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COVID-19 Evidence Bulletin 114NICE GuidelineCOVID-19 rapid guideline: managing COVID-19NICE Guideline NG191Updated: 19 May 2022UK Health Security AgencyJCVI provides interim advice on an autumn COVID-19 booster programmeThe Joint Committee on Vaccination and Immunisation (JCVI) has provided interim advice to governmentregarding coronavirus (COVID-19) booster doses this autumn.Updated: 19 May 2022Coronavirus (COVID-19) testing for hospicesSets out how hospices can access COVID-19 testing for staff and patients on-site, for staff visiting patientsin their own homes, and for visitors to hospices.Updated: 19 May 2022.COVID-19: background informationInformation on COVID-19 including epidemiology, virology and clinical features.Updated: 13 May 2022.COVID-19 test validation approved productsFind out which COVID-19 test products have been approved.Updated: 17 May 2022.Consensus statements and medium-term projections on COVID-19Consensus statements and medium-term projections from the UK Health Security Agency's EpidemiologyModelling Review Group (EMRG).Updated: 17 May 2022Ventilation to reduce the spread of respiratory infections, including COVID-19Guidance on the ventilation of indoor spaces to reduce the spread of respiratory infections, includingcoronavirus (COVID-19).Updated: 13 May 2022.COVID-19 variants: genomically confirmed case numbersGenomically confirmed case numbers for SARS-CoV-2 variants of concern and variants underinvestigation.Updated: 13 May 2022Vaccine uptake among pregnant women increasing but inequalities persistLatest UKHSA data shows increasing numbers coming forward for COVID-19 vaccine, but uptakecontinues to differ by ethnicity and areas of higher deprivation.Published: 13 May 2022Almost 80% of eligible over-75s receive spring boosterLatest UKHSA data shows 79.2% of those aged 75 who became eligible at the end of March forcoronavirus (COVID-19) booster have taken up the vaccine.Published: 13 May 2022.
NHS COVID-19 app: download and set up guideRead our help guides on how to download and set up the NHS COVID-19 app.Updated: 13 May 2022.COVID-19: guidance for people whose immune system means they are at higher riskGuidance for people aged 12 and over whose immune system means they are at higher risk of seriousillness if they become infected with coronavirus (COVID-19).Updated: 12 May 2022Vaccine update: issue 328, May 2022, Shingrix special editionLatest developments in vaccines, vaccination policies and procedures for immunisation practitioners.Updated: 11 May 2022.Office for Health Improvement and DisparitiesCOVID-19 Health Inequalities Monitoring in England tool (CHIME)A national tool that brings together data to monitor the direct impacts of COVID-19 on health inequalities.Updated: 19 May 2022.Wider impacts of COVID-19 on health monitoring toolNational monitoring tool that brings together metrics to assess the wider impacts of coronavirus (COVID19) on health.Updated: 19 May 2022.Wider Impacts of COVID-19 on Health (WICH) monitoring tool: June 2022 updateThe WICH tool presents a number of metrics across a broad range of themes, such as social determinantsof health, behavioural risk factors and mortality, to enable users to assess the indirect impacts of COVID-19on health. Updated: 17 May 2022.NHS England and NHS ImprovementNext steps on transitioning from COVID-19 response to recoveryLetter from Amanda Pritchard, NHS Chief Executive and Sir David Sloman, Chief Operating Officer forNHS England and NHS Improvement setting out the next steps on transitioning from COVID-19 responseto recovery.Published: 19 May 2022.Letter to patients: Important information about new treatments for coronavirusLetter from Professor Stephen Powis (National Medical Director, NHS England and NHS Improvement)about new COVID-19 treatments for patients who are at highest risk of becoming seriously ill.Updated: 17 May 2022.Vaccination sitesThere are now around 3,000 vaccination sites across England, with 99% of the country living within tenmiles of a site.Updated: 12 May 2022NHS ConfederationProgress against the 104-week wait targetJoseph PlewesPublished: 17 May 2022Imperial College ReportsREACT studyBreakthrough SARS-CoV-2 infections in double and triple vaccinated adults and single dosevaccine effectiveness among children in Autumn 2021 in England: REACT-1 studyEclinical Medicine, June 2022
