Bibliography And Online Oral-Systemic References


BibliographyandOnlineOralSystemicReferencesG.Lee sreallyamedicalcondition tlerDDSBuildingBridgesBetweenMedicineandDentistry

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Bibliography and Online Oral-Systemic ReferencesBibliography and OnlineOral-Systemic ReferencesCompiled by G. Lee Ostler DDSwww.MDReferrals.netNote to reader: This is a time-sensitive report. All items and links are ‘live’ as of the date of the originalcompilation. You may find some links not active at later times, especially news reports or digests or periodicalmagazines and news reports.Table of Contents:Alzheimer’s Disease and Inflammation. 2Antimicrobial & Laser Assisted Periodontal Therapy. 3Arthritis, Systemic Lupus & Inflammation . 7Biofilms and Microbiology. 10Cancer and Inflammation. 14Cardiovascular Disease and Inflammation . 16Consensus Report. 26C-reactive Protein / Inflammatory Mediators . 26Diabetes, Inflammation & Periodontal Disease. 40Endodontics and Inflammation . 50General Interest – Misc. 51Genetics and Periodontal Disease. 52Hypertension and Inflammation . 55Kidney Disease, Inflammation and Periodontal Disease. 57Lung Disease and Periodontal Disease . 58Microbiology. 59Mouth Rinse, Volatile Sulfur Compounds, Halitosis . 61Nutrition. 63Obesity and Inflammation. 69OralDNALabs – Bacterial DNA & Periodontal Susceptibility Testing . 71Pathogen Threshold Levels and Bacterial Risk . 71MyPerioPath Description/Clinical Utility of Periodontal Testing. 71MyPerioID PST Reference . 72Oral Hygiene Devices . 73Osteoporosis and Inflammation . 74Periodontal Disease and Inflammation . 74PerioProtectTM . 82Pharmacology – Subantimicrobial-Dose Doxycycline. 86Pregnancy, Periodontal Disease and Inflammation . 98Ulcers and Periodontal Disease . 104

Alzheimer’s Disease and Inflammation1.'s Disease and Periodontal Disease: The Inflammatory Link. [This study is designed to obtain data exploringthe role of periodontal disease in the pathogenesis of Alzheimer's disease. PD is a chronic infection resulting from theinteraction of periodontopathic bacteria and a host response. This interaction leads to localized and systemic inflammationcharacterized by elevation of inflammatory molecules such as IL-1ß, IL-6, IL8, TNF-Α, CRP; and high antibodies levels. PDthrough bacteria and/or inflammatory molecules may contribute to already elevated brain inflammatory molecules, thereforeincreasing risk of AD. We hypothesize that subjects with periodontal infections will be at an increased risk of developingAD. Objectives: We will determine whether a greater proportion of subjects developing AD had elevated levels of antibodytiters to Aa, Pg, Td and Tf (markers of periodontopathic bacteria) and of systemic inflammatory markers (IL-1ß, Il-6, TNF-Α,CRP and others) at baseline as compared control subjects. Methods: Stored plasma samples collected at baseline evaluation atthe NYU ADCC and the affiliated CBH from cohorts of subjects are used in a nested case-control. Cases (AD) and Controls(NL, MCI) will be compared for the existence of exposures at baseline (antibodies to Aa, Pg, Td, Tf, CRP and cytokines). Inthis project we characterized the study population using several parameters, such as age, gender and race. Results: Sincecytokine levels may differ based on the year of collection we characterized our study population by year. Our results showedthat in 1998, 1999, 2000 and 2001 age was statistically greater in AD subjects compared to controls. In 1997 and 2004 agedifference approached statistical significance. In contrast there was no significant difference in gender and race amonggroups. Conclusion: Our results showed that AD subjects are older than controls subjects suggesting that this parameter hasto be considered in the final study analysis.] Akhtar S, Kamer AR. IADR General Session, Miami, FL April ram/Paper119192.htmlInflammation and Alzheimer's disease: Possible role of periodontal diseases. [The molecular and cellular mechanismsresponsible for the etiology and pathogenesis of Alzheimer's disease (AD) have not been defined; however, inflammationwithin the brain is thought to play a pivotal role. Studies suggest that peripheral infection/inflammation might affect theinflammatory state of the central nervous system. Chronic periodontitis is a prevalent peripheral infection that is associatedwith gram-negative anaerobic bacteria and the elevation of serum inflammatory markers including C-reactive protein.Recently, chronic periodontitis has been associated with several systemic diseases including AD. In this article we review thepathogenesis of chronic periodontitis and the role of inflammation in AD. In addition, we propose several potentialmechanisms through which chronic periodontitis can possibly contribute to the clinical onset and progression of AD. Becausechronic periodontitis is a treatable infection, it might be a readily modifiable risk factor for AD.] Kamer AR, Craig RG. et al.Alzheimer’s & Dementia, Vol 4, Issue 4, pp242-250, July 2008. 5260(07)00621-8/abstractInflammation Linked to Alzheimer’s Disease. [Exposure to inflammation early in life quadruples one’s risk of developingAlzheimer’s disease, said researchers in a presentation on June 19 at the first Alzheimer’s Association InternationalConference on Prevention of Dementia in Washington. A research team led by Margaret Gatz, Ph.D. (a professor ofpsychology at the University of Southern California) and including researchers from the Karolinska Institute in Stockholm,Sweden, sifted through data on the 20,000 participants in the Swedish Twin Registry and found 109 "discordant" pairs oftwins in which only one twin had been diagnosed with dementia. Previous studies by Dr. Gatz and colleagues have shownthat Alzheimer’s disease is strongly genetic; if one twin has the disease, his or her identical twin has a 60 percent chance ofdeveloping it. Information about participants’ education, activities and health histories came from surveys they completed inthe 1960s, when the registry was created, as well as from hospital discharge records. The surveys included questions aboutloose or missing teeth. Researchers used the answers to the dental-related questions to build a crude indicator of periodontaldisease. They concluded that an inflammatory burden early in life, as represented by chronic periodontal disease, might havesevere consequences later. "If what we’re indexing with periodontal disease is some kind of inflammatory burden, then it isprobably speaking to general health conditions," said Dr. Gatz. If the link between inflammation and periodontal disease isconfirmed, researchers said it would add inflammatory burden to the short list of preventable risk factors for Alzheimer’sdisease. ] News - J Am Dent Assoc, Vol 136, No 8, 1084. nflammatory Markers and Cognition in well-functioning African-American and White Elders. [Serum markers ofinflammation, especially IL-6 and CRP, are prospectively associated with cognitive decline in well-functioning elders. Thesefindings support the hypothesis that inflammation contributes to cognitive decline in the elderly.] Yaffe, K, Lindquist K, et al.Neurology 2003;61:76-80. http://www

“Dr Ostler’s materials fulfill a much needed and essential role in dentistry today in helping dentists achieve a two–way referral system between the dentist and physician.” Norman R Thomas DDS “It is truly refreshing when once every decade or so a new idea is born that promises to revolutionize our profession.” Bill Blatchford DDS