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Analytical Control De Mori - MicroDay 2019 – Padova & MilanoUltra fast microbiology testing solutionan Indicia Trademark
What is Metis technology about ? A rapid method for microbiological testingusing flow cytometry for Quality Controlin food and cosmetic industries Key advantagesSpeedEasyworkflowSensitive Ultimate benefit for your company2FlexibleReliableEnhanceyourprofitability
Save time and moneyTesting of rawmaterials and waterStandard platecount methodRapid method3-7 days1-2 daysIn-process testing3-7 days1-2 daysFinal producttesting3-7 days1-2 daysTotal gain in the production cycle : up to 12 daysReduce leadtime3Release your product fasterwith maximum reliabilityDecrease up to 20%Of the storage area
A 3 steps easy to achive workflow123EnrichmentLabeling withMETIS Fluo4Life viability markers counterstaining withMETISol Blue Inhibition ofnatural autofluorescenceCounting of the viable cells withBecton Dickinson Accuri C6 PLUS flow-cytometerMinimum 12 hOptimum 24 h45 min430 s per sampleResults on METISoft :positive and negativesamples at a glance.
PrincipleMETIS has developpedproprietary fluorescent mixesfor viable micro-organismslabelling :Bacteria, Yeast, MoldsFlow cytometerPhysical parametersMeasure &Fluorescence detectionfor individual viablemicroorganisms counting5Direct correlationwith traditional plate counton more than hundred species
High sensitive resultsPRESENCE / ABSENCE RESULTS in 24 to 48 hSensitivity 1 CFU / gTotal Viable Count Sterility testing10 to 100 times more sensitive than ATP metryTYPE OF CONTAMINATIONYEASTS&MOLDSPORES6BACTERIAa unique multiparametric detectionallowing the discrimination betweenbacteria and yeasts & mold spores
Methods comparison ConventionnalPlate zurinSpeed
FlexibilityScalable automation solutions with 2 separate devicesfor a minimum operator time Semi-automatedManual labeling automatic readingUsing BD Accuri C6 PLUS Labelling automation high throughputAutomated labeling on an Integra pipeting robot automatic reading using BD Accuri C6 PLUS Full automation high throughputAutomated dilution, pooling and labelingon a pipeting Hamilton workstation automatic reading using BD Accuri C6 PLUS 8
FlexibilityMETIS adapts to the lab’s testing throughput and can be scaled-up564 tests in one shift9
A large panel of validated SOPFOOD and BEVERAGESA LARGEPANEL OFVALIDATEDPRODUCTSRaw milk, whole milk, semi-skimmed / skimmed milk, delactosed,concentrate milkInfant formulaChocolate or flavoured milk (vanilla, strawberry, banana )Soya and vegetable drinks (rice, almond, oats )Dairy cream, vegetable creamYoghurtSoups and high-protein content drinks (diet or medical)Water, flavoured water and diluted fruit juicesFruit juices with or without pulpCarbonated beveragesPrepared baby-foods, baby-soups, compotesCakes, sweet-bread rolls, milk breadCOSMETIC – Personnal Care ProductsBACERIAMoisturing cream, anti-aging cream, solar cream, scrub, Make-up : foundation, lipstick, mascara, khôl, powder, Shampoo, after-shampoo, hair mask, tooth paste, dental bath, Oil, micellar solution, make-up removing solution, cleansing gel, 10
Reliable and user-friendly cytometerReduced cost:water as sheathfluid, lowvolume of wasteBD AccuriC6 PLUS Plug and Playfully automated24-48hswapping incase ofbreakdownRobustand compactLow and easymaintenance,automated QC11
Reliable team and know howOver15 yearsexperienceR&IlabApplicationengineers Validation studies Validation supports : IQ / OQ / PQ BACERIADetailed technical documentation : SOP/user’s guide On-site training Telephone and on-site technical support Swapping of the flow cytometer in 24-48h12
Metis key customersBeverageDairyBaby-foodBakeryFood & BeverageCosmetic13
Save time and moneyBenefits forSupply chain/StorageBenefits forProductionEnhanceyourprofitabilitySave up to 12 days on quarantine timeand up to 20% of the required storage areBenefitsfor QC LabReduce leadtimeReduce workloadRapid response tocontamination incidentsor non conform raw materialReduce wasteBetween 6 and 12 months Return On Investment14
Take home messageMetis technology provides An ultra rapid microbial testing solution easy to implement A unique combination of speed with sensitivity Reach your objectives of profitability and quality lmethodMetissolution
Grazie milleStéphane GAVOILLELaetitia DA COSTAInternational Sales and Marketing DirectorExport Application EngineerM. 33 (0)7 89 50 72 66sgavoille@indicia.frwww.indicia.frM. 33 (0)7 84 38 24 36ldacosta@indicia.fr
Metis vs. Biomerieux Chemunex No multiparametric detection /- results but NO discrimination betweenmicroorganisms types Instrument reliability : Frequent loss of laser alignment complex microfluidic Important volumes of sheath fluid and waste to discard Weaked flexibility Automated labeling and reading by the same device Testing only per batch of 25 or 50 samples in tubes : loss of reagents Max 300 samples / day Expensive after sale services Expensive maintenance contracts ( 10 k ) “On-site intervention of service engineer” needed to repair17
Indicia Production – ZA La Parlière 69610 St Genis L’Argentière - FRANCE – 33 (0)4 74 72 36 10
A propos d’IndiciaSpécialiste du contrôle de stérilité Fabricant de milieux et de produits stériles Produits et méthodes pour le contrôle de trôle
A propos d’Indicia
A propos d’Indicia Création1998 3 sitesSt Genis L’Argentière (Lyon)Taden (Dinan)Panazol (Limoges) Staff60 personnes CA 20188,4 M ( 13%) Business ModelContract Manufacturing Organisation Savoir-FaireFabrication GMP de liquides stérilesMicrobiolologie rapide en cytométrie ClientsPharma/biotech, IAA, Cosmétique
Becton Dickinson Accuri C6 PLUS flow-cytometer 3 30 s per sample. Principle 5 METIS has developped proprietary fluorescent mixes for viable micro-organisms labelling : Bacteria, Yeast, Molds . Swapping of the flow cytometer in 24-48h Over 15 years experience Application engineers R&I lab. Metis key customers 13 Dairy Baby-food Bakery .
