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Updated 04-13-15CURRICULUM VITAEDineo Khabele, MD, FACOG, FACSAssociate Professor of Obstetrics and GynecologyDirector, Gynecologic Oncology Translational ResearchDivision of Gynecologic OncologyDepartment of Obstetrics and GynecologyVanderbilt University Medical Center1161 21st Ave S, B-1100 MCNNashville, TN 37232-2516(615) 322-8702 (P) (615) 343-8403 (F)e-mail: dineo.khabele@vanderbilt.eduEDUCATION1985 – 19891990 – 1994BA, Premedical Studies and Political ScienceColumbia College, Columbia University, New York, NYMD, MedicineCollege of Physicians and Surgeons, Columbia University, New York, NYPOST-DOCTORAL TRAINING1994 – 1997Resident, Obstetrics and GynecologyThe New York Presbyterian Hospital, Weill-Cornell University Medical Center, NewYork, NY1997 – 1998Chief Resident, Obstetrics and GynecologyThe New York Presbyterian Hospital, Weill-Cornell University Medical Center, NewYork, NY1998 – 2001Clinical Fellow, Gynecologic OncologyAlbert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY2001 – 2004Research Fellow, Cancer Biology (Ovarian Cancer)(Mentors: Raju Kucherlapati, PhD and Leonard Augenlicht, PhD)Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NYLICENSURE/CERTIFICATION1995Federation of Licensing Examination1995New York (Active)2004Tennessee (Active)2005Certification in Obstetrics & Gynecology2005Fellow, American College of Obstetricians & Gynecologists2007Subspecialty Certification in Gynecologic Oncology2008Fellow, American College of SurgeonsACADEMIC APPOINTMENTS2001 – 2004Assistant Professor, Department of Obstetrics & Gynecology and Women’s Health,Albert Einstein College of Medicine, Bronx, NY2002 – 2004Laboratory Director, Molecular Genetics and Translational Research Program forWomen’s Cancers and Other DisordersAlbert Einstein College of Medicine, Bronx, NY2004 – 2011Adjunct Assistant Professor, Department of Obstetrics & Gynecology and Women’sHealth, Albert Einstein College of Medicine, Bronx, NY2004 – 2008Assistant Professor, Department of Obstetrics and GynecologyDirector, Division of Gynecologic OncologyDirector, Women’s Cancer Research LaboratoryDepartment of Obstetrics & GynecologyMeharry Medical College, Nashville, TN1
2005 – 20082008 – 20142008 – present2008 – present2008 – 20142008 – 20142015 - presentAdjunct Clinical Instructor, Department of Obstetrics and GynecologyAdjunct Assistant Professor, Department of Cancer BiologyVanderbilt University, Nashville, TNAssistant Professor, Department of Obstetrics and GynecologyAssistant Professor, Department of Cancer BiologyVanderbilt University, Nashville, TNDirector, Gynecologic Oncology Translational Research, Department of Obstetrics andGynecology, Vanderbilt University, Nashville, TNMember, Genome Maintenance Program, Vanderbilt-Ingram Cancer Center,Vanderbilt University, Nashville, TNAdjunct Assistant Professor, Department of Obstetrics and GynecologyMeharry Medical College, Nashville, TNVisiting Faculty, Chemical Biology Program, the Broad Institute of MIT and Harvard,Cambridge, MAAssociate Professor, Department of Obstetrics and GynecologyAssociate Professor, Department of Cancer BiologyVanderbilt University, Nashville, TNHOSPITAL APPOINTMENTSAttending Physician1998-2004Weiler Hospital, Bronx, NYMontefiore Medical Center, Bronx, NYJacobi Medical Center, Bronx, NYNorth Central Bronx Hospital, Bronx, NYBronx Lebanon Hospital, Bronx NY2004-2009Nashville General Hospital, Nashville, TNSt. Thomas Hospital, Nashville, TNBaptist Hospital, Nashville, TNCentennial Hospital, Nashville, TNMiddle Tennessee Medical Center, Murfreesboro, TN2004-presentVanderbilt University Hospital, Nashville, TNOTHER EMPLOYMENT1989 – 1990Health