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Agnes Ming-Fong WONG2003Selected by Ophthalmology residents in honour of the Best Teacher in Ophthalmology.J.D. Morin Award, Department of Ophthalmology and Vision Sciences, University of Toronto.(Postgraduate MD)Selected by Ophthalmology residents for a teacher who makes the most contribution toenhancing their training experience.3.3 Student/Trainee 4ARVO Member-in-Training Award for the Best Poster, Supervisor, Awardee Name: Dr.Shaobo Lei (fellow). Association for Research in Vision and Ophthalmology (ARVO)James A. Sharpe Award for the Best Fellow Paper, Supervisor, Awardee Name: Dr. MichaelRichards (fellow). 42nd Annual North American Neuro-ophthalmology Society (NANOS)MeetingSfN Postdoctoral Fellow Travel Award, Supervisor, Awardee Name: Dr. Inna Tsirlin (PhDpostdoctoral fellow). Society for Neuroscience (SfN)ARVO International Travel Grant Award, Supervisor, Awardee Name: Dr. Kim Le (medicalstudent). Association for Research in Vision and Ophthalmology (ARVO)Best Student Paper, Supervisor, Awardee Name: Dr. Matt Schlenker (medical student). 34thAnnual North American Neuro-Ophthalmology Society (NANOS) MeetingBest Student Paper, Supervisor, Awardee Name: Dr. Michael Richards (medical student).32nd Annual North American Neuro-Ophthalmology Society (NANOS) MeetingGold Award, Pfizer Film Festival for surgical technique and medical cases, Supervisor,Awardee Name: Dr. Shuan Dai (fellow). Royal Australian and New Zealand College ofOphthalmologists (RANZCO) MeetingBest Fellow Award (Inaugural), Supervisor, Awardee Name: Dr. Margaret Wong (fellow).Frank B. Walsh Session of the 30th Annual North American Neuro-ophthalmology Society(NANOS) MeetingNATIONAL2010200920062004Third Prize (Clinical Research Section), The 2nd Canadian National Medical StudentResearch Symposium, Supervisor, Awardee Name: Dr. Kay Lam (medical student).Canadian Federation of Medical StudentsFirst Prize, COS Award for Excellence in Ophthalmic Research, Supervisor, AwardeeName: Dr. Kay Lam (medical student). Canadian Ophthalmological Society (COS) AnnualMeeting 2009Best Research Paper, Supervisor, Awardee Name: Dr. Leo Sin (medical student). AnnualMeeting of the Canadian Association of Pediatric OphthalmologistsBest Research Paper, Supervisor, Awardee Name: Dr. Kylen McReelis (resident). CanadianNeuro-Ophthalmology Society MeetingLOCAL2016201520142014Best Vision Science Research Program (VSRP) Student Paper, Supervisor, AwardeeName: Michael Richards (MSc student). 58th Annual Research Day, Department ofOphthalmology and Vision Sciences, University of TorontoBest Poster Presentation. Supervisor, Awardee Name: Ivy Liu. The Hospital for Sick ChildrenSummer Research Program.Reva Gerstein Endowment Fund Award, Supervisor, Awardee Name: Dr. Inna Tsirlin (PhDpostdoctoral fellow). The Hospital for Sick ChildrenResearch Training Centre Fellowship Funding, Supervisor, Awardee Name: Dr. Inna TsirlinPage 6 of 51Generated by Web CV – 2017 September 17CONFIDENTIAL DOCUMENT