Covid Symptom Study – latest researchSmoking and COVID-19Updated: 10 May 2022.The ZOE Health Study’s COVID rash galleryUpdated: 10 May 2022.PHARMACYMHRARegulatory approval of Spikevax (formerly COVID-19 Vaccine Moderna)Information for healthcare professionals and the public about SpikevaxUpdated: 18 May 2022COVID-19 vaccines and medicines: updates for May 2022Recent information relating to COVID-19 vaccines and medicines that has been published since the April2022 issue of Drug Safety Update, up to 13 May 2022.Published: 17 May 2022.EVIDENCE BASED SUMMARIESFor adult workers outside healthcare settings after contact with an infected person, how does atest‐based attendance strategy compare with a standard 10‐day self‐isolation in terms of rates ofSARS‐CoV‐2 infection?Cochrane Clinical AnswerPublished: 16 May 2022.Thoracic imaging tests for the diagnosis of COVID‐19Cochrane reviewPublished: 16 May 2022CURRENT RESEARCHSelected Papers:GeneralVenous or arterial thrombosis and deaths among COVID-19 cases: a European network cohortstudyThe Lancet Infectious DiseasesBurn, E et al.Published: May 13, 2022Clinical severity of COVID-19 in patients admitted to hospital during the omicron wave inSouth Africa: a retrospective observational studyThe Lancet Global HealthJassat, W.Published: May 18, 2022Transforming or tinkering: the world remains unprepared for the next pandemic threatThe LancetClark, HPublished: May 18, 2022
Do Bigger Health Budgets Cushion Pandemics? An Empirical Test of COVID-19 Deaths Across theWorldNumber of pages: 30Posted 13 May 2022Working Paper SeriesArusha Cooray[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Pathophysiology of COVID-19: SARS-CoV-2 mimics neoplastic cells, and long COVID-19 syndromecan be a Warburg effect and ACE-2 internalization consequenceLuiz Gonzaga Research Square,Posted: 18 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]The estimated disease burden of acute COVID-19 in the Netherlands in 2020, in disability-adjustedlife-yearsScott A. McDonald, Research SquarePosted: 18 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]S100A9 as an inflammatory marker in hospitalized COVID-19 patientsLarissa Gomes Barbosa Research SquarePosted: 18 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Systematic levels of IL-29 and microRNA185-5p were not associated with severe COVID-19 in theIranian populationOmidreza Sarrafi, Research Square,Posted: 16 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Comparative study on ventilation and air conditioning system schemes based on virus pollutioncontrol in hospital infusion roomWeixue Cao, Research SquarePosted: 17 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]A machine learning analysis of the relationship between some underlying medical conditions andCOVID-19 susceptibilityMostafa Rezapour, Colin A. Varady Research Square,Posted: 17 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Personal Health Record Implementation in Rural Primary Care: A Descriptive Exploratory Studyusing RE-AIM FrameworkSelena Davis, Research Square Under review at BMC Medical Informatics and Decision Making.Posted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]The Impact of COVID-19 on an Irish Emergency Department (ED): Unlocking the Factors influencingDecision to Attend the ED in a Repeated Measure, Cross-sectional Study
Niamh M. Cummins, Research SquarePosted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Sequence Proven Reinfections with SARS-CoV-2 at a Large Academic CenterMorris, C. P., MedRxiv,10.1101/2022.05.17.22275210 — Posted: 2022-05-19[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]CHARACTERISTICS AND OUTCOMES OF INDIVIDUALS WITH COVID-19: EVIDENCE FROM AHOSPITAL BASED STUDYZambwe, M., Chipimo, P. J. MedRxiv,10.1101/2022.05.13.22274812 — Posted: 2022-05-14[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]A study protocol for a retrospective cohort study and interrupted time series analysis to assess theeffect of the COVID-19 pandemic on major trauma presentations and patient outcomes in Englishhospitals.Marincowitz, C. MedRxiv,10.1101/2022.05.10.22274804 — Posted: 2022-05-13[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Modelling long-term COVID-19 hospital admission dynamics using immune protection waning dataReyne, B., MedRxiv,10.1101/2022.05.16.22275130 — Posted: 2022-05-16[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Healthcare WorkersRecording and evaluating affect and coping during COVID-19 in healthcare workers and outcomes(REACCH-Out): mental health implications for our junior doctor cohortBy Sarah Akbar and Samantha McNally BMJ Open QualityPublished: May 2022Medical Occupation Preference under the Influence of the COVID-19 pandemic: The role of socialand risk preferenceEdward Cartwright, Research SquarePosted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]The impact of the SARS-CoV-2 pandemic on stress and anxiety in dentistry studentsAndreas Zenthöfer, Research SquarePosted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Effectiveness of prevention of SARS-CoV-2 transmission among unvaccinated Italian healthcareworkers: a nested case-control studyGiulia Collatuzzo Research SquarePosted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]
