WIXLIB

IN vice & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

Leading the way in molecular imagingYour path to discovery starts hereGain a greater understandingof disease and therapeuticefficacy using our wide range ofin vivo imaging solutions.InjectAnalyzeBioluminescent, Fluorescent &Radionuclide Imaging AgentsResearchers trust our invivo imaging solutions togive them reliable, calibrateddata that reveals pathwaycharacterization andtherapeutic efficacies for abroad range of indications.Our reagents, instruments,and applications support havehelped hundreds of researchprojects over the years. Andour hard-earned expertisemakes us a trusted provider ofpre-clinical imaging solutions—with thousands of peerreviewed articles as proof.Advanced Imaging SoftwareImage2D & 3D optical and microCTimaging systemsHomeReagentsSystemsSoftwareService & SupportCase StudiesSupportService & Application ExpertiseINTERACTIVE PRODUCT SELECTOR »

In Vivo Imaging ReagentsMetastases of Bioware Brite Cancer Cell Line imaged using the IVIS SpectrumCTIn vivo imaging solutions startwith our comprehensive portfolioof optical imaging reagents builtaround your applications.Bioluminescent Reagents »Fluorescent Reagents »Radioimaging Nuclides »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

IN VIVO IMAGING REAGENTSBioluminescent ReagentsBioware Brite MCF7 Red-FLuc bioluminescent cells (BW119262) imaged using IVISObtain more information from yourtarget with PerkinElmer’s widerange of bioluminescent reagentsoptimized on the IVIS platform. Bioluminescent Substrates Bioluminescent Cancer Cell Lines Bioluminescent Bacteria Lentiviral ParticlesBioluminescent ReagentsFluorescent Reagents »Radioimaging Nuclides »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

IN VIVO IMAGING REAGENTSFluorescent ReagentsAnnexin-Vivo 750 Fluorescent Agent (Cat# NEV11053) imaged using the IVIS SpectrumCTOur comprehensive suite offluorescent in vivo imaging agentsenables unmatched imaging ofa broad range of disease-relatedbiomarkers and pathways in yourresearch models. Activatable Fluorescent Agents Targeted Fluorescent Agents Vascular Fluorescent Agents Fluorescent Labeling Dyes & KitsBioluminescent Reagents »Fluorescent ReagentsRadioimaging Nuclides »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

IN VIVO IMAGING REAGENTSRadioimaging Nuclides89-Zirconium labelled peptide imaged using PET.Courtesy: Richard Tavare, UCLADo you have the right radionuclidefor your research? We provideradionuclides for many imagingmodalities, including PET, SPECT,and Cerenkov Light Imaging. Zirconium-89 Yttrium-90 Chromium-51 Phosphorus-32 Iodine-124 Iodine-131Bioluminescent Reagents »Fluorescent Reagents »Radioimaging NuclidesHomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

In Vivo Imaging SystemsGain greater understanding ofdisease and therapeutic efficacyusing our wide range of in vivoimaging systems. Our systems areavailable in single- and multipleimaging modalities.IVIS Lumina Series Benchtop2D Optical SystemsIVIS Spectrum Series2D & 3D OpticalTomography SystemsQuantum GX2 microCT SystemOptical Imaging Systems »MicroCT Imaging Systems »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

IN VIVO IMAGING SYSTEMSOptical ImagingBioware Brite cell line 4T1-Red-FLuc (BW124087) knee metastasis model imaged using the IVIS Lumina X5With thousands of peer-reviewedpublications, PerkinElmer’soptical imaging platform is thegold standard for imaging. IVIS Lumina Benchtop Series for2D optical imaging with optionalintegrated X-ray IVIS Spectrum Series for 2D and3D optical imaging with optionalintegrated microCT FMT Series for 3D fluorescencetomographyOptical Imaging SystemsMicroCT Imaging Systems »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