Educator, Student Health Services, Columbia CollegeColumbia University, New York, NYPROFESSIONAL ORGANIZATIONSAmerican College of Obstetricians and Gynecologists, FellowAmerican College of Surgeons, FellowAmerican Association for Cancer Research, MemberAmerican Society of Clinical Oncology, MemberGynecologic Oncology Group, MemberNational Medical Association, MemberSociety of Gynecologic Oncology, MemberSociety of Black Academic Surgeons, MemberHONORS AND AWARDSPre-doctoralCollege of Physicians and Surgeons, Columbia University1991NIH/Dean’s Fellowship for Research, 19921992Metropolitan Life Foundation Scholarship1992 – 1994Malcolm X ScholarshipJohn Bohmfalk Scholarship2
19941994Aaron Diamond Foundation Award in Human Rights and Medicine, Externship inMalawi and MozambiqueDr. Cecil G. Marquez/B.A.L.S.O. Student Award for Excellence Gate PharmaceuticalAchievement Award in Obstetrics & GynecologyHarvard Medical School1993Minority Faculty Development Visiting Clerkship ProgramPost-doctoral2000 – 20062003 – 200820042004Reproductive Scientist Development Program AwardAPGO/CREOG-NICHD Scholar (2000-2002)NIH Scholar (2002-2003)Ovarian Cancer Research Fund Scholar (2003-2006)Harold Amos Medical Faculty Development Program ScholarRobert Wood Johnson FoundationDistinguished Faculty Mentor Recognition Award, Hispanic Center of ExcellenceAlbert Einstein College of MedicineLeo M. Davidoff Society, Outstanding Achievement Award in TeachingAlbert Einstein College of MedicineSpecial Awards or Recognition for Professional Activity2014Five Star Customer Service Award, Vanderbilt Medical GroupINTRAMURAL PROFESSIONAL ACTIVITIESUniversity Committees1997 – 1998Resident Representative, Quality Assurance Committee, Department of Obstetrics andGynecology Weill-Cornell University Medical Center, New York, NY2003 – 2004Member, Quality Improvement Committee, Department of Obstetrics & Gynecology andWomen’s Health, Albert Einstein College of Medicine & Montefiore Medical Center,Bronx, NY2004 – 2008Member, Quality Assurance Committee, Department of Obstetrics & Gynecology,Meharry Medical College, Nashville, TN2005 – 2007Member, Faculty Senate, Meharry Medical College, Nashville, TN2006 – 2008Member, OB/GYN Executive Faculty Committee, Meharry Medical College, Nashville,TNMember, OB/GYN Finance Committee, Meharry Medical College, Nashville, TNMember, OB/GYN Education Committee, Meharry Medical College, Nashville, TN2007Member, Search Committee, Director of the Center for Molecular and BehavioralNeuroscience, Meharry Medical College, Nashville, TNMember, Research Committee, Presidential Transition Team, Meharry Medical College,Nashville, TNMember, Technology Policy and Intellectual Transfer Committee,Meharry Medical College, Nashville, TN2008 – presentMember, Multi-disciplinary Tumor Conference, Vanderbilt University,Nashville, TN2011 – presentMember, Departmental Research Committee, Department of Obstetrics & Gynecology,Vanderbilt University, Nashville, TNChair, Departmental Research Infrastructure Sub-Committee, Department of Obstetrics &Gynecology, Vanderbilt University, Nashville, TNSupervisor, Research Support Staff, Department of Obstetrics & Gynecology, VanderbiltUniversity, Nashville, TNMember, Health Disparities Task Force, Vanderbilt-Ingram Cancer Center, VanderbiltUniversity, Nashville, TN3