Agnes Ming-Fong 0820072007200620052003(PhD postdoctoral fellow). The Hospital for Sick ChildrenP. K. Basu Graduate Scholar Award for Vision Health Research, Awardee Name: Dr.Shaobo Lei (MSc student). University of TorontoVision Science Research Scholarship Program, Awardee Name: Dr. Shaobo Lei (MScstudent). University of TorontoFirst Prize, Alan Wu Poster (Clinical Sciences) Competition, Institute of Medical ScienceScientific Day. Supervisor, Awardee Name: Jaime Sklar (MSc student). Institute of MedicalScience, University of TorontoVision Science Research Scholarship Program, Awardee Name: Jaime Sklar (MScstudent). University of TorontoFirst Prize, Summer Undergraduate Research Program, Supervisor, Awardee Name: SeanKennedy. Institute of Medical Science, University of TorontoBest Vision Science Research Program (VSRP) Student Paper, Supervisor, AwardeeName: Rana Arham Raashid (MSc student). 54th Annual Research Day, Department ofOphthalmology and Vision Sciences, University of TorontoBest Student Paper, Supervisor, Awardee Name: Dr. Ewa Niechwiej-Szwedo (PhDpostdoctoral fellow). 53rd Annual Research Day, Department of Ophthalmology and VisionSciences, University of TorontoRestracomp Award, Supervisor, Awardee Name: Dr. Ewa Nichwiej-Szwedo (PhDpostdoctoral fellow). The Hospital for Sick ChildrenBest Student Paper, Supervisor, Awardee Name: Dr. Kay Lam (medical student). 52ndAnnual Research Day, Department of Ophthalmology and Vision Sciences, University ofTorontoBest Fellow Paper, Supervisor, Awardee Name: Dr. Filomeno Cortese (PhD postdoctoralfellow). 51st Annual Research Day, Department of Ophthalmology and Vision Sciences,University of TorontoBest Student Paper, Supervisor, Awardee Name: Dr. Kim Le (medical student). 51st AnnualResearch Day, Department of Ophthalmology and Vision Sciences, University of TorontoBest Student Paper, Supervisor, Awardee Name: Dr. Matt Schlenker (medical student). 50thAnnual Research Day, Department of Ophthalmology and Vision Sciences, University ofTorontoBest Student Paper, Supervisor, Awardee Name: Dr. Michael Richards (medical student).49th Annual Research Day, Department of Ophthalmology and Vision Sciences, University ofTorontoGeorge Brown Award (Best paper in Clinical Science), Supervisor, Awardee Name: Dr.Michael Richards (medical student). The 21st Medical Students Research Day, University ofTorontoBest Student Paper, Supervisor, Awardee Name: Dr. Michael Richards (medical student).48th Annual Research Day, Department of Ophthalmology and Vision Sciences, University ofTorontoBest Student Paper, Supervisor, Awardee Name: Dr. Maryam Fesharaki (MSc student). 47thAnnual Research Day, Department of Ophthalmology and Vision Sciences, University ofTorontoAlumni Award (Best Resident Paper), Supervisor, Awardee Name: Dr. Kylen McReelis(resident). 46th Annual Research Day, Department of Ophthalmology and Vision Sciences,University of TorontoPage 7 of 51Generated by Web CV – 2017 September 17CONFIDENTIAL DOCUMENT

Agnes Ming-Fong WONG4. PROFESSIONAL AFFILIATIONS AND ACTIVITIES4.1 Professional Associations2011 - present2010 - present2006 - present2006 - present2005 - present2003 - present2003 - present2002 - present1997 - present1995 - present1994 - present1993 - present1999 - 2005Member, Canadian Society for Brain, Behaviour and Cognitive ScienceMember, Vision Sciences SocietyMember, Center for Vision Research, York University, Toronto, Ontario, CanadaMember, The Bárány SocietyFellow, North American Neuro-Ophthalmological SocietyMember, American Association of Pediatric Ophthalmology and StrabismusMember, Canadian Association of Pediatric OphthalmologistsMember, Society for NeuroscienceMember, American Academy of OphthalmologyMember, Canadian Ophthalmological SocietyMember, Ontario Medical AssociationMember, Association of Research in Vision and OphthalmologyMember, North American Neuro-Ophthalmological Society4.2 Professional ActivitiesINTERNATIONALNorth American Neuro-Ophthalmology Society (NANOS)2012 - 2014Member, Scientific Program Subcommittee2009 - 2012Member, Nominating Committee2006 - 2012Member, Pilot Grant Award Subcommittee2003 - 2012Chair, Young Investigator Award Subcommittee2002 - 2012Member, Research Committee2009 - 2012Member, Board of Directors2009Member, (Ad hoc) Long Range Planning Committee2008 - 2009Co-Chair, Pediatric Eye Movement Disorders Symposium2007Moderator, Scientific Platform Presentations2004 - 2012Member, Abstract Committee2004 - 2006Member, Scientific Program Committee2003 - 2004Co-Chair, Ocular Motility SymposiumThe Association for Research in Vision and Ophthalmology (ARVO)2010 - 2011Chair, Annual Meeting Program Committee2008 - 2011Moderator, Papers and Posters Sessions2008 - 2010Member, Annual Meeting Program CommitteeInternational Society for Eye Research (ISER) Biennial Meeting 20102009 - 2010Co-Chair, “Amblyopia and Strabismus” sectionAmerican Association of Pediatric Ophthalmology and Strabismus (AAPOS)2006 - 2010Member, Research and Children’s Eye Foundation (CEF) Medical Advisory CommitteePage 8 of 51Generated by Web CV – 2017 September 17CONFIDENTIAL DOCUMENT