Infection ControlCOVID-19: The Awareness of Coronavirus Symptoms and Preoccupying the Preventive MeasuresUsing Doctor’s ConsultancyNumber of pages: 4Posted 17 May 2022Working Paper SeriesHeena Jadhav[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Mask-Associated Dry Eye During the Covid-19 PandemicBengisu Karakose, Research SquarePosted: 16 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Long CovidIdentifying who has long COVID in the USA: a machine learning approach using N3C dataThe Lancet Digital HealthPfaff, E et al.Published: May 16, 2022The Costs of Long COVIDCutler DMJAMA Health Forum May 12, 2022Long-COVID in immunocompromised childrenKarolina Kuczborska, Research SquarePosted: 19 May 2022 Under review at European Journal of Paediatrics[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Reduced Exercise Capacity, Chronotropic Incompetence, Inflammation and Symptoms in PostAcute COVID-19Durstenfeld, M. S MedRxiv,10.1101/2022.05.17.22275235 — Posted: 2022-05-19[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]NeurologyAcquired peripheral nerve injuries associated with severe COVID-19Colin K. Franz Research SquarePosted: 17 May 2022An explanatory model of depressive symptoms from anxiety, post-traumatic stress, somaticsymptoms and symptom perception: The role of inflammatory markers in hospitalized COVID-19patientsDavid Villarreal-Zegarra, Research SquarePosted: 17 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Staying Strong, But for How Long? Mental Health During COVID-19 in ItalyCEIS Working Paper No. 541, 2022Number of pages: 18Posted 13 May 2022Working Paper Series[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]
Clinical Findings in Patients with Nervous System Involvement Hospitalized at the COVID-19Isolation Hospital in Alexandria University, Egypt: A Case Control StudyOsama S. Research SquarePosted: 16 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Mortality in Psoriatic Arthritis patients, changes over time and the impact of COVID-19: Resultsfrom a multicenter Psoriatic Arthritis Registry (PsART-ID)Abdulsamet Erden, Research SquarePosted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Neuropathic symptoms with SARS-CoV-2 vaccinationSafavi, F., Medxiv,10.1101/2022.05.16.22274439 — Posted: 2022-05-17[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Mental health outcomes following COVID-19 infection: Evidence from 11 UK longitudinal populationstudiesThompson, E. J. MedRxiv,10.1101/2022.05.11.22274964 — Posted: 2022-05-16[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Acceptability of a behavioural intervention to mitigate the psychological impacts of COVID-19restrictions in older people with long-term conditions: a qualitative studyShearsmith, L., MedRxiv,10.1101/2022.05.10.22274892 — Posted: 2022-05-14[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]ObstetricsPregnancy and Infant Outcomes by Trimester of SARS-CoV-2 Infection in Pregnancy – SETNET, 22 Jurisdictions, January 25, 2020 - December 31, 2020Varsha Neelam, Research Square,Posted: 18 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]COVID-19 booster dose antibody response in pregnant, lactating, and nonpregnant womenAtyeo, C., MedRxiv,10.1101/2022.05.17.22275154 — Posted: 2022-05-19[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]PaediatricsA Retrospective Analysis of Metabolic Control in Children with PKU in the COVID-19 EraNumber of pages: 17Posted 17 May 2022Working Paper SeriesDóra Becsei[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]The Impact of COVID-19 on the Reduction of Child Stunting Over the Next Two Decades
Number of pages: 3Posted 17 May 2022Working Paper SeriesWillem Verhagen[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Exploring pandemic-related health literacy among adolescents in Germany: A focus group studyLoer, A.M. et al. Research Square, https://doi.org/10.21203/rs.3.rs-1662173/v118 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]RespiratoryBradykinin and Galectin-3 in Survived and Died Patients With Covid-19 Pneumonia: An IncreasinglyPromising Biochemical TargetTamara Nikolic Turnic, Research SquarePosted: 19 May 202218 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Artificial Intelligence-based Point-of-care Lung Ultrasound for Screening COVID-19 Pneumoniae:Comparison with CT ScansYumi Kuroda, Research SquarePosted: 16 may 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]SARS-CoV-2 pneumonia: association between findings of CT and SF ratios in inpatients andcritically ill patientsSerpil Öcal, Research SquarePosted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDSBatra, R., MedRxiv,10.1101/2022.05.16.22274587 — Posted: 2022-05-17[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Assessment of oxidative stress markers in elderly patients with SARS-CoV-2 infection and potentialprognostic implications. An observational studyVazquez-Agra, N., MedRxiv,10.1101/2022.05.11.22274952 — Posted: 2022-05-16[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Smoking trajectories over the first year of the pandemic in UK middle-aged adults: evidence fromthe UKHLS COVID-19 studyGagne, T. MedRxiv,10.1101/2022.05.11.22274937 — Posted: 2022-05-16[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]TestingAnalytical performance of rapid antigen tests for the detection of SARS-CoV-2 during widespreadcirculation of the Omicron variant