Liaison to Office of Diversity, Department Obstetrics & Gynecology, VanderbiltUniversity, Nashville, TNHospital Committees1997 – 19982004 – 20082006 – 2008Resident Representative, The New York Hospital Quality Assessment and ImprovementCommittee, The New York Presbyterian Hospital, New York, NYMember, Cancer Committee, Nashville General Hospital at Meharry,Nashville, TNMember, Tumor Board, Nashville General Hospital at Meharry, Nashville, TN,Member, Operative and Other Invasive Procedures Committee, Nashville GeneralHospital at Meharry, Nashville, TNEXTRAMURAL PROFESSIONAL ACTIVITIESLocal and Regional Community Health Advisory Boards2005 – presentPhysician Volunteer and Advocate, American Cancer Society,Nashville, TN2005 – presentMember, National Black Leadership Initiative on Cancer III,Nashville, TN2006 – presentMember, Advisory Board, The Witness Project of Nashville, Nashville, TN2006 – 2008Chair, Vaccine Delivery and Financing Working Group, Cervical Cancer EliminationCommittee (Governor-Appointed Task Force), Nashville, TN2007 – presentMember, Advisory Committee, Tennessee Breast and Cervical Cancer ScreeningProgram, Nashville, TN2008 – 2012Member, Advisory Board, Susan G. Komen for the Cure, Nashville Affiliate, Nashville,TNNational Advisory Boards and Committees2000 – 2001Member, Fellows Committee, Society of Gynecologic Oncologists2008 – 2011Member, Marketing and Communications Committee, Society of GynecologicOncologists2006 – presentMember, Scientific and Medical Advisory Committee, Ovarian Cancer National Alliance2011 – 2014Member, Health Disparities Task Force, Society of Gynecologic Oncology2015Member, Scientific Advisory Committee, the Ovarian Cancer Research FundOther Community Service2006 – 2010Member, Board of the Hadley Park Junior Tennis Development Program,Nashville, TNJournal ReviewerAnnals of Surgical Oncology; Cancer Research; Chemotherapy; Clinical Cancer Research; GynecologicOncology; Journal of the National Medical Association; Molecular Cancer Research; Neoplasia; PLoS Medicine;BMC Cancer; Cancer Prevention ResearchGrant Reviewer2006 - 20072012 - 20132013 - 201420142015Special Emphasis Panel Study Section, National Institutes of Health, Ad HocDepartment of Defense Ovarian Cancer ProgramSpecial Emphasis Panel Study Sections, National Institutes of Health, Ad HocNational Institutes of Health: Molecular and Integrative Signal Transduction (MIST)Study Section, Ad Hoc; Reducing Health Disparity, SBIR Study Section, NationalInstitute of Biomedical Imaging and Bioengineering, Ad Hoc; National Institute onMinority Health and Health Disparities (U54), Ad HocHearing the Ovarian Cancer Whisper (HOW) Foundation GrantsSpecialized Programs of Research Excellence (SPORE) Review I, National Institutes ofHealth4
TEACHING ACTIVITIES2001 – 2004Lecturer and Clinical Preceptor for medical students, residents and fellowsObstetrics & Gynecology, Gynecologic Oncology RotationAlbert Einstein College of Medicine, Bronx, NY2002 – 2004Lecturer for 1st year medical students, Unit 3: Growth Control and Cancer Molecular andCellular Foundations of Medicine2003 – 2004Course Director, for 1st year medical students, Unit 3: Growth Control and CancerMolecular and Cellular Foundations of MedicineAlbert Einstein College of Medicine, Bronx, NY2004 – presentLecturer and Clinical Preceptor for medical students and residents, Obstetrics &Gynecology Clerkship, Gynecologic Oncology RotationMeharry Medical College, Nashville, TN2004 – 2008Lecturer for 1st year medical students, Molecular Cell Biology and Genetics IIMeharry Medical College, Nashville, TN2005 – presentLecturer for medical and graduate students, Cancer Biology IVanderbilt University, Nashville, TN2008 – presentClinical Preceptor for medical students and residentsVanderbilt University, Nashville, TN2008 – presentResearch Preceptor for medical and graduate studentsVanderbilt University and Meharry Medical College, Nashville, TN2008 – presentLecturer for graduate students, Cancer Biology I and IIMeharry Medical College, Nashville, TN2010 – presentGuest lecturer, Belmont University School of