IN VIVO IMAGING SYSTEMSMicroCT ImagingHeart, lung and vasculature imagedusing the Quantum GX2 microCTLow-dose, high-speed 3D X-rayimaging of anatomical andfunctional readouts—ideal forlongitudinal imaging. Quantum GX2 high-resolutionmicroCT system IVIS SpectrumCT optical systemwith integrated microCTOptical Imaging Systems »MicroCT Imaging SystemsHomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

High-Performance Imaging SoftwareAnalyze even the most compleximaging data with ease. Oursoftware features intuitiveworkflows that streamlinedata analysis to expediteturnaround from acquisition topresentation. Living Image designedfor the IVIS platform TrueQuant for streamlinedanalysis with the FMT platform AccuCT for advancedmicroCT analysisLiving Image Software »TrueQuant Software »AccuCT Imaging Software »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

IN VIVO IMAGING SOFTWARELiving Image SoftwareLiving Image advanced softwaredesigned for the IVIS platformsimplifies even the most compleximage acquisition and analysis ofbioluminescent and fluorescentprobes in vivo. Imaging Wizard to streamlineacquisition setup Longitudinal imaging analysis tools Comprehensive set of toolsfor 2D or 3D data analysisLiving Image SoftwareTrueQuant Software »AccuCT Imaging Software »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

IN VIVO IMAGING SOFTWARETrueQuant SoftwareDesigned for the FMT platform,TrueQuant software makes 3Dfluorescence tomography easy withstreamlined tools for data analysis. Advanced study managementtools for streamlined acquisition Automated quantification Automated reconstruction withadvanced algorithmsLiving Image Software »TrueQuant SoftwareAccuCT Imaging Software »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

IN VIVO IMAGING SOFTWAREAccuCT Imaging SoftwarePerform bone morphology andBMD analysis in just a few clickswith AccuCT advanced microCTimaging software designed for theQuantum imaging system. Workflow-based software interface Automated bone segmentation User-friendly analysis, reducingvariation between usersLiving Image Software »TrueQuant Software »AccuCT Imaging SoftwareHomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

Service & Application SupportThe more you know, thebetter research decisions youcan make. With our expertapplication and service support,we ensure that you keep yourinstruments running and yourresearch moving forward. Scientific expertise across awide range of application areas Hands-on training throughIn Vivo University OneSource LaboratoryService SupportHomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

eagentsCardiovascular DiseasePulmonary DiseaseSystemsCell TrackingToxicologySoftwareGastrointestinal DiseaseTumor HypoxiaBreast CancerService & SupportImmunology & InflammationProstate CancerColon CancerCase StudiesInfectious DiseaseBrain CancerNeurological DiseaseLung CancerINTERACTIVE PRODUCT SELECTOR »

CASE STUDY:OncologyJen Koblinski, PhDAssistant Professor of PathologyMassey Cancer Center, VirginiaCommonwealth UniversityDr. Koblinski has had a long interest in therelationship between tumor cells and theirspecific microenvironments during themetastatic cascade, with a specific interest inthe brain. Her research focuses on elucidatingthe role of syndecans, heparan sulfateproteoglycans, in facilitating breast cancermetastasis to the brain. With the IVIS Spectrumimaging system, Dr. Koblinski is able to trackand quantify brain metastases in vivo and exvivo, gaining insights into the mechanisms thatfacilitate breast cancer brain metastasis.NEXT »HomeReagentsSystemsSoftwareService & SupportCase StudiesINTERACTIVE PRODUCT SELECTOR »

