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J Glob Health 2019; 9: 010425A landscape review of the published research output relating to respiratorysyncytial virus (RSV) in North & Central America and Europe between 2011-2015 –AppendicesAppendix 1 – Literature review search strategiesNorth/Central America Scopus search strategy:(TITLE-ABS-KEY(Respiratory syncytial virus) OR TITLE-ABS- KEY(Respiratory syncytialvirus infection) ORTITLE-ABS- KEY(RSV) OR TITLE-ABS- KEY(RSV infection)) AND PUBYEAR > 2010AND ( LIMITTO(AFFILCOUNTRY,"UnitedStates" ) OR LIMITTO(AFFILCOUNTRY,"Canada" ) OR LIMITTO(AFFILCOUNTRY,"Mexico" ) OR LIMITTO(AFFILCOUNTRY,"Guatemala" ) OR LIMITTO(AFFILCOUNTRY,"Honduras" ) OR LIMITTO(AFFILCOUNTRY,"Nicaragua" ) OR LIMITTO(AFFILCOUNTRY,"Panama" ) OR LIMITTO(AFFILCOUNTRY,"Haiti" ) OR LIMIT-TO(AFFILCOUNTRY,"ElSalvador" ) OR LIMIT-TO(AFFILCOUNTRY,"CostaRica" ) OR LIMITTO(AFFILCOUNTRY,"Trinidad andTobago" ) OR LIMIT-TO(AFFILCOUNTRY,"Cuba" ) OR LIMITTO(AFFILCOUNTRY,"Greenland" ) OR LIMITTO(AFFILCOUNTRY,"Belize" ) OR LIMITTO(AFFILCOUNTRY,"Barbados" ) OR LIMITTO(AFFILCOUNTRY,"Anguilla" ) OR LIMITTO(AFFILCOUNTRY,"Antigua and Barbuda" ) OR LIMITTO(AFFILCOUNTRY,"Aruba" ) OR LIMITTO(AFFILCOUNTRY,"Bahamas" ) OR LIMITTO(AFFILCOUNTRY,"Bonaire, Sint Eustatius and Saba" ) OR LIMITTO(AFFILCOUNTRY,"British VirginIslands" ) OR LIMIT-TO(AFFILCOUNTRY,"CaymanIslands" ) OR LIMITTO(AFFILCOUNTRY,"Curaçao") ORLIMIT-TO(AFFILCOUNTRY,"Dominica" ) OR LIMITTO(AFFILCOUNTRY,"DominicanRepublic" ) OR LIMITTO(AFFILCOUNTRY,"Grenada" ) OR LIMITTO(AFFILCOUNTRY,"Guadeloupe" ) OR LIMITTO(AFFILCOUNTRY,"Jamaica" OR LIMITTO(AFFILCOUNTRY,"Martinique" ) OR LIMITTO(AFFILCOUNTRY,"Montserrat" ) OR LIMITTO(AFFILCOUNTRY,"PuertoRico" ) OR LIMITTO(AFFILCOUNTRY,"Saint-Barthélemy" ) OR LIMITTO(AFFILCOUNTRY,"Saint Kitts and Nevis" ) OR LIMIT-