Pharmacy, Nashville, TNFormal DidacticsOvarian Cancer Lecture – Obstetrics and Gynecology Residents (2 hour/year)Ovarian Cancer Lecture - Medical Oncology Fellows (2 hours/year)Cancer Biology Science Hour Reviewer (2 hours/year)Cancer Biology I and II (2 hours/year)Cancer Biology I and II (Meharry Medical College) (4 hours/year)Ovarian Cancer and Pharmacology (Belmont Pharmacy School) (2 hours/year)Clinical TeachingBedside Medical Student/Resident Rounds at Vanderbilt University Hospital (2 hours/week)Intraoperative/Surgical Medical Student/Resident Training (one day/week)Boards review and mock oral examinations at Meharry Medical College and Vanderbilt University (once a year)Multi-disciplinary Tumor Board, Vanderbilt University, Resident Supervisor/Mentor, (2 hours/week) - 2008-2013Community Medical Education (CME) through the Vanderbilt Outreach Program on new Screening Guidelinesand Primary Prevention of Cervical Cancer (2012-2013)Graduate Student TeachingPreceptor, Cancer Biology Science Hour (2 hours/year)Qualifying Examination Committee Member:Shenika Poindexter, PhD. Candidate, Cancer Biology (2010)Jennifer Malinowski, PhD Candidate, Center for Human Genetics Research (2012-2013)Keisha Nicole Hardeman, PhD Candidate, Cancer Biology (2013)Katherine Venmar, PhD Candidate, Cancer Biology (2013-present)Thesis Committee Member:Elizabeth Vargis, PhD, Biomedical Engineering (2012-2013), graduated 2013Christine O’Brien, PhD Candidate, Biomedical Engineering, (2014-2015)David Austin, PhD Candidate, Cancer Biology (2014-2015)5
Thesis Examiner:Bee Shin Tan, PhD Candidate University of Melbourne, Australia (2013)Research Supervision -Vanderbilt University Translational Gynecologic Oncology ResearchSponsor and mentor medical, graduate, resident, undergraduate and high school student laboratory rotators (4hours/week)Faculty MentorAndrew Wilson, PhD, Research Assistant Professor, Obstetrics and Gynecology, Vanderbilt University,Nashville, TN (2008-present)Alicia Beeghly-Fadeil, PhD, Assistant Professor, Epidemiology, Vanderbilt University, Nashville, TN(2012-present)Fellows/ResidentsHye-Joeng Lee, PhD, Research Instructor, Pediatrics, Vanderbilt University, Nashville, TN (2007-2010)Syeda S. Zaidi, MD, Fellow, Endocrinology, Internal Medicine, Vanderbilt University, Nashville, TN(2012-2013)Andres Ayuso, MD, Resident, Obstetrics and Gynecology, Vanderbilt University, Nashville, TN (20122013)Amy Zhai, MD, Resident, Obstetrics and Gynecology, Vanderbilt University, Nashville, TN (2013present)Tara Nielsen, MD, Resident, Obstetrics and Gynecology, Vanderbilt University, Nashville, TN (2014present)Medical StudentsAnnie Y. Liu, MD, Resident, Obstetrics and Gynecology, Tufts University, Boston, MA (2010-2011)Oluwafunmilayo B. Adebayo, Resident, Surgery, Ohio State University, Columbus, OH (2012)Carmen Adams, MD, Resident, Obstetrics and Gynecology, Northwestern University, Chicago, Ill (20112012)Lanzi Sinaise, Medical student, Meharry Medical College (Summer 2012)Dembi Huya-Kouadio, MS, Medical student, Meharry Medical College (Summer 2013, Summer 2014)Stacey Smith, Medical student, Meharry Medical College (Summer 2014)Graduate StudentsElizabeth Vargis, PhD, Assistant Professor, Biological Engineering, Utah State University, Logan, UT(2007-2013)Erica Wass, Pharm D, Clinical Staff Pharmacist, Pinnacle Health System, Harrisburg, PA (2011-2012)Undergraduate StudentsMaggie Williams, BS, College of Veterinary Medicine, Auburn University, Auburn, AL (2011-2012)Tiffany (Edwards) Keith, Took time off after college. Recently accepted to several physician’s assistantschools (2011-2012)Jade Readus, Student, Tennessee State University, Nashville, TN (Summer 2012)Marcella