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Cary50 Bro PDF28/11/00 4:30 PMPage 1UV-VISVarianCary 50 SeriesSpectrophotometer

Cary50 Bro PDF28/11/00 4:30 PMPage 2Cary—More than 50 years of excellenceFor investigators who on occasion must pusha spectrophotometer to the very limits of itsperformance capability to obtain the information theyneed, and yet have to have an instrument whichis adaptable to many different applications“Fifty years ofexperience, startingwith the Cary 11,serial number 2,circa 1947.”Howard CaryThe Cary Philosophy 1947Applied Physics Corporation(known later as Caryinstruments) was founded inJanuary, 1946, by Howard Cary,William W. Miller, George W. Downs,and Russell E. Vaniman. Howard Cary madeimportant contributions to analyticalinstrumentation in the mid 1930s and early1940s. He founded Cary instruments justafter leaving his position as vice-presidentin charge of development with BeckmanInstruments, where he had been for11 years.In April 1947 Applied Physics Corporationdelivered the first commercial recordingUV-Vis spectrophotometer, a Cary 11,to Mellon Institute in Pittsburgh, USA.At that time Applied Physics Corp had only12 employees. In 1954 the Cary family grewto include the Cary 14.By that time the Cary name had becomesynonymous with high performanceand reliability.In 1966 Cary merged into Varianand in 1972 the Cary operationmoved from Monrovia toVarian’s main facilities in PaloAlto, California. In 1982 the Caryoperation was moved to the VarianTechtron facility in Melbourne, Australia.During the mid to late 1980s the Melbournebased factory was very busy researchingand developing a whole new generation ofCary instruments.Using the best optical and performancecharacteristics of the past Cary instrumentsand the latest technology in electronicsand software the Cary 1, 3, 4 and 5 werecreated. On the 50th anniversary of thefirst Cary a whole new series of Caryinstruments, the Cary 50, Cary 100, Cary300, Cary 400 and Cary 500 were born.In 1999, the Cary range was extended toinclude the Cary Eclipse fluorescencespectrophotometer, offering the excellentspecifications and modern software thathas become the Cary standard.2Cary 11UV-VisCary 14UV-Vis-NIRCary 15UV-VisCary 16UV-VisCary 17UV-Vis-NIRCary 118UV-Vis194719541961196419701972

Cary50 Bro PDF28/11/00 4:30 PMPage 3You’re not just buying a Cary,you’re buying a relationshipIf you need help with your Cary instrument,there are many options and sources ofinformation available to you, including: Servicing and supportYou can call your Varian office and get overthe-phone support or request an on-siteservice call. Varian’s Tele-diagnostics optionconnects you to our worldwide networkof support personnel for online assistance.This remote diagnosis service minimizeson-site calls and reduces downtime. Join our user groupAll Cary users can subscribe to our freeemail forum, which keeps you up to datewith the latest product and applicationinformation. You can also exchangequestions and experiences with Variansupport staff and other Cary users. www.varianinc.comVarian’s web site www.varianinc.com isanother part of our on-goingcommitment to customer support.To go directly to the UV-Vis-NIR section,visit http://www.varianinc.com/osi/uv/.You can access application notes,download free ADL programs, find outabout the latest product developments oremail us if you have a question. Use ouronline Parts and Supplies catalog toidentify any consumables you need.If you’re not connected to the Internetthen you can receive the parts andsupplies catalog on CD ROM.Cary 50This innovativeinstrument representsthe budget end of theCary line.Cary 100*A low to mid-pricedinstrument, the Cary 100is suitable for routine andresearch laboratory work.Cary 300*Represents a costeffective, research-gradeinstrument forlaboratories doinganalyses of biological orhighly absorbing samples.Cary 400*This research-gradeinstrument represents thetop-of-the-line UV-Visspectrophotometer.(Optional deep UV versionalso available.)Cary 500*Extends the capabilitiesof the Cary 400 up to3300 nm. If you want aninstrument that willmeasure any samplethen the Cary 500 is thebest choice.Cary Eclipse*This Fluorescencespectrophotometercompliments the CaryUV-Vis range by offeringthe first truly newmid-range fluorescenceinstrument in more than10 years.* Refer to separatebrochures for details3Cary 17DUV-Vis-NIRCary 219UV-VisCary 2400UV-Vis-NIRCary 1 & 3UV-VisCary 4 UV-VisCary 5 UV-Vis-NIRCary 50 SeriesCary 100-500 SeriesCary EclipseSeries1975197719871989199019971999