TO(AFFILCOUNTRY,"SaintLucia" ) OR LIMITTO(AFFILCOUNTRY,"SaintMartin" ) OR LIMITTO(AFFILCOUNTRY,"Saint Vincent and the Grenadines" ) OR LIMITTO(AFFILCOUNTRY,"SintMaarten") OR LIMIT-TO(AFFILCOUNTRY,"Turks and Caicos Islands" ) OR LIMITTO(AFFILCOUNTRY,"United StatesVirgin Islands" ) OR LIMIT-TO(AFFILCOUNTRY,"Bermuda" ) OR LIMITTO(AFFILCOUNTRY,"Saint Pierre andMiquelon" )North/Central America Web of Science search strategy:TOPIC:(Respiratory syncytial virus) OR TOPIC: (Respiratory syncytial virusinfection) OR TOPIC: (RSV) ORTOPIC: (RSV infection)Refined by:COUNTRIES/TERRITORIES: ( USA OR CANADA OR MEXICO ORGUATEMALA OR HONDURAS ORPANAMA OR EL SALVADOR OR COSTA RICA OR NICARAGUA OR GREENLAND ORGRENADA ORGUADELOUPE OR HAITI OR TRINID TOBAGO )Timespan: 2011-2015. Indexes: SCI-EXPANDED, SSCI, A&HCI, CPCI-S, CPCISSH, BKCI-S, BKCI-SSH, ESCI,CCR-EXPANDED, IC.Europe Scopus Search Strategy:TITLE-ABS-KEY ( Respiratory syncytial virus )OR TITLE-ABS- KEY ( Respiratory syncytial virus infection )OR TITLE-ABS-KEY ( Rsv )OR TITLE-ABS- KEY ( Rsv infection )AND PUBYEAR 2010AND ( LIMIT-TO ( AFFILCOUNTRY , "United Kingdom" )OR LIMIT-TO ( AFFILCOUNTRY , "France" )OR LIMIT-TO ( AFFILCOUNTRY , "Spain" )OR LIMIT-TO ( AFFILCOUNTRY , "Netherlands" )OR LIMIT-TO ( AFFILCOUNTRY , "Italy" )OR LIMIT-TO ( AFFILCOUNTRY , "Germany" )OR LIMIT-TO ( AFFILCOUNTRY , "Belgium" )OR LIMIT-TO ( AFFILCOUNTRY , "Turkey" )OR LIMIT-TO ( AFFILCOUNTRY , "Finland" )OR LIMIT-TO ( AFFILCOUNTRY , "Sweden" )OR LIMIT-TO ( AFFILCOUNTRY , "Switzerland" )OR LIMIT-TO ( AFFILCOUNTRY , "Poland" )OR LIMIT-TO ( AFFILCOUNTRY , "Israel" )OR LIMIT-TO ( AFFILCOUNTRY , "Austria" )OR LIMIT-TO ( AFFILCOUNTRY , "Greece" )OR LIMIT-TO ( AFFILCOUNTRY , "Denmark" )OR LIMIT-TO ( AFFILCOUNTRY , "Russian Federation" )