Riley, Fulltime health administration position at the Truman Medical Centers, Kansas City, MO(2011-2012)Michelle Park, Medical Student, Case Western Reserve University, Cleveland, OH (2012-2013)Anum Lalani, Student, Vanderbilt University, Nashville, TN (2012-2014)High School StudentsAmna Asad, High School Student, Harpeth Hall School, Nashville, TN (2013-2014)Formal mentoring programMentor for Dembi Huya-Kouadio, Meharry Medical College student, Recipient of the Conquer CancerFoundation of ASCO 2014 Medical Student Rotation Award (8 week summer rotation, 2014)6
Mentor for Danielle O. Wright, Medical University of South Carolina student, ASCO Diversity MentoringProgram (1 hour/month)Informal mentor for faculty, high school, undergraduate, graduate and medical students with interests in women’scancer, cancer disparities, and biomedical sciences (4 hours/month)PROFESSIONAL DEVELOPMENTThe Berlex Oncology Foundation, Clinical Pharmacology of Anticancer Drugs, 1999AACR/ASCO Methods in Clinical Cancer Research, 2001The Berlex Oncology Foundation, Genetics in Oncology Workshop, 2001The Berlex Foundation, Faculty Development Course, 2003AAMC, Early Career Women Faculty Professional Development Program, 2006Joy McCann Junior Faculty Development for Women in Medicine, Meharry Medical College, 2005-2006Women on Track, Vanderbilt University, 2008-presentdaVinci Gynecologic Surgery Training Program. (Arnold Advincula, MD). Sunnydale, CA, 2009Newman Society, Vanderbilt University, 2010-presentCLINICAL RESEARCH2006-2008Co-investigator, Gynecologic Oncology Group trials MBCCOP, Meharry MedicalCollege, Nashville, TN2008-presentCo-investigator, Gynecologic Oncology Group and investigator-initiated trials,Vanderbilt University, Nashville, TNTRANSLATIONAL RESEARCH2008-presentDirector, Gynecologic Oncology Translational Research, Vanderbilt University,Nashville, TNThis research program focuses on the development of individualized molecular diagnostics and therapeutics basedon genetic and epigenetic alterations in DNA damage response, inflammatory, and cell death pathways in ovariancancer. My laboratory uses patient-derived xenografts and genetically engineered and syngeneic mouse models ofovarian cancer to study these pathways and to test novel diagnostics and therapeutics for eventual translation tothe clinic. We have generated a clinically annotated tumor bank of fresh tissue samples and paraffin-embeddedtissue microarrays that serve as an ongoing and valuable resource for translational research. My laboratory iscurrently funded by intramural and extramural fundingGRANT AWARDSACTIVEK08CA148887 Khabele (PI)5/1/10 – 10/31/15NIH/NCI 736,500Targeting Histone Deacetylases with Small Molecule Inhibitors in Ovarian CancerRole: PIWomen’s Final Four Grant Khabele and Marnett (Co-PIs)05/01/14 – 04/30/15Kay Yow Cancer Fund 100,000Imaging Ovarian Cancer with Novel Small Molecule Radiotracers of Cyclooxygenase-1Role: Co-PI9.0 months0.6 monthsOC130355 Beeghly-Fadiel (PI)09/01/2014-08/31/20160.6 monthsDOD/Ovarian Cancer Research Pilot Award 120,507The Pharmacogenetics Ovarian Cancer Knowledge to Individualize Treatment (POCKIT) StudyRole: Co-investigator7