Suzuki, H. MedRxiv,10.1101/2022.05.17.22275034 — Posted: 2022-05-19[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]TreatmentDeterminants of hydroxychloroquine-mediated hemolytic anemia in G6PD-deficient COVID-19patientsShaik Mohammad Naushad, Research Square,Posted: 19 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Mortality Predictors Of Pre-variant SARS-CoV-2 Infected ARDS Patients Receiving Favipiravir andTocilizumabFatma YILDIRIM, Research Square,Posted: 18 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]VaccinationFactors Associated with Severe Covid-19 Despite Vaccination: A Nationwide, Retrospective CohortStudyAustin D. Vo, Jennifer La, Julie T. Y. Wu, Judith M. Strymish, Matthew Ronan, Mary Brophy, Nhan V. Do,and 3 more authors Research SquarePosted: 16 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Neutralizing Antibodies Against the SARS-CoV-2 Omicron Variant (BA.1) 1 to 18 Weeks After theSecond and Third Doses of the BNT162b2 mRNA VaccineLassaunière R, Polacek C, Frische A, et al.JAMA Network Open May 13, 2022Association of Prior BNT162b2 COVID-19 Vaccination With Symptomatic SARS-CoV-2 Infection inChildren and Adolescents During Omicron PredominanceFleming-Dutra KE, Britton A, Shang N, et al.JAMA May 13, 2022Risk of Infection and Hospitalization Among Vaccinated and Unvaccinated Children andAdolescents in New York After the Emergence of the Omicron VariantDorabawila V, Hoefer D, Bauer UE, Bassett MT, Lutterloh E, Rosenberg ESJAMA May 13, 2022Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian AdultsBrown, P. et al. NEJM,May 18, 2022DOI: 10.1056/NEJMc2202879Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 VaccineMoreira, E. et al. NEJM,N Engl J Med 2022; 386:1910-1921DOI: 10.1056/NEJMoa2200674Reduced sensitivity of commercial Spike-specific antibody assays after primary infection with theSARS-CoV-2 Omicron variantDavid Niklas Springer, Research Square,
Posted: 19 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Design and baseline description of an observational population-based cohort study on COVID-19vaccine effectiveness in the Netherlands - The VAccine Study COvid-19 (VASCO)Anne J. Huiberts, Research SquarePosted: 19 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Impact of COVID-19 Vaccination on Breast Cancer Patients; the Negative Effects of the PandemicHave Started to Decrease.Gokhan AVSAR, Rıza DERYOL, Musluh HAKSEVEN, Ozhan CETINDAG, Selim TAMAM, Ali EkremUNAL, Sancar BAYAR Research SquarePosted: 18 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Multicenter case-control study evaluating the safety of anti-SARS-CoV-2 vaccines in a cohort ofpatients with systemic vasculitisEdoardo Simoncelli, Research SquarePosted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Is large-scale vaccination sufficient for controlling the Covid-19 pandemic with uncertainties? Amodel-based studyAbhijit Majumder, Nandadulal Bairagi Research SquarePosted: 13 May 2022[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Reduced antibody acquisition with increasing age following vaccination with BNT162b2: resultsfrom a large study performed in the general population aged 12 to 92 yearsvan den Hoogen, L. L., MedRxiv,10.1101/2022.05.18.22275209 — Posted: 2022-05-19[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Self-Reported SARS-CoV-2 Vaccination is Consistent with Electronic Health Record Data among theCOVID-19 Community Research PartnershipTjaden, A. H. MedRxiv,10.1101/2022.05.13.22275054 — Posted: 2022-05-16[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]VariantsNeutralization of the SARS-CoV-2 Deltacron and BA.3 VariantsEvans, J.P. NEJM,May 18, 2022DOI: 10.1056/NEJMc2205019Omicron Infection Induces Low-Level, Narrow-Range SARS-CoV-2 Neutralizing ActivityNumber of pages: 16Posted 16 May 2022Working Paper SeriesPriscilla Turelli
[This article is a preprint and has not been certified by peer review. It reports new medical research that hasyet to be evaluated and so should not be used to guide clinical practice.]Academy of Fabstuff: https://fabnhsstuff.net/campaigns/cv-19If you require an evidence search on a particular aspect of covid-19 or with regards to a particular patientgroup please get in touch:Colchester Hospital LibraryLibrary.services@esneft.nhs.ukTel: 01206 742146Ipswich Hospital LibraryHospital.library@esneft.nhs.ukTel: 01473 702544Published: 20th May 2022
COVID-19 Health Inequalities Monitoring in England tool (CHIME) A national tool that brings together data to monitor the direct impacts of COVID-19 on health inequalities. Updated: 19 May 2022. . Selena Davis, Research Square Under review at BMC Medical Informatics and Decision Making. Posted: 13 May 2022