Cary50 Bro PDF28/11/00 4:30 PMPage 4The power of XenonThe Xenon lamp flashesonly when acquiring adata point, unlike adiode array whichexposes the sample tothe whole wavelengthrange with eachreading, causingdegradation ofphotosensitive samples.As fast as a diode array,but better performanceBy incorporating a Xenon flash lamp,the Cary 50* offers many advantages overtraditional UV-Vis spectrophotometers: The maximum scan rate is 24 000 nmper minute. That means you can scan thewhole wavelength range of 190-1100 nmin less than 3 seconds. With a data collection rate of animpressive 80 points per second you’ll haveall the information you need about yourkinetics assay. The Cary 50 can measure samples up to3 Abs so you won’t have to dilute as often. The Xenon lamp has a very long lifetime—3 x 109 flashes actually. This means thateven if you measure continuously, 7 daysa week, the lamp will last at least a year.If you use the instrument less frequentlyyou may never need to change it.That makes the Cary 50 very cheap to run. The Cary 50’s super-concentratedbeam makes it ideal for fibre optic work.The coupling efficiency and light throughputare both excellent. The room-light immunityof the Cary 50 also means shielding of afibre optic probe is unnecessary.* Patent pending4The light beam isnarrow and veryintense, so even ifyou are usingmicrocells with asmall aperture youwill still get excellentnoise performance.As the Xenon lamp isvery intense, the Cary50 can use a beamsplitter without theloss in energy causingexcessive photometricnoise. The beam splitterallows simultaneousreference beamcorrection, so peakswill not shift as thescan speed changes.The Cary 50 isunaffected by roomlight. You can operatewith the samplecompartment open orclosed, you won’tnotice the difference.So, if your samplewon’t quite fit in thesample compartment,it’s OK, you can leavethe lid off. If youwant to keep dust,dirt and room lightout of the samplecompartment, thenyou can use the lid.

Cary50 Bro PDF28/11/00 4:30 PMPage 5The Cary 50 gets itspower from the PC,so it is only on whenthe PC is switched on.The Sipper accessorydelivers liquid samplesto a flow cellThe Fibre Optics dipprobe is a trouble-freealternative to aconventional sipperA range of fibre opticprobes are availablefor Abs, %T and %RmeasurementsThe single cell peltieraccessory is used forprecise temperaturecontrolThe Temperature Probeaccessory measuresthe temperature insidethe cuvetteThe Multicell holderhouses up to 18 cellsand can be connectedto a water bathFixed angle relativeSpecular ReflectanceAccessories are availablein 12.5 , 30 , 45 , 60 The solid sampleholders cater for arange of sample typesThe Rapid Mixaccessory is ideal forstopped flow kineticsmeasurements5The PCB-150 water bathconnects to any of thewater-thermostattedcell holdersA range of cellholders caters for mostcell typesThe Fibre Optic Couplerallows you to connecta fibre optic probe tosuit your application

Cary50 Bro PDF28/11/00 4:30 PMPage 6Cary Win UV software—just what you asked forThe Cary WinUV software’s modular designmeans that you are only buying thefunctionality that you need. If your use ofthe spectrophotometer changes in thefuture you can simply upgrade to meet yournew requirements.Of course, the Cary Win UV software takesadvantage of Windows 32-bit functionalitysuch as multitasking and file association,for example you can drag and drop a datafile onto a Cary application and it will beimmediately loaded.Cary packages are available for the commonUV-Vis-NIR applications. These packagesbundle appropriate software modules withan instrument to suit each application.The three general use packages are Scan,Conc and Bio. Packages are also availablefor Tablet Dissolution, Color Analysis andUltra-Violet Protection and the list iscontinually growing. Of course, you canthen add any of the Cary accessories thatyou need.Auto load iconsJust click on theappropriate icon andthe application andthe correct methodwill load, ready for youto measure samples.6Hint textHaving trouble figuringout what a particularbutton or control does?Just hold the mousepointer over the objectuntil the hint text popsup with an explanation.The Cary WinUVcomes with the inbuiltApplicationsDevelopment Language(ADL), a computerlanguage which canbe used to automateyour laboratory’smeasurements.You can download arange of customizedADL programs (such asthe Wine Wizard ADLshown above) fromVarian’s website ordevelop your own.

Cary50 Bro PDF28/11/00 4:30 PMPage 7Cary 50 ScanSingle window operationAll controls can be accessedfrom this window, makingoperation quick and easy.Graphics tool barThe Cary softwarefeatures a toolbar to giveyou quick access to themost common graphicsoperations such aszooming, adding text andchanging the axes ranges.Customized reportsReports can include yourcompany logo or anybitmap you like. You caneven use the Print Previewfunction to check yourreport before printing.Scanning—any way you wantThe Cary Scan package consists of thefollowing software modules: Scanning software with Maths module Simple Reads module Advanced Reads module Instrument Validate module GLP module for file security Applications Development Language (ADL)Making measurements simpleAll you want to do is to find the absorbanceof a sample at a single wavelength?It should be easy. With the Cary WinUVsoftware, it is:1. Double click on the Simple Reads iconon the desktop.Fast data collectionThe use of the Xenon flash lamp in theCary 50 allows scan speeds up to 24000 nmper minute to be attained. This means thatif you typically measure a wavelength rangeof 300 nm, you can complete the scan inless than 1 second. Imagine the productivityimprovements you will see in your lab!Lid on or lid offThe Xenon lamp in the Cary 50 also meansthat you can scan samples with the samplecompartment open, just like a diode arrayinstrument. So if you have samples thatwill not quite fit in the sample compartmentyou can leave it open without affectingyour measurement.2. Click on the Setup button,set the wavelength.3. Press the Zero button.4. Press the Read button.Batch filesYou can store all methodand report parameters,calculations and graphicaldisplays, and the actualdata in one file. This savestime as you simply recallone file instead of several.7