss10%Did not report hair loss90%Reported hair loss5%Did not report hair loss95%In clinical trials, 15 out of more than 2000 people stopped taking AUBAGIOdue to hair thinning or loss.1**Out of 2047 patients taking AUBAGIO in studies,1.3% of patients (13 people) on 14 mg and 0.2%(2 people) on 7 mg discontinued due to hairthinning or loss vs. 0.1% (1 person) on placebo.816BE READY FOR THE "SIDE-EFFECTSCONVERSATION" WITH YOUR HCPIf you are already on treatment:1. Has your experience with side effects changed or gotten worse since you first began your treatment?2. Are side effects getting in the way of your everyday activities and responsibilities?3. Do you sometimes wish you could skip your treatment because of side effects?4. Which potential side effects do you feel you can manage and which are deal-breakers?If you are new to treatment:1. Which possible side effects are deal-breakers for you?2. Have you weighed the benefits and possible risks of options you’re considering?3. Could possible side effects keep you from taking your treatment as prescribed?If side effects are getting in the way of your daily life, it may be time toreevaluate your relapsing MS treatment. And if you are looking to start yourfirst treatment, remember different treatments have different side effects.So take a moment to think about which ones are deal-breakers for you.Watch the sciencebehind hair thinningPlease see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.

G E T T I N G S TA R T E D & I M P O R TA N T S A F E T Y I N F O R M AT I O NBEGINNING TREATMENTWITH AUBAGIOBEFORE YOU START1Your healthcare provider will need to run a few tests beforebeginning treatment, including: NINAAUBAGIO PROVIDESSUPPORT THAT’STRULY PERSONAL- On AUBAGIO for 2 years- Likes that AUBAGIO fitsher life- Proud educator1-855-676-6326Once you start taking AUBAGIO, you’ll have access to optional supportservices through MS One to One, including: B (tuberculosis) skin test or blood test for mycobacteriumTtuberculosis infection (before starting AUBAGIO) Dedicated Nurse Support Pregnancytest. If you are a woman of childbearing potential,pregnancy should be ruled out– Your Nurse will be availableMonday-Friday during normalbusiness hours* blood pressure check (before starting AUBAGIO, andAperiodically throughout treatment)– You won’t have to start over withyour story lood tests to check your liver (within 6 months before startingBAUBAGIO and monthly for 6 months after)– Additional support from on-callNurses 24/7 complete blood count (within 6 months before startingAAUBAGIO) These tests are often done at the same time. inancial Assistance for EligibleFPatients– Help finding and navigatingfinancial assistance programsyou are eligible for Tools & Tips– Helpful tools and smart tips tohelp manage MS ssistance Navigating InsuranceA– Benefits verification*Your dedicated Nurse will provide you with her/his specific work hours anddirect extension for your convenience.AFTER YOU START1Your healthcare provider will need to: Monitor your liver enzymes for the first 6 months Check your blood pressure periodically after starting treatment17Please see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.Scan or call 1-855-676 -6326 ifyou don’t have commercia l insurancePatient Portrayal

G E T T I N G S TA R T E D & I M P O R TA N T S A F E T Y I N F O R M AT I O NMS ONE TO ONE SURVEYof people were somewhat tovery satisfied with MS One to Onesupport services.ONCE YOU’RE ON AUBAGIO, THERE’S ANENTIRE COMMUNITY WAITING FOR YOUWatch people talk abouttheir experience withMS One to OneConnect. Inspire. Support.COMMON THREADS is an online community forpeople who have been prescribed AUBAGIO and theirsupport partners. It’s a welcoming and supportiveresource for people living with relapsing MS.Here’s an inside look at what you’ll find when you havean account on COMMON THREADS. Educational webinars Life hacks and practical hints Helpful articles and videos Tips and stories from others with MS Tools and info about AUBAGIO Recipes to help you live wellWatch people like you discussingCommon Threads18Patient PortrayalPlease see Important Safety Information on page 19 and click to see fullPrescribing Information, including boxed WARNING and Medication Guide.

G E T T I N G S TA R T E D & I M P O R TA N T S A F E T Y I N F O R M AT I O NINDICATION AND IMPORTANT SAFETY INFORMATIONINDICATIONAUBAGIO (teriflunomide) is aprescription medicine used to treatrelapsing forms of multiple sclerosis(MS), to include clinically isolatedsyndrome, relapsing-remittingdisease, and active secondaryprogressive disease, in adults.IMPORTANT SAFETYINFORMATIONDO NOT TAKE AUBAGIO IF YOU: Have severe liver problems.AUBAGIO may cause serious liverproblems, including liver failurethat can be life-threatening andmay require a liver transplant. Yourrisk may be higher if you alreadyhave liver problems or take othermedicines that affect your liver.Your healthcare provider shoulddo blood tests to check your liverwithin 6 months before you startAUBAGIO and monthly for 6months after starting AUBAGIO.Tell your healthcare provider rightaway if you develop any of thesesymptoms of liver problems:nausea, vomiting, stomachpain, loss of appetite, tiredness,yellowing of your skin or whites ofyour eyes, or dark urine.19 Are pregnant. AUBAGIO mayharm an unborn baby. You shouldhave a pregnancy test beforestarting AUBAGIO. After stoppingAUBAGIO, continue to use effectivebirth control until you have madesure your blood levels of AUBAGIOare lowered. If you becomepregnant while taking AUBAGIOor within 2 years after stopping,tell your healthcare provider rightaway and enroll in the AUBAGIOPregnancy Registry at1-800-745-4447, option 2. Are of childbearing potential andnot using effective birth control.It is not known if AUBAGIO passesinto breast milk. Your healthcareprovider can help you decideif you should take AUBAGIO orbreastfeed — you should not doboth at the same time.If you are a man whose partnerplans to become pregnant, youshould stop taking AUBAGIO andtalk with your healthcare providerabout reducing the levels ofAUBAGIO in your blood. If yourpartner does not plan to becomepregnant, use eff

starting AUBAGIO. After stopping AUBAGIO, continue to use effective birth control until you have made sure your blood levels of AUBAGIO are lowered. If you become pregnant while taking AUBAGIO or within 2 years after stopping, tell your healthcare provider right away and enroll in the AUBAGIO Pregnancy Registry at 1-800-745-4447, option 2.