COMPLETED1999 - 2001 Ovarian Cancer Research Fund Grant Khabele (PI)Patterns of Gene Expression in Ovarian Cancer(Mentor: Raju Kucherlapati, Ph.D.)Role: PI2000 - 2004 Reproductive Scientist Development ProgramGene Expression Profiles in Ovarian CancerNICHD (5K12HD0084) Scholar Khabele (PI)(Mentors: Raju Kucherlapati, Ph.D., Leonard Augenlicht, Ph.D.)Role: PI2004 - 2006Reproductive Scientist Development ProgramCOX-1 Gene Expression and Apoptosis: Profiling Potential Mechanisms of Chemotherapy Resistance in OvarianCancer Khabele (PI)Mentors: Raju Kucherlapati, Ph.D., Leonard Augenlicht, Ph.D. and Sudhansu K. Dey, Ph.D.Role: PI2004 - 2008AMFDP/ Robert Wood Johnson FoundationKhabele (PI)Using TNFalpha gene expression profiles to predict PTX-based chemotherapy responseMentors: Leonard Augenlicht and Samuel Adunyah, Ph.D.Role: PI2005 - 2008G2 RR 03032, NIH/RCMITownsel (PI)Dissecting COX-1 related gene pathways in ovarian cancersMentor: Sudhansu K. Dey, Ph.D.Role: PI of pilot project2006 - 20095 U54 CA091405-08Moses (PI)MMC and VICC: Partners in Eliminating Cancer DisparitiesCOX-1 and HDAC inhibitors suppress ovarian cancer growth in vitro and in vivo.Role: Co-investigator of pilot project2006Gynecologic Cancer Foundation Daikoku (PI)PPAR delta is a downstream target of COX-1 derived prostaglandins in ovarian cancer.Mentor: Sudhansu K. Dey, Ph.D.Role: Co-investigator2006 - 2007Cytyc CorporationIdentification of cellular markers of cervical neoplasiaRole: PIKhabele (PI)2007 - 2008Gloucester PharmaceuticalsFK228 and Taxol in Ovarian Cancer CellsRole: PIKhabele (PI)2007 - 2009R01 CA095405-05A2Mahadevan-Jansen (PI)Diagnosis of Cervical Precancers Using Raman SpectroscopyRole: Co-investigator2008 - 2009CA091408 5 U54Moses (PI)MMC and VICC: Partners in Eliminating Cancer DisparitiesIncreasing HPV Vaccine Utilization among Hispanic Girls to Reduce Cervical Cancer DisparitiesRole: Co-investigator8
2009Gynecologic Cancer Foundation Khabele (PI)Selective Targeting of HDAC3 in Ovarian CancerRole: PI2008 - 20105 P30 CA068485-13NCICancer Center Support GrantRole: Recipient of start-up fundsPietenpol (PI)2011 - 2013Celgene Corp.Khabele (PI)Orthotopic propagation of primary human ovarian tumors for preclinical investigation of IstodaxRole: PIPUBLICATIONS(Asterisk (*) - Khabele trainee/mentee)Peer-Reviewed Original Publications1.Xiao E, Xia L, Shanen D, Khabele D, Ferin M. Stimulatory effects of interleukin-induced activation ofthe hypothalamo-pituitary-adrenal axis on gonadotropin secretion in ovariectomized monkeys replacedwith estradiol. Endocrinol 135: 2093-2098, 1994; PMID: 79569322.Khabele D, Chasen S. Cardiac tamponade: An unusual presentation of advanced breast cancer in apregnant woman. J Reprod Med. 44: 989-91, 1999. PMID: 105894153.Gross SJ, Ferreira JC, Morrow B, Dar P, Funke B, Khabele D, Merkatz I. Gene expression profile oftrisomy 21 placentas: A potential approach for designing noninvasive techniques of prenatal diagnosis.Am J Obstet Gynecol; 187: 457-62, 2002; PMID: 121939433.Khabele D, Runowicz CD, Fields AL, Anderson PS, Goldberg, GL. Evaluation of low-doseintraperitoneal interferon-alpha for palliation of ascites in patients with non-ovarian gynecologicmalignancies. Gynecol Oncol; 89: 420-3, 2003; PMID:127987054.Sood B, Jones J, Gupta S, Khabele D, Guha C, Runowicz C, Goldberg G, Fields A, Anderson P, VikramB. Patterns of failure after the multimodality treatment of uterine papillary serous carcinoma. Int JRadiat Oncol Biol Phys; 57: 208-16, 2003; PMID:129092355.Mani S, McDaid H, Hamilton A, Hochster H, Cohen MB, Khabel(l)e (sic) D, Griffin T, Lebwhol DE,Liebes L , Muggia F, Horwitz SB. Phase I clinical and pharmacokinetic study of BMS-247550, a novelderivative of Epothilone B, in solid tumors. Clin Cancer Res; 10: 1289-98, 2004; PMID: 149778276.Gorelick C , Lopez-Jones M, Goldberg GL, Romney SL, Khabele D. Coenzyme Q10 lipid-related geneinduction in HeLa cells. Amer J Obstet Gynecol: 190: 1432-4, 2004; PMID: 151678607.Khabele D, Lopez-Jones M, Yang W, Arango D, Gross SJ, Augenlicht L, Goldberg G. Tumor NecrosisFactor-α Related Gene Response to Epothilone B. Gynecol Oncol: 93: 19-26, 2004; PMID:50472098.Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM Montgomery Rice V. Druginduced inactivation or gene silencing of Class I histone deacetylases suppresses ovarian cancer cellgrowth: implications for therapy. Cancer Biol Ther: 6: 795-801, 2007; PMID: 173872709.Son DS, Parl AK, Montgomery Rice V, Khabele D. Keratinocyte chemoattractant (KC)/human growthregulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and humanovarian epithelial cancer cells, Cancer Biol Ther; 6: 1302-12, 2007; PMID: 177122710.Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, DuBois RN, DeySK. ERK is a target of COX-1-PPARδ signaling in epithelial ovarian cancer, Cancer Res: 67: 5285-92,2007; PMID: 1754560811.Lyshchik A, Hobbs SB, Fleischer AC, Khabele D, Son DS, Gore JC, Price RR. Ovarian volumemeasurements in mice with high-resolution ultrasonography. J Ultrasound Med: 26:1419-25, 2007;PMID:1790114412.Klugman SD, Gross SJ, Khabele D, Liang J, Livne K , Lopez-Jones M, Gross B, Cordero DR*, ReznikS. Expression of Keratin 8 and TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Down SyndromePlacentas. Placenta: 29:382-4, 2008; PMID:18343496;PMCID: 247567813.Son DS, Wilson AJ*, Parl AK, Khabele D. The effects of the histone deacetylase inhibitor romidepsin(FK2288) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation ofp21. Cancer Biol Ther: 9: 928-35, 2010; PMID: 204045649
.Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ*, Zheng S, Yenamandra A, LockeK, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW,Xia F, Holson EB, Khabele D, Hiebert SW. Hdac3 is essential for the maintenance of chromatin structureand genome stability. Cancer Cell: 18: 436-47, 2010; PMID: 21075309; PMCID: 3004468Fadare, O, Khabele, D. Pleomorphic liposarcoma of the uterine corpus with focal smooth muscledifferentiation. Int J Gynecol Pathol, 30: 282-7, 2011 ; PMID: 21464725Wilson AJ*, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, SchreiberSL, Khabele D. The DNA damage mark pH2AX differentiates the cytotoxic effects of small moleculeHDAC inhibitors in ovarian cancer cells. Cancer Biol Ther, 12: 484-93, 2011; PMID: 21738006; PMCID:3218590Vargis E , Byrd T, Logan Q, Khabele D, Mahadevan-Jansen A. Sensitivity of Raman spectroscopy tonormal patient variability. J Biomed Opt, 16: e117004, 2011; PMID: 22741036; PMCID: 3384271Khabele D, Fadare O, Liu AY , Wilson AJ*, Wass E , Osteen K, Crispens MA. An orthotopic model ofplatinum-sensitive high grade serous fallopian tube carcinoma. Int J Clin Exp Pathol, 5: 37-45, 2012;PMID: 22295145; PMCID: 3267484Wilson AJ*, Cheng YQ, Khabele D. Thailandepsins are new small molecule class I HDAC inhibitorswith potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancertherapy. J Ovarian Res. 5: e12, 2012; PMID: 22531354; PMCID: 3394212Vargis E , Tan YW, Khabele D, Mahadevan-Jansen A. Using Near-Infrared Raman Microspectroscopyfor the Detection of High-Risk Strains of Human Papillomavirus. Transl Oncol, 5: 172-9, 2012; PMID:22741036; PMCID: 3384271Wilson AJ*, Lalani AS*, Wass E*, Saskowski J, Khabele D. Romidepsin (FK228) combined withcisplatin stimulates DNA damage-induced cell death in ovarian cancer. Gynecol Oncol. 27: 579-86,2012; PMID: 23010348; PMCID: 3541411Fadare O, Khabele D. Salpingo-oophorectomy specimens for endometrial cancer staging: acomparative analysis of representative sampling versus whole tissue processing. Hum Pathol, 44: 64350, 2013; PMID:23084582Fadare O, Zheng W, Crispens MA, Jones HW, Khabele D, Gwin K, Liang SX, Mohammed K, DesoukiMM, Parkash V, Hecht JL. Morphologic and other clinicopathologic features of endometrial clear cellcarcinoma: a comprehensive analysis of 50 rigorously classified cases. Am J Cancer Res, 3: 70-95, 2013;PMID: 23359866; PMCID: 3555196Fadare O, Liang SX, Crispens MA, Jones HW 3rd, Khabele D, Gwin K, Zheng W, Mohammed K,Parkash V, Hecht JL, Desouki MM. Expression of the oncofetal protein IGF2BP3 in endometrial clearcell carcinoma: assessment of frequency and significance. Hum Pathol. 