Agnes Ming-Fong WONGOther Organizations20162008 - 2009External Reviewer, The Scheie Eye Institute, Department of Ophthalmology at the Universityof Pennsylvania, USA.Chair, Practical Pearls in Neuro-Ophthalmology, Ontario, Canada.An International Symposium in Honour of Dr. James Sharpe.NATIONALCanadian Neuro-Ophthalmology Society2008 - 2009Co-Chair, Program CommitteeLOCALUniversity of Toronto2012 - 20172012 - 20172012 - 20162011 - 20172005 - present2004 - 20112002 - present201120102008 - 2011200820062003 - 20122003 - 20122003 - 20062002 - 20122002 - 20052002 - 20042002 - 20032002 - 20032002 - 2003Vice Chair, Research and Academic Affairs, Department of Ophthalmology and VisionSciencesMember, Vision Science Research Program (VSRP) Adjudicating CommitteeChair, Appointment Committee, Department of Ophthalmology and Vision SciencesMember, Promotion Committee, Department of Ophthalmology and Vision SciencesChair, Annual Departmental Faculty Research Day, Department of Ophthalmology andVision SciencesHead, Neuroscience Section of the Toronto Ophthalmology Residency Introductory CourseMember, Research Committee, Department of Ophthalmology and Vision SciencesMember, Advisory Committee for the Appointment of Chair, Dept. of Ophthalmology andVision Sciences, (Ad hoc)Member, Scientific Program Committee, Walter Wright Day, Department of Ophthalmologyand Vision SciencesMember, Faculty of Medicine Faculty CouncilReviewer, Laidlaw manuscript competition (graduate students), Institute of Medical ScienceMember, Search Committee for Chair in Ophthalmology, (Ad hoc)Chair, Annual Departmental Research Day, Department of Ophthalmology and VisionSciencesDirector, Residents Research, Department of Ophthalmology and Vision SciencesMember, Student Awards Committee, Institute of Medical ScienceMember, Postgraduate Education Committee, Department of Ophthalmology and VisionSciencesMember, Scientific Program Committee, Walter Wright Day, Department of Ophthalmologyand Vision SciencesMember, Promotion Committee, Department of Ophthalmology and Vision SciencesCo-Director, Residents Research, Department of Ophthalmology and Vision SciencesCo-Chair, Annual Departmental Research Day, Department of Ophthalmology and VisionSciencesMember, Resident Admissions Committee, Department of Ophthalmology and VisionSciencesThe Hospital for Sick Children2016 - 2017Member, International Advisory Council—Asia, SickKids International2013 - 2017Member, Perioperative Services Chiefs Committee2013 - 2017Member, Medical Advisory CommitteePage 9 of 51Generated by Web CV – 2017 September 17CONFIDENTIAL DOCUMENT

Agnes Ming-Fong WONG2013 - 20172010 - 20132003 - 20112003 - present201020092007 - 20122007 - 200920072006 - 200720062003Member, Quality Management CommitteeChair, Academic Research Fund Committee, Department of Ophthalmology and VisionSciencesCo-Chair, Education Committee, Department of Ophthalmology and Vision SciencesMember, Fellows Selection Committee, Department of Ophthalmology and Vision SciencesChair, Program Committee, The 21st Jack Crawford Day.Member, Search Committees for Neuro-Ophthalmology and General PediatricOphthalmology Positions, Department of Ophthalmology and Vision Sciences, (Ad hoc)Chair, Residents Evaluation Committee, Department of Ophthalmology and Vision SciencesMember, Academic Research Fund Committee, Department of Ophthalmology and VisionSciencesMember, Five-year Review Committee of the Department of Ophthalmology and VisionSciences, (Ad hoc)Member, Medical Staff CommitteeMember, Program Head Selection Committee for Neuroscience and Mental Health Program,The Hospital for Sick Children Research Institute (Ad hoc), Toronto.Co-Chair, Scientific Committee (ad hoc)The First Eye Movement Symposium: A Tribute to J. Raymond Buncic.4.3 Peer Review ActivitiesASSOCIATE OR SECTION EDITINGEditor2010 - 20132007 - 2013Associate Editor, Journal of Neuro-OphthalmologySection Editor (Neuro-Ophthalmology), Canadian Journal of OphthalmologyEDITORIAL BOARDSEditor2003 - 2014Member, StrabismusGRANT REVIEWSGrant Committee Reviewer2012Canadian Institutes of Health Research (CIHR) Behavioral Science – C2008Canadian Institutes of Health Research (CIHR) Clinical Investigation – A2007Canadian Institutes of Health Research (CIHR) Clinical Investigation – AExternal Grant Reviewer2006 - presentLeaders Opportunity Fund (LOF) College of Reviewers, Canada Foundation for Innovation2009Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant2005Canadian Foundation for Innovation Leaders Opportunity Fund2004Swiss National Science Foundation2003Austrian Science FundInternal Grant Reviewer2008 - presentThe Hospital for Sick Children Research InstituteMANUSCRIPT REVIEWSReviewerPage 10 of 51Generated by Web CV – 2017 September 17CONFIDENTIAL DOCUMENT