TO ( AFFILCOUNTRY , "Ireland" )LIMIT-TO ( AFFILCOUNTRY , "Norway" )LIMIT-TO ( AFFILCOUNTRY , "Croatia" )LIMIT-TO ( AFFILCOUNTRY , "Portugal" )LIMIT-TO ( AFFILCOUNTRY , "Slovenia" )LIMIT-TO ( AFFILCOUNTRY , "Czech Republic" )LIMIT-TO ( AFFILCOUNTRY , "Bulgaria" )LIMIT-TO ( AFFILCOUNTRY , "Romania" )LIMIT-TO ( AFFILCOUNTRY , "Serbia" )LIMIT-TO ( AFFILCOUNTRY , "Iceland" )LIMIT-TO ( AFFILCOUNTRY , "Slovakia" )LIMIT-TO ( AFFILCOUNTRY , "Estonia" )LIMIT-TO ( AFFILCOUNTRY , "Cyprus" )LIMIT-TO ( AFFILCOUNTRY , "Hungary" )LIMIT-TO ( AFFILCOUNTRY , "Lithuania" )LIMIT-TO ( AFFILCOUNTRY , "Ukraine" )LIMIT-TO ( AFFILCOUNTRY , "Georgia" )LIMIT-TO ( AFFILCOUNTRY , "Latvia" )LIMIT-TO ( AFFILCOUNTRY , "Azerbaijan" )LIMIT-TO ( AFFILCOUNTRY , "Belarus" )LIMIT-TO ( AFFILCOUNTRY , "Kazakhstan" )LIMIT-TO ( AFFILCOUNTRY , "Monaco" )Europe Web of Science search strategy:TOPIC: (Respiratory syncytial virus) ORTOPIC: (Respiratory syncytial virus Infection) ORTOPIC:(RSV) ORTOPIC: (RSV infection)Time Span 2011-2015Refined by COUNTRIES/TERRITORIES: (RUSSIA OR AUSTRIA OR ENGLAND ORFRANCE OR NORWAY OR NETHERLANDS OR ITALY OR SPAIN OR LATVIA ORCROATIA OR ESTONIA OR GERMANY OR WALES OR NORTH IRELAND OR UK OR UNITED KINGDOM OR BELGIUM OR PORTUGAL OR ICELAND ORFINLAND OR SWEDEN OR SLOVENIA OR CZECH REPUBLIC OR SWITZERLAND ORREUNION OR TURKEY OR SCOTLAND OR ISRAEL OR UKRAINE OR POLAND ORBULGARIA OR ROMANIA OR DENMARK OR SLOVAKIA OR GREECE OR HUNGARYOR CYPRUS OR IRELAND ) AND COUNTRIES/TERRITORIES: ( ENGLAND ORSLOVENIA OR ICELAND OR FRANCE OR CZECH REPUBLIC OR NETHERLANDS ORREUNION OR ITALY OR SPAIN OR GERMANY OR UKRAINE OR UK OR BELGIUM ORFINLAND OR BULGARIA OR CYPRUS OR SWEDEN OR ROMANIA OR SWITZERLANDOR SLOVAKIA OR TURKEY OR SCOTLAND OR HUNGARY OR ISRAEL OR POLANDOR DENMARK OR GREECE OR IRELAND OR LATVIA OR REP OF GEORGIA ORRUSSIA OR AUSTRIA OR ESTONIA OR NORWAY OR CROATIA OR WALES ORBYELARUS OR NORTH IRELAND OR UNITED KINGDOM OR PORTUGAL )

Appendix 2 – Publications by country throughout North America, Central Americaand the CaribbeanFigure A2.1 Total RSV publications by country in North/Central AmericaFigure A2.2 Epidemiological RSV publications by country in North/Central America

Figure A2.3 Clinical RSV publications by country in North/Central AmericaFigure A2.4 Laboratory RSV publications by country in North/Central America

Appendix 3 – Publications by US StateTable A3 Number of publications by US StateUS StateNumber ofepidemiologicalpublicationsUS StateNumber ofclinicalpublicationsUS StateNumber oflaboratorypublicationsMarylandGeorgiaNew ennessee27242119California11New oloradoNew Jersey644AlabamaPennsylvaniaNew ecticut22WashingtonWest 1Arkansas1WashingtonDC21754

US StateNumber ofepidemiologicalpublicationsUS StateNumber ofclinicalpublicationsUS StateNumber noisLouisiana11IllinoisIndiana11New Jersey1Michigan1New Mexico1New ampshire0Nevada0Nevada0New Mexico00North Dakota0North Dakota0NewHampshireNew JerseyOklahoma0Oregon0North Dakota0Oregon0Rhode Island0Oregon00

US StateNumber ofepidemiologicalpublicationsUS StateNumber ofclinicalpublicationsUS StateNumber oflaboratorypublicationsRhode Island00Rhode Island0South Dakota0SouthCarolinaSouth Dakota00Vermont0Utah0SouthCarolinaSouth DakotaVirginia0Vermont0Utah0West Virginia0West : Totals do not add up to the total number of clinical, epidemiological and laboratory studiesreported for the USA elsewhere in this study due to publications where first and last authors were fromdifferent US states

Appendix 4 – Publications by institutionTable A4 Number of publications by institutionResearch niversity Medical Center Utrecht7National Institutes of Health14Imperial College London4Emory University8Vanderbilt University8University of Michigan4Ohio State University1Centers for Disease Control &10PreventionGeorgia State University10University of Texas Medical Branch1GalvestonChildren's Healthcare Atlanta7University of Toronto11University of Tennessee Health4Science CenterHarvard Unviersity6Univeristy of Edinburgh2Radboud University Nijmegen Medical 0CenterJohn Hopkins University9Instituto de Salud Carlos III1University Groningen7McMaster University8University of Rochester2King's College London2Le Bonheur Children's Hospital0University of Washington3Karolinska Institutet5Rega Institute for Medical Research0US Food & Drug Administration4Erasmus Medical Center4Medical University of Graz5Boston University0Iowa State University0University of Saskatchewan5Institut 8888424035282323212017