44: 1508-15, 2013; PMID:23465280Fadare O, Gwin K, Desouki MM, Crispens MA, Jones HW 3rd, Khabele D, Liang SX, Zheng W,Mohammed K, Hecht JL, Parkash V. The clinicopathologic significance of p53 and BAF-250a (ARID1A)expression in clear cell carcinoma of the endometrium. Mod Pathol. 26: 1101-10, 2013; PMID: 23524907Fadare O, James S*, Desouki MM, Khabele D. Coordinate patterns of estrogen receptor, progesteronereceptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrialserous adenocarcinomas. Ann Diagn Pathol. 2013 May 21. [Epub ahead of print]; PMID: 23706170Ayuso A*, Fadare O, Khabele D. A case of extrauterine endometrial stromal sarcoma in the colondiagnosed three decades after hysterectomy for benign disease. Case Rep Obstet Gynecol.2013;2013:202458. doi: 10.1155/2013/202458. Epub 2013 Apr 24. PMID: 23710389; PMCID: 3655501.Wilson AJ*, Liu AY*, Roland JT, Adebayo OB*, Fletcher SA, Slaughter JC, Saskowski J, Crispens MA,Jones HW 3rd, James S, Fadare O, Khabele D. TR3 modulates platinum resistance in ovarian cancer.Cancer Res. 73: 4758-69, 2013; PMID: 23720056Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ,Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW. Inhibition of histone deacetylase3 causes replication stress in cutaneous T cell lymphoma. PLoS One. 8: e68915, 2013; PMID: 23894374;PMCID: 3718806Zaidi SS*, Lakhani VT, Fadare O, Khabele D. Adrenal Gland Metastasis Is an Unusual Manifestation ofEndometrial Cancer. Case Rep Surg. 4284562013;2013:. doi: 10.1155/2013/428456. Epub 2013 Aug 6.PMID: 23984164; PMCID: 3748408.10
31.32.33.34.35.36.37.38.39.40.Basu A, Bodycombe NE, Jaime H. Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, ItoD, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ*, Stransky N, Kryukov GV, DancikV, Barretina J, Garraway LA, Hon C SY, Muno B, Bittker JA, Stockwell BR, Khabele D, Stern AM,Clemons PA, Shamji AF, Schreiber SL. An interactive resource to identify cancer genetic and lineagedependencies targeted by small molecules. Cell. 54: 1151-61, 2013; PMID: 23993102Wilson AJ*, Barham W, Saskowski J, Tikhomirov O, Chen L, Lee HJ, Yull F, Khabele D. Tracking NFkappaB activity in tumor cells during ovarian cancer progression in a syngeneic mouse model. J OvarianRes. 6: e63, 2013; PMID: 24020521Cho M*, Kabir SM, Dong Y, Lee E, Rice VM, Khabele D, Son DS. Aspirin Blocks EGF-stimulated CellViability in a COX-1 Dependent Manner in Ovarian Cancer Cells. J Cancer. 2013 Sep 27;4(8):671-8. doi:10.7150/jca.7118. PMID: 24155779Hull PC, Williams EA, Khabele D, Dean C, Bond B, Sanderson M. HPV vaccine use among AfricanAmerican girls: Qualitative formative research using a participatory social marketing approach. GynecolOncol. 2014 Jan 31. pii: S0090-8258(14)00106-1. doi: 10.1016/j.ygyno.2014.01.046. [Epub ahead ofprint] PMID: 24491412Collins Y, Holcomb K, Chapman-Davis E, Khabele D, Farley JH. Gynecologic cancer disparities: Areport from the Health Disparities Taskforce of the Society of Gynecologic Oncology. Gynecol Oncol.2014. May;133(2):353-61 PMID: 24406291; PMCID: PMC4079541Khabele D. The therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancer.Frontiers in Oncology 2014 May 20;4:111. doi: 10.3389/fonc.2014.00111. eCollection 2014. Review.PMID: 24904826Konstantinopoulos PA, Wilson AJ*, Saskowski J, Wass E*, Khabele D.Suberoylanilide hydroxamic ac
2005 - 2007 Member, Faculty Senate, Meharry Medical College, Nashville, TN 2006 - 2008 Member, OB/GYN Executive Faculty Committee, Meharry Medical College, Nashville, TN