Agnes Ming-Fong WONGBritish Journal of OphthalmologyExpert Review of OphthalmologyInvestigative Ophthalmology and Visual ScienceArchives of OphthalmologyNeuro-OphthalmologyStrabismusMovement DisordersCanadian Journal of OphthalmologyClinical and Experimental OphthalmologyVision ResearchSurvey of OphthalmologyJournal of Neuro-OphthalmologyBrainJournal of AAPOS4.4 Leadership and Administrative Development Activities20162016201320132012 - 2013“Self-awareness and Effective Leadership”, Physician Leadership Institute, Canadian MedicalAssociation, Toronto.“Leadership Strategies for Sustainable Physician Engagement”, Physician LeadershipInstitute, Canadian Medical Association, Toronto.“Creating flow in the Ambulatory Setting” workshop. Virginia Mason Institute, Seattle, USA.“Fundamentals of Lean Six Sigma”. Continuous Improvement Program Yellow Belt Training,The Hospital for Sick Children.“The Hospital for Sick Children: Partners in Leadership Program”. Rotman School ofManagement, University of Toronto.C. Academic Activities1. RESEARCH STATEMENTI am a clinician-scientist who spends 80% of my time in research and 20% of my time in clinical work. The primary goalof my research is to understand neuroplasticity, the fundamental dynamic processes that allow the brain to adapt toinputs from, and changes in, the environment. I investigate the neuroplasticity in the developing and mature visual systemin normal and diseased states. I am particularly interested in understanding the brain mechanisms that cause abnormaleye movements, strabismus (eye misalignment), and amblyopia (lazy eye), as well as how to treat these diseases. Mylaboratories use a variety of techniques, including anatomic, behavioural, psychophysical, and neuroimaging methods,to investigate how the normal brain functions and how these brain functions change in the diseased state. Currentprojects include:1. Lazy Eye (Amblyopia) is a visual impairment of one eye caused by inadequate use during early childhood; it cannotbe corrected by prescription glasses. It is the most common cause of visual impairment in one eye in the westernworld, and affects about 4% of the general population. Although tremendous amount of resources are spent onpreventing and treating lazy eye, approximately 50% of children do not respond to therapies, and thus, many patientswith lazy eye continue to have abnormal vision throughout their adult lives. Our goal is to understand how lazy eyeaffects the visual brain and to find a cure for it. Specifically, our research aims to answer four major questions: (1)How do the brain circuits in people with lazy eye differ from those with normal vision? (2) How does lazy eye affectthree-dimensional (3D) depth perception and eye movements? (3) How do the eye-hand coordination skills in peoplewith lazy eye differ from those with normal vision? (4) How can we develop more effective treatments for lazy eye?Page 11 of 51Generated by Web CV – 2017 September 17CONFIDENTIAL DOCUMENT

Agnes Ming-Fong WONGRecent achievements include: We are the first group to demonstrate that people with lazy eye have impaired perception of images of real-worldscenes. We demonstrate that people with lazy eye have abnormal eye movements as well as eye-hand coordination. We are the first to show that people with lazy eye have abnormal adaptation to perturbations in the visual world. We provide the first evidence that lazy eye is not only a visual disorder, it also affects multisensory integrationincluding auditory perception.2. Using Pupillometry to Probe Different Visual Disorders. The melanopsin-containing intrinsically photosensitiveretinal ganglion cells (ipRGCs) are a new subset of retinal photoreceptors discovered about a decade ago. ipRGCscontain a novel photopigment called melanopsin, and can generate action potentials in response to light with (extrinsicphotoactivity) or without (intrinsic photoactivity) synaptic input from rods or cones. ipRGCs detect environmental lightirradiance for non-image forming visual functions independent of conscious visual perception,and provide the primaryafferent signals for the pupillary light reflex and circadian rhythm. Recently, a novel technique called chromaticpupillometry was developed to assess the activity of all light sensing cells by measuring the pupil response to light ofdifferent wavelengths. Our overall goal is to introduce a newly modified chromatic pupillometry protocol we developedas a clinical probe to detect and monitor diseases, and as a scientific probe to elucidate pathogenic mechanisms thatremain poorly understood. Specifically, we are: (1) testing whether chromatic pupillometry offers a new objectiveassessment for the detection and monitoring of glaucoma; (2) using chromatic pupillometry to investigate whetherthe activity of ipRGCs plays a role in the development of severe myopia; (3) investigating whether a hyper-sensitizedipRGC

Agnes Ming-Fong Wong MD, PhD, FRCSC A. Date of Preparation: September 4, 2017 B. Biographical Information Primary Office Department of Ophthalmology and Vision Sciences The Hospital for Sick Children 555 University Avenue Toronto, Ontario, Canada M5G 1X8 Telephone 416-813-7654 x202642 Fax 416-813-5159 Email agnes.wong@utoronto.ca