CASE STUDY:Alzheimer’s DiseaseChongzhao Ran, PhDAssistant Professor of RadiologyMartinos Imaging Center, MassachusettsGeneral Hospital, Harvard Medical SchoolDr. Ran’s research has been focused ondeveloping probes for systemic molecularimaging of Alzheimer’s disease. In the past years,Dr. Ran’s group has invented curcumin-basedfluorescence probe library, CRANAD-X, for imagingvarious amyloid beta (Aß) species and oxidativestress (H2O2 and ROS). With the IVIS Spectrumimaging system, Dr. Ran’s group demonstratedthat NIRF brain imaging with CRANAD-X could beused to detect soluble and insoluble Aßs of ADmouse models. Recently his group showed thatNIRF ocular imaging (NIRFOI) could detect andmonitor Aßs in the eyes of AD mice. NIRFOI hasthe potential for clinical applications in the future.« PREVIOUSHomeReagentsSystemsSoftwareService & SupportCase StudiesNEXT »INTERACTIVE PRODUCT SELECTOR »

CASE STUDY:PET Probe DevelopmentCristina Müller, PhDGroup LeaderCenter for RadiopharmaceuticalSciences (ETH/PSI), Zurich, Switzerland(a) 64Cu-NODAGA-folate static PET scan in CD1 nude mice with cervical cancer xenografts(b) 18F-AzaFol static PET in CD1 nude mice with cervical cancer xenografts(c) 44Sc-labeled PSMA-617 static PET/CT scan of SCID mouse with LNCaP prostate cancer xenograftT TumorK KidneyB BladderDr. Müller’s research has been focused ondeveloping probes for Positron EmissionTomography (PET) for use in a number ofapplications, including development andevaluation of folate-based radioconjugatesand the imaging and therapy of cancer andinflammatory diseases. For Dr. Müller’s group,the G8 PET/CT has proven to be particularlyeffective for the evaluation of novel in-houseproduced radiotracers, which are initially onlyavailable in small quantities. The fact thatthe scanner is small and mobile has allowedher group to transport it to other facilities,enabling them to recently use the G8 PET/CT for imaging in vivo 11C production afterproton irradiation of tumor xenografts in mice.All PET /CT images courtesy of Dr. Cristina Müller, Center for Radiopharmaceutical Sciences (ETH/PSI),Zurich, Switzerland, used with permission.« PREVIOUSHomeReagentsSystemsSoftwareService & SupportCase StudiesNEXT »INTERACTIVE PRODUCT SELECTOR »

aCT (Quantum GX)bPET & CT (G8)CASE STUDY:Multimodality ImagingDr. David Shackelford, PhDAssociate ProfessorUCLA David Geffen School of MedicineContrastc18F-FDG3D BLI (IVIS Spectrum)dD-luciferin3D BLI (IVIS Spectrum)PeroxyTrace (H2O2)Multimodality imaging of genetically engineered mouse models (GEMMs) of lung cancer.(a) Computed tomography (CT) imaging with contrast in a GEMM of lung cancer. T tumor. H heart.(b) 18F-FDG positron emission tomography (PET) and CT imaging of the same mouse from (A).(c) 3D bioluminescent imaging (BLI) of the same mouse using D-luciferin.(d) 3D bioluminescent imaging (BLI) of the same mouse using a caged luciferin, PeroxyTrace,to measure intra-tumoral peroxide levels in tumors.All PET/CT and BLI images courtesy of Dr. David Shackelford, UCLA David Geffen School of Medicine,Los Angeles CA, USA, used with permission.HomeReagentsSystemsSoftwareService & SupportDr. Shackelford’s research focuses onunderstanding key genetic, molecular, andmetabolic events that drive lung tumordevelopment and progression. His focus is onusing complementary multimodality imagingapproaches on genetically engineered mousemodels (GEMMs) of lung cancer in order tofunctionally map key metabolic events thatshape tumorigenesis. His approach combines 3Dbioluminescent imaging using the IVIS Spectrumwith positron emission tomography (PET) imagingusing the G8 PET/CT scanner. By coupling the useof caged luciferins with 18F-labeled radiotracers,Dr. Shackelford has begun to non-invasivelyprofile key metabolic events that dictate how lungtumors form and evolve from early to advancedstages of the disease.« PREVIOUSCase StudiesINTERACTIVE PRODUCT SELECTOR »