Research InstitutionNational Institute for Public Health andthe Environment (RIVM)Turku University HospitalUniversity of TampereBaylor College of MedicineUniversity of GeorgiaINRA, Unité de Virologie etImmunologie Moléculaires, Jouy-enJosasEpidemiologica Footnote: Table displays only institutions who were identified as having 5 or more publicationsAppendix 5 – Publications by funding bodyTable A5 Number of publications by funding bodyEpidemiologicalFunding BodyNational Institutes of pean Commission8Medical Research Council8Wellcome Trust6Centers for Disease Control & Prevention19Canadian Institutes of Health Research5National Institute for Health Research5(NIHR)Bill & Melinda Gates Foundation14GlaxoSmithKline6Consejo Nacional de Ciencia y Tecnologia4(CONACYT)Emory University5Virgo Consortium0Georgia Research Alliance7Institute for the Promotion of Innovation by3Science and Technology (IWT)Novartis6University Medical Center Utrecht0March of Dimes4US Department of Veterans Affairs1Top Institute Pharma, the Netherlands3Sanofi6Vanderbilt University3Children's Healthcare of Atlanta2Flight Attendant Medical Research Institute 1490103125126871543111110101010988

Funding BodyItalian Ministry of HealthAmerican Lebanese Syrian AssociatedCharitiesDutch GovernmentSapienza Universita di Roma (FondiRicerche Universitari)Agency For Healthcare Research andQuality (AHRQ)American Heart AssociationAsthma UKBurroughs Wellcome FoundationNational Science FoundationNetherlands Genomics Initiative (NGI)US Department of 87234212775106002403140021524242666666Footnote: Table displays only funding bodies who were identified as providing funding for 5 or morepublications

Appendix 6 – Highly cited RSV publications on Web of Science published between 2011-2015TitleAuthorInstitutionof firstauthorRespiratory Syncytial Virus and Recurrent Wheeze inHealthy Preterm InfantsStructure-Based Design of a Fusion GlycoproteinVaccine for RespiratorySyncytial VirusHospitalizations Associated With Influenzaand Respiratory Syncytial Virus in the United States,1993-2008Progress in understanding andcontrolling respiratory syncytial virus: Still crazy after allthese yearsBlanken MOUniv Med Ctr UtrechtNetherlands 2013Timescited (By12 March2018)248McLellan JSNIAID, Vaccine Res Ctr, NIH,Bethesda, MDCtr Dis Control & Prevent,Influenza Div, Atlanta, GAUSA2013219USA2012215USA, Spain2011214Identification of nucleolin as a cellular receptor forhuman respiratorysyncytial virusStructure of Respiratory Syncytial Virus FusionGlycoprotein in the Postfusion Conformation RevealsPreservation of Neutralizing EpitopesCord Blood Vitamin D Deficiency Is AssociatedWith Respiratory SyncytialVirus BronchiolitisUpdated Guidance for Palivizumab Prophylaxis AmongInfants and Young Children at Increased Risk ofHospitalization for Respiratory Syncytial VirusInfectionTayyari FNIAID, Infect Inst Salud CarlosDis Lab, NIH, III, CIBERBethesda,EnferrnedadesMD 20892Resp, MadridUSA28220, SpainUniv British ColumbiaCanada2011153McLellan JSNIAID, Vaccine Res Ctr, NIH,Bethesda, MDUSA2011152BelderbosMEBrady MTUniv Med Ctr UtrechtNetherlands 2011149Zhou HColline PLInstitution of lastauthor (ifdifferent)CountryAmerican Academy of Paediatrics USAYear2014133